Salts and Derivatives of Active Pharmaceutical Ingredients (API)
The salts of Active Pharmaceutical Ingredients (APIs) are compounds formed by the reaction of an acid with a base, resulting in an ionic equilibrium. These salts often improve the solubility and stability of APIs, facilitating their absorption in the body. API derivatives are chemical variants of an active ingredient that may have enhanced or modified properties to optimise therapeutic efficacy. API salts are used in the formulation of oral, injectable, and topical medications. Additionally, API derivatives can improve the pharmacokinetics of drugs, such as enabling controlled release of active substances.
At CymitQuimica, we provide API salts and derivatives with the necessary purity and quality for research and pharmaceutical formulation development.
Found 79381 products of "Salts and Derivatives of Active Pharmaceutical Ingredients (API)"
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2-Chloro-N,N-Dimethylethan-1-Amine Hydrochloride
CAS:Formula:C4H10ClNHClMolecular weight:107.58 : 36.46Nicotine Ditartrate Dihydrate
CAS:Formula:C10H14N2(C4H6O6)(H2O)Molecular weight:162.24 : 2(150.09) : 2(18.02)4-amino-N-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)benzenesulfonamide
CAS:Formula:C10H10N4O4SMolecular weight:282.274'-O-Methylcatechin
CAS:<p>Applications A metabolite of (+)-Catechin, a major polyphenol in many fruits and vegetables.<br>References Heptinstall, S., et al.: J. Cardiovas. Pharmacol., 47, S197 (2006), Gonzalez-Manzano, S., et al.: J. Agric. Food Chem., 57, 1231 (2009), Frank, J., et al.: J. Nut., 139, 58 (2009),<br></p>Formula:C16H16O6Color and Shape:NeatMolecular weight:304.293(4-Aminophenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one
CAS:Controlled Product<p>Applications AMDP3 (4-Aminophenyl)-4-methyl-4,5-dihydro-1H-pyridazin-6-one) acts as a cardiac troponin effecter, resulting in activation of cardiac muscle contractions. It’s an analogue to Levosimendan (L378000), positive inotropic agent with vasodilating activity.<br>References Sandell, E.-P., et al.: J. Cardiovasc. Pharmacol., 26, S57 (1995), Pagel, P.S., et al.: Cardiovasc. Drug Rev., 14, 286 (1996); Robertson, I. et al.: Biochem., 47, 7485 (2008);<br></p>Formula:C11H13N3OColor and Shape:Light Yellow To BrownMolecular weight:203.24Tiotropium Bromide
CAS:Formula:C19H22NO4S2·BrColor and Shape:White To Off-WhiteMolecular weight:472.423-Hydroxypyridine
CAS:Controlled ProductFormula:C5H5NOColor and Shape:White To Light BeigeMolecular weight:95.107-[(Hydroxy-2-thienyl-3-thienylacetyl)oxy]-9,9-dimethyl-3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide
CAS:Controlled Product<p>Applications 7-[(Hydroxy-2-thienyl-3-thienylacetyl)oxy]-9,9-dimethyl-3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane Bromide is an impurity in the synthesis of Tiotropium Bromide (T444850), a muscarinic receptor antagonist. Bronchodilator.<br>References Rodgers, T. et al.: J. Med. Chem., 20, 591 (1977); Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994); Donohue, J. F., et al.: Chest, 122, 47 (2002); Profita, M., et al.: Allergy, 60, 1361 (2005); Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006);<br></p>Formula:C19H22BrNO4S2Color and Shape:NeatMolecular weight:472.422-Oxo Clopidogrel Hydrochloride(Mixture of Diastereomers)
CAS:Controlled Product<p>Applications The essential intermediate metabolite from which the active metabolite of Clopidogel is formed.<br>References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)<br></p>Formula:C16H17Cl2NO3SColor and Shape:NeatMolecular weight:374.28Tacrolimus (FK506)
CAS:<p>Applications An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)<br></p>Formula:C44H69NO12Color and Shape:NeatMolecular weight:804.02trans-Nerolidol
CAS:Controlled Product<p>Applications Nerolidol (cas# 40716-66-3) is a terpene standard found in cannabis.<br></p>Formula:C15H26OColor and Shape:NeatMolecular weight:222.37Rivaroxaban
CAS:<p>Applications A novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C19H18ClN3O5SColor and Shape:White To BeigeMolecular weight:435.88Tacrolimus Hydrate
CAS:<p>Applications Tacrolimus Hydrate is a disease-modifying antirheumatic drugs (DMARDs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ogasawara, M., et al.: Mod. Rheumatol., 22, 831-836 (2012)<br></p>Formula:C44H69NO12·H2OColor and Shape:NeatMolecular weight:822.03Iopromide
CAS:<p>Applications Nonionic, injectable radio-contrast medium. Diagnostic aid (radiopaque medium).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Muetzel, W., et al.: Am.J. Neuroradiol., 4, 350 (1983), Dawson, P., et al.: Acta Radiol. Diagn., 25, 253 (1984),<br></p>Formula:C18H24I3N3O8Color and Shape:NeatMolecular weight:791.11rac-2-[(1-Amino-3-methyl)butyl]aniline
CAS:Controlled ProductFormula:C11H18N2Color and Shape:NeatMolecular weight:178.274’-Hydroxy Diclofenac-13C6 (Contain 3% unlabeled)
CAS:Formula:C6C8H11NO3Cl2Color and Shape:White To Light GreyMolecular weight:318.10Ticagrelor
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>Formula:C23H28F2N6O4SColor and Shape:WhiteMolecular weight:522.57Rivaroxaban Diol
CAS:Controlled Product<p>Applications A metabolite of Rivaroxaban (R538000).<br>References Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005), Roehrig, S., et al.: J. Med. Chem., 48, 5900 (2005), Biemond, B., et al.: Thromb. Haemost., 97, 471 (2007), Lang, D., et al.: Drug Metab. Dispos., 37, 1046 (2009),<br></p>Formula:C19H20ClN3O6SColor and Shape:White To Off-WhiteMolecular weight:453.9Edoxaban-d6
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Edoxaban-d6 is the isotope labelled analog of Edoxaban (E555520); an anticoagulant drug which acts as a direct factor Xa inhibitor.<br>References Ruff, C., et al.: Am. Heart J., 160, 635 (2010); Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)<br></p>Formula:C24H24D6ClN7O4SColor and Shape:Light Beige To Light BrownMolecular weight:554.09Treprostinil Ethyl Ester
CAS:Controlled ProductFormula:C25H38O5Color and Shape:NeatMolecular weight:418.566Ramipril-d5
CAS:Controlled Product<p>Applications A labelled antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite.<br>References Teetz, V., et al.: Arzneim.-Forsch., 34, 1399 (1984), Ruggenenti, P., et al.: Lancet, 352, (1998), Bosch, J., et al.: Br. Med. J., 324, 1 (2002),<br></p>Formula:C23H27D5N2O5Color and Shape:WhiteMolecular weight:421.54Riociguat
CAS:Controlled Product<p>Applications Riociguat is used in the treatment for pulmonary hypertension.<br>References Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);<br></p>Formula:C20H19FN8O2Color and Shape:NeatMolecular weight:422.4157Dronedarone Hydrochloride
CAS:<p>Stability Hygroscopic<br>Applications A drug used for the treatment of atrial fibrillation and atrial flutter in patients who have suffered cardiac arrhythmias.<br>References Singh, B., et al.: J. Cardiovas. Pharmacol., 52, 300 (2008), Hoy, S., et al.: Drugs, 69, 1647 (2009), Hohnloser, S., et al.: New Eng. J. Med., 360, 668 (2009),<br></p>Formula:C31H44N2O5S·ClHColor and Shape:NeatMolecular weight:593.22Bimatoprost
CAS:<p>Stability Light Sensitive<br>Applications Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.<br>References Brandt, J.D., et al.: Ophthalmology, 108, 1023 (2001), Woodward, D.F., et al.: J. Pharmacol. Exp. Ther., 305, 772 (2003), Quinones, R., et al.: J. Ocul. Pharmacol. Ther., 20, 115 (2004),<br></p>Formula:C25H37NO4Color and Shape:WhiteMolecular weight:415.57A77 1726-d4
CAS:Controlled Product<p>Applications The active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function.<br>References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)<br></p>Formula:C122H4H5F3N2O2Color and Shape:Off-WhiteMolecular weight:274.235-Chloro-2-thiophenecarboxylic Acid
CAS:Controlled Product<p>Applications 5-Chloro-2-thiophenecarboxylic Acid is a metabolite of Rivaroxaban (R538000).<br>References Brickner, S., et al.: J. Med. Chem., 39, 673 (1996), Sato, K., et al.: Eur. J. Pharmacol., 347, 231 (1998), Chang, P., et al.: IDrugs, 7, 50 (2004), Weinz, C., et al.: Drug Metab. Dispos., 37, 1056 (2009)<br></p>Formula:C5H3ClO2SColor and Shape:NeatMolecular weight:162.59Trandolapril Diketopiperazine
CAS:Controlled Product<p>Impurity Trandolapril EP Impurity D<br>Applications Trandolapril Diketopiperazine (Trandolapril EP Impurity D) is a metabolite of the antihypertensive Trandolapril (Ru44570) (T713500), an angiotensin-converting enzyme inhibitor.<br>References Bakshi, M., et al.: J. Pharm. Biomed. Anal., 28, 1011 (2002), Cedrowska, I., et al.: Acta Pol. Pharm., 60, 141 (2003), Singh, S., et al.: J. Pharm. Biomed. Anal., 41, 1037 (2006),<br></p>Formula:C24H32N2O4Color and Shape:NeatMolecular weight:412.52Probenecid-d14
CAS:Controlled Product<p>Applications Uricosuric.<br>References McKinney, S.E., et al.: J. Pharmacol. Exp. Ther., 102, 208 (1951), Israili, Z.H., et al.: J. Med. Chem., 15, 709 (1972), Al-Badr, A.A., et al.: Anal. Profiles Drug Subs., 10, 639 (1981), Cunningham, R.F., et al.: Clin. Pharmacokinet., 6, 135 (1981),<br></p>Formula:C13D14H5NO4SColor and Shape:NeatMolecular weight:299.45Ramipril (1 mg/mL in Methanol)
CAS:Formula:C23H32N2O5Color and Shape:Single SolutionMolecular weight:416.51Ivermectin
CAS:Controlled Product<p>Applications Semi-synthetic derivative of Abamectin; consists of a mixture of not less than 80% component B1a and not more than 20% component B1b. Anthelmintic (Onchocerca).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chabala, J.C., et al.: J. Med. Chem., 23, 1134 (1980); Campbell, W.C., et al.: Science, 221, 823 (1983); Bennett, J.L., et al.: Parasitol. Today, 4, 226 (1988); Plaisier, A.P., et al.: J. Infect. Dis., 172, 204 (1995);<br></p>Formula:C48H74O14·C47H72O14Color and Shape:White To Off-WhiteMolecular weight:1736.16Diclofenac Levomenthol Ester
CAS:Controlled ProductFormula:C24H29Cl2NO2Color and Shape:NeatMolecular weight:434.399Ramiprilat Acyl-β-D-glucuronide >65%
CAS:Controlled ProductFormula:C27H36N2O11Purity:>65%Color and Shape:NeatMolecular weight:564.58Allopurinol-d2
CAS:Controlled Product<p>Applications Labelled xanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>Formula:C52H2H2N4OColor and Shape:Light BrownMolecular weight:138.12Cyclosporin B
CAS:<p>Applications An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.A group of nonpolar cyclic oligopeptides with immunosupppressant activity.<br>References van Wartburg, A., et al.: Prog. Med. Chem., 25, 1 (1988), Jorgensen, K.A., et al.: Scand. J. Imunol., 57, 93 (2003), Vollenbroeker, et al.: Transplant. Proc., 37, 1741 (2005),<br></p>Formula:C61H109N11O12Purity:>80%Color and Shape:NeatMolecular weight:1188.584-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone
CAS:Controlled Product<p>Impurity Rivaroxaban Impurity E<br>Applications 4-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone (Rivaroxaban Impurity E) is an impurity of Rivaroxaban (R538000), which is a antithrombotic agent and a FXa inhibitor.<br>References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),<br></p>Formula:C13H17ClN2O3Color and Shape:NeatMolecular weight:284.74Dofetilide
CAS:Controlled Product<p>Applications Dofetilide is a potassium channel blocker. Antidysrhythmic drug.<br>References Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992); Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999); Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999);<br></p>Formula:C19H27N3O5S2Color and Shape:White Or BeigeMolecular weight:441.56Travoprost
CAS:<p>Stability Light Sensitive<br>Applications Travoprost is a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).<br>References (1) Hellberg, M.R., et al.: J. Ocul. Pharmacol. Ther., 17, 421 (2001) (2) Schuman, J.S., et al.: Am. J. Ophthalmol., 140, 242 (2005)<br></p>Formula:C26H35F3O6Color and Shape:Colourless To BeigeMolecular weight:500.55Cyclosporin AM 1 (>80%)
CAS:Controlled Product<p>Applications A cyclosporine metabolite specifically inhibits growth of renal cells in culture.<br>References Schultz, J.C.; et al.: Biochem. Pharma., 42, 1403 (1991), Johnson, B., et al.: Drug Metab. Dispos., 34, 556 (2006), Westley, I.S., Drug Metab. Dispos., 36, 46 (2008).<br></p>Formula:C62H111N11O13Purity:>80%Color and Shape:NeatMolecular weight:1218.61Febuxostat
CAS:<p>Applications Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formula:C16H16N2O3SColor and Shape:White To Off-WhiteMolecular weight:316.37Eltrombopag Olamine
CAS:<p>Stability Hygroscopic<br>Applications Eltrombopag is an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bussel, J., et al.: New Eng. J. Med., 357, 2237 (2007), Marsilje, T., et al.: Bioorg. Med. Chem. Lett., 18, 5259 (2008), Alper, P., et al.: Bioorg. Med. Chem. Lett., 18, 5255 (2008)<br></p>Formula:C25H22N4O4·2C2H7NOColor and Shape:Dark RedMolecular weight:564.63Diclofenac-d4
CAS:Controlled Product<p>Applications Labelled Diclofenac is a known nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004)<br></p>Formula:C142H4H7Cl2NO2Color and Shape:White To Light PinkMolecular weight:300.172,5-Ethyl Acetate Febuxostat
CAS:Controlled Product<p>Applications Febuxostat (F229000) is the parent compound for 2,5-Ethyl Acetate Febuxostat. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>Formula:C20H25NO5SColor and Shape:NeatMolecular weight:391.48Bosentan-d4
CAS:Controlled Product<p>Applications Labelled Bosentan (B675900). A mixed endothelin receptor antagonist. Used as a vasodilator. Antihypertensive.<br>References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)<br></p>Formula:C27H25D4N5O6SColor and Shape:NeatMolecular weight:555.645-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).<br>References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008<br></p>Formula:C8H11ClN2O2SColor and Shape:Light BrownMolecular weight:234.76-Hydroxy Warfarin β-D-Glucuronide D Disodium Salt Hydrate
CAS:Controlled Product<p>Applications 6-Hydroxy Warfarin β-D-Glucuronide Disodium Salt Hydrate, is a metabolite of Warfarin (W498500) in humans.<br>References Barbato, F., et al.: J. Pharm. Sci., 86, 225 (1997), Kavana, M., et al.: Biochemistry, 42, 10238 (2003), Franco, A., et al.: Environ. Toxicol. Chem., 28, 458 (2009),<br></p>Formula:C25H22Na2O11•xH2OColor and Shape:NeatMolecular weight:544.4218021-(4-(Trifluoromethoxy)phenyl)-2-thiourea
CAS:Controlled ProductFormula:C8H7F3N2OSColor and Shape:NeatMolecular weight:236.21
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