Proteins

<p>Noggin/NOG Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 23.1 kDa and the accession number is Q13253.</p>

<p>CDK2 is a member of the Ser/Thr protein kinase family.</p>

Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of

IL-23 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.

<p>CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune</p>

<p>PD-L1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Nucleoprotein/NP Protein (I116M, His), Biotinylated is expressed in Baculovirus insect cells with His tag.</p>

IFN gamma Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 16.7 kDa and the accession number is A0A7R8GUN6.

<p>IFN-beta Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 20 kDa and the accession number is P01574.</p>

TNF alpha Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.39 kDa and the accession number is P06804.

TIMP-1 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 21 kDa and the accession number is P01033.

<p>IL-2 Protein, Human, Recombinant (E. coli) is expressed in E. coli expression system. The accession number is P60568.</p>

IL-2 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4kDa and the accession number is P04351.

<p>Hepatocyte growth factor (HGF) is an important component of the pathophysiology of IR, with increased levels in most common IR conditions, including obesity.</p>

<p>FGF-13, also known as FGF17, belongs to the fibroblast growth factor (FGF) family.</p>

<p>IL-21 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.6 kDa and the accession number is Q9HBE4-1.</p>

<p>Glucocorticoid receptor agonist; anti-inflammatory; immunosuppressant</p>

<p>Androgen receptor antagonist</p>

<p>Budesonide is a glucocorticoid receptor drug that is used to treat inflammatory diseases of the lungs such as COPD, Crohn’s disease and asthma. This drug promotes anti-inflammatory genes such as interleukin-10. Budesonide aims to reduce inflammation in patients suffering from respiratory disease.</p>

<p>Glucocorticoid; anti-inflammatory; anti-asthmatic agent</p>

<p>Fulvestrant is an estrogen receptor antagonist that is used in the treatment of HR+ breast cancer. This drug can be used as monotherapy or in combination with Alpelisib. Fulvestrant works both by down-regulating and by degrading the estrogen receptor.</p>

<p>Synthetic estradiol derivative</p>

<p>Retinoic acid receptor alpha agonist; antineoplastic</p>

<p>Bezafibrate is an antilipemic agent that is used in the management of primary and secondary hyperlipidaemia. This mechanism of action for this drug is not well known however it is generally accepted that this drug is an agonist of Peroxisome proliferator-activated receptor (PPAR-alpha). This drug aids in lowering cholesterol level and triglycerides.</p>

<p>Androgen receptor antagonist; therapy for endometriosis</p>

<p>Tazarotene is an acetylenic retinoid that is used for the treatment of wrinkles, pigmentation of the skin and acne. Although, the mechanism of action for this drug is not yet fully understood, it is thought to bind to all three members of the retinoic acid receptor family. Studies have shown that this drug is associated with increased collagen production.</p>

<p>Inhibits EZH2 methyltransferase; antineoplastic</p>

<p>A potent antagonist of androgen receptor with IC50 value of 16 nM. Binds androgen receptors, thereby inhibiting nuclear translocation, DNA binding and transcriptional activation. Has therapeutic applications in non-metastatic, castration-resistant prostate cancer.</p>

<p>Androgen receptor antagonist; anti-cancer agent</p>

<p>PPARα transcription factor agonist</p>

<p>Canrenone is a steroidal antimineralcorticoid that is used as a diuretic. It has been shown to reduce blood pressure and increase urine volume. Also, this drug has shown to be effective in treating hirsutism in women.</p>

<p>Rho/MRTF/SRF mediated gene transcription inhibitor</p>

<p>Dual agonist of PPARα and PPARδ receptors</p>

<p>Tamoxifen is used as an antineoplastic agent in the treatment of breast cancer. Tamoxifen has been shown to be a competitive antagonist at the estrogen receptor, preventing estrogen from binding and activating it. <br>Tamoxifen is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Farnesoid X receptor agonist</p>

<p>Acitretin is a synthetic retinoid that can be used to treat skin conditions such as acne, psoriasis, and eosinophilic fasciitis. It has been shown to be an active inhibitor of squamous cell carcinoma in the laboratory. Acitretin works by inhibiting the excessive cell growth and keratinisation seen in psoriasis therefore reducing the thickening of the skin, plaque formation and scaling.</p>

<p>Estrogen receptor degrader; therapeutic use in breast cancer</p>

<p>Inhibitor of HIF1-α transcription factor and repressor of HIF1-α-regulated genes in adult and embryonic stem cell models as well as in tumoral cell lines. FM19G11 inhibits the expression of undifferentiating factors Oct4, Sox2, Nanog, and Tgf-α at transcriptional and protein level. FM 19G11 affects also epigenetic events by reducing histone acetylation and leading to repression of p300, a HIF-transcription activation co-factor.</p>

<p>Calcitriol is a steroid hormone, vitamin D metabolite and agonist of vitamin D receptor (VDR), also known as calcitriol receptor. It regulates absorption of calcium from intestine, resorption of bone calcium and calcium excretion via kidneys. This compound also controls cell cycle, promotes cell differentiation, triggers apoptosis and acts as anti-inflammatory factor within the tumor microenvironment. It has anti-proliferative effects in malignant epithelial cells and in tumour-derived endothelial cells (TDEC). Also, it is a potent inhibitor of retinal neoangiogenesis in vitro.</p>

<p>Corticosteroid; anti-inflammatory; treats dermatological conditions</p>

<p>Agonist of peroxisome proliferator-activated receptor δ/β (PPARδ/β). The compound activates the nuclear receptor PPARδ downstream signalling and affects hepatic AMPK levels. It boosts the activity of the lipin 1-PPARα-PPARγ coactivator 1 (PGC-1)-α pathway and increases hepatic fatty acid oxidation. It was reported that GW 501516 prevents high-fat diet induced hypertriglyceridemia.</p>

<p>Modulator of RBP protein; activator of sphingomyelinase; pro-apoptotic</p>

<p>Used to treat psoriasis; teratogenic</p>

<p>Tretinoin is a type of retinoic acid that can be used for the treatment of acne. It is a chemical inhibitor that binds to nuclear receptors and leads to an increase in apoptosis. This type of retinoic acid helps with cell detachment and increases shedding thus increasing cell turnover. Tretinoin has been shown to have antibacterial efficacy against Staphylococcus aureus, as well as synergistic effects when combined with other agents, such as cyclic lipopeptide antibiotics and quinolones. Additionally, Tretinoin is used in the research and treatment for promyelocytic leukaemia.</p>

<p>CYP17 lyase inhibitor; androgen receptor antagonist</p>

<p>Pioglitazone is a thiazolidinedione drug that is used in combination with diet change and exercise to treat glycemic levels in patients with type 2 diabetes mellitus. This drug is an agonist of peroxisome proliferator-activated receptor-gamma and increases glucose uptake. In animal studies, Pioglitazone has shown to have anti-inflammatory properties.</p>

<p>Mineralocorticoid (aldosterone) receptor antagonist</p>

<p>Glucocorticoid receptor agonist</p>

<p>Antagonist of androgen receptor</p>

<p>Eplerenone is a drug known as an aldosterone antagonist. It is a type of potassium-sparing diuretic that is used to treat chronic heart failure and high blood pressure, particularly for patients with resistant hypertension due to elevated aldosterone. It does this by blocking the activity of the enzyme that produces aldosterone, which increases levels of sodium and water in the body. This leads to a decrease in blood pressure.</p>

<p>Full antagonist to the estrogen beta receptor (ERβ) with 36-fold selectivity for the β over α receptor. ERβ is a tumour suppressor and PHTPP is a useful tool to study the biology of estrogen-dependent tumours.</p>

<p>LGD 3303 is an investigational selective androgen receptor modulator (SARM), which is a compound designed to selectively interact with androgen receptors in the body. SARMs like LGD 3303 are researched for their potential to mimic anabolic activity with reduced androgenic effects compared to traditional anabolic steroids. LGD 3303 acts by binding to androgen receptors, and it is believed to promote muscle growth and bone health without significantly affecting other tissues.</p>

<p>Inhibits binding of endogenous ligands to peroxisome proliferator-activated receptor gamma (PPARγ), blocking its activation and transcription. Unlike orthosteric antagonists GW 9662 and T 0070907, SR 16832 blocks both allosteric and orthosteric activation of PPARγ.</p>

<p>Pioglitazone is a thiazolidinedione drug that is used in combination with diet change and exercise to treat glycemic levels in patients with type 2 diabetes mellitus. This drug is an agonist of peroxisome proliferator-activated receptor-gamma and increases glucose uptake. In animal studies, Pioglitazone has shown to have anti-inflammatory properties.</p>

<p>Bexarotene is a retinoid and antineoplastic agent that is used for the treatment of solid tumours and t-cell lymphomas. It inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin and research has shown that it induces tumor regression in vivo in some animal models.</p>

<p>Spironolactone is an aldosterone receptor antagonist that is used to treat hypertension, heart failure and edema. This drug binds to mineralocorticoid receptors and acts as an aldosterone antagonist. Spironolactone promotes sodium and water excretion and potassium retention. It also activates pro-inflammatory pathways.</p>

<p>Estrogen receptor alpha (ERα) agonist</p>

<p>Gestodene is a progestogen hormonal contraceptive. It is an agonist of the progesterone receptor. Additionally, this drug is used in menopausal hormone therapy.</p>

<p>As a synthetic trifluorinated glucocorticoid receptor agonist, Fluticasone exhibits anti-inflammatory properties. When binding to and activating glucocorticoid receptors, Fluticasone initiates the activation of lipocortin which inhibits cytosolic phospholipase A2. Consequently, the cascade of inflammatory mediator synthesis reactions are inactivated and the production of inflammatory cells namely mast cells, dendritic cells, macrophages and eosinophils and the cytokines that they produce are greatly reduced.It is this anti-inflammatory role which has enabled Fluticasone to successfully treat conditions such as asthma, emphysema, allergic rhinitis and atopic dermatitis. It has also been seen to increase anti-inflammatory effects of annexoin-1 and mitogen-activated kinase phosphatase-1; reduce mucus gland secretions and increase the number of beta-2 receptors on smooth muscles of the airways.<br>Fluticasone is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Agonist of estrogen-related receptors ERRβ and ERRγ. In primary mouse myotubes, GSK 4716 activated ERRβ/γ transcriptional activity and increased expression of mitochondrial genes.</p>

<p>Potent inverse agonist of peroxisome proliferator-activated receptor PPARβ and PPARδ with IC50 value of 27 nM. In mouse myoblasts, DG 172 enhanced recruitment of transcriptional corepressor and down-regulated transcription of PPARβ/δ target gene Angptl4. DG 172 also possess a PPARβ/δ-independent activity on bone marrow cells and promotes dendritic cell differentiation.</p>

<p>Pan-EGFR inhibitor (HER1, HER2 and HER4); antineoplastic</p>

<p>Nilutamide is an antineoplastic agent that is used to treat prostate cancer. This drug is an androgen receptor antagonist and binds with androgen receptors thus blocking its action and resulting in growth arrest.</p>

<p>Progesterone receptor antagonist; contraceptive agent</p>

<p>The racemic mixture of cis-trans isomers of clomiphene citrate The cis-isomer, now termed zuclomiphene, is more estrogenic, while the trans-isomer, presently known as enclomiphene, is relatively anti-estrogenic. The racemic mixture utilized for ovulation induction typically contains 38% zuclomiphene and 62% enclomiphene.</p>

<p>Rosiglitazone is an anti-diabetic drug that belongs to the thiazolidinedione class of drugs. It is used as an adjunct to diet and exercise to maintain glycaemic control in type 2 diabetes. This drug acts as a selective agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of these receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization.</p>

<p>Endogenous non-toxic agonist of the aryl hydrocarbon receptor (AhR) with immunosuppressive activity. The compound also inhibits the nuclear translocation of Smad2/3/4 leading to aberrant Transforming Growth Factor-β1 (TGFβ1) signaling. It inhibits myofibroblast differentiation and is a potential anti-scarring agent.</p>

<p>Ciprofibrate is a fibrate drug that is used as a lipid-lowering agent. This drug reduces both LDL and VLDL cholesterol levels in the blood. Ciprofibrate works by reducing the production of triglycerides in the liver and increasing the removal of triglycerides from the blood. This drug is an agonist of peroxisome proliferator-activated receptor alpha.</p>

<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Raloxifene is an estrogen receptor modulator that is used in the prevention and treatment of osteoporosis and breast cancer in postmenopausal women. This drug acts as an estrogen agonist and antagonist. Also, Raloxifene has antiproliferative effects.</p>

<p>Rosiglitazone is an anti-diabetic drug that belongs to the thiazolidinedione class of drugs. It is used as an adjunct to diet and exercise to maintain glycaemic control in type 2 diabetes. This drug acts as a selective agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of these receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization.</p>

<p>Flutamide is an antiandrogen drug that is used in the treatment of metastatic prostate carcinoma. This drug is a non-steroidal drug that works by blocking the binding of androgens to their receptors in the body, which helps to inhibit the growth and spread of prostate cancer cells.</p>

<p>Glucocorticoid receptor agonist; anti-inflammatory</p>

<p>PPARγ antagonist</p>

<p>UGCG Protein, Human, Recombinant (His) is expressed in E.</p>

<p>The B subunit is responsible for the binding of the holotoxin to specific receptors on the target cell surface, such as globotriaosylceramide (Gb3) in human</p>

<p>Acts as a coactivator of transcriptional activity.</p>

<p>Acts as histone chaperone in nucleosome assembly.</p>

<p>Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.</p>

<p>GJA1 Protein, Human, Recombinant (His) is expressed in E.</p>

<p>Along with McjC, necessary and sufficient to process the inactive microcin J25 (McjA) precursor into the active peptide.</p>

<p>Plays an important role in galactose metabolism.</p>

<p>Could be a guanine-nucleotide releasing factor.</p>

<p>N/A.</p>

<p>Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters.</p>

<p>PARP4 Protein, Human, Recombinant (His) is expressed in E. coli.</p>

<p>Cleaves peptides in various proteins in a process that requires ATP hydrolysis.</p>

<p>PYCR1 Protein, Human, Recombinant (His &amp; SUMO) is expressed in E.</p>

<p>Pore-forming toxin that specifically binds sphingomyelin in the plasma membrane of various cells.</p>

<p>Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral.</p>

<p>Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.</p>

<p>Prevents the establishment of the cellular antiviral state by inhibiting TRIM25-mediated DDX58 ubiquitination, which normally triggers the antiviral</p>

<p>LASP1 Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag.</p>

<p>Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose.</p>

<p>CYP26B1 Protein, Human, Recombinant (His) is expressed in E.</p>

<p>S100A4 Protein, Rat, Recombinant (His &amp; Myc) is expressed in E.</p>

<p>Wnt5a Protein, Human, Recombinant (His) is expressed in E. coli.</p>

<p>Actin-binding protein.</p>

<p>During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation.</p>

<p>SH3BGRL Protein, Human, Recombinant (GST &amp; His) is expressed in E. coli.</p>

<p>Single-stranded DNA-binding protein that participates in viral DNA replication, formation of concatemers, recombination and repair of double-stranded breaks.</p>

<p>Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</p>

<p>Leukocidin causes cytotoxic changes in polymorphonuclear leukocytes.</p>

<p>Encapsidates the negative strand viral RNA, protecting it from nucleases.</p>

<p>Not known; suppressor of MIF2 mutations.</p>

<p>Intrinsic membrane protein of small synaptic vesicles.</p>

<p>Exerts antimicrobial activity against both Gram-positive and negative bacteria at concentrations of 2-16 micro molar.</p>