Metabolismo

<p>Eflucimibe (L0081), an ACAT inhibitor, treats cardiovascular, endocrine, and metabolic diseases, and helps in atherosclerosis and hyperlipidemia research.</p>

<p>Bipolamine G is an antibacterial polyketide alkaloid [1] .</p>

<p>Kouitchenside G, a natural compound extracted from Swertia kouitchensis, demonstrates inhibitory activity against α-Glucosidase, showcasing an IC 50 value of</p>

<p>ACAT-IN-7 inhibits ACAT enzyme; blocks NF-κB mediated transcription.</p>

<p>Nordoxepin hydrochloride (Desmethyldoxepin hydrochloride) has antidepressant activity and is useful for studying depression and peptic ulcer disease.</p>

<p>'(25R)-12α-Hydroxyspirost-4-en-3-one is a minor metabolite resulting from Nocardia globerula's metabolization of Hecogenin [1].'</p>

<p>DepNA, a nitroaniline fatty acid amide, measures FAAH activity by releasing yellow dye p-nitroaniline upon exposure, detectable via spectrophotometer.</p>

<p>Hydroxypyruvic acid: a metabolic intermediate for glycine, serine, threonine; used by serine-pyruvate aminotransferase, glyoxylate reductase.</p>

<p>Sphingomyelin phosphodiesterase, a hydrolase, converts sphingomyelin into phosphocholine and ceramide, affecting cellular processes and cholesterol metabolism.</p>

<p>ND-011992: Quinazoline inhibitor of E. coli respiratory enzymes; IC50s: 0.12-2.47 μM; potential tuberculosis research.</p>

<p>Xanthine Oxidase-IN-9 (also known as Icarisids E or Compound 2) effectively inhibits xanthine oxidase (XOD) with an IC50 value of 31.81 μM [1].</p>

<p>13,14-dehydro-15-cyclohexyl Carbaprostacyclin, a stable PGI2 analog, impedes ADP-induced platelet aggregation; ED50 ~40 nM in PRP, 77 nM in washed platelets.</p>

<p>13-cis-Retinyl acetate: active 13-cis isomer of Retinyl acetate, metabolite of vitamin A.</p>

<p>Senecionine acetate, a pyrrolizidine alkaloid, blocks Ca2+ storage in cells by inactivating sulfhydryl groups.</p>

<p>Kazusamycin A is a new antitumor antibiotic.</p>

Fmoc-Cys-Asp10 (TFA) is a non-releasable oligopeptide linker involved in synthesizing releasable oligopeptide linkers. These releasable linkers are used to deliver drugs to fracture-targeting oligopeptides, thereby reducing the healing time of fractured femurs.

Anticanceragent 232 (compound 12f) is a sugar hybrid designed from 1-azide glycosides derived from d-glucose, d-galactose, and d-mannose. The IC50 values for this compound are 1.05 μM against MCF-7 cells and 18.03 μM for MDA-MB231 cells.

Dimethylpropiothetin hydrochloride (s,s-Dimethyl-β-propionic acid thetine) represents the hydrochloride variant of dimethylpropiothetin. This compound is extractable from marine algae and serves as a precursor to dimethylsulfide (DMS). Additionally, it plays a role in the osmoregulation processes within Hymenomonas carterae.

RORγ Allosteric Probe-1 (Compound 12h), with excitation and emission wavelengths of 490/524 nm respectively, serves as an allosteric fluorescent probe for investigating RORγ allosteric inhibitors and the function of RORγ [1].

<p>OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.</p>

<p>Desmethylene Paroxetine hydrochloride is a non-conjugated metabolite of Paroxetine, a catechol intermediate.</p>

<p>GP4G, from Artemia salina cysts, regulates epithelial cells &amp; hair growth.</p>

<p>PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligands to VH032 VHL to induce endogenous SGK3 degradation.</p>

<p>'(S)-ICMT-IN-3 (compound ent 1-27) is an ICMT inhibitor with an IC50 value of 0.23 μM [1].'</p>

Purine nucleoside phosphorylase deficiency impairs T cells; it breaks bonds in DNA components, releasing bases and ribose phosphate.

<p>Vitamin D4 is the active Vitamin D analog.</p>

<p>2,8-Dihydroxyadenine causes urinary crystals, kidney stones, and helps diagnose APRT deficiency.</p>

<p>Nampt-IN-10 trihydrochloride, a NAMPT inhibitor, is effective on A2780 &amp; CORL23 cells (IC50: 5/19 nM); potential ADC payload.</p>

(R)-Mephenytoin ((–)-Mephenytoin) is the the R-enantiomer of Mephenytoin which is an anticonvulsant agent.

<p>Myoregulin (MLN peptide), a regulin family member, modulates muscle performance through intracellular calcium handling.</p>

<p>MK-4074 is a liver-specific acetyl-CoA carboxylase ACC1 and ACC2 inhibitor(IC50 of 3 nM).</p>

<p>DPPS is a negatively charged diacyl-phospholipid used to create cationic vesicles and liposomes.</p>

<p>HIF-1 alpha (556-574) TFA is a 19-residue fragment of hypoxia-inducible factor-1 (HIF-1), which serves as the master regulator of oxygen homeostasis [1].</p>

<p>Aclimostat (ZGN-1061) is a MetAP2 inhibitor with strong preclinical results, improving obesity-related metrics and gene expression.</p>

<p>DSPE-PEG2000-K237 is a PEG compound consisting of DSPE and the KDR-targeting peptide (K237). K237 functionally disrupts the interaction between VEGF and KDR receptors, resulting in significant biological effects such as inhibition of angiogenesis and tumor growth. DSPE-PEG2000-K237 is applicable in drug delivery.</p>

<p>ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.</p>

<p>MAGL-IN-8 (compound 13) serves as a reversible inhibitor of monoacylglycerol lipase (MAGL), exhibiting an inhibitory concentration half-maximal (IC50) value of</p>

<p>α-Glucosidase-IN-32 (compound f26) is a reversible, noncompetitive inhibitor of α-glucosidase that is orally active and exhibits an IC50 of 3.07 μM.</p>

<p>hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8</p>

<p>α-Glucosidase-IN-42 (Compound 26), a 9-O-berberrubine carboxylate derivative, exhibits potent α-glucosidase inhibitory activity with an IC50 value of 1.61 μM</p>

<p>Octapeptide-2 is a bioactive peptide known for its hair growth-promoting effects and is reported to be used as a cosmetic ingredient [1].</p>

(24R)-MC 976 is a derivative of Vitamin D3.

<p>Myristoyl coenzyme A lithium, a compound marked by lithium in its myristoylated form, plays a crucial role in the biochemical mechanism of myristoylation, essential for both viral functionalities and tumor growth in colon epithelial cells. This process is predominantly governed by N-myristoyltransferase (NMT), which exhibits increased activity in colon epithelial tumors compared to normal cells. The activity of NMT is significantly influenced by the reduction of coenzyme A (CoA), a vital regulator that enhances NMT's ability to induce myristoylation, unlike its oxidized form which impedes this process. Consequently, Myristoyl coenzyme A serves as an inhibitor to the demyristoylation activity, showcasing its potential as an anticancer and antiviral agent.</p>

<p>FABP4-IN-2 (Compd 10g), a selective and orally active FABP4 inhibitor, exhibits K i values of 0.51 μM for FABP4 and 33.01 μM for FABP3, demonstrating its</p>

<p>α-Glucosidase-IN-89 (8g) is an inhibitor of α-glucosidase, with an IC50 of 0.5 μM and a Ki of 0.46 μM.</p>

<p>α-Glucosidase-IN-33 (compound 7c), with an IC50 of 2.39 μM, is a potent inhibitor of α-glucosidase and is relevant in research on type 2 diabetes and</p>

<p>γ-Glutamylserine TFA (γ-Glu-Ser TFA) serves as a calcium receptor activator and is utilized in research focused on Parkinson's disease, diabetes, and obesity [1</p>

<p>A4333, a biotinylated derivative of A3373, selectively inhibits Phospholipase D1 (PLD1) while sparing PLD2.</p>

<p>FS-2 is a potent, specific inhibitor of L-type CaV channels, effectively impeding high K+ or glucose-induced L-type Ca2+ influx in RIN beta cells [1].</p>

<p>ω-Hexatoxin-Hv1a, a neurotoxin extracted from the venom of the spider Hadronyche versuta, inhibits voltage-gated calcium channels [1] [2].</p>

<p>1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides .</p>

<p>hCAI/II/IV-IN-28(WAY-638358) is a potent carbonic anhydrase inhibitor with potential anticonvulsant activity.</p>

<p>Maltodextrin (DE 16.5-19.5) is an inactive pharma excipient that enhances drug stability, solubility, and processing.</p>

<p>ARL67156 trisodium hydrate inhibits ecto-ATPase, NTPDase1, NTPDase3, NPP1 (Kis 11-18µM), for calcific valve disease, asthma research.</p>

<p>ROS-IN-2 (compound 85), a seco-lupane triterpenoid derivative, inhibits reactive oxygen species (ROS) production and shields mitochondria from oxidative damage</p>

<p>(-)-Dihydroguaiaretic acid is a useful organic compound for research related to life sciences and the catalog number is T126154.</p>

<p>β-Cryptoxanthin is isolated from Satsuma mandarin orange with an anti-stress effect. It is an oxygenated carotenoid and an antioxidant.</p>

<p>PROTAC PTPN2 degrader-2 (example 187B) TFA is a potent degrader of Protein Tyrosine Phosphatase Non-receptor Type 2 (PTPN2), with potential applications in</p>

<p>'10'-Desmethoxystreptonigrin antibiotic derived from streptonigrin combats various bacteria and cancer cells, and inhibits p21ras farnesylation (IC50 = 21 nM).</p>

<p>MAGL-IN-10, a reversible monoacylglycerol lipase (MAGL) inhibitor, exhibits favorable ADME properties and low in vivo toxicity.</p>

<p>Ozolinone, an etozoline metabolite, is a loop diuretic treating hypertension and edema.</p>

<p>trans-5-Hydroxyferulic acid is a useful organic compound for research related to life sciences. The catalog number is T126397 and the CAS number is 110642-42-7.</p>

<p>Ovotransferrin (328-332), with an IC50 of 20 μM, exhibits protective activity against hypertension by inhibiting the Angiotensin-Converting Enzyme (ACE) and</p>

<p>BBOX-IN-1 (compound 58) is a potent BBOX inhibitor with an IC50 of 0.02 μM, and it is applicable in research related to triple-negative breast cancer (TNBC).</p>

<p>'(2-Hydroxyethoxy)acetic acid is 1,4-Dioxane's primary urine metabolite and a reliable short-term biomarker.'</p>

<p>α-Glucosidase-IN-36 (compound 5g) is a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 6.69 ± 0.18 μM and inhibition constants Ki and Kis of 1.65</p>

<p>9(S)-HpOTrE, a product of 5-LO on α-linolenic acid, transforms into colnelenic acid and 9,16-dihydroperoxy acid; it inactivates LOs through epoxide formation.</p>

<p>Myoregulin (MLN peptide) TFA, belonging to the regulin family, is a regulator of muscle performance through modulation of intracellular calcium dynamics.</p>

<p>VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α and</p>

<p>Alternaphenol B2, a selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1m), is sourced from the coral-derived fungus Parengyodontium album SCSIO</p>

<p>Sp-cAMPS triethylamine activates PKA I/II and inhibits PDE3A (Ki 47.6µM), binds PDE10 GAF (EC50 40µM).</p>

<p>hCAIX/VII-IN-1 is a selective inhibitor of human carbonic anhydrase isoforms VII and IX.</p>

<p>Lysinoalanine is an unusual amino acid, not a dipeptide, which exists in proteins of cooked foods. It is formed in food that is heated or treated with alkali.</p>

Methiocarb is a carbamate insecticide acting as a reversible AChE or ChE inhibitor, inducing oxidative stress in rats.

<p>Caloxin 3A1, a biologically active peptide, is a member of the caloxins, which are inhibitors of the extracellular plasma membrane (PM) Ca2+ pumps.</p>

<p>Rawsonol is a HMG-CoA reductase inhibitor from the tropical green alga Avrainvillea rawsoni.</p>

<p>α-Glucosidase-IN-24 (Compound 13), an α-Glucosidase inhibitor, exhibits an IC50 value of 451 μM and can be derived from Swertia kouitchensis [1].</p>

<p>5,6-Dihydroabiraterone, a metabolite of Abiraterone, is a strong, irreversible CYP17A1 inhibitor, effective in CRPC.</p>

<p>DMPG sodium is a phospholipid analog commonly used in the preparation of artificial lipid bilayers to mimic the structure and function of biological membranes.</p>

<p>Anti-ANGPTL4 Antibody is a humanized antibody targeting ANGPTL4.</p>

<p>Ganoderenic acid K, from Ganoderma lucidum, inhibits HMG-CoA reductase with an IC50 of 16.5 μM.</p>

<p>CAY10640 (sEH inhibitor-1) is a potent, orally active, water-soluble epoxide hydrolase (sEH) inhibitor that inhibits sEH in humans and mice with IC50s of 0.4</p>

<p>BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.</p>

<p>13-epi-12-oxo PDA is a lipoxygenase derivative of α-linolenic acid in green plant leaves, often isomerizing during extraction and storage.</p>

<p>PTP1B-IN-13 inhibits PTP1B at an allosteric site with 1.59 μM IC50.</p>

<p>2-NP-AMOZ, a 2-nitrophenyl AMOZ, detects protein-bound AMOZ, a Furaltadone metabolite.</p>

<p>Clostripain is a protease from Clostridium with esterase, amidase activities, targeting arginine.</p>

<p>BNTA is a potent extracellular matrix (ECM) modulator.</p>

<p>IGUANA-1: selective ALDH1 B1 inhibitor, IC50=30 nM, hinders SW480 cell growth with IC50=2.46/0.39 μM in adherent/spheroid forms, for cancer research.</p>

<p>Morin 3-O-β-D-glucopyranoside, a natural flavonoid, exhibits antifungal, anticancer, and antioxidant properties.</p>

<p>Atagabalin HCl is a novel voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) ligand that affects slow-wave sleep and can be used to treat insomnia.</p>

<p>EGCase II is an enzyme breaking down the glycan-ceramide bond in glycosphingolipids.</p>

MSNBA inhibits GLUT5 fructose uptake (KI: 3.2±0.4 μM) in MCF7 cells, serving as a potent GLUT5 probe.

<p>Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。</p>

<p>D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase (BiGalHexNAcP), belonging to the CAZy glycoside hydrolase family GH112, plays a pivotal role in</p>

<p>RORγt inhibitor 1 is a RORγt allosteric inhibitor with an IC 50 value of 1 nM.</p>

<p>R 80123 is a highly selective inhibitor of phosphodiesterase,is the Z-isomer of R 79595</p>

<p>Z-Thioprolyl-Thioproline, a bovine brain PEP inhibitor; IC50=16 µM, Ki=37 µM, used in cognitive disorder research.</p>

<p>Thymopentin acetate: an immunomodulatory peptide from thymus cells with a 30-sec half-life, boosts T-cell production from hESCs.</p>

<p>4-Hydroxy hexenal (4-HHE) are toxic aldehydes that are enriched in flavored gravies and cooking oils with storage time and elevated temperatures.</p>