Metabolismo

<p>TLK117 is an inhibitor of GSTs that reduces the severity of pulmonary fibrosis and may be used in the study of idiopathic pulmonary fibrosis.</p>

<p>Cyhalofop-butyl is an ACCase (acetyl-coenzyme A carboxylase) inhibitor and herbicide that suppresses plant lipid synthesis at the meristematic level.</p>

<p>(9Z,12E)-Tetradecadien-1-yl acetate is the main component of the pheromone of insects Plodia Interpunctella and Ephestia Kuehniella, and cereal pests.</p>

<p>Migalastat hydrochloride (GR181413A) 是一种可口服且具有有效和竞争性的 α-galactosidase A 抑制剂，可促进α-半乳糖苷酶A向溶酶体的运输，可用于研究法布里病。</p>

<p>alpha-Amyl cinnamaldehyde is a common additive in the perfume and cosmetic industry as an aroma substance.</p>

<p>1,10-Diiododecane: Crosslinks polygalacturonic acid, alkylates bis-cryptophanes, produces decane at 20°C.</p>

<p>Iodoacetic anhydride is a biologically active compound known for its enzyme inhibitory properties. It participates in the modification of proteins and is extensively used in biochemical research and compound development. Additionally, Iodoacetic anhydride is employed in the synthesis of various biologically active molecules, demonstrating its versatility as a chemical reagent.</p>

<p>1,3,4,6-Tetrachloro-3α,6α-diphenylglycouril is recognized for its enzyme inhibitory properties within biological organisms. It is employed as a potential anti-cancer agent in compound development. Additionally, it plays a role in the modulation of cellular signaling pathways, making it useful for cellular biology research. This compound is considered effective in exerting biological activity under specific conditions.</p>

<p>Aglepristone: synthetic steroid, antiprogestogen, some antiglucocorticoid effect, used as abortifacient in animals.</p>

<p>Lomitapide Mesylate (BMS-201038 mesylate) is a methanesulfonic acid form of lomitapide, a small molecule inhibitor of microsomal triglyceride transfer protein.</p>

<p>Fmoc-Lys(Z)-OH is a lysine derivative with an Fmoc protecting group, widely used in biochemical experiments and drug synthesis research.</p>

Vitamin K1-d4 is a deuterated compound of Vitamin K1. Vitamin K1 has a CAS number of 84-80-0. Vitamin K1 (Phylloquinone) is a naturally-occurring vitamin. Vitamin K1 is essential for blood clotting, bone and vascular metabolism.

VitaminA-d6 is a deuterated compound of VitaminA. VitaminA has a CAS number of 68-26-8.

<p>Hydroxylamine hydrochloride(Hydroxylammonium chloride) is a selective and potent monoamine oxidase (MAO) inhibitor with inhibitory effects on platelet aggregation.</p>

<p>N,N-Dimethylglycine hydrochloride (N-Methylsarcosine hydrochloride) is a dietary supplement.</p>

<p>(+)-Ketoconazole ((+)-R 41400) is a antifungal compound, a CYP3A4 inhibitor, used for the study of fungal infections and seborrheic dermatitis.</p>

<p>DL-α-tocopherol acetate (Vitamin E acetate) is a vitamin E derivative used as a vitamin E supplement in poultry feed.</p>

<p>(E)-3-(p-Tolyl)acrylaldehyde is a cinnamaldehyde and endogenous metabolite commonly used as a food flavoring with inhibitory effect on Coxsackievirus B3</p>

<p>p-Tolualdehyde is a RIFM flavor that shows inhibition of mushroom tyrosinase.</p>

Protoporphyrin IX disodium, as a radiation sensitizer, enhances the production of ROS and induces DNA damage even under hypoxic conditions. It also acts as a photosensitizer, undergoing direct degradation through photobleaching upon light exposure. This compound accumulates in rat tumor cells following administration of 5-aminolevulinic acid (5-ALA). When activated with a peak wavelength of 405 nm, Protoporphyrin IX disodium selectively improves basal cell carcinoma. It shows promise in pharmacological research of sonodynamic and photodynamic therapy for cancers such as bladder cancer and nodular basal cell carcinoma.

<p>Nalpha-Fmoc-L-Glutamine (Fmoc-Gln-OH) is a glutamine derivative.</p>

<p>Albendazole sulfone is a metabolite of albendazole with antiparasitic and anthelmintic activity, exhibiting cytotoxicity HuH-7</p>

<p>T-2307 is an antibiotic commonly used against Candida, exhibiting broad-spectrum antifungal activity against most pathogenic fungi in vitro and in vivo</p>

<p>N,N'-Dimethylarginine-d6 (SDMA-d6) is the deuterated form of N,N'-Dimethylarginine.</p>

<p>N-Hippuryl-His-Leu hydrate (N-Benzoyl-Gly-His-Leu hydrate) is an ACE substrate and can be used as a model peptide for measuring ACE-I inhibitory activity.</p>

<p>11(Z),14(Z),17(Z)-Eicosatrienoic acid is an unsaturated fatty acid capable of being found in Saccharomyces cerevisiae (KD115).</p>

<p>Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.</p>

NeurokininBromoenol lactone ((6E)-Bromoenol lactone) is an iPLA2β and serine protease inhibitor that attenuates nicotine-induced breast cancer cell proliferation.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse GROα/CXCL1. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse GROα/CXCL1. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse GROα/CXCL1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse GROα/CXCL1. You can calculate the concentration of Mouse GROα/CXCL1 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IL-6. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human IL-6. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human IL-6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human IL-6. You can calculate the concentration of Human IL-6 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse TNF-α. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse TNF-α. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse TNF-α, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse TNF-α. You can calculate the concentration of Mouse TNF-α in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IFN-γ. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse IFN-γ. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IFN-γ, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse IFN-γ. You can calculate the concentration of Mouse IFN-γ in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human VEGF-A. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human VEGF-A. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human VEGF-A, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human VEGF-A. You can calculate the concentration of Human VEGF-A in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-6. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse IL-6. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IL-6, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse IL-6. You can calculate the concentration of Mouse IL-6 in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human IFN-α. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human IFN-α. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human IFN-α, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human IFN-α. You can calculate the concentration of Human IFN-α in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to TGF-β1. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for TGF-β1. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain TGF-β1, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of TGF-β1. You can calculate the concentration of TGF-β1 in the samples by comparing the OD of the samples to the standard curve.

<p>JNJ-42165279 selectively inactivates FAAH without notably affecting other enzymes, ion channels, receptors, or CYPs/hERG at 10 μM.</p>

<p>ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis.</p>

<p>TM5275 sodium (TM5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).</p>

<p>Minaprine dihydrochloride: reversible MAO-A inhibitor, mild on acetylcholinesterase, used for depression.</p>

<p>2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.</p>

<p>Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM</p>

<p>Aramchol (C20-FABAC), a mix of arachidic &amp; cholic acid, lessens cholesterol crystallization &amp; dissolves crystals in bile.</p>

<p>LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR.</p>

<p>L-Propargylglycine ((S)-Propargylglycine) is an inhibitor of the enzyme.</p>

<p>Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in</p>

<p>Nidufexor is an agonist for the farnesoid X receptor (FXR).</p>

<p>NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1, IC50 = 7 nM) and a weak inhibitor of hALDH1A2, hALDH1A3, hALDH2, hALDH3A1 with</p>

<p>D-Histidine is an enantiomer of L-histidine. L-Histidine is an inhibitor of mitochondrial glutamine transport and also an essential amino acid for infants.</p>

<p>Chondroitin sulfate is an important structural component of cartilage and has been used as a dietary supplement for the treatment of joint discomfort.</p>

<p>KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor.</p>

<p>Hydramethylnon (AC217300) is an insecticide primarily. Hydramethylnon is used for fire ants.</p>

<p>PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor.</p>

<p>Lanthanum(III) chloride blocks divalent cation channels, useful for biochemical research.</p>

<p>Dichlorphenamide disodium: an oral carbonic anhydrase inhibitor that lowers eye pressure, promising for glaucoma study.</p>

<p>(Rac)-Brassinazole is a phytohormone with essential roles in plant growth and development, including the promotion of stem elongation and cell division.</p>

<p>IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.</p>

<p>FEMA 4774 (S9632) is a positive allosteric modulator of T1R2/T1R3. FEMA4774 shows obvious enhancement of the sweetness of sucrose in sensory evaluation tests</p>

<p>LDHA-IN-4 (AZ33) is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA expressed in E.coli BL21 (DE3) by SPR analysis with an active value of 93 nM.</p>

<p>Roflumilast N-oxide is an inhibitor of PDE type 4.</p>

<p>HET0016: potent, selective 20-HETE synthase/CYP450 inhibitor; IC50s: 17.7-20.6 nM; inhibits angiogenesis, tumor growth.</p>

<p>Tipifarnib (IND 58359), a quinolinone, inhibits farnesyl transferase, blocks Ras activation, arrests cell growth, and curbs angiogenesis.</p>

<p>Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).</p>

<p>2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine</p>

<p>Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.Cost-effective and quality-assured.</p>

<p>Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).</p>

<p>Kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of V. inaequalis isolates from apple orchards .</p>

<p>Bismuth subgallate (Dermatol Puder) is an astringent and antiseptic and is applied to skin diseases such as eczema.</p>

<p>L-Cysteinesulfinic acid monohydrate activates rat mGluR1/2/4/5/6/8 with pEC50s of 3.92, 3.9, 2.7, 4.6, 4.0, 3.94 respectively.</p>

<p>S18-000003: Oral retinoic acid receptor gamma-t inhibitor, IC50 29 nM, reduces IL-17 production.</p>

<p>GNE-617, a specific NAMPT inhibitor(IC50=5 nM), shows potency in xenograft models of cancer.</p>

<p>Synthetic fatty acid TTA has β-sulfur, resists β-oxidation, and activates PPARs, especially PPARα.</p>

<p>IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.</p>

<p>Cinacalcet metabolite M4 (Rarechem AL BW 1078) is a metabolite of Cinacalcet. Cinacalcet is an allosteric agonist of Ca receptor.</p>

<p>GAK inhibitor 49 is a highly selective and ATP-competitive cyclin G associated kinase (GAK) inhibitor (IC50: 56 nM; Ki: 0.54 nM ).</p>

<p>BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling</p>

<p>Cytidine 5′-diphosphate, from CMP/UMP via phosphoryl transfer by uridylate kinase.</p>

<p>CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 μM).</p>

<p>4-Oxoisotretinoin (Ro 22-6595) is the major blood metabolite.</p>

<p>Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects</p>

<p>BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.</p>

<p>N-ε-propargyloxycarbonyl-L-lysine hydrochloride (N6-((Prop-2-yn-1-yloxy)carbonyl)-L-lysine hydrochloride) is a modified amino acid for cancer therapy</p>

<p>U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.</p>

<p>Paricalcitol is a vitamin D receptor agonist.</p>

<p>Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With Diabetes</p>

<p>SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity.</p>

1-phenyl-3,4-dihydroisochinoline: dopamine analog, interacts with CNS receptors, studied for Parkinson's, Alzheimer's, and Huntington's.

<p>(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl ditetradecanoate (DMPE) is a phosphatidylethanolamine (PE or GPEtn).</p>

<p>PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).</p>

<p>DIPQUO activates ALP and osteoblasts via p38MAPK-β; EC50 in C2C12 cells is 6.27 μM.</p>

<p>ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.</p>

<p>Voglibose (Glustat), an N-substituted derivative of valiolamine, exhibits excellent inhibitory activity against α-glucosidases and action against hyperglycemia</p>

<p>Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity</p>

<p>Olesoxime (TRO 19622) (TRO19622), A Mitochondrial-Targeted Neuroprotective Compound,is an experimental neuroprotective drug.</p>

<p>Elafibranor (GFT505) is an agonist of the peroxisome proliferator-activated receptor-α (PPAR-α) and peroxisome proliferator-activated receptor-δ (PPAR-δ) with</p>

<p>CHIKV-IN-2 inhibits DHODH to thwart viruses like CHIKV by depleting pyrimidine, showing strong antiviral action (EC90=270 nM) and liver stability.</p>

<p>Atglistatin: ATGL inhibitor, IC50 ~0.7 μM, inhibits lipolysis, non-toxic up to 50 μM.</p>

<p>LB-60-OF61 hydrochloride is a potent NAMPT enzyme inhibitor with cytotoxic effects, targeting MYC-overexpressing cell lines.</p>

<p>WWL229 selectively inhibits Ces3 without affecting Ces1f, ABHD6, or other serine hydrolases, mimicking WWL113 in adipocytes.</p>

<p>BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).</p>