Metabolismo
Os inibidores do metabolismo são compostos que interferem nas vias metabólicas, alterando a produção e utilização de energia dentro das células. Esses inibidores são usados para estudar a regulação do metabolismo, o papel das vias metabólicas em doenças como o câncer e o diabetes, e para desenvolver novas estratégias terapêuticas. Os inibidores do metabolismo podem direcionar várias enzimas e processos envolvidos na glicólise, na oxidação de ácidos graxos e em outras funções metabólicas. Na CymitQuimica, oferecemos uma ampla gama de inibidores do metabolismo de alta qualidade para apoiar sua pesquisa em bioquímica, distúrbios metabólicos e desenvolvimento de medicamentos.
Subcategorias de "Metabolismo"
- AhR(41 produtos)
- Aminopeptidase(67 produtos)
- CETP(18 produtos)
- Anidrase carbónica(177 produtos)
- Caseína quinase(130 produtos)
- DHFR(32 produtos)
- Descarboxilase(4 produtos)
- Desidrogenase(267 produtos)
- FAAH(63 produtos)
- FXR(58 produtos)
- Factor Xa(80 produtos)
- Sintase de Ácidos graxos(32 produtos)
- Ferroptose(215 produtos)
- GR(3 produtos)
- GSNOR(3 produtos)
- Glucoquinase(53 produtos)
- HIF/HIF Prolil-Hidroxilase(142 produtos)
- HMG-CoA Reductase(32 produtos)
- Hidroxilase(30 produtos)
- IDO(82 produtos)
- LDL(8 produtos)
- Lipase(96 produtos)
- Lipídio(59 produtos)
- Lipoxigenase(124 produtos)
- MAO(87 produtos)
- MPO(2 produtos)
- NAMPT(36 produtos)
- P450(6 produtos)
- PAI-1(25 produtos)
- PDE(165 produtos)
- PED(1 produtos)
- PKM(15 produtos)
- PPAR(164 produtos)
- Fosfolipase(82 produtos)
- ROR(42 produtos)
- Receptor de Retinóide(29 produtos)
- SGK(11 produtos)
- Tiorredoxina(12 produtos)
- Transferase(30 produtos)
- Tansportador(42 produtos)
- UGT(4 produtos)
- Inibidores de Xantina Oxidase (XO)(9 produtos)
Exibir 34 mais subcategorias
Foram encontrados 8597 produtos de "Metabolismo"
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LTA4H-IN-3
CAS:<p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>Fórmula:C17H15ClN4O3Cor e Forma:SolidPeso molecular:358.78ACLY Inhibitor 7
CAS:<p>ACLY Inhibitor 7 is a potent, selective hACLY inhibitor (IC50<1 nM) for metabolic disease and oncology research.</p>Fórmula:C21H14ClF2NO6SPureza:99.74%Cor e Forma:SoildPeso molecular:481.85DC360
CAS:<p>DC360 is a synthetic analog of all-trans retinoic acid (ATRA) that can induce the expression of RARβ. It is useful for studies characterizing the retinoic acid signaling pathway.</p>Fórmula:C23H23NO2Cor e Forma:SolidPeso molecular:345.434CP 524515
CAS:<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Fórmula:C27H27F9N2O4Cor e Forma:SolidPeso molecular:614.5L 731735
CAS:<p>L 731735 is a farnesyltransferase inhibitor.</p>Fórmula:C19H40N4O4SPureza:98%Cor e Forma:SolidPeso molecular:420.61Oxythiamine diphosphate ammonium
<p>Oxythiamin diphosphate ammonium is a potent inhibitor of transketolase (TK).</p>Cor e Forma:SolidPAT-347
CAS:<p>PAT-347 is a potent inhibitor of Autotaxin, an enzyme linked to cell survival and diseases like cancer and fibrosis.</p>Fórmula:C28H21ClF2N2O3SCor e Forma:SolidPeso molecular:538.99A-800141
CAS:<p>A-800141 is an orally active and selective MetAP2 inhibitor with an IC50 of 12 nM, while showing weaker inhibitory activity against MetAP1 (IC50: 36 μM). GAPDH can serve as a biomarker for monitoring the inhibition of MetAP2 by A-800141. This compound exhibits anti-angiogenic and anticancer properties in various xenograft tumor models.</p>Fórmula:C24H30N2O4SCor e Forma:SolidPeso molecular:442.571Ro 23-9358
CAS:<p>Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.</p>Fórmula:C30H51NO6Cor e Forma:SolidPeso molecular:521.729CK2 inhibitor 3
<p>CK2 inhibitor 3: potent CK2 blocker, IC50 of 280 nM, suppresses tumor cell growth, highly selective among 320 kinases.</p>Fórmula:C13H9BrN4O3SCor e Forma:SolidPeso molecular:381.2β-Glucuronidase/hCAII-IN-2
<p>β-Glucuronidase/hCAII-IN-2 is a potent inhibitor of β-glucuronidase and hCA II, and their IC50 values were 670.7 μM and 21.77 μM, respectively.</p>Fórmula:C31H23NO8Cor e Forma:SolidPeso molecular:537.52Lp-PLA2-IN-5
CAS:<p>Lp-PLA2-IN-5 inhibits Lp-PLA2 and PAF-AH, potentially useful in Alzheimer's and atherosclerosis studies.</p>Fórmula:C23H18F5N3O4Cor e Forma:SolidPeso molecular:495.4Epoxykynin
CAS:<p>Epoxykynin is a potent soluble epoxide hydrolase (sEH) inhibitor [1].</p>Fórmula:C19H20BrF3N2O2Cor e Forma:SolidPeso molecular:445.27PLAP-IN-1
CAS:<p>PLAP-IN-1: Potent, selective inhibitor of PLAP, IC50 of 32 nM; doesn't notably inhibit TNAP.</p>Fórmula:C25H21Cl2N3O5Cor e Forma:SoildPeso molecular:514.36FAAH/MAGL-IN-1
<p>FAAH/MAGL-IN-1 (SIH 3) inhibits FAAH & MAGL with IC50 of 31 & 29 nM, useful in neuropathic pain research.</p>Fórmula:C15H9Cl2N3O3Cor e Forma:SolidPeso molecular:350.16T-3764518
CAS:<p>T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).</p>Fórmula:C20H17F6N5O2Pureza:98%Cor e Forma:SolidPeso molecular:473.37Valerate sodium
CAS:<p>Valerate sodium is a potential Carbonic anhydrase 1/2 inhibitor for biochemical experiments.</p>Fórmula:C5H9NaO2Pureza:99.84%Cor e Forma:SolidPeso molecular:124.11(R,R)-BMS-986397
CAS:<p>(R,R)-BMS-986397 is a CK1α degrader with a DC50 ranging from 0.1 to 0.5 pM. This compound is applicable in leukemia research.</p>Fórmula:C21H16ClF3N4O4Cor e Forma:SolidPeso molecular:480.82RORγt inverse agonist 34
CAS:<p>RORγt inverse agonist 34 (compound 5a) is an inverse agonist for RORγt, exhibiting an IC50 of 0.094 μM for the inhibition of RORγt-LBD. This compound is utilized in psoriasis research.</p>Fórmula:C31H37N3O3SCor e Forma:SolidPeso molecular:531.709Dihydrokainic acid
CAS:<p>EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake</p>Fórmula:C10H17NO4Pureza:98%Cor e Forma:SolidPeso molecular:215.25Lecufexor
CAS:<p>Lecufexor is an agonist of the farnesoid X receptor (FXR).</p>Fórmula:C32H21Cl3N2O5Cor e Forma:SolidPeso molecular:619.88Diacylglycerol acyltransferase inhibitor-2
CAS:<p>Diacylglycerolacyltransferaseinhibitor-2 (Example 8) acts as an inhibitor for diacylglycerol acyltransferase 2 (DGAT2), exhibiting an IC50 value of 3.7 nM.</p>Fórmula:C21H20FN5O4Cor e Forma:SolidPeso molecular:425.41Lipoxin A5
CAS:<p>LXA5 is made from EPA by leukocytes, contracts guinea pig lungs like LXA4/LXB4, but doesn't dilate aorta.</p>Fórmula:C20H30O5Cor e Forma:SolidPeso molecular:350.45PDE4-IN-14
CAS:<p>PDE4-IN-14 (Compound 1) serves as an inhibitor of phosphodiesterase 4 (PDE4), applicable in research concerning diseases associated with PDE4, including</p>Fórmula:C19H20F2N4O3SCor e Forma:SolidPeso molecular:422.45α-Glucosylrutin
CAS:<p>α-Glucosylrutin is an effective antioxidant known for its activity in scavenging free radicals. Due to its high epidermal bioavailability, it is commonly utilized in studies related to skin aging.</p>Fórmula:C33H40O21Cor e Forma:SolidPeso molecular:772.66Casein kinase 1δ-IN-18
CAS:<p>Casein kinase1δ-IN-18 (compound 660) is an inhibitor of casein kinase 1δ (CK1δ), which can be utilized for research in neurodegenerative diseases.</p>Fórmula:C16H12ClN3O2S2Cor e Forma:SolidPeso molecular:377.8686-trans-12-epi-Leukotriene B4
CAS:<p>6-trans-12-epi-Leukotriene B4, a metabolite of arachidonic acid, serves as a potent anti-inflammatory agent.</p>Fórmula:C20H32O4Cor e Forma:SolidPeso molecular:336.47PDE4-IN-12
<p>PDE4-IN-12 is a potent and safe PDE4 ubiquitous inhibitor that acts on PDE4 (IC50: 3.5 nM, SI: 2.71) and PDE7 (IC50: 15 nM, SI: 4.27).</p>Fórmula:C34H35NO6Cor e Forma:SolidPeso molecular:553.64GC-IN-2
CAS:<p>GC-IN-2 (Compound 25) is an effective and selective non-sugar-based glucocerebrosidase inhibitor with an IC50 value of 6.46 μM. It is utilized in research related to Gaucher's disease.</p>Fórmula:C19H16N2O3SCor e Forma:SolidPeso molecular:352.41(Rac)-8-Hydroxy-efavirenz
CAS:<p>(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1.</p>Fórmula:C14H9ClF3NO3Cor e Forma:SolidPeso molecular:331.674Darlifarnib
CAS:<p>Darlifarnib (Compound (S)-058) is an inhibitor of farnesyl transferase and geranylgeranyltransferase, with IC50 values of ≤ 10 nM and > 1000 nM, respectively. It exhibits high metabolic stability in human and mouse liver microsomes, with a half-life of over 100 minutes.</p>Fórmula:C29H20N6OCor e Forma:SolidPeso molecular:468.509BMS-214662 mesylate
CAS:<p>BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research.</p>Fórmula:C26H27N5O5S3Cor e Forma:SolidPeso molecular:585.718(S)-CPP sodium
CAS:<p>(S)-CPP sodium serves as an inhibitor of the branched-chain α-keto acid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, (S)-CPP (IC50 of 6.3 μM) inhibits BDK, which activates the complex, leading to a significant reduction in the levels of leucine/isoleucine and valine in the plasma of wild-type mice.</p>Fórmula:C9H8ClNaO2Cor e Forma:SolidPeso molecular:206.60TNP-470
CAS:<p>TNP-470 is a methionine aminopeptidase-2 inhibitor. TNP-470 is also an angiogenesis inhibitor.</p>Fórmula:C19H28ClNO6Pureza:98%Cor e Forma:SolidPeso molecular:401.88IMR687
CAS:<p>IMR687: a PDE9 inhibitor that could improve memory in Alzheimer's by slowing cGMP hydrolysis.</p>Fórmula:C21H26N6O2Pureza:98%Cor e Forma:SolidPeso molecular:394.47ent-8-iso-15(S)-Prostaglandin F2α
CAS:<p>Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid.</p>Fórmula:C20H34O5Cor e Forma:SolidPeso molecular:354.48PTP1B-IN-21
<p>PTP1B-IN-21 inhibits PTP1B (IC50=1.56μM) selectively over TCPTP, a type 2 diabetes target.</p>Fórmula:C22H22O11Cor e Forma:SolidPeso molecular:462.4DSM705 hydrochloride
<p>DSM705 hydrochloride: potent antimalarial, pyrrole-based DHODH inhibitor effective against Plasmodium, non-toxic to mammalian DHODH.</p>Fórmula:C19H20ClF3N6OCor e Forma:SolidPeso molecular:440.85ABHD antagonist 1
CAS:<p>ABHD antagonist 1 is an inhibitor of ABHD6 (α/β-Hydrolase domain containing 6), involved in modulating biochemical pathways affected by ABHD6, thereby influencing cell function and inflammatory responses. This compound is applicable for research in fields such as pain, neurological disorders, inflammatory diseases, autoimmune diseases, metabolic disorders, and cancer.</p>Fórmula:C19H20BrN3O3SCor e Forma:SolidPeso molecular:450.35RBM14C12
CAS:<p>RBM14C12 is a compound known for its cell signaling activity. It plays a crucial role in researching lipid metabolism and cell membrane structure. Additionally, RBM14C12 can be utilized in the development of novel compounds aimed at modulating the biological mechanisms associated with lipid-related diseases.</p>Fórmula:C26H39NO6Cor e Forma:SolidPeso molecular:461.59BAY-179
CAS:<p>BAY-179 is a potent, selective, species cross-reactive complex I inhibitor for the study of cancer.</p>Fórmula:C23H21N5OSPureza:98.29%Cor e Forma:SolidPeso molecular:415.51α-Glucosidase-IN-18
<p>α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM.</p>Fórmula:C23H19NO2SCor e Forma:SolidPeso molecular:373.47SMase-IN-1
CAS:<p>SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase (SMase) inhibitor with an IC50 value of 6.43 µM against Bacillus cereus SMase. It also inhibits eqBuChE with an inhibition rate of 59.50% at a concentration of 50 µM. SMase-IN-1 forms a complex with Cu2+ through bio-metal interactions and can inhibit hemolysis of sheep red blood cells induced by Bacillus cereus.</p>Fórmula:C8H5ClN2OSCor e Forma:SolidPeso molecular:212.656PF-00489791
CAS:<p>PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.</p>Fórmula:C20H28N8O4SPureza:99.97%Cor e Forma:SolidPeso molecular:476.55LRAT-IN-1
CAS:<p>LRAT-IN-1 (compound 1) is an inhibitor of lecithin retinol acyltransferase (LRAT) with an IC50 value of 21.1 μM. This compound works by inhibiting the esterification of retinol to form retinyl esters, thereby increasing the availability of retinol in the skin to deliver anti-aging benefits. LRAT-IN-1 is under investigation for its potential use as an anti-aging ingredient in cosmetics.</p>Fórmula:C27H47N5O5S2Cor e Forma:SolidPeso molecular:585.82ZSH-2208
CAS:<p>ZSH-2208 is a retinoic acid A analogue that inhibits tumour cell proliferation and survival through RARγ-TNFAIP3 and retinoid receptors.</p>Fórmula:C20H18O3SPureza:99.81%Cor e Forma:SolidPeso molecular:338.42VHR-IN-1
CAS:<p>VHR-IN-1 (Compound SA1) is an effective and selective VHR phosphatase inhibitor with an IC50 of 18 nM. It hinders the proliferation of cervical cancer cells, demonstrating antitumor activity.</p>Fórmula:C28H22ClN3O5S3Cor e Forma:SolidPeso molecular:612.139Magnesium ionophore III
CAS:<p>Magnesium ionophore III (ETH 4030) is an ion carrier that regulates intracellular magnesium ion concentrations. It enhances cellular functions and metabolic activities by increasing the permeability of cell membranes to magnesium ions. Additionally, Magnesium ionophore III is utilized in research to explore the significance of magnesium ions in biological processes and their impact on cellular physiology.</p>Fórmula:C30H58N4O4Cor e Forma:SolidPeso molecular:538.81DOCP
CAS:<p>DOCP (2-((2,3-Bis(oleoyloxy)propyl)dimethylammonio)ethyl hydrogen phosphate) is a lipid characterized by an opposite charge orientation compared to traditional phosphatidylcholine (PC) lipids, featuring quaternary ammonium near the bilayer interface and phosphate groups projecting into the aqueous environment. This unique structure of iPC lipids presents an excellent opportunity to investigate the biophysical characteristics and biological activities influenced by the reversal of surface charges on bilayers.</p>Fórmula:C43H82NO8PCor e Forma:SolidPeso molecular:772.09BAY 74-4113
CAS:<p>BAY 74-4113 is a DGAT1 inhibitor with an IC50 of 72 nM. It is utilized in research related to obesity.</p>Fórmula:C26H20F2N2O3SCor e Forma:SolidPeso molecular:478.51PPARδ agonist 11
CAS:<p>Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.</p>Fórmula:C19H15F3N2O3S2Cor e Forma:SolidPeso molecular:440.46OSI-413 free base
CAS:<p>OSI-413 (free base) (CP 373413) is the primary metabolite of Erlotinib. Erlotinib (CP-358774) acts as a direct EGFR tyrosine kinase inhibitor with an IC50 of 2 nM against human EGFR.</p>Fórmula:C21H21N3O4Cor e Forma:SolidPeso molecular:379.409Ketomethylenebestatin
CAS:<p>Ketomethylenebestatin, a weaker carba-analog of aminopeptidase inhibitor bestatin, is 10x less potent.</p>Fórmula:C17H25NO4Pureza:98%Cor e Forma:SolidPeso molecular:307.38α-Amylase-IN-10
CAS:<p>α-Amylase-IN-10 (Compound 15n) is an inhibitor of α-Amylase, with an IC50 of 5.00 µM. This compound is applicable for research in type 2 diabetes.</p>Fórmula:C21H15ClN2O4SCor e Forma:SolidPeso molecular:426.873TAK-915
CAS:<p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>Fórmula:C19H18F4N4O5Pureza:98%Cor e Forma:SolidPeso molecular:458.36(+)-Potassium Ds-threo-isocitrate monobasic
CAS:<p>(+)-Potassium Ds-threo-isocitrate monobasic is a bioactive compound known for its role in enhancing cellular metabolism and regulating energy production. This substance is also utilized in researching metabolic pathways and the regulation of enzyme activities. Widely applied in biochemical research, (+)-Potassium Ds-threo-isocitrate monobasic is studied for its potential functions in cellular processes and disease mechanisms.</p>Fórmula:C6H7KO7Cor e Forma:SolidPeso molecular:230.21BAY R3401
CAS:<p>BAY R3401 is an orally active inhibitor of glycogen phosphorylase, leading to irreversible and non-selective inhibition of liver glycogenolysis. It suppresses glycogen breakdown in hepatocytes with IC50 values of 27.06 μM in HL-7702 cells and 52.83 μM in HepG2 cells. BAY R3401 is applicable for research in type 2 diabetes.</p>Fórmula:C20H22ClNO4Cor e Forma:SolidPeso molecular:375.846(rel)-Mirogabalin
CAS:<p>(rel)-Mirogabalin ((rel)-DS5565) is an inhibitor of voltage-dependent calcium channels, specifically targeting the α2δ-1 subunit.</p>Fórmula:C12H19NO2Cor e Forma:SolidPeso molecular:209.28CK1δ-IN-10
CAS:<p>CK1δ-IN-10 (Compound 85) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ (CSNKID), with an IC50 value of 0.255 μM.</p>Fórmula:C17H11F4N5Cor e Forma:SolidPeso molecular:361.296BAR-2227
CAS:<p>BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.</p>Fórmula:C24H17Cl2NO4Cor e Forma:SolidPeso molecular:454.30S-15176
CAS:<p>S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). It effectively suppresses mitochondrial swelling induced by tert-butyl hydroperoxide, with an IC50 value of 45.7 μM. S-15176 prevents the opening of PTP, thus averting the dissipation of mitochondrial membrane potential and the oxidation of NAD(P)H, while enhancing mitochondrial calcium loading capacity. It holds potential for research into ischemia-reperfusion injury.</p>Fórmula:C31H48N2O4SCor e Forma:SolidPeso molecular:544.797-Hydroxy-4-phenylcoumarin
CAS:<p>7-Hydroxy-4-phenylcoumarin is a dual inhibitor of ALDH-2 and MAO, with IC50 values of 1.5 µM and 0.5 µM, respectively.</p>Fórmula:C15H10O3Cor e Forma:SolidPeso molecular:238.238Anticancer agent 142
CAS:<p>Compound 142 (also known as Compound 235) is a PTPN inhibitor with potential applications in cancer research [1].</p>Fórmula:C13H14BrF2N2O7PS2Pureza:98%Cor e Forma:SolidPeso molecular:523.26Turoctocog alfa
CAS:<p>Turoctocog alfa: recombinant FVIII from CHO cells for hemophilia A study.</p>Cor e Forma:Solid4-(4-Bromophenyl)-4-hydroxypiperidine
CAS:<p>4-(4-Bromophenyl)-4-hydroxypiperidine (BPHP) is a metabolite of Bromperidol (BRO), produced through the N-dealkylation of BRO.</p>Fórmula:C11H14BrNOCor e Forma:SolidPeso molecular:256.139ZK168281
CAS:<p>ZK168281 is a 1α,25(OH)2D3 analog, VDR antagonist with 0.1 nM Kd, and blocks receptor CoA interaction.</p>Fórmula:C32H46O5Pureza:98%Cor e Forma:SolidPeso molecular:510.70ZK159222
CAS:<p>ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.</p>Fórmula:C32H48O5Pureza:98%Cor e Forma:SolidPeso molecular:512.72DPM-1003
CAS:<p>DPM-1003 is an allosteric inhibitor of PTP1B, targeting the non-catalytic, disordered C-terminal segment of the PTP1B protein, and has shown beneficial effects in reducing pulmonary inflammation in mice.</p>Fórmula:C35H57N3O3Cor e Forma:SolidPeso molecular:567.845NNC 55-0396
CAS:<p>NNC 55-0396: Selective T-type calcium channel blocker, IC50 6.8 μM, inhibits human ovarian cancer cell growth.</p>Fórmula:C30H40Cl2FN3O2Pureza:99.00%Cor e Forma:SolidPeso molecular:564.56BRD7539
CAS:<p>BRD7539B: PfDHODH inhibitor, IC50 0.033μM; selective vs HsDHODH, IC50 >50μM.</p>Fórmula:C23H22FN3O2Pureza:98%Cor e Forma:SolidPeso molecular:391.44GSK2945 hydrochloride
<p>GSK2945 HCl is a specific Rev-erbα antagonist, EC50: 21.5 μM (mouse), 20.8 μM (human), increases cholesterol 7α-hydroxylase.</p>Fórmula:C20H19Cl3N2O2SCor e Forma:SolidPeso molecular:457.8MK-3168 (12C)
CAS:<p>MK-3168 (12C) functions as a FAAH inhibitor, exhibiting IC50 values of 1.0 nM, 5.5 nM, and 1.7 nM for human, rhesus, and rat respectively. It demonstrates effective brain uptake and FAAH-specific signaling. Additionally, 11 C MK-3168 is applicable as a FAAH PET tracer.</p>Fórmula:C21H21ClN4OSCor e Forma:SolidPeso molecular:412.94Fonadelpar
CAS:<p>Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.</p>Fórmula:C25H23F3N2O4SPureza:98%Cor e Forma:SolidPeso molecular:504.52CB30865
CAS:<p>CB30865 (ZM 242421) is a selective and highly effective nicotinamide phosphoribosyltransferase (Nampt) inhibitor with potential antitumor activity.</p>Fórmula:C26H22BrN5O2Pureza:99.04%Cor e Forma:SolidPeso molecular:516.39Mitochondrial-IN-1
CAS:<p>Mitochondrial-IN (C458) is a potent inhibitor of mitochondrial complex I. It offers significant protection against Aβ toxicity, exhibits favorable pharmacokinetic properties, and has minimal off-target effects.</p>Fórmula:C22H30N2OCor e Forma:SolidPeso molecular:338.49Thioquinapiperifil dihydrochloride
CAS:<p>Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.</p>Fórmula:C24H29ClN6OSPureza:98.73%Cor e Forma:SolidPeso molecular:485.05UGT1A1-IN-1
CAS:<p>UGT1A1-IN-1 (compound 2) acts as a non-competitive inhibitor of UGT1A1, effectively inhibiting the 1-O-glucuronidation process mediated by UGT1A1 with a Ki value of 5.02 μM. This compound binds to the same ligand-binding site on UGT1A1 as bilirubin and additionally functions as a 'turn-on' fluorescent probe substrate for UGT1A1 [1].</p>Fórmula:C22H19NO3Cor e Forma:SolidPeso molecular:345.39ABT-046
CAS:<p>ABT-046 is an orally active, selective, and highly efficient Diacylglycerol Acyltransferase 1 (DGAT-1) inhibitor that can be used in metabolic disease research.</p>Fórmula:C20H22N4O2Pureza:98.13%Cor e Forma:SolidPeso molecular:350.41Nomelidine
CAS:<p>Nomelidine, the active N-demethylated metabolite of zimelidine, has been used as an antidepressant and analgesic.</p>Fórmula:C15H15BrN2Pureza:98%Cor e Forma:SolidPeso molecular:303.20NTPDase-IN-2
CAS:<p>NTPDase-IN-2 inhibits h-NTPDase-2/-8 (IC50: 0.04, 2.27 µM), non-competitive for h-NTPDase-1/-2 (Km: 74 µM); useful in cancer, immune, bacterial research.</p>Fórmula:C24H20FN3OS2Cor e Forma:SolidPeso molecular:449.56CK1δ-IN-8
CAS:<p>CK1δ-IN-8 (Compound 429) is a CK1δ inhibitor suitable for Alzheimer's disease research.</p>Fórmula:C14H9N3O2S2Cor e Forma:SolidPeso molecular:315.37Casein kinase 1δ-IN-16
CAS:<p>Casein kinase1δ-IN-16 (compound 506) is an inhibitor of casein kinase 1δ (CK1δ). This compound is applicable in research related to neurodegenerative diseases.</p>Fórmula:C17H12N4S2Cor e Forma:SolidPeso molecular:336.434PTP1B-IN-17
<p>PTP1B-IN-17, a benzimidazole derivative, inhibits PTP1B (Ki: 30.2 μM) and may help study type 2 diabetes.</p>Fórmula:C26H19N3O4SCor e Forma:SolidPeso molecular:469.513'-Hydroxy Repaglinide
CAS:<p>'3'-Hydroxy Repaglinide, a CYP2C8 metabolite of Repaglinide, treats type II diabetes.</p>Fórmula:C27H36N2O5Pureza:98%Cor e Forma:SolidPeso molecular:468.59CK1δ-IN-3
CAS:<p>CK1δ-IN-3 (compound 376) is a CK1δ (casein kinase 1δ) inhibitor that can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>Fórmula:C24H19N3O2SPureza:99.27%Cor e Forma:SolidPeso molecular:413.49AChE/hCA I-IN-1
CAS:<p>AChE/hCA I-IN-1 (Compound L3) is an inhibitor of acetylcholinesterase (AChE) and carbonic anhydrase (CA), effectively inhibiting AChE, hCA I, and hCA II with IC50 values of 302 nM, 265 nM, and 283 nM, respectively.</p>Fórmula:C13H9BrNNaO4SCor e Forma:SolidPeso molecular:378.174PDE4B-IN-3
<p>PDE4B-IN-3 is a potent inhibitor of PDE4B (IC50: 0.94 μM) and exhibits anti-inflammatory effects.</p>Fórmula:C30H35N3O4S2Cor e Forma:SolidPeso molecular:565.754-MDM
CAS:<p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>Fórmula:C14H14OCor e Forma:SolidPeso molecular:198.26FTI-2153 TFA
<p>FTI-2153 TFA inhibits farnesyltransferase with high selectivity (IC50: 1.4 nM), over 3000x more than Rap1A processing.</p>Fórmula:C27H31F3N4O5SCor e Forma:SolidPeso molecular:580.62Dopaminechrome
CAS:<p>Dopaminechrome (DACHR) is an oxidation product of dopamine that promotes the generation of H2O2 at mitochondrial complex I in the brain in a concentration- and respiration-dependent manner. It possesses neurotoxic properties and can be utilized in Parkinson's disease research.</p>Fórmula:C8H7NO2Cor e Forma:SolidPeso molecular:149.147NAMPT activator-6
CAS:<p>NAMPT activator-6, a regulatory molecule for the optical control system of NAMPT and NAD+, can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) for light-dependent, reversible regulation of NAMPT and NAD+, thereby reducing toxicity associated with inhibitor-based PS-PROTACs. This enables antitumor activity and in vivo modulation of NAMPT and NAD+ through optical manipulation [1].</p>Fórmula:C17H21N5O3SCor e Forma:SolidPeso molecular:375.45(E)-10-Hydroxynortriptyline maleate
CAS:<p>(E)-10-Hydroxy Nortriptyline maleate, a derivative of antidepressant Nortriptyline, eases depression symptoms.</p>Fórmula:C23H25NO5Pureza:98%Cor e Forma:SolidPeso molecular:395.455ERAP1 modulator-2
CAS:<p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>Fórmula:C22H25F3N2O4SCor e Forma:SolidPeso molecular:470.505CAII-IN-3
<p>CAII-IN-3, a thiosemicarbazone, potently inhibits CA-II with an IC50 of 13.4 μM.</p>Fórmula:C18H18F2N4SCor e Forma:SolidPeso molecular:360.42GSK 366
CAS:<p>GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).</p>Fórmula:C17H16ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:361.78RORγ-IN-2
CAS:<p>RORγ-IN-2 (Compound 22) is an inhibitor of RORγ, with a Ki value of 16.6 nM for hRORγ. It is useful for research in IL-17-dependent autoimmune diseases.</p>Fórmula:C28H32F3N5O4S2Cor e Forma:SolidPeso molecular:623.71RXR antagonist 2
<p>RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases.</p>Fórmula:C29H35F3N2O3Cor e Forma:SolidPeso molecular:516.6sEH inhibitor-1
<p>TCPU (sEH inhibitor-1) is a potent oral human sEH blocker with IC50s of 0.4 nM (human) and 5.3 nM (mouse).</p>Cor e Forma:SolidhCAVII/IX-IN-1
CAS:<p>hCAVII/IX-IN-1 (compound 4) functions as an inhibitor of hCAVII/IX, exhibiting Ki values of 56.5 nM and 38.2 nM, respectively. It is applicable in the field of cancer research.</p>Fórmula:C7H7N3O2S2Cor e Forma:SolidPeso molecular:229.279RXR antagonist 1
<p>RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes.</p>Fórmula:C28H33F3N2O3Cor e Forma:SolidPeso molecular:502.57
