Metabolismo
Os inibidores do metabolismo são compostos que interferem nas vias metabólicas, alterando a produção e utilização de energia dentro das células. Esses inibidores são usados para estudar a regulação do metabolismo, o papel das vias metabólicas em doenças como o câncer e o diabetes, e para desenvolver novas estratégias terapêuticas. Os inibidores do metabolismo podem direcionar várias enzimas e processos envolvidos na glicólise, na oxidação de ácidos graxos e em outras funções metabólicas. Na CymitQuimica, oferecemos uma ampla gama de inibidores do metabolismo de alta qualidade para apoiar sua pesquisa em bioquímica, distúrbios metabólicos e desenvolvimento de medicamentos.
Subcategorias de "Metabolismo"
- AhR(41 produtos)
- Aminopeptidase(73 produtos)
- CETP(20 produtos)
- Anidrase carbónica(184 produtos)
- Caseína quinase(136 produtos)
- DHFR(34 produtos)
- Descarboxilase(4 produtos)
- Desidrogenase(288 produtos)
- FAAH(65 produtos)
- FXR(59 produtos)
- Factor Xa(83 produtos)
- Sintase de Ácidos graxos(36 produtos)
- Ferroptose(218 produtos)
- GR(3 produtos)
- GSNOR(4 produtos)
- Glucoquinase(56 produtos)
- HIF/HIF Prolil-Hidroxilase(142 produtos)
- HMG-CoA Reductase(34 produtos)
- Hidroxilase(34 produtos)
- IDO(84 produtos)
- LDL(8 produtos)
- Lipase(104 produtos)
- Lipídio(61 produtos)
- Lipoxigenase(133 produtos)
- MAO(87 produtos)
- MPO(2 produtos)
- NAMPT(38 produtos)
- P450(6 produtos)
- PAI-1(26 produtos)
- PDE(166 produtos)
- PED(1 produtos)
- PKM(15 produtos)
- PPAR(167 produtos)
- Fosfolipase(82 produtos)
- ROR(43 produtos)
- Receptor de Retinóide(28 produtos)
- SGK(12 produtos)
- Tiorredoxina(12 produtos)
- Transferase(29 produtos)
- Tansportador(43 produtos)
- UGT(4 produtos)
- Inibidores de Xantina Oxidase (XO)(9 produtos)
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Foram encontrados 9007 produtos de "Metabolismo"
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α-Glucosidase-IN-65
<p>α-Glucosidase-IN-65 (compound 5) is a Schiff base derivative of 3,4-dihydroxyphenylacetic acid. It acts as a potent α-glucosidase inhibitor with an IC50 of 12.84 μM.</p>Fórmula:C15H14N2O6Peso molecular:318.08519GZ22-4
<p>GZ22-4 is a near-infrared (NIR) fluorescent probe with a high affinity for carbonic anhydrase IX (CAIX), exhibiting a dissociation constant (Kd) of 0.2 nM. It is applicable in studies for visualizing CAIX-positive tumors.</p>Fórmula:C88H126F3N6NaO24S4Peso molecular:1858.75561α-Amylase/α-Glucosidase-IN-13
α-Amylase/α-Glucosidase-IN-13 (Compound 5d) is a dual inhibitor of α-amylase and α-glucosidase, and is useful in diabetes research.Fórmula:C22H16N2O5Peso molecular:388.10592Fmoc-Cys-Asp10 TFA
Fmoc-Cys-Asp10 (TFA) is a non-releasable oligopeptide linker involved in synthesizing releasable oligopeptide linkers. These releasable linkers are used to deliver drugs to fracture-targeting oligopeptides, thereby reducing the healing time of fractured femurs.Fórmula:C60H68F3N11O36SPeso molecular:1607.35012Antibacterial agent 218
<p>Antibacterialagent 218 (compound d28) is an orally active inhibitor of sterol 24-C-methyltransferase with an IC50 value of 0.273 μM. It also displays antifungal activity against Candida albicans SC5314, with an IC50 of 0.25 μg/mL.</p>Fórmula:C30H24N4OSPeso molecular:488.16708α-Glucosidase-IN-49
<p>α-Glucosidase-IN-49 (compound C23) is a potent inhibitor of α-Glucosidase, with an IC50 of 0.52 μM. This compound exhibits oral bioactivity, effectively lowering blood glucose levels and enhancing glucose tolerance in mice.</p>Fórmula:C21H13F3N4O3S3Peso molecular:522.01019HSP90-IN-30
<p>HSP90-IN-30 (compound 3e) inhibits the activity of the HSP90 molecular chaperone. Under hypoxic conditions, HSP90-IN-30 suppresses HIF-1 transcriptional activity with an IC50 value of 2.16 μM.</p>Fórmula:C20H39B12N4O2Peso molecular:499.41897hCAIX/XII-IN-11
<p>hCAIX/XII-IN-11 (Compound 6c) is an inhibitor of hCA IX and hCA XII, exhibiting Ki values of 0.7 μM for both isoforms. This compound is applicable in cancer research.</p>Fórmula:C13H10FN3O4Peso molecular:291.06553IDO1-IN-24
IDO1-IN-24 (compound 2c) inhibits the production of IDO1 during cell assays, with an IC50 value of 17 μM.Fórmula:C18H22N2O4Peso molecular:330.15796AChE/BChE-IN-17
<p>AChE/BChE-IN-17 (compound 8m) is a potent inhibitor of AChE and BChE, displaying IC50 values of 125.06 nM and 119.68 nM, respectively. Additionally, AChE/BChE-IN-17 inhibits α-glucosidase, with an IC50 of 41050 nM.</p>Fórmula:C28H25N3O4Peso molecular:467.18451Human Factor VIIa
HumanFactor VIIa is a vitamin K-dependent serine protease involved in the blood coagulation process. It has the ability to activate coagulation factor X, which in turn converts prothrombin into thrombin, leading to the transformation of fibrinogen into fibrin and resulting in the formation of blood clots. HumanFactor VIIa holds potential for improving hemophilia.α-Amylase/α-Glucosidase-IN-11
<p>α-Amylase/α-Glucosidase-IN-11 (Compound 5d) is an isoxazoline-indigo hybrid with notable antidiabetic properties. It acts as a competitive inhibitor of the key digestive enzymes α-amylase (IC50 = 30.39 μM) and α-glucosidase (IC50 = 65.1 μM). Additionally, it does not penetrate the blood-brain barrier.</p>Fórmula:C33H40ClN5O5Peso molecular:621.2718MPO-IN-6
<p>MPO-IN-6 (compound ADC) is an electrophilic agent with excellent antioxidant and anti-inflammatory properties. It acts as an inhibitor of myeloperoxidase (MPO), dipeptidyl peptidase-4 (DPP-4), and α-glucosidase (α-GD), with IC50 values of 10 μM, 31.02 μM, and 46.05 μM, respectively. MPO-IN-6 may serve as a potential cardiovascular protective agent.</p>Fórmula:C16H12N2O6Peso molecular:328.06954α-Glucosidase-IN-57
α-Glucosidase-IN-57 (Compound 10c) is a competitive, orally active α-glucosidase inhibitor with an IC50 of 0.180 μM and a Ki of 0.15 μM. It effectively reduces fasting and overall blood glucose levels in mice, making it suitable for antidiabetic research.Fórmula:C32H23FN4OSPeso molecular:530.15766PTP1B-IN-25
<p>PTP1B-IN-25 (Compound 19) is an inhibitor of PTP1B with notable antiviral, antibacterial, and antidiabetic activities. It exhibits IC50 values of 0.37 μM for PTP1B, 8.6 μM for HIV, 3.7 μM for α-Glucosidase, and 29 μM for methicillin-resistant Staphylococcus aureus (MRSA).</p>Fórmula:C44H66O17Peso molecular:866.43CYP51-IN-17
<p>CYP51-IN-17 (compound 7a) is a potent CYP51 inhibitor with an IC50 of 0.377 μg/mL. It exhibits significant fungicidal activity against B. cinerea, with an EC50 of 0.326 μg/mL.</p>Fórmula:C24H20N2O7Peso molecular:448.12705Simvastatin Acyl-β-D-glucuronide
CAS:Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.Fórmula:C31H48O12Cor e Forma:SolidPeso molecular:612.71Thalifendine chloride
CAS:Thalifendine chloride is a metabolite of berberine,the methoxy group at the C-10 position undergoes demethylation by CYP51. cytotoxicity against P-388 cells.Fórmula:C19H16ClNO4Cor e Forma:SolidPeso molecular:357.79(24S)-24,25-Dihydroxyvitamin D3
CAS:(24S)-24,25-Dihydroxyvitamin D3 undergoes various levels of hydroxylation to form active vitamin D3 analogs.Fórmula:C27H44O3Pureza:98.98%Cor e Forma:SolidPeso molecular:416.642',5,6',7-Tetrahydroxyflavone
CAS:2',5,6',7-Tetrahydroxyflavone is a useful organic compound for research related to life sciences.Fórmula:C15H10O6Cor e Forma:SolidPeso molecular:286.239
