Metabolismo

<p>HMG-CoA Reductase-IN-1 is an inhibitor of HMG-CoA reductase, demonstrating strong inhibitory activity on HMGR and affinity for OATP1B1, with pIC50 and pKm</p>

<p>Meproscillarin is a glycoside with high bioavailability (about 70%) and an elimination independent of renal function.</p>

<p>MTHFD2-IN-4, a tricyclic coumarin derivative, serves as a potent inhibitor of MTHFD2 and has applications in cancer research [1].</p>

<p>CP-LC-1422 is a homocysteine-derived ionizable amino lipid known for its efficient RNA delivery capabilities, enabling high-level protein expression in vivo. When formulated in lipid nanoparticles (LNP) and administered intravenously, it demonstrates significant spleen-targeting properties without observed notable toxicity.</p>

<p>LysoFos Glycerol 14 is a useful organic compound for research related to life sciences. The catalog number is TF0117 and the CAS number is 326495-21-0.</p>

<p>GGACK (H-Glu-Gly-Arg-CMK) hydrochloride is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).</p>

<p>Senecionine acetate, a pyrrolizidine alkaloid, blocks Ca2+ storage in cells by inactivating sulfhydryl groups.</p>

<p>Imidazole-d4 is an isotope-labeled variant of imidazole, which is a heterocyclic aromatic compound. Imidazole molecules serve as inhibitors for acetylcholinesterase (AChEI) and xanthine oxidase (XO) and have been utilized as corrosion inhibitors. They display a range of biological activities, including antifungal, antitubercular, anti-inflammatory, antioxidant, and analgesic properties. Imidazole inhibits platelet microsomes from converting endoperoxides (PGG2 and PGH2) into thromboxane A2. Additionally, imidazole derivatives show inhibitory effects on the SARS-CoV-2 3CLpro enzyme, offering potential for research in Alzheimer’s disease, gout, COVID-19, and thrombotic disorders.</p>

<p>ATP ditromethamine is key for energy storage, metabolism, and acts as a coenzyme and signaling molecule in immunity and inflammation.</p>

<p>T-705RMP, a T-705 byproduct, mildly inhibits IMPDH in host cells; IC50 = 601 μM.</p>

<p>Malonyl CoA: needed for fat creation, stops fat breakdown, reversibly inhibits CPT1 in mitochondria.</p>

<p>N-Desalkyludenafil, a metabolite of Udenafil, functions as a PDE5 inhibitor and is utilized in the study of erectile dysfunction [1].</p>

<p>4-Phytase is a phosphohydrolase of inositol hexaphosphate [1] .</p>

<p>DSPE-PEG2000-Azide ammonium is a lipid-based azide compound used in forming micelles for nanoparticle drug delivery. It serves as a click chemistry reagent and includes an azide group that reacts with molecules containing an alkyne group through a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc). Additionally, it can engage in a strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.</p>

<p>C12 DG PEG (1,2-Didodecanoyl-rac-glycero-3-methoxypolyethylene glycol) (MW 2000) is a polyethylene glycol lipid that can be utilized in the formation of lipid nanoparticles and liposomes. C12 DG PEG (MW 2000) shows potential for use in cancer research.</p>

<p>α-Glucosidase-IN-75 (compound 13) is an inhibitor of α-glucosidase, exhibiting an IC50 value of 3.81 μM. It is employed in the study of cardiovascular diseases induced by high glucose levels.</p>

<p>CK1-IN-4 (Compound 59) is an inhibitor of casein kinase CK1δ with an IC50 of 2.74 μM. It exhibits neuroprotective activity in SH-SY5Y cells treated with Ethacrynic acid.</p>

<p>DSPE-PEG5000-F3 consists of DSPE and the nucleolin-targeting peptide (F3) and is a PEGylated compound. The F3 peptide specifically binds to nucleolin on the cell surface, facilitating efficient transport from the cell surface to the nucleus. DSPE-PEG5000-F3 is applicable for drug delivery.</p>

<p>Dextranase, a glucan hydrolase, breaks down α-(1,6)-glucosidic bonds in dextran, useful in food, sugar modification, medicine, and more.</p>

<p>3,3'-Bipyridine is an inhibitor of CYP2A6, CYP3A4, and CYP2B6, and also inhibits gastric acid secretion in rats.</p>