Metabolismo

<p>ACK, found in bacteria/archaea, phosphorylates acetate with ATP and cations, yielding acetyl-CoA; used in biochemistry.</p>

<p>α-Glucosidase-IN-73 (compound 16b), an α-Glucosidase inhibitor, exhibits an IC 50 value of 0.158 μM and possesses the ability to activate PPAR γ. This compound is applicable in studies focusing on anti-diabetic and anti-inflammatory treatments.</p>

<p>DSPE-PEG1000-pPB is a PEG compound consisting of DSPE and a cyclic oligopeptide (pPB). The pPB component exhibits a strong binding affinity to PDGFRβ, which is overexpressed in activated hepatic stellate cells (HSC). DSPE-PEG1000-pPB is applicable for drug delivery.</p>

<p>Coprosterol is a stanol formed from the biohydrogenation of cholesterol as a biomarker for the presence of human faecal matter in the environment.</p>

<p>3-Nitro-L-tyrosine ethyl ester hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T124433.</p>

CarboxypeptidaseY, Baker's yeast (S. cerevisiae) serves as a biocatalyst and is a crucial enzyme in advanced biocatalyst technology. Enzyme engineering focuses on improving the kinetics of enzyme reactions, substrate selectivity, and performance under challenging conditions, such as low or high pH. Introducing stimulus-responsive modifications to these enzymes also enables dynamic control of their activity.

<p>Z-Thioprolyl-Thiazolidine is a potent, specific inhibitor of bovine brain prolyl endopeptidase, demonstrating an inhibition constant (K i value) of 0.36 nM [1].</p>

<p>Adriamycin Aglycone, also known as Doxorubicinone, is an oncolytic agent. It is a metabolite of Doxorubicin which binds to the DNA minor-groove.</p>

<p>Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity.</p>

<p>3-O-Dihydro-p-coumaroyltohogenol functions as a PTP1B inhibitor (IC50 = 6.27 μM), exhibiting anti-diabetic and anti-obesity activities.</p>

<p>GLX481369 is a redox-active substance that functions as an NOX4 inhibitor, exhibiting antioxidant effects [1].</p>

<p>ADP-specific glucokinase, expressed in thermophilic archaea, is an ADP-specific enzyme that catalyzes the conversion of glucose to glucose-6-phosphate, thereby facilitating glycolysis. This enzyme can activate T cells and enhance the phagocytic activity of macrophages. It is used in research related to metabolic disorders, neurological diseases, and tumors.</p>

CE(20:5(5Z,8Z,11Z,14Z,17Z) is an endogenous metabolite.

<p>XW-032 is an apo-IDO1 inhibitor with an IC50 of 21 nM. In the CT26 syngeneic mouse model, XW-032 demonstrates significant in vivo antitumor efficacy with a TGI of 63%, showing potential for cancer research applications.</p>

<p>m-Tyramine has effects on the adrenergic and dopaminergic receptor.m-Tyramine is an endogenous trace amine neuromodulator.</p>

<p>IONIS PTP1BRx (ISIS 404173) acts as an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). This compound exhibits anti-diabetic properties, making it suitable for research into insulin resistance related to obesity and type 2 diabetes.</p>

<p>m-PEG8-DSPE is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.</p>

<p>Clocortolone, a medium-strength corticosteroid, treats dermatitis as a cream ester called clocortolone pivalate.</p>

<p>Anti bacterial agent 237 (compound Ru-8) acts as a potent antibacterial agent against Staphylococcus aureus, exhibiting minimum inhibitory concentrations (MICs) ranging from 0.78 to 1.56 μg/mL. It works by disrupting bacterial cell membranes, altering their permeability, and inducing the production of reactive oxygen species, which leads to bacterial cell death without promoting resistance. Additionally, Anti bacterial agent 237 demonstrates low hemolytic toxicity towards rabbit erythrocytes and Raw 264.7 cells. It has shown significant antibacterial activity in models of skin wound infections in mice and larval infections by the greater wax moth, effectively combating Staphylococcus aureus infections.</p>

<p>Trimetazidine-N-oxide, main active metabolite of Trimetazidine, blocks 3-ketoyl CoA thiolase (IC50: 75nM) and has multiple protective properties.</p>