Metabolismo
Os inibidores do metabolismo são compostos que interferem nas vias metabólicas, alterando a produção e utilização de energia dentro das células. Esses inibidores são usados para estudar a regulação do metabolismo, o papel das vias metabólicas em doenças como o câncer e o diabetes, e para desenvolver novas estratégias terapêuticas. Os inibidores do metabolismo podem direcionar várias enzimas e processos envolvidos na glicólise, na oxidação de ácidos graxos e em outras funções metabólicas. Na CymitQuimica, oferecemos uma ampla gama de inibidores do metabolismo de alta qualidade para apoiar sua pesquisa em bioquímica, distúrbios metabólicos e desenvolvimento de medicamentos.
Subcategorias de "Metabolismo"
- AhR(41 produtos)
- Aminopeptidase(67 produtos)
- CETP(18 produtos)
- Anidrase carbónica(178 produtos)
- Caseína quinase(130 produtos)
- DHFR(33 produtos)
- Descarboxilase(4 produtos)
- Desidrogenase(269 produtos)
- FAAH(64 produtos)
- FXR(58 produtos)
- Factor Xa(80 produtos)
- Sintase de Ácidos graxos(32 produtos)
- Ferroptose(215 produtos)
- GR(3 produtos)
- GSNOR(3 produtos)
- Glucoquinase(54 produtos)
- HIF/HIF Prolil-Hidroxilase(142 produtos)
- HMG-CoA Reductase(33 produtos)
- Hidroxilase(30 produtos)
- IDO(82 produtos)
- LDL(8 produtos)
- Lipase(97 produtos)
- Lipídio(59 produtos)
- Lipoxigenase(124 produtos)
- MAO(87 produtos)
- MPO(2 produtos)
- NAMPT(36 produtos)
- P450(6 produtos)
- PAI-1(25 produtos)
- PDE(166 produtos)
- PED(1 produtos)
- PKM(15 produtos)
- PPAR(164 produtos)
- Fosfolipase(82 produtos)
- ROR(42 produtos)
- Receptor de Retinóide(29 produtos)
- SGK(11 produtos)
- Tiorredoxina(12 produtos)
- Transferase(30 produtos)
- Tansportador(42 produtos)
- UGT(4 produtos)
- Inibidores de Xantina Oxidase (XO)(9 produtos)
Exibir 34 mais subcategorias
Foram encontrados 8626 produtos de "Metabolismo"
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PENAO
CAS:<p>PENAO is a potent mitochondrial toxin for tumor cells. It deactivates the mitochondria of tumor cells by targeting the adenine nucleotide translocase in the cell membrane.</p>Fórmula:C13H19AsN2O5SCor e Forma:SolidPeso molecular:390.29BAR-2227
CAS:<p>BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.</p>Fórmula:C24H17Cl2NO4Cor e Forma:SolidPeso molecular:454.30DGAT2-IN-3
CAS:<p>DGAT2-IN-3 (compound 9) is an inhibitor of DGAT2 with an IC50 value of 0.4 nM. It is utilized in research related to fatty liver disease, diabetes, and cardiovascular diseases.</p>Fórmula:C21H20F4N4O5SCor e Forma:SolidPeso molecular:516.47ACLY-IN-1
CAS:<p>ACLY-IN-1 (compound 55) is a potent ACLY inhibitor with an IC50 of 8.3 nM, and it can be utilized in hyperlipidemia research.</p>Fórmula:C20H12BrClF2N2O4SCor e Forma:SolidPeso molecular:529.74Nampt-IN-15
CAS:Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.Fórmula:C24H30N4O2Cor e Forma:SolidPeso molecular:406.52DEL-I25
CAS:<p>DEL-I25 is an effective activator of GPX4 that protects cells from ferroptosis (iron-dependent cell death).</p>Fórmula:C21H23N5O3Cor e Forma:SolidPeso molecular:393.44HIF-1/2α-IN-1
<p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>Fórmula:C17H16N6O4Cor e Forma:SolidPeso molecular:368.35Antidiabetic agent 5
CAS:<p>Compound S1 (antidiabetic agent 5) is an antidiabetic agent that effectively inhibits the enzymes α-glucosidase and α-amylase, demonstrating IC50 values of 3.91 µM and 8.89 µM, respectively. It reduces sugar levels and holds potential for type-II diabetes research [1].</p>Fórmula:C17H15N3O4SCor e Forma:SolidPeso molecular:357.38Estradiol 3-glucuronide
CAS:<p>Estradiol 3-glucuronide is an immunogen with antigenic properties. The antiserum induced in rabbits exhibits high affinity and specificity for Estradiol 3-glucuronide. This compound shows promise for use in research involving radioimmunoassay.</p>Fórmula:C24H32O8Cor e Forma:SolidPeso molecular:448.51MGAT2-IN-1
CAS:<p>MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).</p>Fórmula:C27H21ClF5N7O3SCor e Forma:SolidPeso molecular:654.01MD 770222
CAS:<p>MD 770222, the principal plasma O-demethylated metabolite of Cimoxatone, is an orally active selective and reversible inhibitor of MAO A. The potency of MD 770222 is lower than that of Cimoxatone.</p>Fórmula:C18H16N2O4Cor e Forma:SolidPeso molecular:324.33Z21090
CAS:<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Fórmula:C12H14ClN3O3Cor e Forma:SolidPeso molecular:283.71Alkannin
CAS:<p>Alkannin: potent, tumor-specific PKM2 inhibitor; non-inhibitory to PKM1/PKL; potential anticancer agent.</p>Fórmula:C16H16O5Cor e Forma:SolidPeso molecular:288.3Dihydrokainic acid
CAS:<p>EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake</p>Fórmula:C10H17NO4Pureza:98%Cor e Forma:SolidPeso molecular:215.25Fonadelpar
CAS:<p>Fonadelpar is an agonist of PPARδ. It also is used in the research of neuroparalytic keratopathy.</p>Fórmula:C25H23F3N2O4SPureza:98%Cor e Forma:SolidPeso molecular:504.52Emopamil
CAS:<p>Emopamil, a calcium channel inhibitor, reduces neuronal damage caused by ischemia.</p>Fórmula:C23H30N2Cor e Forma:SolidPeso molecular:334.5KY-455
CAS:<p>KY-455 is a novel acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor. It demonstrates inhibition of ACAT in rabbit intestines, liver, macrophages, and adrenal glands with IC50 values of 0.4, 0.9, 2.9, and 4.1 μmol/L, respectively.</p>Fórmula:C20H32N2OCor e Forma:SolidPeso molecular:316.48CIT-ALD
CAS:<p>CIT-ALD is an aldehyde intermediate formed during the metabolism of Citalopram. It has potential applications in the research of neurological disorders.</p>Fórmula:C18H14FNO2Peso molecular:295.31CYP11B1-IN-2
<p>CYP11B1-IN-2 selectively inhibits human and rat CYP11B1 (IC50: 9/25 nM) orally to research cortisol-related diseases.</p>Cor e Forma:SolidLipid PPz-2R1
CAS:Lipid PPz-2R1 is an ionizable cationic lipid employed in crafting lipid nanoparticles (LNPs) for mRNA delivery both in vitro and in vivo. LNPs with lipid PPz-2R1, encapsulating an mRNA reporter, target the lungs preferentially over the heart, liver, spleen, and kidneys in mice. Additionally, these LNPs, when encapsulating mRNA encoding phosphatase and tensin homolog (PTEN), enhance PTEN protein levels in PTEN-deficient Lewis lung carcinoma (LLC) cells. In an orthotopic murine LLC model, these Lipid PPz-2R1-containing LNPs, carrying PTEN mRNA, reduce tumor growth either when administered alone or alongside an antibody against programmed cell death protein 1 (PD-1).Fórmula:C48H94N2O4Peso molecular:763.27Cephapirin lactone
CAS:Cephapirinlactone is a metabolite of the antibiotic Cephapirin.Fórmula:C15H13N3O4S2Peso molecular:363.41Desmonomethylpromazine
CAS:<p>Desmonomethylpromazine is a demethylated metabolite of Promazine that can penetrate the brain. It enters red blood cells and tissues via passive diffusion and is distributed in organs such as the lungs, liver, and kidneys in rats.</p>Fórmula:C16H18N2SCor e Forma:SolidPeso molecular:270.397-hydroxychlorpromazine
CAS:<p>7-Hydroxychlorpromazine, an active metabolite of Chlorpromazine, can reversibly counteract the suppression of regionally dense dopaminergic neurons induced by Amphetamine.</p>Fórmula:C17H19ClN2OSCor e Forma:SolidPeso molecular:334.86Lipoxin A5
CAS:<p>LXA5 is made from EPA by leukocytes, contracts guinea pig lungs like LXA4/LXB4, but doesn't dilate aorta.</p>Fórmula:C20H30O5Cor e Forma:SolidPeso molecular:350.45Rivaroxaban diol
CAS:<p>Rivaroxabandiol is a metabolite of Rivaroxaban, which is a potent and selective direct inhibitor of coagulation factor Xa (FXa) with an IC50 of 0.7 nM and a Ki of 0.4 nM.</p>Fórmula:C19H20ClN3O6SCor e Forma:SolidPeso molecular:453.897Fluopimomide
CAS:<p>Fluopimomide (LH2010A), a powerful insecticide, is extensively utilized in the control of agricultural pests. It adversely affects the growth, locomotor behavior, reproduction, and lifespan of nematodes. Concurrently, it leads to increased production of reactive oxygen species (ROS), accumulation of lipids and lipofuscins, as well as a rise in malondialdehyde content. Additionally, Fluopimomide inhibits the antioxidant system of nematodes.</p>Fórmula:C15H8ClF7N2O2Cor e Forma:SolidPeso molecular:416.68PDE4-IN-14
CAS:<p>PDE4-IN-14 (Compound 1) serves as an inhibitor of phosphodiesterase 4 (PDE4), applicable in research concerning diseases associated with PDE4, including</p>Fórmula:C19H20F2N4O3SCor e Forma:SolidPeso molecular:422.45CK2-IN-3
<p>CK2-IN-3: potent, selective CK2 inhibitor; Kd=12 nM, IC50: 1.51 μM (CK2α), 7.64 μM (CK2α'). For cancer research.</p>Fórmula:C22H26N4O7Cor e Forma:SolidPeso molecular:458.46AChE/PDE4-IN-1
<p>AChE/PDE4-IN-1, compound 12c, dual inhibitor; IC50: 0.28μM for AChE, 1.88μM for PDE4D, may reduce Alzheimer's neuroinflammation.</p>Fórmula:C23H28N2O3Cor e Forma:SolidPeso molecular:380.48RMGPa-IN-1
CAS:<p>RMGPa-IN-1 (Compound 10C) is an inhibitor of rabbit muscle glycogen phosphorylase a (RMGPa), exhibiting an IC50 value of 82.5 μM. This compound holds potential for research in diabetes.</p>Fórmula:C33H54O4Cor e Forma:SolidPeso molecular:514.779Lecufexor
CAS:<p>Lecufexor is an agonist of the farnesoid X receptor (FXR).</p>Fórmula:C32H21Cl3N2O5Cor e Forma:SolidPeso molecular:619.88Carbonic anhydrase inhibitor 17
CAS:<p>Carbonic anhydrase inhibitor 17 (compound 7c) is a pyrazine-based sulfonamide that acts as a carbonic anhydrase II inhibitor, with an IC50 value of 0.63 nM.</p>Fórmula:C18H15ClN4O3S2Peso molecular:434.92PKR Inhibitor, negative control
CAS:<p>The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.</p>Fórmula:C15H8Cl3NO2Peso molecular:340.59Mucidin
CAS:<p>Mucidin is an antifungal antibiotic that inhibits electron transfer reactions within the mitochondrial respiratory chain's cytochrome bc1 complex.</p>Fórmula:C16H18O3Peso molecular:258.3111-Mercaptoundecanoate-NHS
CAS:<p>11-Mercaptoundecanoate-NHS is a lipid utilized in the synthesis of Linkers.</p>Fórmula:C15H25NO4SCor e Forma:SolidPeso molecular:315.428GGACK
CAS:<p>GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).</p>Fórmula:C14H25ClN6O5Peso molecular:392.84Aripiprazole N,N-Dioxide
CAS:<p>AripiprazoleN,N-Dioxide is a metabolite of the atypical antipsychotic drug aripiprazole, formed through its oxidation.</p>Fórmula:C23H27Cl2N3O4Peso molecular:480.38Raloxifene N-Oxide
CAS:<p>Raloxifene N-Oxide is a Raloxifene oxidative degradation product.</p>Fórmula:C28H27NO5SPureza:98%Cor e Forma:SolidPeso molecular:489.58Miaosporone A
<p>Miaosporone A: angucyclic quinone, cytotoxic to MCF-7, NCI-H187, Vero cells; anti-TB and anti-malaria with IC50 of 2.4 μM, 2.5 μM.</p>Fórmula:C19H18O5Cor e Forma:SolidPeso molecular:326.34hCAII-IN-4
CAS:<p>hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.</p>Fórmula:C31H23NO9Cor e Forma:SolidPeso molecular:553.52L-690330 hydrate
<p>L-690330 hydrate inhibits IMPase; Ki: 0.30 μM (human), 0.42 μM (bovine cortex); 0.27 μM (recom. human), 0.19 μM (bovine).</p>Fórmula:C8H14O9P2Cor e Forma:SolidPeso molecular:316.14PTP1B-IN-3 diammonium
<p>PTP1B-IN-3 diammonium, an oral enzyme inhibitor, has potent antidiabetic and anticancer effects, with a 120 nM IC50.</p>Fórmula:C12H13BrF2N3O3PCor e Forma:SolidPeso molecular:396.12hMAO-B/MB-COMT-IN-2
<p>Dual inhibitor hMAO-B/MB-COMT-IN-2 targets hMAO-B (IC50: 4.27μM) & MB-COMT (IC50: 2.69μM), aids in neurodegenerative research.</p>Fórmula:C17H18N2O3Cor e Forma:SolidPeso molecular:298.34α-Glucosidase-IN-17
CAS:<p>α-Glucosidase-IN-17 (Compound 12B) is a potent and orally active inhibitor of α-glucosidase, demonstrating antidiabetic activity with an inhibitory</p>Fórmula:C30H27NO2SCor e Forma:SolidPeso molecular:465.61L 668411
CAS:<p>L 668411, the 2,3-ditritiated methyl ester of L 659699, inhibits HMG-CoA synthase.</p>Fórmula:C19H30O5Pureza:98%Cor e Forma:SolidPeso molecular:338.4420-HEDE
CAS:<p>20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist.</p>Fórmula:C20H36O3Pureza:98%Cor e Forma:SolidPeso molecular:324.50Myxothiazol
CAS:<p>Myxothiazol blocks mitochondrial complex III and triggers SESN2, a gene important for stress response.</p>Fórmula:C25H33N3O3S2Cor e Forma:SolidPeso molecular:487.68Zaragozic acid C
CAS:<p>Zaragozic acid C is an effective inhibitor of squalene synthase.</p>Fórmula:C40H50O14Pureza:98%Cor e Forma:SolidPeso molecular:754.82FXIa-6f
CAS:<p>FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species</p>Fórmula:C31H29ClF2N4O4Cor e Forma:SolidPeso molecular:595.043'-Hydroxy Repaglinide
CAS:<p>'3'-Hydroxy Repaglinide, a CYP2C8 metabolite of Repaglinide, treats type II diabetes.</p>Fórmula:C27H36N2O5Pureza:98%Cor e Forma:SolidPeso molecular:468.59
