Metabolismo
Os inibidores do metabolismo são compostos que interferem nas vias metabólicas, alterando a produção e utilização de energia dentro das células. Esses inibidores são usados para estudar a regulação do metabolismo, o papel das vias metabólicas em doenças como o câncer e o diabetes, e para desenvolver novas estratégias terapêuticas. Os inibidores do metabolismo podem direcionar várias enzimas e processos envolvidos na glicólise, na oxidação de ácidos graxos e em outras funções metabólicas. Na CymitQuimica, oferecemos uma ampla gama de inibidores do metabolismo de alta qualidade para apoiar sua pesquisa em bioquímica, distúrbios metabólicos e desenvolvimento de medicamentos.
Subcategorias de "Metabolismo"
- AhR(41 produtos)
- Aminopeptidase(67 produtos)
- CETP(18 produtos)
- Anidrase carbónica(177 produtos)
- Caseína quinase(130 produtos)
- DHFR(32 produtos)
- Descarboxilase(4 produtos)
- Desidrogenase(267 produtos)
- FAAH(63 produtos)
- FXR(58 produtos)
- Factor Xa(80 produtos)
- Sintase de Ácidos graxos(32 produtos)
- Ferroptose(215 produtos)
- GR(3 produtos)
- GSNOR(3 produtos)
- Glucoquinase(53 produtos)
- HIF/HIF Prolil-Hidroxilase(142 produtos)
- HMG-CoA Reductase(32 produtos)
- Hidroxilase(30 produtos)
- IDO(82 produtos)
- LDL(8 produtos)
- Lipase(96 produtos)
- Lipídio(59 produtos)
- Lipoxigenase(124 produtos)
- MAO(87 produtos)
- MPO(2 produtos)
- NAMPT(36 produtos)
- P450(6 produtos)
- PAI-1(25 produtos)
- PDE(166 produtos)
- PED(1 produtos)
- PKM(15 produtos)
- PPAR(164 produtos)
- Fosfolipase(82 produtos)
- ROR(42 produtos)
- Receptor de Retinóide(29 produtos)
- SGK(11 produtos)
- Tiorredoxina(12 produtos)
- Transferase(30 produtos)
- Tansportador(42 produtos)
- UGT(4 produtos)
- Inibidores de Xantina Oxidase (XO)(9 produtos)
Exibir 34 mais subcategorias
Foram encontrados 8595 produtos de "Metabolismo"
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ACLY-IN-1
CAS:<p>ACLY-IN-1 (compound 55) is a potent ACLY inhibitor with an IC50 of 8.3 nM, and it can be utilized in hyperlipidemia research.</p>Fórmula:C20H12BrClF2N2O4SCor e Forma:SolidPeso molecular:529.74EB-0156
<p>EB-0156: potent ER α-glucosidase inhibitor, IC50 of 0.0479/ <0.001 μM, N-substituted valerian, broad-spectrum antiviral potential.</p>Fórmula:C21H32N6O7Cor e Forma:SolidPeso molecular:480.51α-Glucosidase-IN-18
<p>α-Glucosidase-IN-18 (7B) is an orally active inhibitor of α-glucosidase, displaying an IC 50 value of 3.96 μM.</p>Fórmula:C23H19NO2SCor e Forma:SolidPeso molecular:373.47DEL-I25
CAS:<p>DEL-I25 is an effective activator of GPX4 that protects cells from ferroptosis (iron-dependent cell death).</p>Fórmula:C21H23N5O3Cor e Forma:SolidPeso molecular:393.44(-)-Mesembrine
CAS:<p>Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4).</p>Fórmula:C17H23NO3Cor e Forma:SolidPeso molecular:289.37SAL-0010042
CAS:<p>SAL-0010042 is an inhibitor of Plasmodium phosphodiesterase β (PDEβ), effectively blocking the hydrolysis of cAMP and cGMP in gametocytes with an IC50 of 48.9 nM, thereby activating PKG and inhibiting the growth and development of Plasmodium (IC50s for 3D7 and Dd2 are 142 nM and 218 nM, respectively). It also inhibits hPDE5 and hPDE6 with IC50 values of 632 nM and 73 nM, respectively.</p>Fórmula:C15H15FN4OCor e Forma:SolidPeso molecular:286.304PLAP-IN-1
CAS:<p>PLAP-IN-1: Potent, selective inhibitor of PLAP, IC50 of 32 nM; doesn't notably inhibit TNAP.</p>Fórmula:C25H21Cl2N3O5Cor e Forma:SoildPeso molecular:514.36Implitapide
CAS:<p>Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).</p>Fórmula:C35H37N3O2Pureza:98%Cor e Forma:SolidPeso molecular:531.69FAAH/MAGL-IN-1
<p>FAAH/MAGL-IN-1 (SIH 3) inhibits FAAH & MAGL with IC50 of 31 & 29 nM, useful in neuropathic pain research.</p>Fórmula:C15H9Cl2N3O3Cor e Forma:SolidPeso molecular:350.16Nampt-IN-15
CAS:Nampt-IN-15 (Example 3) is a Nampt inhibitor that exhibits cytotoxic effects on various cell lines, including BxPC-3, HepG2, L540cy, and MOLM-13. The respective IC50 values for these cell lines are 38.5 nM, 8 nM, 8.5 nM, and 7 nM.Fórmula:C24H30N4O2Cor e Forma:SolidPeso molecular:406.52FXIa-IN-8
<p>FXIa-IN-8: potent FXIa blocker (IC50: 14.2 nM), anti-thrombotic, low bleeding/toxicity risk.</p>Cor e Forma:SolidIDO1 ligand-1
CAS:<p>IDO1ligand-1 is the target protein ligand for PROTAC NU227326, which is utilized for degrading IDO1.</p>Fórmula:C29H34FN3O2Cor e Forma:SolidPeso molecular:475.598PTP1B-IN-21
<p>PTP1B-IN-21 inhibits PTP1B (IC50=1.56μM) selectively over TCPTP, a type 2 diabetes target.</p>Fórmula:C22H22O11Cor e Forma:SolidPeso molecular:462.4PD-224378
CAS:<p>PD-224378 is the lactam form of glycamine (β-isomer), produced through a Maillard reaction between pregabalin and lactose.</p>Fórmula:C20H35NO11Cor e Forma:SolidPeso molecular:465.492Etoricoxib N1'-oxide
CAS:<p>EtoricoxibN1'-oxide is a metabolite of Etoricoxib. It does not inhibit COX-1 and does not significantly inhibit COX-2.</p>Fórmula:C18H15ClN2O3SCor e Forma:SolidPeso molecular:374.841TS010
<p>TS010 is a highly potent inhibitor of GLO-I, with an IC50 value of 0.57 μM. It holds significant promise for advancements in cancer research [1].</p>Fórmula:C16H12N4O4SCor e Forma:SolidPeso molecular:356.36Enpp-1-IN-7
<p>Enpp-1-IN-7: potent enpp-1 inhibitor, broad specificity, potential in cancer/infectious disease research. (WO2021203772A1)</p>Fórmula:C18H19N7O4SCor e Forma:SolidPeso molecular:429.45RORγt inhibitor 2
CAS:<p>RORγt Inhibitor 2, a potent inhibitor of RORγt, exhibits an IC50 of 9.2 nM and is utilized in the study of cancer, inflammation, or autoimmune diseases that are</p>Fórmula:C31H33F5N2O7SCor e Forma:SolidPeso molecular:672.66PDHK-IN-4
<p>PDHK-IN-4 inhibits PDHK2 (IC50: 0.0051 μM) & PDHK4 (IC50: 0.0122 μM), with potential for cancer research.</p>Fórmula:C24H25N5O3Cor e Forma:SolidPeso molecular:431.49Porphobilinogen
CAS:<p>Porphobilinogen act as a phytotoxin, a metabotoxin, and a neurotoxin.</p>Fórmula:C10H14N2O4Pureza:98%Cor e Forma:SolidPeso molecular:226.23FXR/CES2 modulator 1
CAS:<p>Compound LE-77, known as FXR/CES2 modulator 1, functions as a dual regulator that activates FXR and inhibits CES2. It effectively mitigates the intestinal toxicity of irinotecan.</p>Fórmula:C27H21Cl2NO5Cor e Forma:SolidPeso molecular:510.36Lp-PLA2-IN-10
<p>Lp-PLA2-IN-10, a potent Lp-PLA2 inhibitor, may research neurodegenerative and cardiovascular diseases.</p>Fórmula:C21H15F5N4O4Cor e Forma:SolidPeso molecular:482.36sEH inhibitor-2
<p>SEH inhibitor-2 is an orally active sEH blocker (IC50=0.9 nM) with predicted 71.2-88.4% absorption, potentially aiding cardiovascular health.</p>Fórmula:C23H18N4O3Cor e Forma:SolidPeso molecular:398.41RORγt modulator 5
CAS:<p>RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM.</p>Fórmula:C27H22F5N3O6SCor e Forma:SolidPeso molecular:611.54Carbonic anhydrase inhibitor 5
<p>Potent hCA inhibitor: targets hCA II, IX & XII with IC50s of 42.9, 47.6, & 6.7 nM respectively.</p>Fórmula:C24H20ClN3O3SCor e Forma:SolidPeso molecular:465.95LDHA-IN-5
CAS:<p>LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primary</p>Fórmula:C27H22FN7O6S3Cor e Forma:SolidPeso molecular:655.7Deltasonamide 2 hydrochloride
<p>Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.</p>Fórmula:C30H40Cl2N6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:683.71S-15176
CAS:<p>S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). It effectively suppresses mitochondrial swelling induced by tert-butyl hydroperoxide, with an IC50 value of 45.7 μM. S-15176 prevents the opening of PTP, thus averting the dissipation of mitochondrial membrane potential and the oxidation of NAD(P)H, while enhancing mitochondrial calcium loading capacity. It holds potential for research into ischemia-reperfusion injury.</p>Fórmula:C31H48N2O4SCor e Forma:SolidPeso molecular:544.79Xanthosine-5'-monophosphate
CAS:<p>Xanthosine 5'-monophosphate is produced from inosine monophosphate (IMP) through the catalytic action of inosine monophosphate dehydrogenase (IMPDH).</p>Fórmula:C10H13N4O9PCor e Forma:SolidPeso molecular:364.21BT-114143
CAS:<p>BT-114143 is a plasminogen activator inhibitor with an IC50 of 8.42 μM. It is applicable in research related to hemorrhagic diseases caused by excessive fibrinolysis, including traumatic bleeding, severe menorrhagia, postpartum hemorrhage, and complications of hemophilia.</p>Fórmula:C8H11N2O3PCor e Forma:SolidPeso molecular:214.158Z57346765
CAS:<p>Z57346765 is a specific PGK1 inhibitor that inhibits PGK1-dependent cell proliferation by decreasing the metabolic enzyme activity of PGK1 during glycolysis.</p>Fórmula:C17H18N4OPureza:99.85%Cor e Forma:SolidPeso molecular:294.35Casein kinase 1δ-IN-30
CAS:<p>Casein kinase1δ-IN-30 (Compound 581) is an inhibitor of casein kinase 1δ (CK1δ). It can be utilized in research related to neurodegenerative diseases.</p>Fórmula:C18H15BrN6O2SCor e Forma:SolidPeso molecular:459.32PRL3-CNNM4 interaction-IN-1
CAS:<p>PRL3-CNNM4 interaction-IN-1 (Compound C28d52) is an inhibitor of the PRL3-CNNM4 interaction that also suppresses CNNM inhibition mediated by PRL. This compound exhibits favorable pharmacokinetic and drug metabolism properties.</p>Fórmula:C8H8O2SCor e Forma:SolidPeso molecular:168.21m-APTA
CAS:<p>m-APTA (5'-S-(3-aminophenyl)-5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase (MTAP). It can be converted into adenine, which is a crucial step in shielding normal cells from the toxicity of nucleobase analogs (NBA). m-APTA holds potential for research in MTAP-deficient cancers.</p>Fórmula:C16H18N6O3SCor e Forma:SolidPeso molecular:374.418AZ513
CAS:<p>AZ513 is a reversible FAAH inhibitor, exhibiting an IC50 of 551 nM for human FAAH and 27 nM for rat FAAH. It inhibits the hydrolysis of arachidonoyl ethanolamide in HEK293 cells transfected with human FAAH, with an IC50 of 360 nM.</p>Fórmula:C14H9Cl2N3OCor e Forma:SolidPeso molecular:306.147QGC583
CAS:<p>QGC583 is an effective and selective AminopeptidaseA (APA) inhibitor, demonstrating an IC50 of 4 nM. It inhibits APA activity in the brain, kidneys, and heart of rats.</p>Fórmula:C13H20NO5PCor e Forma:SolidPeso molecular:301.28DGAT2-IN-3
CAS:<p>DGAT2-IN-3 (compound 9) is an inhibitor of DGAT2 with an IC50 value of 0.4 nM. It is utilized in research related to fatty liver disease, diabetes, and cardiovascular diseases.</p>Fórmula:C21H20F4N4O5SCor e Forma:SolidPeso molecular:516.47(Rac)-8-Hydroxy-efavirenz
CAS:<p>(Rac)-8-Hydroxy-efavirenz is a metabolite of Efavirenz, a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of HIV-1.</p>Fórmula:C14H9ClF3NO3Cor e Forma:SolidPeso molecular:331.674BAR-2227
CAS:<p>BAR-2227 (compound 3a) functions as an FXR agonist and a LIFR inhibitor. It is utilized in the study of liver fibrosis and inflammation.</p>Fórmula:C24H17Cl2NO4Cor e Forma:SolidPeso molecular:454.30(rel)-Mirogabalin
CAS:<p>(rel)-Mirogabalin ((rel)-DS5565) is an inhibitor of voltage-dependent calcium channels, specifically targeting the α2δ-1 subunit.</p>Fórmula:C12H19NO2Cor e Forma:SolidPeso molecular:209.28L 668411
CAS:<p>L 668411, the 2,3-ditritiated methyl ester of L 659699, inhibits HMG-CoA synthase.</p>Fórmula:C19H30O5Pureza:98%Cor e Forma:SolidPeso molecular:338.44Yck2-IN-1
CAS:<p>Yck2-IN-1 (Compound 2a) is an inhibitor of the fungus Candida albicans Yck2. It has an IC50 of approximately 80 nM for Yck2 and an MIC80 of 12.5 µM for C. albicans, demonstrating good metabolic stability [66% remaining in mouse liver microsomes]. In a mouse model with drug-resistant Candida, Yck2-IN-1 significantly reduced fungal load in the kidneys. Yck2-IN-1 shows potential for research in antifungal infection treatments.</p>Fórmula:C19H11FN4Cor e Forma:SolidPeso molecular:314.31620-HEDE
CAS:<p>20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist.</p>Fórmula:C20H36O3Pureza:98%Cor e Forma:SolidPeso molecular:324.50AD011
<p>AD011, a cACE/NEP inhibitor derived from lenopril-tryptophan, may offer strong anti-hypertensive, cardioprotective benefits.</p>Fórmula:C27H33N3O5Cor e Forma:SolidPeso molecular:479.57Casein kinase 1δ-IN-17
CAS:<p>Casein kinase1δ-IN-17 (compound 753) is an inhibitor of casein kinase 1δ (CK1δ). It is applicable in research related to neurodegenerative diseases.</p>Fórmula:C14H14N4SCor e Forma:SolidPeso molecular:270.3537-hydroxychlorpromazine
CAS:<p>7-Hydroxychlorpromazine, an active metabolite of Chlorpromazine, can reversibly counteract the suppression of regionally dense dopaminergic neurons induced by Amphetamine.</p>Fórmula:C17H19ClN2OSCor e Forma:SolidPeso molecular:334.864-Hydroxyclonidine
CAS:<p>4-Hydroxyclonidine is a metabolite of Clonidine. It is equally effective as Clonidine in displacing labeled Clonidine from antibodies.</p>Fórmula:C9H9Cl2N3OCor e Forma:SolidPeso molecular:246.093GPX4-IN-15
CAS:<p>GPX4-IN-15 (Compound C1) is an inhibitor of GPX4, demonstrating an inhibition rate of 19.8% at a concentration of 1 μM. This compound effectively inhibits the proliferation of cancer cell lines MDA-MB-468, BT-549, and MDA-MB-231, with IC50 values of 0.86 μM, 0.96 μM, and 0.48 μM respectively.</p>Fórmula:C17H15Cl2NO4Cor e Forma:SolidPeso molecular:368.21WR 199507 trihydrobromide
CAS:<p>WR 199507 trihydrobromide is a primary aminoquinoline metabolite that induces the formation of methemoglobin in canine erythrocyte lysates.</p>Fórmula:C15H24Br3N3O2Cor e Forma:SolidPeso molecular:518.08Perfluorohexane sulfonamide
CAS:<p>Perfluorohexane sulfonamide (FHxSA) serves as an inhibitor of carbonic anhydrase (CA), effectively inhibiting bovine CA and human CAII with IC50 values of 0.122 and 1.38 μM, respectively. Additionally, it acts as a delayed-action insecticide for controlling red imported fire ants (Solenopsis invicta). Furthermore, Perfluorohexane sulfonamide is considered a potential environmental pollutant.</p>Fórmula:C6H2F13NO2SCor e Forma:SolidPeso molecular:399.13
