Metabolismo
Os inibidores do metabolismo são compostos que interferem nas vias metabólicas, alterando a produção e utilização de energia dentro das células. Esses inibidores são usados para estudar a regulação do metabolismo, o papel das vias metabólicas em doenças como o câncer e o diabetes, e para desenvolver novas estratégias terapêuticas. Os inibidores do metabolismo podem direcionar várias enzimas e processos envolvidos na glicólise, na oxidação de ácidos graxos e em outras funções metabólicas. Na CymitQuimica, oferecemos uma ampla gama de inibidores do metabolismo de alta qualidade para apoiar sua pesquisa em bioquímica, distúrbios metabólicos e desenvolvimento de medicamentos.
Subcategorias de "Metabolismo"
- AhR(41 produtos)
- Aminopeptidase(67 produtos)
- CETP(18 produtos)
- Anidrase carbónica(177 produtos)
- Caseína quinase(130 produtos)
- DHFR(32 produtos)
- Descarboxilase(4 produtos)
- Desidrogenase(267 produtos)
- FAAH(63 produtos)
- FXR(58 produtos)
- Factor Xa(80 produtos)
- Sintase de Ácidos graxos(32 produtos)
- Ferroptose(215 produtos)
- GR(3 produtos)
- GSNOR(3 produtos)
- Glucoquinase(53 produtos)
- HIF/HIF Prolil-Hidroxilase(142 produtos)
- HMG-CoA Reductase(32 produtos)
- Hidroxilase(30 produtos)
- IDO(82 produtos)
- LDL(8 produtos)
- Lipase(96 produtos)
- Lipídio(59 produtos)
- Lipoxigenase(124 produtos)
- MAO(87 produtos)
- MPO(2 produtos)
- NAMPT(36 produtos)
- P450(6 produtos)
- PAI-1(25 produtos)
- PDE(165 produtos)
- PED(1 produtos)
- PKM(15 produtos)
- PPAR(164 produtos)
- Fosfolipase(82 produtos)
- ROR(42 produtos)
- Receptor de Retinóide(29 produtos)
- SGK(11 produtos)
- Tiorredoxina(12 produtos)
- Transferase(30 produtos)
- Tansportador(42 produtos)
- UGT(4 produtos)
- Inibidores de Xantina Oxidase (XO)(9 produtos)
Exibir 34 mais subcategorias
Foram encontrados 8597 produtos de "Metabolismo"
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LRAT-IN-1
CAS:<p>LRAT-IN-1 (compound 1) is an inhibitor of lecithin retinol acyltransferase (LRAT) with an IC50 value of 21.1 μM. This compound works by inhibiting the esterification of retinol to form retinyl esters, thereby increasing the availability of retinol in the skin to deliver anti-aging benefits. LRAT-IN-1 is under investigation for its potential use as an anti-aging ingredient in cosmetics.</p>Fórmula:C27H47N5O5S2Cor e Forma:SolidPeso molecular:585.82Magnesium ionophore III
CAS:<p>Magnesium ionophore III (ETH 4030) is an ion carrier that regulates intracellular magnesium ion concentrations. It enhances cellular functions and metabolic activities by increasing the permeability of cell membranes to magnesium ions. Additionally, Magnesium ionophore III is utilized in research to explore the significance of magnesium ions in biological processes and their impact on cellular physiology.</p>Fórmula:C30H58N4O4Cor e Forma:SolidPeso molecular:538.811-Stearoyl-sn-glycerol 3-phosphate sodium
CAS:<p>1-Stearoyl-sn-glycerol 3-phosphate sodium, a biologically active phospholipid, plays a crucial role in regulating cell motility, proliferation, invasion, survival, and the production of growth factors through interactions with G protein-coupled receptors (GPCR). Synthesized during the formation of membrane phospholipids, this compound typically has a low plasma concentration (approximately 100nM) and originates from various cell types, including activated platelets, epithelial cells, leukocytes, neuronal cells, and tumor cells. Its distinctive structure features stearic acid at the sn-1 position and a hydroxyl group at the sn-2 position.</p>Fórmula:C21H42NaO7PCor e Forma:SolidPeso molecular:460.52PDE4-IN-6
<p>PDE4-IN-6: Potent PDE4 inhibitor, IC50 - 0.125μM (B), 0.43μM (D), anti-inflammatory, for arthritis research.</p>Fórmula:C25H20FNO5SCor e Forma:SolidPeso molecular:465.498-Hydroxychlorpromazine
CAS:<p>8-Hydroxychlorpromazine is a metabolite of Chlorpromazine that can enhance the hyperglycemic response following glucose loading, suggesting a possible synergistic role in Chlorpromazine-induced glucose metabolism disorders. It holds potential for research into metabolic diseases.</p>Fórmula:C17H19ClN2OSCor e Forma:SolidPeso molecular:334.864D-2-Phosphoglyceric acid
CAS:<p>D-2-Phosphoglyceric acid is a crucial metabolic intermediate known for its role in enhancing cellular energy metabolism and regulating biosynthesis. It plays a key role in both glycolysis and photosynthesis, which are essential for cellular energy supply. Additionally, D-2-Phosphoglyceric acid serves as a biomarker for monitoring metabolic states in various organisms.</p>Fórmula:C3H7O7PCor e Forma:SolidPeso molecular:186.06CYP2C9/CYP2C19-IN-1
<p>CYP2C9/CYP2C19-IN-1 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.</p>Fórmula:C27H28N2O6SCor e Forma:SolidPeso molecular:508.59AXKO-0046
<p>AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.</p>Fórmula:C25H33N3Cor e Forma:SolidPeso molecular:375.55Lp(a)-IN-5
CAS:<p>Lp(a)-IN-5 (Compound A) is an orally active inhibitor of lipoprotein (a) [Lp(a)]. It effectively inhibits the assembly of Apo(a) and ApoB proteins, with an IC50 value of 0.41 nM. Lp(a)-IN-5 shows potential for research into diseases associated with elevated plasma Lp(a) levels, such as cardiovascular diseases.</p>Fórmula:C43H56N4O7Cor e Forma:SolidPeso molecular:740.927TMX-4113
<p>TMX-4113 has potential to be used in cancer that is a phosphodiesterase 6D(PDE6D) and casein kinase 1α(CK1α) degrader [1].</p>Fórmula:C12H12N4O2S2Cor e Forma:SolidPeso molecular:308.38LTA4H-IN-3
CAS:<p>LTA4H-IN-3 (compound 9) functions as an inhibitor of LTA4H, demonstrating an IC50 of 28 nM [1].</p>Fórmula:C17H15ClN4O3Cor e Forma:SolidPeso molecular:358.78SGK1-IN-3
<p>SGK1-IN-3: Potent oral inhibitor of SGK1, may target osteoarthritis.</p>Fórmula:C23H20Cl2N6O3SCor e Forma:SolidPeso molecular:531.41Z21090
CAS:<p>Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].</p>Fórmula:C12H14ClN3O3Cor e Forma:SolidPeso molecular:283.71CK1δ-IN-5
CAS:<p>CK1δ-IN-5 (Compound 24) is an inhibitor of casein kinase 1δ (CK1δ) and can be used in the study of neurodegenerative diseases.</p>Fórmula:C22H21N5Cor e Forma:SolidPeso molecular:355.436Salacinol
CAS:<p>Salacinol is a naturally occurring alpha-glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata.</p>Fórmula:C9H18O9S2Cor e Forma:SolidPeso molecular:334.37Pyrocatechol sulfate
CAS:<p>Pyrocatechol sulfate, a phenolic metabolite found in human plasma, is associated with the intake of specific foods such as berries and the state of the gut microbiome. It serves as a potential urinary biomarker for kidney function, dialysis clearance rates, whole grain consumption, and regular coffee intake. Additionally, in conjunction with other phenolic sulfates, pyrocatechol sulfate plays a role in regulating various biological functions, including those related to brain health and the rhythmic beating of cardiac cells.</p>Fórmula:C6H6O5SCor e Forma:SolidPeso molecular:190.17Sphingomyelin (d18:1/12:0)
CAS:<p>Sphingomyelin (d18:1/12:0) is a polar lipid known for its role in modulating cell signal transduction. It plays a critical role in cell membranes, influencing their fluidity and stability. Additionally, sphingomyelin (d18:1/12:0) is involved in lipid metabolism and has potential in promoting neuronal cell growth. This compound is essential for the functioning and development of the nervous system.</p>Fórmula:C35H71N2O6PCor e Forma:SolidPeso molecular:646.92CP 524515
CAS:<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Fórmula:C27H27F9N2O4Cor e Forma:SolidPeso molecular:614.5Darlifarnib
CAS:<p>Darlifarnib (Compound (S)-058) is an inhibitor of farnesyl transferase and geranylgeranyltransferase, with IC50 values of ≤ 10 nM and > 1000 nM, respectively. It exhibits high metabolic stability in human and mouse liver microsomes, with a half-life of over 100 minutes.</p>Fórmula:C29H20N6OCor e Forma:SolidPeso molecular:468.509RORγ-IN-2
CAS:<p>RORγ-IN-2 (Compound 22) is an inhibitor of RORγ, with a Ki value of 16.6 nM for hRORγ. It is useful for research in IL-17-dependent autoimmune diseases.</p>Fórmula:C28H32F3N5O4S2Cor e Forma:SolidPeso molecular:623.71AChE/hCA I-IN-1
CAS:<p>AChE/hCA I-IN-1 (Compound L3) is an inhibitor of acetylcholinesterase (AChE) and carbonic anhydrase (CA), effectively inhibiting AChE, hCA I, and hCA II with IC50 values of 302 nM, 265 nM, and 283 nM, respectively.</p>Fórmula:C13H9BrNNaO4SCor e Forma:SolidPeso molecular:378.174CK1δ-IN-3
CAS:<p>CK1δ-IN-3 (compound 376) is a CK1δ (casein kinase 1δ) inhibitor that can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>Fórmula:C24H19N3O2SPureza:99.27%Cor e Forma:SolidPeso molecular:413.49PDE4B-IN-3
<p>PDE4B-IN-3 is a potent inhibitor of PDE4B (IC50: 0.94 μM) and exhibits anti-inflammatory effects.</p>Fórmula:C30H35N3O4S2Cor e Forma:SolidPeso molecular:565.751,2-Dipentadecanoyl-rac-glycerol
CAS:<p>1,2-Dipentadecanoyl-rac-glycerol (DG(15:0/15:0/0:0)) is a compound referenced in studies examining the effect of insulin on the content of 1,2-diacylglycerol in rat hearts. Insulin is observed to increase the amount of 1,2-diacylglycerol containing specific fatty acid compositions in the heart, which may be linked to cardiac contractility.</p>Fórmula:C33H64O5Cor e Forma:SolidPeso molecular:540.863-Benzylidenecamphor
CAS:<p>3-Benzylidenecamphor, a UV absorber, is noted for its excellent photostability and antioxidant activity. It is extensively utilized in sunscreen products to shield the skin from UV damage. Additionally, 3-Benzylidenecamphor is used in cosmetics to enhance product shelf life and safety.</p>Fórmula:C17H20OCor e Forma:SolidPeso molecular:240.34BPU17
CAS:<p>BPU17 interacts with PHB1 and disrupts the PHB1-PHB2 interaction, causing slight mitochondrial dysfunction. This damage hinders transcription dependent on SRF/CArG-box, thereby inhibiting epithelial-mesenchymal transition (EMT) in retinal pigment epithelial cells (RPEs). BPU17 has demonstrated anti-fibrotic activity in vivo. It holds potential as a research agent for anti-angiogenic age-related macular degeneration (nAMD).</p>Fórmula:C12H13ClN2O2Cor e Forma:SolidPeso molecular:252.70SAR114137
CAS:<p>SAR114137 is a highly effective pharmaceutical compound characterized by potent bioactivity. It exhibits variations in its amorphous content during the physical processing of crystalline active pharmaceutical ingredients (APIs). The amorphous API content of SAR114137 significantly decreases when subjected to various jet milling techniques. Additionally, SAR114137 demonstrates good chemical stability in drug formulations.</p>Fórmula:C17H24F2N4O2Cor e Forma:SolidPeso molecular:354.39RORγt modulator 5
CAS:<p>RORγt modulator 5, a potent RORγt modulator, exhibits a dissociation constant (K_i) of <100 nM.</p>Fórmula:C27H22F5N3O6SCor e Forma:SolidPeso molecular:611.54APOL1-IN-3
CAS:<p>APOL1-IN-3 is an APOL1 inhibitor used for kidney disease research.</p>Fórmula:C16H19F3N4O2SCor e Forma:SolidPeso molecular:388.41HIF-1α-IN-4
<p>HIF-1α-IN-4 is an inhibitor of HIF-1α with IC50 of 24 nM in HEK293T cells which has potential antitumor effects.</p>Fórmula:C16H12N2O3Cor e Forma:SolidPeso molecular:280.28Diethylumbelliferyl phosphate
CAS:<p>Diethylumbelliferyl phosphate (DEUP) is a potent and selective inhibitor of cholesterol esterase that does not inhibit protein kinase A activity in vitro. It disrupts steroidogenesis by blocking cholesterol transport to mitochondria in steroidogenic cells, with an IC50 of 11.6 μM. This compound may also limit the absorption of dietary cholesterol.</p>Fórmula:C14H17O6PCor e Forma:SolidPeso molecular:312.25α-Glucosidase-IN-13
<p>α-Glucosidase-IN-13 is an inhibitor of α-glucosidase (IC50: 5.69 μM).</p>Fórmula:C25H28N4O3S2Cor e Forma:SolidPeso molecular:496.649-cis-β-Carotene
CAS:<p>9-cis-β-Carotene, a precursor of retinal, is cleaved by beta-carotene oxygenase 1 (BCMO1) to produce 9-cis-retinal.</p>Fórmula:C40H56Pureza:98%Cor e Forma:SolidPeso molecular:536.872,4-Dihydroxybutanoic acid
CAS:<p>2,4-Dihydroxybutanoic acid is typically not found in extracts of normal human urine and is present only in trace amounts in newborns, while cases of succinic semialdehyde dehydrogenase deficiency consistently exhibit elevated levels of this metabolite.</p>Fórmula:C4H8O4Cor e Forma:SolidPeso molecular:120.10CAII-IN-1
<p>CAII-IN-1 (3n) is a selective bovine CA-II inhibitor with 10.3 μM IC50, used in carbonic anhydrase disorder studies.</p>Fórmula:C19H21FN4SCor e Forma:SolidPeso molecular:356.46GJG057
CAS:<p>GJG057 is a highly efficient and selective Leukotriene C4 synthase (LTC4S) inhibitor with an IC50 of 44 nM in human whole blood LTC4 release assays and oral activity. It demonstrates anti-inflammatory efficacy in a mouse asthma exacerbation model and can be used for the treatment of allergic inflammation.</p>Fórmula:C21H21F5N4O2Pureza:99.8%Cor e Forma:SolidPeso molecular:456.41(-)-Mesembrine
CAS:<p>Mesembrine is a serotonin reuptake inhibitor and is also a weak inhibitor of the enzyme phosphodiesterase 4 (PDE4).</p>Fórmula:C17H23NO3Cor e Forma:SolidPeso molecular:289.37Retezorogant
CAS:<p>Retezorogant is a retinoic acid receptor-related orphan receptor gamma (RORγ) antagonist.</p>Fórmula:C23H33ClN2O3Cor e Forma:SolidPeso molecular:420.97JA2
CAS:<p>JA2 is an inhibitor of metalloendopeptidase 24.15 that enhances the hypotensive response to bradykinin in rats.</p>Fórmula:C33H38N4O8Cor e Forma:SolidPeso molecular:618.68Ranosidenib
CAS:<p>Ranolisib is an isocitrate dehydrogenase (IDH) inhibitor known for its antitumor activity.</p>Fórmula:C15H16F9N5OCor e Forma:SolidPeso molecular:453.31Nampt-IN-14
CAS:<p>Nampt-IN-14 (example 3) is an effective NAMPT inhibitor with an IC50 of 0.2 nM, suited for use in the synthesis of antibody-drug conjugates (ADCs).</p>Fórmula:C33H35N7O2Cor e Forma:SolidPeso molecular:561.68Inosine 5′-diphosphate sodium
CAS:<p>Inosine 5'-diphosphate sodium, a purine ribonucleoside diphosphate with inosine as its nucleobase, plays a role in intracellular energy metabolism and signal transduction processes.</p>Fórmula:C10H13N4Na3O12P2Cor e Forma:SolidPeso molecular:512.15DH376
CAS:<p>DH376 inhibits DAGLα in a time and dose dependent manner in mouse brain. DH376 shows picomolar activity.</p>Fórmula:C31H28F2N4O3Cor e Forma:SolidPeso molecular:542.58MAGL-IN-19
CAS:<p>MAGL-IN-19 (compound 7o) is a highly effective and selective inhibitor of MAGL.</p>Fórmula:C21H26F3N3O3Cor e Forma:SolidPeso molecular:425.45ZSH-2208
CAS:<p>ZSH-2208 is a retinoic acid A analogue that inhibits tumour cell proliferation and survival through RARγ-TNFAIP3 and retinoid receptors.</p>Fórmula:C20H18O3SPureza:99.81%Cor e Forma:SolidPeso molecular:338.42HIF-1/2α-IN-1
<p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>Fórmula:C17H16N6O4Cor e Forma:SolidPeso molecular:368.35VHR-IN-1
CAS:<p>VHR-IN-1 (Compound SA1) is an effective and selective VHR phosphatase inhibitor with an IC50 of 18 nM. It hinders the proliferation of cervical cancer cells, demonstrating antitumor activity.</p>Fórmula:C28H22ClN3O5S3Cor e Forma:SolidPeso molecular:612.139Etiocholanolone glucuronide
CAS:<p>Etiocholanolone glucuronide (Etio-G) is a metabolite of Etiocholanolone, produced through the catalysis by UDP glucuronosyltransferase in the liver. Etiocholanolone glucuronide shows potential for research in metabolic-related diseases.</p>Fórmula:C25H38O8Cor e Forma:SolidPeso molecular:466.564BLT-4
CAS:<p>BLT-4 is a specific and reversible inhibitor of scavenger receptor class B type I (SR-BI). It effectively blocks the SR-BI-mediated transfer of lipids between high-density lipoprotein (HDL) and cells.</p>Fórmula:C18H16N2O2Cor e Forma:SolidPeso molecular:292.332T-3764518
CAS:<p>T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).</p>Fórmula:C20H17F6N5O2Pureza:98%Cor e Forma:SolidPeso molecular:473.37
