Metabolismo
Os inibidores do metabolismo são compostos que interferem nas vias metabólicas, alterando a produção e utilização de energia dentro das células. Esses inibidores são usados para estudar a regulação do metabolismo, o papel das vias metabólicas em doenças como o câncer e o diabetes, e para desenvolver novas estratégias terapêuticas. Os inibidores do metabolismo podem direcionar várias enzimas e processos envolvidos na glicólise, na oxidação de ácidos graxos e em outras funções metabólicas. Na CymitQuimica, oferecemos uma ampla gama de inibidores do metabolismo de alta qualidade para apoiar sua pesquisa em bioquímica, distúrbios metabólicos e desenvolvimento de medicamentos.
Subcategorias de "Metabolismo"
- AhR(41 produtos)
- Aminopeptidase(67 produtos)
- CETP(18 produtos)
- Anidrase carbónica(177 produtos)
- Caseína quinase(130 produtos)
- DHFR(32 produtos)
- Descarboxilase(4 produtos)
- Desidrogenase(267 produtos)
- FAAH(63 produtos)
- FXR(58 produtos)
- Factor Xa(80 produtos)
- Sintase de Ácidos graxos(32 produtos)
- Ferroptose(215 produtos)
- GR(3 produtos)
- GSNOR(3 produtos)
- Glucoquinase(53 produtos)
- HIF/HIF Prolil-Hidroxilase(142 produtos)
- HMG-CoA Reductase(32 produtos)
- Hidroxilase(30 produtos)
- IDO(82 produtos)
- LDL(8 produtos)
- Lipase(96 produtos)
- Lipídio(59 produtos)
- Lipoxigenase(124 produtos)
- MAO(87 produtos)
- MPO(2 produtos)
- NAMPT(36 produtos)
- P450(6 produtos)
- PAI-1(25 produtos)
- PDE(165 produtos)
- PED(1 produtos)
- PKM(15 produtos)
- PPAR(164 produtos)
- Fosfolipase(82 produtos)
- ROR(42 produtos)
- Receptor de Retinóide(29 produtos)
- SGK(11 produtos)
- Tiorredoxina(12 produtos)
- Transferase(30 produtos)
- Tansportador(42 produtos)
- UGT(4 produtos)
- Inibidores de Xantina Oxidase (XO)(9 produtos)
Exibir 34 mais subcategorias
Foram encontrados 8597 produtos de "Metabolismo"
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hDHODH-IN-10
<p>hDHODH-IN-10: selective oral inhibitor of hDHODH (IC50: 10.9 nM); blocks cancer cell growth, aids cancer research.</p>Fórmula:C21H15ClF4N2O4Cor e Forma:SolidPeso molecular:470.8NNC 55-0396
CAS:<p>NNC 55-0396: Selective T-type calcium channel blocker, IC50 6.8 μM, inhibits human ovarian cancer cell growth.</p>Fórmula:C30H40Cl2FN3O2Pureza:99.00%Cor e Forma:SolidPeso molecular:564.56IRX5010
CAS:<p>IRX5010 (IRX4647F), an analogue of IRX4647, serves as a highly selective RARγ nuclear receptor agonist. It effectively inhibits the growth of EMT-6 triple-negative breast cancer.</p>Fórmula:C24H26FNO3Cor e Forma:SolidPeso molecular:395.466PD-224378
CAS:<p>PD-224378 is the lactam form of glycamine (β-isomer), produced through a Maillard reaction between pregabalin and lactose.</p>Fórmula:C20H35NO11Cor e Forma:SolidPeso molecular:465.492GKA50 quarterhydrate
<p>GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.</p>Fórmula:C26H30N2O7Cor e Forma:SolidPeso molecular:469.01Casein kinase 1δ-IN-28
CAS:<p>Casein kinase1δ-IN-28 (Compound 4) is an inhibitor of CK1ε, with an IC50 of 0.0146 μM. The human liver microsome metabolism rate for Casein kinase1δ-IN-28 is 52%.</p>Fórmula:C23H23FN6Cor e Forma:SolidPeso molecular:402.467Hcyb1
<p>Hcyb1 specifically inhibits PDE2A with 0.57 μM IC50, over 250x selective, and has neuroprotective and antidepressant effects.</p>Fórmula:C24H20N4OCor e Forma:SolidPeso molecular:380.44hCAII-IN-3
<p>hCAII-IN-3 inhibits key hCA isoforms with Ki: hCA I (403.8 nM), hCA II (5.1 nM), hCA IX (10.2 nM), hCA XII (5.2 nM); shows anticancer potential.</p>Fórmula:C17H21N3O3SCor e Forma:SolidPeso molecular:347.43CK1δ-IN-5
CAS:<p>CK1δ-IN-5 (Compound 24) is an inhibitor of casein kinase 1δ (CK1δ) and can be used in the study of neurodegenerative diseases.</p>Fórmula:C22H21N5Cor e Forma:SolidPeso molecular:355.436PDE4-IN-5
<p>PDE4-IN-5: potent PDE4 inhibitor, IC50 = 3.1 nM, superb skin penetration, anti-psoriasis effect.</p>Fórmula:C21H28N2O3Cor e Forma:SolidPeso molecular:356.46Glucosylceramide synthase-IN-3
<p>Glucosylceramide synthase-IN-3 (BZ1) is a potent, brain-accessible, oral GCS inhibitor with a 16 nM IC50, relevant for Gaucher's disease study.</p>Fórmula:C21H20FN3O3Cor e Forma:SolidPeso molecular:381.4CYP2C9/CYP2C19-IN-1
<p>CYP2C9/CYP2C19-IN-1 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.</p>Fórmula:C27H28N2O6SCor e Forma:SolidPeso molecular:508.59TMX-4113
<p>TMX-4113 has potential to be used in cancer that is a phosphodiesterase 6D(PDE6D) and casein kinase 1α(CK1α) degrader [1].</p>Fórmula:C12H12N4O2S2Cor e Forma:SolidPeso molecular:308.38ent-8-iso-15(S)-Prostaglandin F2α
CAS:<p>Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid.</p>Fórmula:C20H34O5Cor e Forma:SolidPeso molecular:354.48Lp-PLA2-IN-5
CAS:<p>Lp-PLA2-IN-5 inhibits Lp-PLA2 and PAF-AH, potentially useful in Alzheimer's and atherosclerosis studies.</p>Fórmula:C23H18F5N3O4Cor e Forma:SolidPeso molecular:495.4L-690330 hydrate
<p>L-690330 hydrate inhibits IMPase; Ki: 0.30 μM (human), 0.42 μM (bovine cortex); 0.27 μM (recom. human), 0.19 μM (bovine).</p>Fórmula:C8H14O9P2Cor e Forma:SolidPeso molecular:316.14PSI-7410
CAS:<p>PSI-7410 is a metabolite of PSI-7851. PSI-7851 acts as an inhibitor of the HCV non-structural protein 5B (NS5B) and exhibits antiviral properties.</p>Fórmula:C10H15FN2O11P2Cor e Forma:SolidPeso molecular:420.179Lp(a)-IN-5
CAS:<p>Lp(a)-IN-5 (Compound A) is an orally active inhibitor of lipoprotein (a) [Lp(a)]. It effectively inhibits the assembly of Apo(a) and ApoB proteins, with an IC50 value of 0.41 nM. Lp(a)-IN-5 shows potential for research into diseases associated with elevated plasma Lp(a) levels, such as cardiovascular diseases.</p>Fórmula:C43H56N4O7Cor e Forma:SolidPeso molecular:740.927AXKO-0046
<p>AXKO-0046 is an indole derivative and small-molecule LDHB selective inhibitor.</p>Fórmula:C25H33N3Cor e Forma:SolidPeso molecular:375.55hCA XII/II/IX-IN-1
<p>hCA XII/II/IX-IN-1 inhibits hCA I/II/IX/XII (IC50: 2.6, 0.004, 0.005, 0.001 μM) with anticancer properties.</p>Fórmula:C25H34N4O7SCor e Forma:SolidPeso molecular:534.63NTPDase-IN-1
<p>NTPDase-IN-1 selectively inhibits NTPDases 1, 2, 8 with IC50 of 0.05, 0.23, 0.54 μM. Non-competitive, K m 21 μM, used in cancer, immune, infection research.</p>Fórmula:C18H25N3OS2Cor e Forma:SolidPeso molecular:363.547-Hydroxyrisperidone
CAS:<p>7-Hydroxyrisperidone (7-RispOH) is a metabolite of Risperidone. Risperidone acts as a 5-HT2 receptor blocker, an inhibitor of P-glycoprotein (P-Glycoprotein), and an antagonist of the dopamine D2 receptor.</p>Fórmula:C23H27FN4O3Cor e Forma:SolidPeso molecular:426.484TAP311
<p>TAP311 is an inhibitor of cholesteryl ester transfer protein (CETP)(IC50 of 62 nM).</p>Fórmula:C34H40F6N6O4Pureza:98%Cor e Forma:SolidPeso molecular:710.718-Hydroxychlorpromazine
CAS:<p>8-Hydroxychlorpromazine is a metabolite of Chlorpromazine that can enhance the hyperglycemic response following glucose loading, suggesting a possible synergistic role in Chlorpromazine-induced glucose metabolism disorders. It holds potential for research into metabolic diseases.</p>Fórmula:C17H19ClN2OSCor e Forma:SolidPeso molecular:334.864Anticancer agent 78
<p>Anticancer agent 78: anti-aromatase (IC50=0.9 μM), cytotoxic, potential in breast cancer research.</p>Fórmula:C19H14BrNO4Cor e Forma:SolidPeso molecular:400.22PDE4-IN-6
<p>PDE4-IN-6: Potent PDE4 inhibitor, IC50 - 0.125μM (B), 0.43μM (D), anti-inflammatory, for arthritis research.</p>Fórmula:C25H20FNO5SCor e Forma:SolidPeso molecular:465.49RORγt/DHODH-IN-1
CAS:<p>RORγt/DHODH-IN-1 (compound (R)-14d) is a potent, orally active dual inhibitor of RORγt (IC50: 0.083 μM) and DHODH (IC50: 0.172 μM), which exhibits significant</p>Fórmula:C24H26ClF6N3O3SCor e Forma:SolidPeso molecular:585.99PKR-IN-1
CAS:<p>PKR-IN-1 (Compound 5s) is a pyruvate kinase (PK) inhibitor with antifungal properties, exhibiting an EC50 of 0.21 μg/mL against Rhizoctonia solani (R. solani).</p>Fórmula:C9HCl5N4OS2Cor e Forma:SolidPeso molecular:422.525Lipoxin A5
CAS:<p>LXA5 is made from EPA by leukocytes, contracts guinea pig lungs like LXA4/LXB4, but doesn't dilate aorta.</p>Fórmula:C20H30O5Cor e Forma:SolidPeso molecular:350.45Atorvastatin 3-Deoxyhept-2E-Enoic Acid
CAS:<p>Atorvastatin 3-Deoxyhept-2E-Enoic Acid, an impurity in Atorvastatin, lowers blood lipids as an HMG-CoA reductase inhibitor.</p>Fórmula:C33H33FN2O4Pureza:98%Cor e Forma:SolidPeso molecular:540.62MDL-100240
CAS:<p>MDL-100240 inhibits ACE/neprilysin, effective against hypertension-induced heart/vascular changes.</p>Fórmula:C26H28N2O5SPureza:98%Cor e Forma:SolidPeso molecular:480.58Lumirubin
CAS:<p>Lumirubin is a water-soluble photoproduct of bilirubin formed in vivo during phototherapy.</p>Fórmula:C33H36N4O6Cor e Forma:SolidPeso molecular:584.66GSK864
CAS:<p>GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).</p>Fórmula:C30H31FN6O4Pureza:97.07%Cor e Forma:SolidPeso molecular:558.6BI-4916
CAS:<p>BI-4916 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor that inhibits SSP and reduces cancer cell migration.</p>Fórmula:C23H24Cl2N2O6SPureza:98.55%Cor e Forma:SolidPeso molecular:527.4211β-HSD2-IN-2
CAS:<p>11β-HSD2-IN-2 (compound 3) is a selective 17β-HSD2 (17β-hydroxysteroid dehydrogenase type 2) inhibitor with an IC50 of 300 nM, studying osteoporosis.</p>Fórmula:C22H21NO2Pureza:99.61%Cor e Forma:SolidPeso molecular:331.41BMS453
CAS:<p>BMS453 (BMS-189453), a synthetic retinoid, is a potent and selective agonist of RARβ and a potent testicular toxin.</p>Fórmula:C27H24O2Pureza:99.93%Cor e Forma:SolidPeso molecular:380.48FABPs ligand 6
CAS:<p>FABPs ligand 6 (MF6) is an inhibitor of FABP5 and FABP7.</p>Fórmula:C28H27FN2O3Pureza:97.45%Cor e Forma:SolidPeso molecular:458.52ALOX15-IN-2
CAS:<p>ALOX15-IN-2: Potent ALOX15 inhibitor. IC50: 1.55 μM for LA; 2.79 μM for AA. Stops linoleic/arachidonic acid oxidation.</p>Fórmula:C23H29N3O4SPureza:98.10%Cor e Forma:SolidPeso molecular:443.56Aleglitazar
CAS:<p>Aleglitazar (R1439) (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively.</p>Fórmula:C24H23NO5SPureza:99.03%Cor e Forma:SolidPeso molecular:437.51Lapaquistat acetate
CAS:<p>Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor that reduces the cytotoxicity induced by statins in human skeletal muscle cells.</p>Fórmula:C33H41ClN2O9Pureza:99.38% - 99.94%Cor e Forma:SolidPeso molecular:645.14STK-15
CAS:<p>STK-15 is a candidate for use as a fatty acid binding protein 5 (FABP5) inhibitor.</p>Fórmula:C34H29NO5Pureza:98.05%Cor e Forma:SolidPeso molecular:531.6Etamicastat hydrochloride
CAS:<p>Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.</p>Fórmula:C14H16ClF2N3OSPureza:98.54%Cor e Forma:SolidPeso molecular:347.81Moiramide B
CAS:<p>Moiramide B is an acetyl coenzyme A carboxylase inhibitor with antimicrobial activity, strongly inhibiting Gram-positive bacteria.</p>Fórmula:C25H31N3O5Pureza:98.53% - 99.90%Cor e Forma:SolidPeso molecular:453.53WAY-213613 hydrochloride
CAS:<p>WAY-213613 hydrochloride: potent, selective GLT-1/EAAT2 inhibitor (IC50 85 nM); weaker for EAAT1/3; inactive at glutamate receptors; research tool for CNS.</p>Fórmula:C16H13BrF2N2O4Pureza:99.14% - 99.37%Cor e Forma:SoildPeso molecular:415.19JNJ-6204
CAS:<p>JNJ-6204 is a deuterated compound that efficiently inhibits CSNK1D and CSNK1E.</p>Fórmula:C19H11D6FN6OPureza:97.42% - 99.87%Cor e Forma:SolidPeso molecular:370.41Glycosyltransferase-IN-1
<p>Glycosyltransferase-IN-1 is a glycosyltransferase inhibitor with bacteriostatic activity, inhibiting MSSA, MRSA, Bacillus subtilis, and Enterobacteriaceae.</p>Fórmula:C19H21N5OPureza:99.76%Cor e Forma:SolidPeso molecular:335.4BE1218
CAS:<p>BE1218 is a liver X receptor (LXR) inverse agonist active on LXRα and LXRβ with an IC50 of 9 nM and 7 nM, respectively.</p>Fórmula:C30H30FNO4S2Pureza:99.7%Cor e Forma:SoildPeso molecular:551.69PREP inhibitor-1
CAS:<p>PREP inhibitor-1 is a prolyl oligopeptidase (PREP) inhibitor for the study of Alzheimer's disease.</p>Fórmula:C22H28N4O2Pureza:98.78%Cor e Forma:SoildPeso molecular:380.48BAY-3827
CAS:<p>BAY-3827 is an AMPK inhibitor with antiproliferative activity and antitumor activity. BAY-3827 inhibits the phosphorylation of acetyl CoA carboxylase 1.</p>Fórmula:C27H25FN6OPureza:99.90%Cor e Forma:SolidPeso molecular:468.53Dual FAAH/sEH-IN-1
CAS:<p>Dual FAAH/sEH-IN-1 inhibits both sEH (IC50: 9.6 nM) and FAAH (IC50: 7 nM), offering potent anti-inflammatory effects.</p>Fórmula:C25H22ClN3O3S2Pureza:99.89%Cor e Forma:SolidPeso molecular:512.04
