Metabolismo
Os inibidores do metabolismo são compostos que interferem nas vias metabólicas, alterando a produção e utilização de energia dentro das células. Esses inibidores são usados para estudar a regulação do metabolismo, o papel das vias metabólicas em doenças como o câncer e o diabetes, e para desenvolver novas estratégias terapêuticas. Os inibidores do metabolismo podem direcionar várias enzimas e processos envolvidos na glicólise, na oxidação de ácidos graxos e em outras funções metabólicas. Na CymitQuimica, oferecemos uma ampla gama de inibidores do metabolismo de alta qualidade para apoiar sua pesquisa em bioquímica, distúrbios metabólicos e desenvolvimento de medicamentos.
Subcategorias de "Metabolismo"
- AhR(41 produtos)
- Aminopeptidase(75 produtos)
- CETP(20 produtos)
- Anidrase carbónica(188 produtos)
- Caseína quinase(137 produtos)
- DHFR(34 produtos)
- Descarboxilase(4 produtos)
- Desidrogenase(296 produtos)
- FAAH(65 produtos)
- FXR(59 produtos)
- Factor Xa(85 produtos)
- Sintase de Ácidos graxos(37 produtos)
- Ferroptose(221 produtos)
- GR(3 produtos)
- GSNOR(4 produtos)
- Glucoquinase(56 produtos)
- HIF/HIF Prolil-Hidroxilase(146 produtos)
- HMG-CoA Reductase(33 produtos)
- Hidroxilase(35 produtos)
- IDO(84 produtos)
- LDL(8 produtos)
- Lipase(105 produtos)
- Lipídio(62 produtos)
- Lipoxigenase(133 produtos)
- MAO(87 produtos)
- MPO(2 produtos)
- NAMPT(40 produtos)
- P450(6 produtos)
- PAI-1(26 produtos)
- PDE(166 produtos)
- PED(1 produtos)
- PKM(15 produtos)
- PPAR(169 produtos)
- Fosfolipase(82 produtos)
- ROR(45 produtos)
- Receptor de Retinóide(28 produtos)
- SGK(11 produtos)
- Tiorredoxina(12 produtos)
- Transferase(29 produtos)
- Tansportador(46 produtos)
- UGT(4 produtos)
- Inibidores de Xantina Oxidase (XO)(9 produtos)
Exibir 34 mais subcategorias
Foram encontrados 9132 produtos de "Metabolismo"
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Enpp-1-IN-7
Enpp-1-IN-7: potent enpp-1 inhibitor, broad specificity, potential in cancer/infectious disease research. (WO2021203772A1)Fórmula:C18H19N7O4SCor e Forma:SolidPeso molecular:429.4520-HEDE
CAS:20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist.Fórmula:C20H36O3Pureza:98%Cor e Forma:SolidPeso molecular:324.50L 668411
CAS:L 668411, the 2,3-ditritiated methyl ester of L 659699, inhibits HMG-CoA synthase.Fórmula:C19H30O5Pureza:98%Cor e Forma:SolidPeso molecular:338.44Cgs 25155
CAS:Cgs 25155 is an orally active inhibitor of NEP 24.11.Fórmula:C25H34N2O6SPureza:98%Cor e Forma:SolidPeso molecular:490.61ZK159222
CAS:ZK159222 is an effective 1α,25-(OH)2D3 receptor (VDR) agonist. ZK159222 has a partial agonistic character.Fórmula:C32H48O5Pureza:98%Cor e Forma:SolidPeso molecular:512.72Carbonic anhydrase inhibitor 5
Potent hCA inhibitor: targets hCA II, IX & XII with IC50s of 42.9, 47.6, & 6.7 nM respectively.Fórmula:C24H20ClN3O3SCor e Forma:SolidPeso molecular:465.95α-Amylase-IN-7
CAS:<p>α-Amylase-IN-7 (Compound 6e) is an inhibitor of α-Amylase, with an IC50 of 40 μM, indicating its potency. This compound shows potential as an anti-diabetic medication.</p>Fórmula:C18H15ClN6O2SPeso molecular:414.874-(4-Bromophenyl)-4-hydroxypiperidine
CAS:<p>4-(4-Bromophenyl)-4-hydroxypiperidine (BPHP) is a metabolite of Bromperidol (BRO), produced through the N-dealkylation of BRO.</p>Fórmula:C11H14BrNOCor e Forma:SolidPeso molecular:256.139ZK168281
CAS:ZK168281 is a 1α,25(OH)2D3 analog, VDR antagonist with 0.1 nM Kd, and blocks receptor CoA interaction.Fórmula:C32H46O5Pureza:98%Cor e Forma:SolidPeso molecular:510.70Aripiprazole N,N-Dioxide
CAS:AripiprazoleN,N-Dioxide is a metabolite of the atypical antipsychotic drug aripiprazole, formed through its oxidation.Fórmula:C23H27Cl2N3O4Peso molecular:480.38ROR1-IN-1
CAS:<p>ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 μM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 μM, 1.37 μM, and 0.47 μM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.</p>Fórmula:C33H27N5O3Peso molecular:541.60FABP1-IN-1
CAS:FABP1-IN-1 (44) is a selective FABP1 inhibitor with an IC50 value of 4.46 μM. It is applicable in research related to alcoholic fatty liver disease.Fórmula:C30H25NO5Peso molecular:479.52GGACK
CAS:GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like inhibitor of the serine protease urokinase-type plasminogen activator (uPA).Fórmula:C14H25ClN6O5Peso molecular:392.84Carbonic anhydrase inhibitor 19
CAS:<p>Carbonic anhydrase inhibitor19 (compound 26a) targets glaucoma-associated isozymes hCA II and hCA XII, with inhibition constants (Kis) of 9.4 nM and 6.7 nM, respectively. This compound is effective in reducing intraocular pressure.</p>Fórmula:C23H25N3O6S2Peso molecular:503.59α-Glucosidase-IN-43
CAS:<p>α-Glucosidase-IN-43 (compound AS14) is an α-glucosidase inhibitor with an IC50 of 4.32 μM, demonstrating acute blood-glucose-lowering properties. It is safe and effective in vivo, showing no toxicity to normal fibroblasts in mice and can ameliorate diabetes induced by streptozotocin in rats. α-Glucosidase-IN-43 is applicable for research on postprandial hyperglycemia in diabetic patients.</p>Fórmula:C27H31N3O4Peso molecular:461.55Mucidin
CAS:<p>Mucidin is an antifungal antibiotic that inhibits electron transfer reactions within the mitochondrial respiratory chain's cytochrome bc1 complex.</p>Fórmula:C16H18O3Peso molecular:258.31PKR Inhibitor, negative control
CAS:<p>The PKR Inhibitor, negative control, is an inactive structural analog of RNA-dependent protein kinase (PKR) inhibitors, serving as a negative control. Additionally, it can inhibit LK-induced neuronal death, demonstrating significant neuroprotective properties.</p>Fórmula:C15H8Cl3NO2Peso molecular:340.59Lp-PLA2-IN-10
Lp-PLA2-IN-10, a potent Lp-PLA2 inhibitor, may research neurodegenerative and cardiovascular diseases.Fórmula:C21H15F5N4O4Cor e Forma:SolidPeso molecular:482.36Enpp-1-IN-12
<p>ENPP1-IN-12 is a potent, oral ENPP1 inhibitor with a Ki of 41 nM and anti-tumor properties.</p>Fórmula:C17H19N5O3SCor e Forma:SolidPeso molecular:373.43Etiocholanolone glucuronide
CAS:Etiocholanolone glucuronide (Etio-G) is a metabolite of Etiocholanolone, produced through the catalysis by UDP glucuronosyltransferase in the liver. Etiocholanolone glucuronide shows potential for research in metabolic-related diseases.Fórmula:C25H38O8Cor e Forma:SolidPeso molecular:466.564CP 524515
CAS:<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Fórmula:C27H27F9N2O4Cor e Forma:SolidPeso molecular:614.5Quinapril
CAS:<p>Quinapril is an orally active, non-peptide, and non-thiol angiotensin-converting enzyme (ACE) inhibitor. It primarily blocks the conversion of angiotensin I to angiotensin II in both plasma and tissues. Upon enzymatic hydrolysis, Quinapril is converted into the pharmacologically active Quinaprilat and is effective in hypertension models.</p>Fórmula:C25H30N2O5Cor e Forma:SolidPeso molecular:438.5164-MDM
CAS:<p>4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the aminopeptidase activity of leukotriene A4 hydrolase (LTA4H). By promoting the degradation of proline-glycine-proline by LTA4H, 4-MDM reduces neutrophil recruitment in the lungs, alleviating inflammation without affecting the epoxide hydrolase activity of LTA4H. This compound is useful for research in pulmonary diseases.</p>Fórmula:C14H14OCor e Forma:SolidPeso molecular:198.26DC360
CAS:<p>DC360 is a synthetic analog of all-trans retinoic acid (ATRA) that can induce the expression of RARβ. It is useful for studies characterizing the retinoic acid signaling pathway.</p>Fórmula:C23H23NO2Cor e Forma:SolidPeso molecular:345.434Dopaminechrome
CAS:<p>Dopaminechrome (DACHR) is an oxidation product of dopamine that promotes the generation of H2O2 at mitochondrial complex I in the brain in a concentration- and respiration-dependent manner. It possesses neurotoxic properties and can be utilized in Parkinson's disease research.</p>Fórmula:C8H7NO2Cor e Forma:SolidPeso molecular:149.147ERAP1 modulator-2
CAS:<p>ERAP1 modulator-2 (compound 10) is a potent ERAP1 inhibitor with an IC50 value of less than 100 nM.</p>Fórmula:C22H25F3N2O4SCor e Forma:SolidPeso molecular:470.505Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Fórmula:C30H40Cl2N6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:683.71Casein kinase 1δ-IN-19
CAS:<p>Casein kinase1δ-IN-19 (compound 492) is a potent inhibitor of casein kinase 1δ. It is utilized in research related to neurodegenerative disorders, such as Alzheimer's disease.</p>Fórmula:C21H19N5O3Cor e Forma:SolidPeso molecular:389.407Anticancer agent 142
CAS:Compound 142 (also known as Compound 235) is a PTPN inhibitor with potential applications in cancer research [1].Fórmula:C13H14BrF2N2O7PS2Pureza:98%Cor e Forma:SolidPeso molecular:523.26PFM046
CAS:<p>PFM046 is an antagonist of the liver X receptor (LXR), effectively inhibiting the activation of LXRα and LXRβ, with IC50 values of 2.04 μM and 1.58 μM respectively. It reduces the expression of SCD1 and FASN while increasing ABCA1 expression, and demonstrates antitumor activity in mouse models.</p>Fórmula:C29H42O2Cor e Forma:SolidPeso molecular:422.643GSK864
CAS:GSK864 is an inhibitor of isocitrate dehydrogenase 1 (IDH1) mutant. GSK864 inhibits IDH1 mutants R132C, R132H, and R132G (IC50: 8.8, 15.2, and 16.6 nM).Fórmula:C30H31FN6O4Pureza:97.07%Cor e Forma:SolidPeso molecular:558.6Mutant IDH1-IN-3
CAS:Mutant IDH1-IN-3 (Compound 1) is a selective allosteric inhibitor targeting the mutant isocitrate dehydrogenase 1 (IDH1), with an IC50 of 13 nM for R132HIDH1. It effectively suppresses the production of D-2-hydroxyglutarate (2HG) in cells and is applicable for research in oncology.Fórmula:C22H30N4OCor e Forma:SolidPeso molecular:366.5GPX4 9i
CAS:GPX4 9i is a ferroptosis inducer that exhibits cytotoxicity towards HT-1080 cells, with an IC50 of 0.007 µM. This cytotoxic effect can be mitigated by the use of the ferroptosis inhibitor, ferrostatin-1.Fórmula:C29H24N4O3S2Peso molecular:540.66Benfooxythiamine
CAS:<p>Benfooxythiamine is a transketolase (TKT) inhibitor that suppresses SARS-CoV-2 replication and enhances the activity of the glycolysis inhibitor 2DG. It exhibits antiviral properties.</p>Fórmula:C19H22N3O7PSCor e Forma:SolidPeso molecular:467.433Anticancer agent 143
CAS:Anticancer Agent 143 (Compound 369), a potent dual inhibitor targeting PTPN2 and PTP1B, exhibits IC50 values below 2.5 nM.Fórmula:C19H15BrF2N3O6PS2Pureza:98%Cor e Forma:SolidPeso molecular:594.34δ-CEHC
CAS:δ-CEHC, a δ-tocopherol metabolite, exhibits antioxidant activity [1].Fórmula:C14H18O4Peso molecular:250.29Herbicide safener-4
CAS:Herbicide safener-4 (Compound I-15) is a herbicide safener designed to enhance crop resistance to herbicides without diminishing the herbicidal effects on target weeds. It competitively binds to the ALS active site alongside Mesosulfuron-methyl. In addition, Herbicide safener-4 boosts the activities of glutathione GSH, glutathione-S-transferase GST, cytochrome P450 CYP450, peroxidase (POD), superoxide dismutase (SOD), and acetolactate synthase (ALS) within plants.Fórmula:C18H14Cl2N6O2Peso molecular:417.249MeS-IMPY
CAS:[11C]MeS-IMPY exhibits a higher binding affinity for β-amyloid plaques extracted from Alzheimer's disease (AD) brains or AD brain homogenates than IMPY, with Ki values of 7.93 nM and 8.95 nM, respectively. [11C]MeS-IMPY is a potential radioactive ligand for positron emission tomography (PET) imaging of β-amyloid plaques.Fórmula:C16H17N3SPeso molecular:283.39TQ05310
CAS:TQ05310 is an orally active inhibitor of mutant IDH2, targeting both IDH2-R140Q (IC50=136.9 nM) and IDH2-R172K (IC50=37.9 nM) mutations. This compound suppresses the production of 2-hydroxyglutarate (2-HG) by inhibiting the enzymatic activity of mutant IDH2, and induces differentiation in cells expressing IDH2-R140Q and IDH2-R172K. TQ05310 is utilized in research on acute myeloid leukemia.Fórmula:C19H17F6N7OPeso molecular:473.38Gcase activator 2
CAS:Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.Fórmula:C21H24N4O2Pureza:99.51% - 99.76%Cor e Forma:SolidPeso molecular:364.44BI-4916
CAS:BI-4916 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor that inhibits SSP and reduces cancer cell migration.Fórmula:C23H24Cl2N2O6SPureza:98.55%Cor e Forma:SolidPeso molecular:527.42Thioquinapiperifil dihydrochloride
CAS:Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.Fórmula:C24H29ClN6OSPureza:99.81%Cor e Forma:SolidPeso molecular:485.05(S)-Ibuprofen acyl-β-D-glucuronide
CAS:(S)-Ibuprofen acyl-β-D-glucuronide ((S)-Ibuprofen glucuronide) serves as a crucial analytical tool in examining the metabolic pathways and pharmacokinetic profile of S-ibuprofen, a widely used non-steroidal anti-inflammatory drug. This compound is specifically an acylglucuronic acid metabolite of S-ibuprofen, synthesized primarily in the liver [1].Fórmula:C19H26O8Peso molecular:382.4Mirivadelgat
CAS:Mirivadelgat is an activator of aldehyde dehydrogenase 2 (aldehyde dehydrogenase2). It is anticipated to be useful in research related to interstitial lung disease, pulmonary arterial hypertension, and cancer.Fórmula:C30H34FN3O5Peso molecular:535.607Human enteropeptidase-IN-2
Human enteropeptidase-IN-2 is a potent inhibitor of enteropeptidase (enteropeptidase) and can be used in anti-obesity studies.Fórmula:C20H19F3N4O7Cor e Forma:SolidPeso molecular:484.3813,14-EDT
CAS:13,14-EDT is an oxylipin and a metabolite of adrenic acid, produced via the cytochrome P450 (CYP) pathway.Fórmula:C22H36O3Peso molecular:348.52CS-003 HCl
CAS:CS-003 HCl is a TNRA - triple neurokinin receptor antagonist.Fórmula:C34H39Cl3N2O6SCor e Forma:SolidPeso molecular:710.1CK1δ-IN-3
CAS:<p>CK1δ-IN-3 (compound 376) is a CK1δ (casein kinase 1δ) inhibitor that can be used to study neurodegenerative diseases such as Alzheimer's disease.</p>Fórmula:C24H19N3O2SPureza:99.27%Cor e Forma:SolidPeso molecular:413.49Casein kinase 1δ-IN-25
CAS:<p>Casein kinase1δ-IN-25 (compound 487) is a potent inhibitor of casein kinase1δ. It is applicable in research on neurodegenerative diseases such as Alzheimer's disease.</p>Fórmula:C20H14FN3O4S2Cor e Forma:SolidPeso molecular:443.471AChE/hCA I-IN-1
CAS:<p>AChE/hCA I-IN-1 (Compound L3) is an inhibitor of acetylcholinesterase (AChE) and carbonic anhydrase (CA), effectively inhibiting AChE, hCA I, and hCA II with IC50 values of 302 nM, 265 nM, and 283 nM, respectively.</p>Fórmula:C13H9BrNNaO4SCor e Forma:SolidPeso molecular:378.174
