Metabolismo
Os inibidores do metabolismo são compostos que interferem nas vias metabólicas, alterando a produção e utilização de energia dentro das células. Esses inibidores são usados para estudar a regulação do metabolismo, o papel das vias metabólicas em doenças como o câncer e o diabetes, e para desenvolver novas estratégias terapêuticas. Os inibidores do metabolismo podem direcionar várias enzimas e processos envolvidos na glicólise, na oxidação de ácidos graxos e em outras funções metabólicas. Na CymitQuimica, oferecemos uma ampla gama de inibidores do metabolismo de alta qualidade para apoiar sua pesquisa em bioquímica, distúrbios metabólicos e desenvolvimento de medicamentos.
Subcategorias de "Metabolismo"
- AhR(41 produtos)
- Aminopeptidase(67 produtos)
- CETP(18 produtos)
- Anidrase carbónica(177 produtos)
- Caseína quinase(130 produtos)
- DHFR(32 produtos)
- Descarboxilase(4 produtos)
- Desidrogenase(267 produtos)
- FAAH(63 produtos)
- FXR(58 produtos)
- Factor Xa(80 produtos)
- Sintase de Ácidos graxos(32 produtos)
- Ferroptose(215 produtos)
- GR(3 produtos)
- GSNOR(3 produtos)
- Glucoquinase(53 produtos)
- HIF/HIF Prolil-Hidroxilase(142 produtos)
- HMG-CoA Reductase(32 produtos)
- Hidroxilase(30 produtos)
- IDO(82 produtos)
- LDL(8 produtos)
- Lipase(96 produtos)
- Lipídio(59 produtos)
- Lipoxigenase(124 produtos)
- MAO(87 produtos)
- MPO(2 produtos)
- NAMPT(36 produtos)
- P450(6 produtos)
- PAI-1(25 produtos)
- PDE(165 produtos)
- PED(1 produtos)
- PKM(15 produtos)
- PPAR(164 produtos)
- Fosfolipase(82 produtos)
- ROR(42 produtos)
- Receptor de Retinóide(29 produtos)
- SGK(11 produtos)
- Tiorredoxina(12 produtos)
- Transferase(30 produtos)
- Tansportador(42 produtos)
- UGT(4 produtos)
- Inibidores de Xantina Oxidase (XO)(9 produtos)
Exibir 34 mais subcategorias
Foram encontrados 8597 produtos de "Metabolismo"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Pomonic acid
CAS:<p>Pomonic acid, a triterpenoid, inhibits cholesterol ester build-up and ACAT activity.</p>Fórmula:C30H46O4Cor e Forma:SolidPeso molecular:470.68α-Glucosidase-IN-25
<p>α-Glucosidase-IN-25 (Compound (R)-8k) serves as a competitive inhibitor for α-glucosidase, demonstrating an inhibitory concentration 50 (IC50) of 1.19μM, making</p>Fórmula:C29H22N6O3Pureza:98%Cor e Forma:SolidPeso molecular:502.52DDC 3′-O-β-D glucuronide
<p>Compound 5, DDC 3′-O-β-D-glucuronide, is a drug metabolite with properties that inhibit the fibrillization and oligomerization of Aβ42, suggesting its potential</p>Pureza:98%Cor e Forma:Odour Solidω-conotoxin MoVIA
<p>ω-Conotoxin MVIIA is a potent, selective inhibitor of Ca_v2.2, exhibiting an IC_50 of 0.33 μM in the SH-SY5Y fluorimetric hCa_v2.2 assay [1].</p>Fórmula:C147H233N45O47S7Pureza:98%Cor e Forma:SolidPeso molecular:3607.15Pyruvate carboxylase
CAS:<p>Pyruvate carboxylase, a biotin-containing enzyme, catalyzes the carboxylation of pyruvate to oxaloacetate, a reaction dependent on HCO3− and MgATP.</p>Pureza:98%Cor e Forma:SolidMicrocystin YR
CAS:<p>Microcystin YR (Cyanoginosin YR) is a cyclic peptide and acts as an inhibitor of protein phosphatase 2A (PP2A).</p>Fórmula:C52H72N10O13Cor e Forma:SolidPeso molecular:1045.19Seco Rapamycin ethyl ester
<p>Seco Rapamycin ethyl ester, an open-ring metabolite of the Rapamycin derivative, reportedly does not impact mTOR function [1].</p>Fórmula:C53H83NO13Cor e Forma:SolidPeso molecular:942.23ASM-IN-3
CAS:<p>ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 μM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.</p>Fórmula:C17H13ClN2O4Cor e Forma:SolidPeso molecular:344.75Impurity C of Alfacalcidol
CAS:<p>Impurity of Alfacalcidol is an impurity of Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication.</p>Fórmula:C35H49N3O4Pureza:98%Cor e Forma:SolidPeso molecular:575.78Diaphorase
CAS:<p>Diaphorase from anaerobic sludge catalyzes RDX biotransformation via denitrification.</p>Cor e Forma:SolidAbiraterone N-oxide
CAS:<p>Abiraterone N-oxide is a metabolite of Abiraterone . Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity [1] .</p>Fórmula:C24H31NO2Cor e Forma:SolidPeso molecular:365.51Dextranase
CAS:<p>Dextranase, a glucan hydrolase, breaks down α-(1,6)-glucosidic bonds in dextran, useful in food, sugar modification, medicine, and more.</p>Cor e Forma:SolidLOC1886
CAS:<p>LOC1886 is a covalent inhibitor of GPX4, with slightly lower potency compared to RSL3 and ML162.</p>Fórmula:C13H11N3O2Cor e Forma:SolidPeso molecular:241.25Carbonic anhydrase inhibitor 31
<p>Carbonic anhydrase inhibitor31 is an mtCA2 inhibitor (Ki: 5.2 nM) that can be used in antituberculosis research.</p>Fórmula:C24H20N6O5SCor e Forma:SolidPeso molecular:504.12159Prunetin 5-O-β-D-glucopyranoside
CAS:<p>Prunetin 5-O-β-D-glucopyranoside, an isoflavone obtained from Potentilla astracanica extracts, is a potent uncompetitive inhibitor of α-glucosidase (IC 50 = 56.</p>Fórmula:C22H22O10Cor e Forma:SolidPeso molecular:446.408Promothiocin A
CAS:<p>Promothiocin A is an antibiotic.</p>Fórmula:C36H37N11O8S2Pureza:98%Cor e Forma:SolidPeso molecular:815.88D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine
CAS:<p>D-Ribofuranose 1-phosphate is used to synthesize 5-fluorouracil via uridine phosphorylase.</p>Fórmula:C11H24NO8PCor e Forma:SolidPeso molecular:329.28BPP
CAS:<p>BPP is a fluorescent microviscosity probe used to image natural HOBr in living cells and zebrafish.</p>Fórmula:C13H13NSCor e Forma:SolidPeso molecular:215.31AK-4
<p>AK-4 is an antidiabetic agent that functions as a mitochondrial uncoupler.</p>Fórmula:C21H14Cl2N2O4SCor e Forma:SolidPeso molecular:461.32Oxodipine
CAS:<p>Oxodipine blocks rabbit aortic contraction and weakens rat cardiac force; reduces Ca currents in myocytes; side effects: mouse constipation, dog gum swelling.</p>Fórmula:C19H21NO6Pureza:99.24%Cor e Forma:SolidPeso molecular:359.37O-Desmethylcarvedilol
CAS:<p>O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of Carvedilol, a non-selective β-adrenergic receptor (β-AR) antagonist. This compound inhibits store overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation (IC50= 7.62 µM). Additionally, O-Desmethylcarvedilol slows the increase in heart rate and prevents diastolic pressure reduction induced by Isoproterenol in conscious rabbits (ED50s = 32 and 5 µg/kg).</p>Fórmula:C23H24N2O4Cor e Forma:SolidPeso molecular:392.45N-Desmethyl clotiazepam
CAS:<p>N-Desmethyl clotiazepam (Desmethylclotiazepam) is an active metabolite of Clotiazepam.</p>Fórmula:C15H13ClN2OSCor e Forma:SolidPeso molecular:304.8HMG-CoA Reductase-IN-1
<p>HMG-CoA Reductase-IN-1 is an inhibitor of HMG-CoA reductase, demonstrating strong inhibitory activity on HMGR and affinity for OATP1B1, with pIC50 and pKm</p>Fórmula:C27H29N3O7Cor e Forma:SolidPeso molecular:507.54α-Glucosidase-IN-77
<p>α-Glucosidase-IN-77 (Compound H7) is a non-competitive α-glucosidase inhibitor with an IC50 of 1.25 μM. It reduces blood glucose levels, improves glucose tolerance, regulates gut microbiota, and exhibits hepatoprotective effects in a mouse model of type 2 diabetes.</p>Fórmula:C25H16F3NO5SCor e Forma:SolidPeso molecular:499.46SH7s
<p>SH7s is an effective carbonic anhydrase inhibitor, exhibiting Ki values of 15.9 nM for hCA IX and 55.2 nM for hCA XII. Additionally, SH7s acts as a hypoxia-mediated chemosensitizer in colorectal cancer cells.</p>Fórmula:C24H19ClF3N5O4SCor e Forma:SolidPeso molecular:565.95DPTIP hydrochloride
CAS:<p>DPTIP hydrochloride is a potent inhibitor of neutral sphingomyelinase (N-SMase 2) that can cross the blood-brain barrier. It acts as an exosome inhibitor with an IC50 value of 30 nM.</p>Fórmula:C21H19ClN2O3SCor e Forma:SolidPeso molecular:414.91Resinacein L
CAS:<p>Resinacein L is an inhibitor of α-glucosidase with an IC50 of 0.635 mM. This compound can slow the digestion and absorption of carbohydrates, thereby reducing postprandial blood glucose levels.</p>Fórmula:C30H40O8Cor e Forma:SolidPeso molecular:528.63Cidofovir diphosphate tri(triethylamine)
<p>Cidofovir diphosphate triethylamine: active metabolite inhibiting HCMV, HSV-1, HSV-2 DNA polymerases with K i values 6.6, 0.86, 1.4 μM.</p>Fórmula:C26H61N6O12P3Cor e Forma:SolidPeso molecular:742.72YYLLVR
CAS:<p>YYLLVR is an inhibitory peptide of angiotensin-converting enzyme (ACE) with an inhibition rate of 89.10%. It demonstrates a low binding energy to ACE at -35.98 kcal/mol. YYLLVR can be utilized in hypertension research.</p>Fórmula:C41H63N9O9Cor e Forma:SolidPeso molecular:825.99(-)-Jasmonoyl-L-isoleucine
CAS:<p>(-)-Jasmonoyl-L-isoleucine ((-)-JA-L-Ile), an enantiomer of (+)-JA-L-Ile [1], is an inactive endogenous hormone.</p>Fórmula:C18H29NO4Cor e Forma:SolidPeso molecular:323.43Efmoroctocog alfa
CAS:<p>Efmoroctocog alfa, a recombinant human coagulation factor VIII-Fc fusion protein (rFVIIIFc), serves as a therapeutic agent for Hemophilia A research [1].</p>Cor e Forma:Solid(±)-Equol 4'-sulfate (sodium salt)
CAS:<p>(±)-Equol 4’-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol .[1] It has been used as a standard for the</p>Fórmula:C15H13NaO6SCor e Forma:SolidPeso molecular:344.32Rostratin C
CAS:<p>Rostratin C, a cytotoxic disulfide, exhibits in vitro cytotoxicity against human colon carcinoma (HCT-116), demonstrating an IC50 value of 0.76 μg/mL.</p>Fórmula:C20H24N2O8S2Cor e Forma:SolidPeso molecular:484.54FXR antagonist 2
CAS:<p>Compound A-26, a diarylamide FXR blocker, may aid hyperlipidemia and diabetes type 2 research.</p>Fórmula:C22H26Cl2N2O2Cor e Forma:SolidPeso molecular:421.363,4-Dihydroxyamphetamine hydrochloride
CAS:<p>3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a minor metabolite of 3,4-Methylenedioxymethamphetamine (MDMA) and exhibits cytotoxicity in rat hepatocytes. Additionally, 3,4-Dihydroxyamphetamine (hydrochloride) is applicable in hypertension research.</p>Fórmula:C9H14ClNO2Cor e Forma:SolidPeso molecular:203.67LH1513
<p>LH1513 is a dioxalate salt derivative of l-lysine that inhibits CaOx crystallization more effectively than citrate and pyruvate. It shows potential preventive activity in hyperoxaluria models and effectively prevents urinary CaOx crystal formation in Agxt knockout mice. AGXT-1 is a mitochondrial protein involved in metabolic processes.</p>Fórmula:C10H11N2Na3O8Cor e Forma:SolidPeso molecular:356.17(±)-CBCQ
CAS:<p>(±)-CBCQ, an oxidation product of cannabidiol, exhibits an EC50 value of 14.7 μM for the activation of peroxisome proliferator-activated receptor γ (PPAR-γ).</p>Fórmula:C21H28O3Cor e Forma:SolidPeso molecular:328.45CMI977
CAS:<p>CMI977 is a potent inhibitor of 5-Lipoxygenase (5-LO).</p>Fórmula:C16H19FN2O4Pureza:98%Cor e Forma:SolidPeso molecular:322.33LXQ-87
CAS:<p>LXQ-87 is an orally administered, non-competitive inhibitor of PTP1B with an IC50 of 1.061 μM, demonstrating hypoglycemic activity. It alleviates insulin resistance and enhances cellular glucose uptake, making it useful for type 2 diabetes research.</p>Fórmula:C23H18Br2O5Cor e Forma:SolidPeso molecular:534.19E0924G
CAS:<p>E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.</p>Fórmula:C12H12N2O3Cor e Forma:SolidPeso molecular:232.245-Aminoisotonitazene
CAS:<p>5-Aminoisotonitazene is a metabolite of the synthetic opioid analgesic agent, Isotonitazene, found in urine.</p>Fórmula:C23H32N4OCor e Forma:SolidPeso molecular:380.535-(3',4'-Dihydroxyphenyl)-γ-valerolactone
CAS:<p>5-(3',4'-Dihydroxyphenyl)-γ-valerolactone is a metabolic byproduct of gut microbiota processing of (-)-Epicatechin. [5-(3',4'-Dihydroxyphenyl)-γ-valerolactone] exhibits antioxidant properties.</p>Fórmula:C11H12O4Cor e Forma:SolidPeso molecular:208.21APL180
CAS:<p>APL180 (L-4F) is an apolipoprotein A-I mimetic peptide that enhances the anti-inflammatory activity of high-density lipoprotein (HDL). It is applicable for cardiovascular disease research.</p>Fórmula:C114H156N24O28Cor e Forma:SolidPeso molecular:2310.64,5-Dimethylthiazole
CAS:<p>4,5-Dimethylthiazole exhibits inhibitory against mitochondrial respiration in liver cells and can be used in biochemical experiments and drug synthesis.</p>Fórmula:C5H7NSCor e Forma:SolidPeso molecular:113.18TXA707
CAS:<p>TXA707, the active metabolite of TXA-709, is an FtsZ inhibitor with antibacterial properties. It shows potential for use in research involving S. aureus.</p>Fórmula:C15H8F5N3O2SCor e Forma:SolidPeso molecular:389.3(R)-Mephenytoin
CAS:<p>(R)-Mephenytoin ((–)-Mephenytoin) is the the R-enantiomer of Mephenytoin which is an anticonvulsant agent.</p>Fórmula:C12H14N2O2Pureza:99.95%Cor e Forma:SolidPeso molecular:218.25Sofosbuvir impurity D
<p>Sofosbuvir impurity D is a less active variant with potent anti-HCV properties.</p>Fórmula:C22H29FN3O9PPureza:98%Cor e Forma:SolidPeso molecular:529.45LZ-007
CAS:<p>LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.</p>Fórmula:C27H29F3N2O5Cor e Forma:SolidPeso molecular:518.53α-Glucosidase-IN-76
<p>α-Glucosidase-IN-76 (Compound 4r) is an inhibitor of α-glucosidase, with an IC50 of 5.44 μM. It can clear ABTS+ free radicals, with a TEAC value of 0.49. Additionally, α-Glucosidase-IN-76 inhibits the proliferation of T24 bladder cancer cells, with an IC50 of 1.74 μM.</p>Fórmula:C21H24N4O10Cor e Forma:SolidPeso molecular:492.44b-Cortolone
CAS:<p>b-Cortolone, a metabolite of Cortisol, exhibits relatively lower biological activity.</p>Fórmula:C21H34O5Cor e Forma:SolidPeso molecular:366.49
