Metabolismo
Os inibidores do metabolismo são compostos que interferem nas vias metabólicas, alterando a produção e utilização de energia dentro das células. Esses inibidores são usados para estudar a regulação do metabolismo, o papel das vias metabólicas em doenças como o câncer e o diabetes, e para desenvolver novas estratégias terapêuticas. Os inibidores do metabolismo podem direcionar várias enzimas e processos envolvidos na glicólise, na oxidação de ácidos graxos e em outras funções metabólicas. Na CymitQuimica, oferecemos uma ampla gama de inibidores do metabolismo de alta qualidade para apoiar sua pesquisa em bioquímica, distúrbios metabólicos e desenvolvimento de medicamentos.
Subcategorias de "Metabolismo"
- AhR(41 produtos)
- Aminopeptidase(67 produtos)
- CETP(18 produtos)
- Anidrase carbónica(177 produtos)
- Caseína quinase(130 produtos)
- DHFR(32 produtos)
- Descarboxilase(4 produtos)
- Desidrogenase(267 produtos)
- FAAH(63 produtos)
- FXR(58 produtos)
- Factor Xa(80 produtos)
- Sintase de Ácidos graxos(32 produtos)
- Ferroptose(215 produtos)
- GR(3 produtos)
- GSNOR(3 produtos)
- Glucoquinase(53 produtos)
- HIF/HIF Prolil-Hidroxilase(142 produtos)
- HMG-CoA Reductase(32 produtos)
- Hidroxilase(30 produtos)
- IDO(82 produtos)
- LDL(8 produtos)
- Lipase(96 produtos)
- Lipídio(59 produtos)
- Lipoxigenase(124 produtos)
- MAO(87 produtos)
- MPO(2 produtos)
- NAMPT(36 produtos)
- P450(6 produtos)
- PAI-1(25 produtos)
- PDE(165 produtos)
- PED(1 produtos)
- PKM(15 produtos)
- PPAR(164 produtos)
- Fosfolipase(82 produtos)
- ROR(42 produtos)
- Receptor de Retinóide(29 produtos)
- SGK(11 produtos)
- Tiorredoxina(12 produtos)
- Transferase(30 produtos)
- Tansportador(42 produtos)
- UGT(4 produtos)
- Inibidores de Xantina Oxidase (XO)(9 produtos)
Exibir 34 mais subcategorias
Foram encontrados 8597 produtos de "Metabolismo"
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FXR agonist 11
CAS:<p>FXR agonist11 (Compound 14) is an FXR activator with an EC50 of 1.2 μM and a maximal effect of 73.7%. It significantly increases GSH levels in the liver and is used to study drug-induced liver injury.</p>Fórmula:C18H16N2O5Cor e Forma:SolidPeso molecular:340.33Conagenin
CAS:<p>Conagenin is a small molecular immunomodulator isolated by Streptomyces roseosporus.</p>Fórmula:C10H19NO6Pureza:98%Cor e Forma:SolidPeso molecular:249.26Beauveriolide I
CAS:<p>Beauveriolide I, a cyclodepsipeptide from Beauveria, inhibits lipid droplet and cholesterol synthesis in mouse macrophages; IC50=0.78 μM.</p>Fórmula:C27H41N3O5Cor e Forma:SolidPeso molecular:487.63Avenacin A 1
CAS:<p>Avenacin A 1 is a biochemical.</p>Fórmula:C55H83NO21Cor e Forma:SolidPeso molecular:1094.255IR-117-17
CAS:<p>IR-117-17 is an ionizable cationic amino lipid that targets the airways. It is degradable via esterase cleavage, making it less likely to accumulate with repeated dosing.</p>Fórmula:C59H110N2O5Cor e Forma:SolidPeso molecular:927.5221-Deoxy Cortisone
CAS:<p>21-Deoxy Cortisone (21-Desoxycortisone; NSC 38722) is a corticosteroid metabolite of 11-ketoprogesterone. It is generated from 11-ketoprogesterone by the cytochrome P450 (CYP) isoform CYP17A1, and can also be produced by oxidation via 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) from 21-deoxycorticosterone. In patients with congenital adrenal hyperplasia, a metabolic disorder characterized by a deficiency of 21-hydroxylase, levels of 21-Deoxy Cortisone are elevated.</p>Fórmula:C21H28O4Cor e Forma:SolidPeso molecular:344.44ROS-IN-3
<p>ROS-IN-3 (compound x38) is an inhibitor of ROS and is utilized in neuro-related research.</p>Fórmula:C25H20F2N2O4Cor e Forma:SolidPeso molecular:450.43sPLA2 inhibitor 3
<p>sPLA2 inhibitor 3 (Compound 6c) functions as a potent α-glucosidase inhibitor (IC50= 0.0953 µM) and has potential applications in diabetes research.</p>Fórmula:C22H16F6N6O4S2Cor e Forma:SolidPeso molecular:606.52α-Glycosidase-IN-2
<p>α-Glycosidase-IN-2 (compound 8b) is an inhibitor of α-glycosidase, displaying Ki values of 74.16 nM and 6.09 nM for aldose reductase and α-glycosidase, respectively. This compound is utilized in research related to diabetes.</p>Fórmula:C25H22N6OS2Cor e Forma:SolidPeso molecular:486.61LH10
<p>LH10 is an FXR agonist based on fexaramine, with an EC50 of 0.14 μM. It offers hepatoprotective effects, mitigating conditions such as cholestasis induced by alpha naphthylisothiocyanate (ANIT), acute liver injury caused by APAP, and non-alcoholic steatohepatitis (NASH).</p>Fórmula:C34H33N3O2Cor e Forma:SolidPeso molecular:515.64Anticancer agent 260
CAS:<p>Anticanceragent 260 (Compound 3g/4d) is an orally effective anticancer agent that inhibits the proliferation of cancer cells HCT-116, MIA-PaCa2, and MDA-MB231, with IC50 values of 98.7, 81.0, and 77.2 µg/mL, respectively. It also promotes ulcer formation and lipid peroxidation, and exhibits anti-inflammatory and analgesic activities.</p>Fórmula:C14H11N3OCor e Forma:SolidPeso molecular:237.262-Amino-5-bromo-2’-chlorobenzophenone
CAS:<p>2-Amino-5-bromo-2’-chlorobenzophenone is an active metabolite of Phenazepam.</p>Fórmula:C13H9BrClNOCor e Forma:SolidPeso molecular:310.57FXR agonist 10
<p>FXR agonist10 (Compound 27) acts as an agonist for FXR with an EC50 of 14.26 μM. It increases the expression of SHP and BSEP proteins while decreasing the expression of NTCP and CYP7A1 proteins. Additionally, FXR agonist10 has been shown to ameliorate ANIT-induced cholestasis in mouse models.</p>Fórmula:C15H22O4Cor e Forma:SolidPeso molecular:266.33Acivicin
CAS:<p>Acivicin (AT-125) is a chlorinated amino acid antibiotic produced by Streptomyces porcineus, a GGT inhibitor with anticancer and antiparasitic activity.</p>Fórmula:C5H7ClN2O3Pureza:98%Cor e Forma:SolidPeso molecular:178.57sEH inhibitor-20
<p>sEH inhibitor-20 is a metabolically stable, orally active sEH inhibitor with an IC50 of 0.2 nM. It exhibits significant analgesic and anti-inflammatory properties, making it a promising candidate for researching neuropathic pain.</p>Cor e Forma:Odour SolidPPARγ agonist 15
<p>PPARγ agonist15 (Compound 7c) functions as an agonist of PPARγ, inhibiting the expression of α-amylase (HPA) and α-glucosidase (HLAG) with IC50 values of 28.35 µM and 26.21 µM, respectively. It enhances glucose uptake in L6 myotubes and improves glucose homeostasis, insulin sensitivity, and lipid metabolism in a rat model of Streptozotocin-induced diabetes.</p>Fórmula:C21H16N4O3S2Cor e Forma:SolidPeso molecular:436.51DSPE-PEG2000-CTT2
<p>DSPE-PEG2000-CTT2 is a PEG compound consisting of DSPE and the gelatinase inhibitor CTT2 (CTTHWGFTLC). It possesses the ability to specifically target tumors. DSPE-PEG2000-CTT2 is suitable for drug delivery applications.</p>Cor e Forma:Odour Solid(3R,5R)-Octahydrocurcumin
CAS:<p>(3R,5R)-Octahydrocurcumin (Compound 7) is a metabolite of Curcumin produced by gut microbiota. It exhibits neuroprotective effects against Aβ25-35-induced cell damage in SH-SY5Y cells and possesses anti-inflammatory properties in LPS-stimulated BV-2 mouse microglia.</p>Fórmula:C21H28O6Cor e Forma:SolidPeso molecular:376.44APOL1-IN-2
CAS:<p>APOL1-IN-2 (Compound 467) acts as an inhibitor of apolipoprotein L1 (APOL1). It effectively reduces HEK293 cell death induced by APOL1 G2/G1, with EC50 values of 4.74 nM and 14.3 nM, respectively. Additionally, APOL1-IN-2 decreases the mortality of trypanosomes triggered by APOL1 G2/G1/G0, with EC50 values of 2.24, 6.03, and 3.72 nM, respectively.</p>Fórmula:C28H30ClF3N4O5Cor e Forma:SolidPeso molecular:595.01DSPE-PEG5000-CREKA
<p>DSPE-PEG5000-CREKA is a PEG compound composed of DSPE and the fibrin-targeting peptide (CREKA). The CREKA peptide is utilized for targeting tumor cells and tumor vasculature, exhibiting anti-tumor activity. DSPE-PEG5000-CREKA is applicable in drug delivery systems.</p>Cor e Forma:Odour SolidCUDA
CAS:<p>CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively.</p>Fórmula:C19H36N2O3Pureza:97.585%Cor e Forma:SolidPeso molecular:340.5Ercalcitriol
CAS:<p>Ercalcitriol, active Vitamin D2 metabolite, boosts immunity by regulating CAMP and DEFB4 genes against infections.</p>Fórmula:C28H44O3Pureza:99.02%Cor e Forma:SolidPeso molecular:428.65Glycerol-3-phosphate oxidase
CAS:<p>Glycerol-3-phosphate oxidase, from E. coli, is crucial in glycerol metabolism and phospholipid formation, producing electrons via oxidation.</p>Cor e Forma:SolidLargazole
CAS:<p>Largazole is a potent and selective histone deacetylase (HDAC) inhibitor and antiproliferative agent from Symploca.</p>Fórmula:C29H42N4O5S3Cor e Forma:SolidPeso molecular:622.86Probestin
CAS:<p>Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.</p>Fórmula:C26H38N4O6Pureza:98%Cor e Forma:SolidPeso molecular:502.60Norpropranolol hydrochloride
CAS:<p>Norpropranolol hydrochloride is the active metabolite of Propranolol.</p>Fórmula:C13H16ClNO2Cor e Forma:SolidPeso molecular:253.732,3-Dehydrosilybin B
CAS:<p>2,3-Dehydrosilybin B is a useful organic compound for research related to life sciences and the catalog number is T125883.</p>Fórmula:C25H20O10Cor e Forma:SolidPeso molecular:480.42hCAII/XII-IN-1
<p>hCAII/XII-IN-1 (compound 4l) is a potent inhibitor of hCAXII and hCAII, with Ki values of 8.4 nM and 9.4 nM, respectively. It plays a significant role in cancer research.</p>Fórmula:C22H20N4O6S2Cor e Forma:SolidPeso molecular:500.547Kahalalide A
CAS:<p>Kahalalide A has antimycobacterial activity isolated from the mollusk Elysia rufescens.</p>Fórmula:C46H67N7O11Pureza:98%Cor e Forma:SolidPeso molecular:894.08PDE1-IN-5
<p>PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor with an IC50 of 15 nM, exhibiting anti-inflammatory properties through the inhibition of iNOS, TNF-α, IL</p>Fórmula:C27H29FN4OCor e Forma:SolidPeso molecular:444.54Cy3-PEG-DSPE (MW 5000)
<p>Cy3-PEG-DSPE (MW 5000) is a fluorescent PEG phospholipid that incorporates Cy3 dye and is utilized for protein/nucleic acid labeling. It can self-assemble into micelles or lipid bilayers in aqueous solutions and is employed in the preparation of liposomes or nanoparticles for the delivery of substances such as mRNA or DNA vaccines.</p>Cor e Forma:SolidPeso molecular:5000 (Average)(+)-Geodin
CAS:<p>(+)-Geodin, a fungal metabolite, boosts fibrinolysis in BAECs (50-150 μM) and glucose uptake in rat adipocytes (1-100 μg/ml).</p>Fórmula:C17H12Cl2O7Cor e Forma:SolidPeso molecular:399.18Acanthifolicin
CAS:<p>Acanthifolicin, an okadaic acid derivative, has been shown top inhibit protein phosphatase 1 with an IC50= 20 nM (similar to that of okadaic acid at 19 nM).</p>Fórmula:C44H68O13SCor e Forma:SolidPeso molecular:837.084,8-Dioxa-3H-perfluorononanoic acid
CAS:<p>4,8-Dioxa-3H-perfluorononanoic acid, a type of per- and polyfluoroalkyl substance (PFAS), exhibits affinity for the human pregnane X receptor (hPXR) and demonstrates potential agonistic activity.</p>Fórmula:C7H2F12O4Cor e Forma:SolidPeso molecular:378.07Tetrahydropteroylpentaglutamate
CAS:<p>H4PteGlu5 strongly inhibits itself and tightly binds in vivo, almost irreversibly, as a coenzyme.</p>Fórmula:C39H51N11O18Pureza:98%Cor e Forma:SolidPeso molecular:961.89GLX481369
<p>GLX481369 is a redox-active substance that functions as an NOX4 inhibitor, exhibiting antioxidant effects [1].</p>Fórmula:C21H24ClN7OCor e Forma:SolidPeso molecular:425.91YF704
<p>YF704 (compound 4w), a selective allosteric inhibitor of SHP2, exhibits antiproliferative effects and induces apoptosis in cancer cells with an IC50 of 0.25 μM.</p>Fórmula:C17H20Cl2N4OS2Cor e Forma:SolidPeso molecular:431.4Reticulol
CAS:<p>Reticulol is an isocoumarin derivative produced by certain species of Streptomyces.</p>Fórmula:C11H10O5Pureza:98%Cor e Forma:SolidPeso molecular:222.19ω-Conotoxin CVIE
<p>ω-Conotoxin CVIE selectively inhibits voltage-gated Ca^2+ channels (Ca_v 2.2) [1].</p>Fórmula:C98H164N40O34S6Pureza:98%Cor e Forma:SolidPeso molecular:2638.99KR-27425
<p>Compound 13, an AChE activator 1, is a non-pyridinium oxime that reactivates paraoxon-inhibited acetylcholinesterase (AChE) [1].</p>Pureza:98%Cor e Forma:Odour SolidHydroxocobalamin
CAS:<p>Hydroxocobalamin (Vitamin B12a) is a naturally occurring, injectable form of vitamin B12 used as a dietary supplement to treat B12 deficiency, including</p>Fórmula:C62H89CoN13O15PPureza:98%Cor e Forma:SolidPeso molecular:1346.36Asperglaucin A
CAS:<p>Asperglaucid A: a phthalide-like compound with strong antibacterial effects against Pseudomonas syringae pv actinidae and Bacillus cereus; MIC: 6.25 μM.</p>Fórmula:C19H26O4SCor e Forma:SolidPeso molecular:350.47ent-Prostaglandin F2α
CAS:<p>ent-Prostaglandin F2α is the enantiomer of PGF2α and is found in urine.</p>Fórmula:C20H34O5Cor e Forma:SolidPeso molecular:354.487MS-PPOH
CAS:<p>MS-PPOH is a potent and selective inhibitor of cytochrome P450 (CYP) epoxygenase. MS-PPOH inhibits CYP2C8 and CYP2C9 with IC50s of 15 and 11 µM, respectively</p>Fórmula:C16H21NO4SPureza:99.39%Cor e Forma:SolidPeso molecular:323.41A32390A
CAS:<p>A32390A, an antibiotic inhibitor, shows antimicrobial activity against gram-positive bacteria and fungi.</p>Fórmula:C18H24N2O8Cor e Forma:SolidPeso molecular:396.39Rennin
CAS:<p>Rennin or Chymosin, a stomach enzyme in some animals, curdles milk by cleaving K-casein; key in cheese making.</p>Cor e Forma:SolidPyridindolol
CAS:<p>Pyrindolol, a S. alboverticillatus metabolite, inhibits bovine β-galactosidase at 2 μg/ml in acid; not effective on other species' enzymes.</p>Fórmula:C14H14N2O3Cor e Forma:SolidPeso molecular:258.277ROR1 ligand-1
<p>ROR1ligand-1 (9-1) serves as the ligand for PROTAC ROR1 degrader-1. By linking with ligands of either the VHL type or CRBN, the first selective and efficient ROR1 PROTAC molecule was designed and synthesized.</p>Fórmula:C23H30BrN7Cor e Forma:SolidPeso molecular:484.44PKM2 activator 6
<p>Compound Z10 (PKM2 activator 6) serves as both a PKM2 activator and a PDK1 inhibitor, exhibiting dissociation constants (K D ) of 121 μM and 19.6 μM,</p>Cor e Forma:Odour SolidPyruvate kinase
CAS:<p>Pyruvate kinase is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP [1] .</p>Cor e Forma:Solid
