Metabolismo
Os inibidores do metabolismo são compostos que interferem nas vias metabólicas, alterando a produção e utilização de energia dentro das células. Esses inibidores são usados para estudar a regulação do metabolismo, o papel das vias metabólicas em doenças como o câncer e o diabetes, e para desenvolver novas estratégias terapêuticas. Os inibidores do metabolismo podem direcionar várias enzimas e processos envolvidos na glicólise, na oxidação de ácidos graxos e em outras funções metabólicas. Na CymitQuimica, oferecemos uma ampla gama de inibidores do metabolismo de alta qualidade para apoiar sua pesquisa em bioquímica, distúrbios metabólicos e desenvolvimento de medicamentos.
Subcategorias de "Metabolismo"
- AhR(41 produtos)
- Aminopeptidase(67 produtos)
- CETP(18 produtos)
- Anidrase carbónica(177 produtos)
- Caseína quinase(130 produtos)
- DHFR(32 produtos)
- Descarboxilase(4 produtos)
- Desidrogenase(267 produtos)
- FAAH(63 produtos)
- FXR(58 produtos)
- Factor Xa(80 produtos)
- Sintase de Ácidos graxos(32 produtos)
- Ferroptose(215 produtos)
- GR(3 produtos)
- GSNOR(3 produtos)
- Glucoquinase(53 produtos)
- HIF/HIF Prolil-Hidroxilase(142 produtos)
- HMG-CoA Reductase(32 produtos)
- Hidroxilase(30 produtos)
- IDO(82 produtos)
- LDL(8 produtos)
- Lipase(96 produtos)
- Lipídio(59 produtos)
- Lipoxigenase(124 produtos)
- MAO(87 produtos)
- MPO(2 produtos)
- NAMPT(36 produtos)
- P450(6 produtos)
- PAI-1(25 produtos)
- PDE(165 produtos)
- PED(1 produtos)
- PKM(15 produtos)
- PPAR(164 produtos)
- Fosfolipase(82 produtos)
- ROR(42 produtos)
- Receptor de Retinóide(29 produtos)
- SGK(11 produtos)
- Tiorredoxina(12 produtos)
- Transferase(30 produtos)
- Tansportador(42 produtos)
- UGT(4 produtos)
- Inibidores de Xantina Oxidase (XO)(9 produtos)
Exibir 34 mais subcategorias
Foram encontrados 8597 produtos de "Metabolismo"
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ω-Conotoxin SO3
CAS:<p>ω-Conotoxin SO3 is an analgesic peptide that functions as an antagonist to N-type voltage-sensitive calcium channels, and can be isolated from the venom of</p>Fórmula:C100H166N36O31S6Pureza:98%Cor e Forma:SolidPeso molecular:2561α-Glucosidase-IN-41
<p>α-Glucosidase-IN-41 (compound 5o), a potent inhibitor of α-glucosidase, induces alterations in the secondary structure of the enzyme, thereby impeding its</p>Pureza:98%Cor e Forma:Odour Solidα-Glucosidase-IN-40
<p>α-Glucosidase-IN-40 (compound 5) serves as a noncompetitive inhibitor of the α-glucosidase enzyme, exhibiting an inhibitory concentration (IC50) of 24.62 μM [1</p>Pureza:98%Cor e Forma:Odour Solidh-NTPDase-IN-1
<p>h-NTPDase-IN-1 (Compound 3i) is an inhibitor of human NTPDase (h-NTPDase) with IC50 values of 2.88 μM for h-NTPDase1 and 0.72 μM for h-NTPDase3, indicating its</p>Fórmula:C17H16BrClN2O4SPureza:98%Cor e Forma:SolidPeso molecular:459.74Calcicludine
CAS:<p>Calcicludine, a protein toxin derived from the green mamba (Dendroaspis angusticeps) venom, selectively inhibits high-voltage-activated, particularly L-type,</p>Fórmula:C321H476N86O78S6Pureza:98%Cor e Forma:SolidPeso molecular:6980.13Caloxin 3A1
<p>Caloxin 3A1, a biologically active peptide, is a member of the caloxins, which are inhibitors of the extracellular plasma membrane (PM) Ca2+ pumps.</p>Fórmula:C83H126N22O30Pureza:98%Cor e Forma:SolidPeso molecular:1912.02hCAIX/VII-IN-1
<p>hCAIX/VII-IN-1 is a selective inhibitor of human carbonic anhydrase isoforms VII and IX.</p>Fórmula:C16H13BFN3O3Pureza:98%Cor e Forma:SolidPeso molecular:325.1Isobutyryl-L-carnitine chloride
CAS:<p>Isobutyryl-L-carnitine chloride is a potential clinical OCT1 biomarker for DDI evaluation and can be used to study heart failure.</p>Fórmula:C11H22ClNO4Pureza:99.93%Cor e Forma:SolidPeso molecular:267.75Endo-1,3-β-glucanase
CAS:<p>Endo-1,3-β-glucanase (Lyticase) is a glucanase from fungi and Chlamydomonas reinhardtii that displays lytic activity on fungal cells.</p>Cor e Forma:Solidwt hMLN
<p>Wild-type human myoregulin (wt hMLN) is a microprotein that inhibits the sarcoplasmic reticulum Ca²⁺ pump (SERCA), playing a crucial role in the regulation of</p>Fórmula:C245H404N54O66SPureza:98%Cor e Forma:SolidPeso molecular:5194.22hCA XII-IN-6
<p>Compound 4d, known as hCA XII-IN-6, is a potent inhibitor of human carbonic anhydrase XII (hCA XII) with a Ki value of 84.2 nM and exhibits anti-proliferative</p>Fórmula:C11H9N5O3S2Pureza:98%Cor e Forma:SolidPeso molecular:323.35α-Glucosidase-IN-26
<p>α-Glucosidase-IN-26 (Compound 7i), with an IC50 value of 4.63 µM, functions as an α-glucosidase inhibitor and is utilized in research related to type 2 diabetes</p>Fórmula:C23H22ClN3O5Pureza:98%Cor e Forma:SolidPeso molecular:455.89D-Pro-Phe-Arg-Chloromethylketone
CAS:<p>D-Pro-Phe-Arg-Chloromethylketone, an inhibitor of coagulation factor XII and plasma kallikrein, is significant in the regulation of thrombosis and inflammation</p>Fórmula:C21H31ClN6O3Pureza:98%Cor e Forma:SolidPeso molecular:450.96Amidase
CAS:<p>Amidases, belonging to the nitrilase superfamily, catalyze amide hydrolysis to yield carboxylic acid and ammonia.</p>Pureza:98%Cor e Forma:SolidIDO1-IN-23
<p>IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), exhibiting an IC50 of 13 μM [1].</p>Pureza:98%Cor e Forma:Odour SolidHIF-1α-IN-6
<p>HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.</p>Pureza:98%Cor e Forma:Odour SolidCalciseptin
CAS:<p>Calciseptine, a neurotoxin isolated from the Black Mamba (Dendroaspis p.</p>Fórmula:C299H468N90O87S10Pureza:98%Cor e Forma:SolidPeso molecular:7036.12ThioLox
CAS:<p>ThioLox, a 15-LOX-1 inhibitor (IC50: 12 μM), has anti-inflammatory, neuroprotective benefits, and guards against glutamate toxicity.</p>Fórmula:C15H18N2OSPureza:99.98%Cor e Forma:SoildPeso molecular:274.38Alanine aminotransferase
CAS:<p>Alanine aminotransferase (ALT), a pyridoxal-dependent enzyme, catalyzes the reversible interconversion of L-alanine and 2-oxoglutarate into pyruvate and L-</p>Pureza:98%Cor e Forma:SolidDPPD-Q
CAS:<p>DPPD-Q, an antioxidant and an oxidative derivative of substituted p-phenylenediamine (DPPD), is identified in tire wear particles, rubber debris, particulate matter 2.5 (PM2.5), and wastewater influents and effluents. At a concentration of 5 µM, DPPD-Q inhibits soybean urease by 91.4%.</p>Fórmula:C18H14N2O2Cor e Forma:SolidPeso molecular:290.32N-Desmethyl Bendamustine
CAS:<p>N-DesmethylBendamustine is a metabolite of Bendamustine. It exerts cytotoxic effects on various lymphoma cell lines and peripheral blood lymphocytes.</p>Fórmula:C15H19Cl2N3O2Cor e Forma:SolidPeso molecular:344.24APP-018
CAS:<p>APP-018 (D-4F) is an 18 D-amino acid peptide that mimics apolipoprotein A-I (apoA-I). It enhances the anti-inflammatory properties of high-density lipoprotein (HDL) and is applicable in cardiovascular disease research.</p>Fórmula:C114H156N24O28Cor e Forma:SolidPeso molecular:2310.611-Hydroxy cannabinol
CAS:<p>11-Hydroxy cannabinol (Compound 5b) is an active metabolite of cannabinol.</p>Fórmula:C21H26O3Cor e Forma:SolidPeso molecular:326.43PF-07238025
<p>PF-07238025, a potent branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with an EC50 of 19 nM, enhances the stability of the BDK-BCKDH core E2</p>Fórmula:C19H18N2O3SPureza:98%Cor e Forma:SolidPeso molecular:354.42b-Cortolone
CAS:<p>b-Cortolone, a metabolite of Cortisol, exhibits relatively lower biological activity.</p>Fórmula:C21H34O5Cor e Forma:SolidPeso molecular:366.49ERAP1 modulator-1
CAS:<p>ERAP1 modulator-1 (Compound 1) is a regulator of endoplasmic reticulum aminopeptidase 1 (ERAP1) with an IC50 of less than 250 nM.</p>Fórmula:C23H23F3N2O5SCor e Forma:SolidPeso molecular:496.5Cyano-myracrylamide
CAS:<p>Cyano-myracrylamide is an inhibitor of zinc finger DHHC domain-containing palmitoyltransferase 20 (zDHHC20) with an IC50 value of 1.35 µM. It also inhibits the S-palmitoylation of EGFR and CD36. In HEK293T cells expressing recombinant E. coli GobX, recombinant human MyD88, or endogenous Ras, Cyano-myracrylamide inhibits the S-palmitoylation of E. coli E3 ligase GobX, MyD88, and Ras, which are substrates of zDHHC20, zDHHC9, and zDHHC6.</p>Fórmula:C19H34N2OCor e Forma:SolidPeso molecular:306.49ZG-2033
CAS:<p>ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.</p>Fórmula:C15H14N2O2SCor e Forma:SolidPeso molecular:286.35LH1513
<p>LH1513 is a dioxalate salt derivative of l-lysine that inhibits CaOx crystallization more effectively than citrate and pyruvate. It shows potential preventive activity in hyperoxaluria models and effectively prevents urinary CaOx crystal formation in Agxt knockout mice. AGXT-1 is a mitochondrial protein involved in metabolic processes.</p>Fórmula:C10H11N2Na3O8Cor e Forma:SolidPeso molecular:356.173,4-Dihydroxyamphetamine hydrochloride
CAS:<p>3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a minor metabolite of 3,4-Methylenedioxymethamphetamine (MDMA) and exhibits cytotoxicity in rat hepatocytes. Additionally, 3,4-Dihydroxyamphetamine (hydrochloride) is applicable in hypertension research.</p>Fórmula:C9H14ClNO2Cor e Forma:SolidPeso molecular:203.67YYLLVR
CAS:<p>YYLLVR is an inhibitory peptide of angiotensin-converting enzyme (ACE) with an inhibition rate of 89.10%. It demonstrates a low binding energy to ACE at -35.98 kcal/mol. YYLLVR can be utilized in hypertension research.</p>Fórmula:C41H63N9O9Cor e Forma:SolidPeso molecular:825.99Resinacein L
CAS:<p>Resinacein L is an inhibitor of α-glucosidase with an IC50 of 0.635 mM. This compound can slow the digestion and absorption of carbohydrates, thereby reducing postprandial blood glucose levels.</p>Fórmula:C30H40O8Cor e Forma:SolidPeso molecular:528.63DPTIP hydrochloride
CAS:<p>DPTIP hydrochloride is a potent inhibitor of neutral sphingomyelinase (N-SMase 2) that can cross the blood-brain barrier. It acts as an exosome inhibitor with an IC50 value of 30 nM.</p>Fórmula:C21H19ClN2O3SCor e Forma:SolidPeso molecular:414.91SH7s
<p>SH7s is an effective carbonic anhydrase inhibitor, exhibiting Ki values of 15.9 nM for hCA IX and 55.2 nM for hCA XII. Additionally, SH7s acts as a hypoxia-mediated chemosensitizer in colorectal cancer cells.</p>Fórmula:C24H19ClF3N5O4SCor e Forma:SolidPeso molecular:565.95α-Glucosidase-IN-77
<p>α-Glucosidase-IN-77 (Compound H7) is a non-competitive α-glucosidase inhibitor with an IC50 of 1.25 μM. It reduces blood glucose levels, improves glucose tolerance, regulates gut microbiota, and exhibits hepatoprotective effects in a mouse model of type 2 diabetes.</p>Fórmula:C25H16F3NO5SCor e Forma:SolidPeso molecular:499.46N-Desmethyl clotiazepam
CAS:<p>N-Desmethyl clotiazepam (Desmethylclotiazepam) is an active metabolite of Clotiazepam.</p>Fórmula:C15H13ClN2OSCor e Forma:SolidPeso molecular:304.8O-Desmethylcarvedilol
CAS:<p>O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of Carvedilol, a non-selective β-adrenergic receptor (β-AR) antagonist. This compound inhibits store overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation (IC50= 7.62 µM). Additionally, O-Desmethylcarvedilol slows the increase in heart rate and prevents diastolic pressure reduction induced by Isoproterenol in conscious rabbits (ED50s = 32 and 5 µg/kg).</p>Fórmula:C23H24N2O4Cor e Forma:SolidPeso molecular:392.45Inostamycin A
CAS:<p>Inostamycin A, a anticancer bacterial metabolite isolated from Streptomyces, is a selective inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase.</p>Fórmula:C38H68O11Cor e Forma:SolidPeso molecular:700.94Glucocerebrosidase
CAS:<p>Glucocerebrosidase (Glucosylceramidase; GBA), a lysosomal enzyme, catalyzes the hydrolysis of the β-glucosidic linkage in glucocerebroside (GC) to yield glucose</p>Pureza:98%Cor e Forma:SolidStevisaliosides D
<p>Stevisaliosides D (Compound 5), extracted from the roots of Stevia serrata, exhibits inhibition of PTP1B with an IC50 of 31.8 μM and has applications in</p>Fórmula:C35H54O16Pureza:98%Cor e Forma:SolidPeso molecular:730.79ω-conotoxin MoVIA
<p>ω-Conotoxin MVIIA is a potent, selective inhibitor of Ca_v2.2, exhibiting an IC_50 of 0.33 μM in the SH-SY5Y fluorimetric hCa_v2.2 assay [1].</p>Fórmula:C147H233N45O47S7Pureza:98%Cor e Forma:SolidPeso molecular:3607.15DDC 3′-O-β-D glucuronide
<p>Compound 5, DDC 3′-O-β-D-glucuronide, is a drug metabolite with properties that inhibit the fibrillization and oligomerization of Aβ42, suggesting its potential</p>Pureza:98%Cor e Forma:Odour Solidα-Glucosidase-IN-25
<p>α-Glucosidase-IN-25 (Compound (R)-8k) serves as a competitive inhibitor for α-glucosidase, demonstrating an inhibitory concentration 50 (IC50) of 1.19μM, making</p>Fórmula:C29H22N6O3Pureza:98%Cor e Forma:SolidPeso molecular:502.52Forrestiacids J
CAS:<p>Forrestiacid J is an inhibitor of ATP-citrate lyase (ACL), exhibiting an IC50 value of 2.6 μM [1].</p>Fórmula:C50H74O6Pureza:98%Cor e Forma:SolidPeso molecular:771.12MAGL-IN-11
<p>MAGL-IN-11 (compound 29) is a selective, reversible inhibitor of monoacylglycerol lipase (MAGL), with potential in researching inflammation, cancer, and</p>Pureza:98%Cor e Forma:Odour Solidα-Amylase/α-Glucosidase-IN-5
<p>α-Amylase/α-Glucosidase-IN-5 (compound 4l) functions as a dual inhibitor, effectively inhibiting both α-glucosidase (Glucosidase) and α-amylase (Amylases) with</p>Fórmula:C30H27BrN3O3PPureza:98%Cor e Forma:SolidPeso molecular:588.43Forrestiacids K
CAS:<p>Forrestiacid K, a terpenoid derived from Pseudotsuga forrestii, functions as an inhibitor of ATP-citrate lyase (ACL) [1].</p>Fórmula:C50H74O6Pureza:98%Cor e Forma:SolidPeso molecular:771.12HIF-1α-IN-2 hydrochloride
<p>HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM in</p>Fórmula:C21H20ClN3OSPureza:98%Cor e Forma:SolidPeso molecular:397.92Mortatarin F
<p>Mortatarin F (Compound 1), a renyleted flavonoid derived from mulberry leaves, functions as an α-glucosidase inhibitor with an IC50 value of 8.7 μM, making it</p>Fórmula:C25H30O7Pureza:98%Cor e Forma:SolidPeso molecular:442.5Ovalbumin (154-159)
CAS:<p>Ovalbumin (154-159), a peptide fragment derived from ovalbumin, acts as a potent inhibitor of the angiotensin-converting enzyme (ACE) and is utilized in</p>Fórmula:C28H52N10O9Pureza:98%Cor e Forma:SolidPeso molecular:672.77
