Metabolismo

<p>Acetazolamide D3 is a deuterium-labeled Acetazolamide. Acetazolamide is a potent carbonic anhydrase inhibitor.</p>

<p>3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol. 3,4-Dehydro Cilostazol is used for pharmacokinetic study[1].</p>

<p>Febuxostat D9 is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with Ki of 0.6 nM.</p>

<p>Maltose phosphorylase (MP) is a dimeric enzyme that catalyzes the conversion of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose.</p>

<p>Compound 9j inhibits Glyoxalase I with 1.13 μM IC50, showing anticancer potential and low toxicity.</p>

<p>Boc-His-OH is a protected amino acid derivative.N-Boc-L-Histidine is used as an intermediate in peptide synthesis with good chemical stability and solubility.</p>

<p>Hippuryl-His-Leu-OH tests for angiotensin I enzyme activity, allowing His-Leu detection by fluorescence.</p>

<p>NCGC00249987 is a highly selective and allosteric Tyr phosphatase activity of inhibitor of Eya2(Eya2 ED and MBP-Eya2 FL with IC50s of 3 μM and 6.9 μM ).</p>

<p>Debrisoquine is an antihypertensive drug similar to guanethidine.</p>

<p>TLK117 is an inhibitor of GSTs that reduces the severity of pulmonary fibrosis and may be used in the study of idiopathic pulmonary fibrosis.</p>

Acetaminophen metabolite 3-hydroxy-acetaminophen is an antioxidant and a non-toxic microsomal metabolite of acetaminophen, suitable for metabolic studies.

<p>N'-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N'-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N'-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2<br>1.Hecht, S.S.Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosaminesChem. Res. Toxicol.11(6)559-603(1998) 2.Yuan, J.-M., Knezevich, A.D., Wang, R., et al.Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokersCarcinogenesis32(9)1366-1371(2011)</p>

<p>Plumbic acetate releases acetate ions, acts as an oxidizer for sulfur (VI) synthesis, and reacts with thiodithiazyl dichloride.</p>

<p>Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase with anti-inflammatory activities.</p>

<p>Atrial natriuretic factor (1-28) (human, porcine) TFA exhibits antihypertensive activity by promoting sodium and urine excretion. It inhibits the release of adrenocorticotropic hormone (ACTH) and β-endorphin by suppressing pro-opiomelanocortin (POMC) expression. Additionally, it elevates cGMP levels in RMIC cells, with an IC50 of 1.2 nM.</p>

<p>Bullatacin is a bis(tetrahydrofuranoid) fatty acid lactone that existed in some fruits from Annonaceae family.</p>

<p>(R)-2-((tert-Butoxycarbonyl)amino)pent-4-ynoic acid is a peptide with the sequence Boc-D-Pra-OH and glycine derivative, containing an alkyne group.</p>

<p>6-Methyluracil (Pseudothymine): a Uracil metabolite, indicates acetoacetyl-CoA build-up, has antiradiation effects.</p>

<p>Z-Asn-OH (N-Cbz-L-asparagine) is a glycine derivative mainly used in peptide synthesis.Cbz-Asn-OH prevents unwanted reactions.</p>

<p>2-Amino-3-mercaptopropanoic acid hydrochloride hydrate is a cysteine derivative, widely used in biochemical experiments and drug synthesis research.</p>

<p>Chst15-IN-1 is a selective, reversible covalent Chst15 inhibitor reducing CS-E sulfation, attenuating CSPG effects, and promoting neuronal repair.</p>

<p>ALDH1A3-IN-3 inhibits ALDH1A3 (IC50: 0.26 μM), acts on ALDH3A1, and is used in prostate cancer research.</p>

<p>Arginine xhydrochloride is used for amino acid chelation analysis.</p>

<p>Diacetolol is the major metabolite of acebutolol, a selective beta blockers used to treat hypertension, angina pectoris and arrhythmia.</p>

<p>(Rac)-IDO1-IN-5 is a racemic, potent IDO1 inhibitor; selective for apo-IDO1, it crosses the blood-brain barrier.</p>

<p>Isavuconazole D4 is a deuterium labeled Isavuconazole. Isavuconazole is a triazole prodrug with antifungal activity against yeasts, molds, and dimorphic fungi.</p>

<p>(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) with Ki of 0.06 nM.</p>

<p>SDH-IN-1 (compound 4i) is an SDH (succinate dehydrogenase) inhibitor (IC50 = 4.53 μM) with antifungal activity against S. sclerotiorum fungicidal purposes.</p>

<p>"(±)-ε-Viniferin, a racemate of ε-Viniferin, exhibits P450 inhibitory antioxidants, along with hepato-protective and antimicrobial activities. It also demonstrates antibacterial and antibiofilm activities against Gram-positive bacteria Streptococcus pneumoniae, with a minimum inhibitory concentration (MIC) of 20 μM [1]."</p>

<p>m-Tolylacetic acid, a urine metabolite of tolueneacetic acid, is a hydroaromatic dicarboxylic acid.</p>

<p>Imidazol-1-yl-acetic acid is a natural product used in life sciences research (Catalog No. T67657, CAS No. 22884-10-2).</p>

<p>O-desmethyl Mebeverine acid D5 is the deuterium labeled O-desmethyl Mebeverine acid.</p>

<p>Trandolaprilate D5 is a deuterium-labeled Trandolaprilate. Trandolaprilate is an inhibitor of angiotensin-converting enzyme (ACE).</p>

<p>21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis.</p>

<p>Mebeverine alcohol D5 is the deuterium labeled Mebeverine alcohol.</p>

<p>4-(Trifluoromethyl)-L-phenylalanine is a phenylalanine derivative suitable for biochemical experiments and drug synthesis research.</p>

<p>Ofloxacin-d3 is a deuterated compound of Ofloxacin.</p>

<p>Dihydrotachysterol (HSDB 3314) is a vitamin D analog.Dihydrotachysterol has been used to study hypocalcemic hypoparathyroidism after surgical removal of the parathyroid glands and growth impairment in children with chronic renal insufficiency.</p>

<p>H-D-Thr(tBu)-OH is a useful organic compound for research in life sciences [Catalog No.: T67086, CAS No.: 201274-81-9].</p>

<p>Sodium 3-methyl-2-oxobutanoate is the precursor of pantothenic acid in Escherichia coli.</p>

<p>Fmoc-Gln(Trt)-Thr(psi(Me,Me)pro)-OH is a dipeptide.</p>

<p>Fmoc-N-Me-Val-OH is a modified peptide.</p>

<p>Cyhalofop-butyl is an ACCase (acetyl-coenzyme A carboxylase) inhibitor and herbicide that suppresses plant lipid synthesis at the meristematic level.</p>

<p>DiFMUP (6,8-Difluoro-4-methylumbelliferyl phosphate) inhibits protein tyrosine phosphatases (PTPs) and can be used to assay threonine phosphatase activity.</p>

<p>Cyclohexanepropanoic acid, α-amino-, hydrate, (αR)- is an alanine derivative for biochemical experiments and drug synthesis research.</p>

<p>Ternidazole hydrochloride (Ternidazole HCl) is a 5-nitroimidazole antibiotic with antimicrobial antioxidant and antiprotozoal activity.</p>

<p>DL-Homocysteic acid is a useful organic compound for research related to life sciences. The catalog number is T124757 and the CAS number is 504-33-6.</p>

<p>(R)-Methyl 2-amino-2-cyclohexylacetate HCl is a glycine derivative that can be used to synthesize biologically active molecules such as inhibitors.</p>

<p>VD3-D6 is the deuterated form of Vitamin D3; tools for determination of Vitamin D3 metabolites in human serum.</p>

<p>Phospholipase A2 (PLA2) is an enzyme that hydrolyzes fatty acids present in the sn-2 position of phospholipids and is closely related to lipid metabolism.</p>