PKC

Dequalinium Chloride, a topical bacteriostat, is a selective blocker of apamin-sensitive K+ channels. It is …

Miltefosine is the treatment of visceral and cutaneous leishmaniasis drug , and is proceeding clinical …

Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a …

Y-33075 is a selective inhibitor of ROCK derived from Y-27632, and is more potent than …

CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, …

AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).

DCP-LA (FR236924), linoleic acid derivatives, selective and direct activation of PKCε.

DCPLA-ME is the methyl ester form of DCPLA and can be used to treat neurodegenerative …

BJE6-106 (B106) is a potent, selective PKCδ inhibitor (IC50: 0.05 μM) and targets selectivity over …

K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor …

(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2 , γ-CRD2). …

PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 …

Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes. Cercosporin is a potent …

(Z)-Butylidenephthalide has antitumor effect, can effectively inhibit the tumor growth in the glioma.

Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.

VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM …

K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b …

20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. …

Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 …

Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it …

(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.

Ro 31-8220 is a pan-PKC inhibitor for PKC-α/βI/βII/γ/ε (IC50: 5/24/14/27/24 nM), and also shows potent …

ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. …

Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.

[Ala113]MBP(104-118) acetate is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC50s ranging …

N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine is a novel 2,6-naphthyridine identified by high throughput screen (HTS) as a dual protein …

Sotrastaurin is a potent pan-PKC inhibitor (Kis: 0.95/0.64/2.1/3.2/1.8/0.22 nM for PKCα/βI/δ/ε/η/θ).

Hypocrellin A is PKC inhibitor, has light-induced antitumor,antifungal and antiviral activities, it also exerts immunomodulatory …

Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - …

Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also …

1,2-Dipalmitoyl-sn-glycerol is an analog of the PKC-activating second messenger diacylglycerol (DAG). It weakly activates PKC.

TAS-301, an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon …

PKC412(Midostaurin; CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C …

PKC-theta inhibitor is a selective PKC-θinhibitor(IC50:12 nM).

Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.

LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor(IC50 values of …

1. Chelerythrine may have antimanic effect . 2. Chelerythrine can inhibit telomerase activity. 3. Chelerythrine …

Pep2m, myristoylated acetate is a Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction …

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate …

Chelerythrine Chloride is a cell-permeable inhibitor of protein kinase C, competitive with respect to the …

Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.

Enzastaurin (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity …

Cholesterol sulfate is a sterol sulfate in human plasma. It is a component of cell …

Procyanidin A1 has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or …

PKC ζ pseudosubstrate acetate is an inhibitor of protein kinase C (PKC) ζ; attached to …

TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).

Staurosporine is a potent PKC inhibitor for PKCα/γ/η (IC50: 2/5/4 nM), less potent to PKCε …

Phorbol, a plant-derived diterpene, is a tumor promoter through the activation of protein kinase C.

Protein Kinase C 19-31 acetate, a peptide inhibitor of protein kinase C (PKC), derived from …

PKCβ inhibitor 1(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 …

Y06137 is an effective and selective BET inhibitor with a Kd of 81 nM for …

1. Ingenol mebutate is an effective treatment for actinic keratosis. 2. Formulating novel derivatives from …

ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, …

Plantainoside D shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme …

Hispidin is a polyphenol originally, including antioxidant, anti-inflammatory, and cytoprotective properties

[Ala107]-MBP (104-118) acetate is synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor …

PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, …

6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which …

Valrubicin (AD 32) inhibits TPA- and PDBu-induced PKC activation (IC50s: 0.85 and 1.25 μM) and …