Topoisomerase
Topoisomerases are enzymes that regulate the topology of DNA during processes such as replication, transcription, and chromosome segregation by introducing transient breaks into the DNA strands to relieve torsional stress. Topoisomerase inhibitors interfere with this process, leading to the accumulation of DNA breaks and the induction of cell death, particularly in rapidly dividing cells. These inhibitors are widely used as chemotherapeutic agents in cancer treatment. At CymitQuimica, we offer a broad range of high-quality topoisomerase inhibitors to support your research in DNA replication, cancer therapy, and cell cycle regulation.
Found 136 products of "Topoisomerase"
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XR-11576 HCl
<p>XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity.</p>Formula:C23H25ClN4O2Purity:98.52%Color and Shape:SoildMolecular weight:424.92Nalidixic acid
CAS:<p>Nalidixic acid (NSC-82174), a synthetic antimicrobial, targets bacterial DNA gyrase A, with a narrow bactericidal range.</p>Formula:C12H12N2O3Purity:99.9% - 99.95%Color and Shape:Pale Buff Crystalline Powder Physical Description Cream-Colored Powder (Ntp 1992)Molecular weight:232.24Oxaquin TEA
<p>Oxaquin TEA (MCB-3837 TEA), a precursor compound to MCB3681, is a DNA topoisomerase inhibitor that can be used to study Clostridium difficile infections and</p>Formula:C37H48F2N5O11PPurity:99.79%Color and Shape:SolidMolecular weight:807.77Hycanthone
CAS:<p>Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.</p>Formula:C20H24N2O2SPurity:98.78%Color and Shape:Yellow-Orange Powder (Ntp 1992)Molecular weight:356.48Irinotecan hydrochloride trihydrate
CAS:<p>Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.</p>Formula:C33H45ClN4O9Purity:98.22% - >99.99%Color and Shape:Pale Yellow To Yellow Crystalline PowderMolecular weight:677.18Irinotecan Hydrochloride
CAS:<p>Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.</p>Formula:C33H39ClN4O6Purity:98% - 99.94%Color and Shape:Yellow Crystalline PowderMolecular weight:623.14Etoposide
CAS:<p>Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).</p>Formula:C29H32O13Purity:99.19% - 99.94%Color and Shape:Crystals From Methanol SolidMolecular weight:588.56Enoxacin
CAS:<p>Enoxacin (NSC-629661) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.</p>Formula:C15H17FN4O3Purity:98.68% - 99.89%Color and Shape:Off-White To Yellow CrystalsMolecular weight:320.32Ledoxantrone trihydrochloride
CAS:<p>Ledoxantrone trihydrochloride is a Top II inhibitor with anticancer activity and is used in the study of digestive disorders and urologic disorders.</p>Formula:C21H30Cl3N5OSPurity:98.13%Color and Shape:SoildMolecular weight:506.92Flumequine
CAS:<p>Flumequine (R-802) is a broad-spectrum antibiotic targeting DNA gyrase and topoisomerase IV in Gram-positive and Gram-negative bacteria.</p>Formula:C14H12FNO3Purity:98.92% - 99.4%Color and Shape:White Crystalline Powder SolidMolecular weight:261.25Mitoxantrone dihydrochloride
CAS:<p>Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.</p>Formula:C22H30Cl2N4O6Purity:97.05% - >99.99%Color and Shape:Blue-Black Solid From Water Ethanol SolidMolecular weight:517.4Berberine chloride
CAS:Berberine chloride (Natural Yellow 18) is an alkaloid from Hydrastis canadensis L., Berberidaceae, and used orally for various fungal and parasitic infections.Formula:C20H18ClNO4Purity:99.47% - 99.93%Color and Shape:Yellow Crystalline PowderMolecular weight:371.8Levofloxacin hydrate
CAS:<p>Levofloxacin hydrate (Cravit hydrate) is a third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Formula:C18H20FN3O4H2OPurity:98.26%Color and Shape:Pale Yellow SolidMolecular weight:370.38Ciprofloxacin monohydrochloride
CAS:<p>Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.</p>Formula:C17H18FN3O3·HClPurity:99.5% - >99.99%Color and Shape:White Or Light Yellow Crystalline PowderMolecular weight:367.80Teniposide
CAS:<p>Teniposide (VM26), a semisynthetic derivative of podophyllotoxin with antitumor activity, inhibits DNA synthesis by forming a complex with topoisomerase II and</p>Formula:C32H32O13SPurity:97.7% - 99.45%Color and Shape:White Or Off-White Crystalline PowderMolecular weight:656.65Pefloxacin Mesylate
CAS:Pefloxacin Mesylate (Pefloxacinium mesylate) is a synthetic broad-spectrum fluoroquinolone antibacterial agent active against most gram-negative and gram-Formula:C18H24FN3O6SPurity:99.86%Color and Shape:SolidMolecular weight:429.46Lurtotecan
CAS:<p>Lurtotecan (GI147211) is a semisynthetic Camptothecin analog. Lurtotecan is a topoisomerase I inhibitor with anticancer effects.</p>Formula:C28H30N4O6Purity:99.18%Color and Shape:SoildMolecular weight:518.56Topotecan hydrochloride
CAS:<p>Topotecan hydrochloride (NSC609699) is an antineoplastic agent used to treat ovarian cancer.</p>Formula:C23H24ClN3O5Purity:97.88% - 99.41%Color and Shape:White Crystalline SolidMolecular weight:457.92DRF-1042 HCl
<p>DRF-1042 HCl is an orally active camptothecin analog with antitumor activity, inhibits DNA topoisomerase I, and is used in the study of refractory solid tumors.</p>Formula:C22H21ClN2O6Purity:97.93%Color and Shape:SolidMolecular weight:444.87Ciprofloxacin
CAS:<p>Ciprofloxacin (Bay-09867) mainly targets bacterial DNA Gyrase (IC50=0.22-0.31 µM) and topoisomerase IV (IC50=0.3-1.9 µM). antibiotic. High-Quality, Low-Cost!</p>Formula:C17H18FN3O3Purity:98.77% - 99.91%Color and Shape:White PowderMolecular weight:331.34Doxorubicin hydrochloride
CAS:Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).Formula:C27H29NO11·HClPurity:98% - 99.52%Color and Shape:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Molecular weight:579.99Enoxacin hydrate
CAS:<p>Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.</p>Formula:C15H17FN4O3H2OPurity:99.50%Color and Shape:SolidMolecular weight:347.34Daunorubicin hydrochloride
CAS:<p>Daunorubicin hydrochloride (Rubidomycin hydrochloride), an anthracycline aminoglycoside antineoplastic, inhibits DNA replication and repair and RNA and protein</p>Formula:C27H29NO10·HClPurity:96.21% - 99.53%Color and Shape:Cancer DrugMolecular weight:563.99Moxifloxacin hydrochloride
CAS:<p>Moxifloxacin hydrochloride (BAY12-8039 HCl) is a fourth generation fluoroquinolone with expanded activity against gram-positive bacteria and atypical pathogens.</p>Formula:C21H25ClFN3O4Purity:99.91% - >99.99%Color and Shape:SolidMolecular weight:437.89Nalidixic acid sodium salt
CAS:<p>Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.</p>Formula:C12H11N2NaO3Purity:99.72% - 99.95%Color and Shape:White To Off-White PowderMolecular weight:254.22Gatifloxacin
CAS:<p>Gatifloxacin (CG5501), a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA gyrase and topoisomerase IV.</p>Formula:C19H22FN3O4Purity:99.50% - 99.85%Color and Shape:White PowderMolecular weight:375.39Epirubicin hydrochloride
CAS:<p>Epirubicin hydrochloride (Pharmorubicin) is a Topo and Foxp3 inhibitor. Epirubicin hydrochloride has antitumor activity. Cost-effective and quality-assured.</p>Formula:C27H30ClNO11Purity:98.13% - 99.79%Color and Shape:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Molecular weight:579.98Lomefloxacin
CAS:<p>Lomefloxacin (SC47111A) is a synthetic broad-spectrum fluoroquinolone with antibacterial activity.</p>Formula:C17H19F2N3O3Purity:98.59%Color and Shape:Off-White To Yellow CrystalsMolecular weight:351.35Topoisomerases/ribosomes-IN-1
<p>Topoisomerases/ribosomes-IN-1 (compound 30f) serves as an inhibitor targeting both ribosomes and topoisomerases, specifically exhibiting inhibitory actions against constitutively macrolide-resistant bacteria. This compound effectively suppresses bacterial protein synthesis (IC 50 : 0.647 μM) and hampers DNA replication (IC 50 : 0.218 μM).</p>Formula:C53H83FN6O15Color and Shape:SolidMolecular weight:1063.26Topoisomerase II inhibitor 13
CAS:<p>WAY-323966 suppresses Topo II, strongly halts HL-60/MX2 cancer cell growth, resists Topo II toxicity.</p>Formula:C22H23N9Purity:98.4%Color and Shape:SoildMolecular weight:413.48TAK1 inhibitor
CAS:<p>TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.</p>Formula:C22H19ClN6O2SPurity:98%Color and Shape:SoildMolecular weight:466.94Garenoxacin
CAS:<p>Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.</p>Formula:C23H20F2N2O4Purity:98%Color and Shape:SolidMolecular weight:426.41Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Formula:C21H21N3O2Color and Shape:SolidMolecular weight:347.41DNA Damage & Repair Compound Library
<p>A unique collection of xnum DNA Damage &amp; Repair related compounds for high throughput screening (HTS) and high content screening (HCS);</p>Color and Shape:Odour SolidGimatecan HCl
<p>Gimatecan HCl (ST1481 HCL) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.</p>Formula:C25H26ClN3O5Purity:97.04%Color and Shape:SoildMolecular weight:483.94Banoxantrone-d12 dihydrochloride
CAS:<p>Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.</p>Formula:C22H30Cl2N4O6Purity:98%Color and Shape:SolidMolecular weight:529.48Banoxantrone (D12)
CAS:<p>Banoxantrone D12, deuterium-labeled version, reduces to AQ4 - a stable DNA-targeting topoisomerase II inhibitor.</p>Formula:C22H28N4O6Purity:98%Color and Shape:SolidMolecular weight:456.55CH-0793076
CAS:<p>CH-0793076: hexacyclic camptothecin, TP300 metabolite, targets BCRP, inhibits DNA topo I (IC50: 2.3 μM).</p>Formula:C26H26N4O4Purity:98%Color and Shape:SolidMolecular weight:458.51Topoisomerase IIα-IN-9
CAS:Compound EN300-20599, with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound EN300-20599 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C14H14O4SColor and Shape:SolidMolecular weight:278.32Dichlorogelignate
CAS:<p>Dichlorogelignate (compound 4) acts as a selective inhibitor of topoisomerase II (Topo II), achieving 100% inhibition at 50 μM [1].</p>Formula:C32H34O18Color and Shape:SolidMolecular weight:706.6Topo I/II-IN-1
<p>Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.</p>Formula:C15H13N3S2Color and Shape:SolidMolecular weight:299.414Chimmitecan
CAS:<p>Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.</p>Formula:C23H20N2O5Purity:98.35%Color and Shape:SoildMolecular weight:404.42AuL1
<p>AuL1 is a topoisomerase IIα (Top II) inhibitor with DNA intercalating properties. It exhibits cytotoxic effects on tumor cells, making it a potential subject for anticancer agent research.</p>Formula:C29H50AuCl2N5Color and Shape:SolidMolecular weight:736.61Voreloxin
CAS:<p>Voreloxin (SNS-595) is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity. Phase 2.</p>Formula:C18H19N5O4SPurity:98%Color and Shape:SolidMolecular weight:401.44DTS-108
CAS:<p>DTS-108 is a prodrug of SN38 (a topoisomerase I inhibitor). It is a conjugate formed by linking SN38 to a human oligopeptide through an esterase-sensitive crosslinker. DTS-108 exhibits anticancer activity against colorectal cancer, lung cancer, and breast cancer.</p>Formula:C145H233N43O33S2Color and Shape:SolidMolecular weight:3170.8AuM1Phe
<p>AuM1Phe, an N-heterocyclic carbene (NHC) metal complex, inhibits both human topoisomerase I activity and actin polymerization.</p>Purity:98%Color and Shape:Odour SolidAuM1Gly
<p>AuM1Gly, a topoisomerase I inhibitor, demonstrates efficacy in inhibiting the proliferation of MDA-MB-231 breast cancer cells, exhibiting IC50 values in the low</p>Purity:98%Color and Shape:Odour SolidNH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride
<p>Compound I, NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride, is a topoisomerase I inhibitor that demonstrates effective antibody-drug conjugate (ADC)</p>Formula:C26H24ClN3O6Purity:98%Color and Shape:SolidMolecular weight:509.94Topoisomerase I inhibitor 10
<p>Compound 13, a topoisomerase I inhibitor 10, selectively inhibits leishmanial topoisomerase IB and exhibits antileishmanial activity.</p>Purity:98%Color and Shape:Odour SolidAntitumor agent-102
<p>Antitumor Agent-102 (Compound 10), a conjugate integrating a Topoisomerase I inhibitor SN38 with a glucose transporter inhibitor, specifically targets</p>Formula:C70H82N8O18SPurity:98%Color and Shape:SolidMolecular weight:1355.51Nifurpirinol
CAS:<p>Nifurpirinol (P-7138) is an antimicrobial compound that is acutely toxic to milkfish species.</p>Formula:C12H10N2O4Purity:99.7%Color and Shape:SolidMolecular weight:246.22(4-NH2)-Exatecan
CAS:(4-NH2)-Exatecan is a topoisomerase inhibitor with potential anticancer activity for the synthesis of antibody drug conjugates (ADCs).Formula:C23H21N3O4Purity:99.89%Color and Shape:SolidMolecular weight:403.43Daun02
CAS:<p>Daun02 is the topoisomerase inhibitor Daunorubicin prodrug.</p>Formula:C41H44N2O20Purity:98%Color and Shape:SolidMolecular weight:884.79EIDD-1931
CAS:<p>EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.</p>Formula:C9H13N3O6Purity:99.14% - 99.73%Color and Shape:SolidMolecular weight:259.22Aurintricarboxylic acid
CAS:Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Formula:C22H14O9Purity:97.1%Color and Shape:Deep Red Coarse Crystalline PowderMolecular weight:422.34Phenoxodiol
CAS:Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Formula:C15H12O3Purity:98.07% - 99.18%Color and Shape:SolidMolecular weight:240.25Marbofloxacin
CAS:<p>Marbofloxacin (Zeniquin) is an effective, broad-spectrum antibiotic of bacterial, which inhibits DNA replication.</p>Formula:C17H19FN4O4Purity:99.76% - 99.84%Color and Shape:SolidMolecular weight:362.36Idarubicin hydrochloride
CAS:<p>Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).</p>Formula:C26H27NO9·HClPurity:98.91% - 99.96%Color and Shape:SolidMolecular weight:533.95Voreloxin hydrochloride
CAS:<p>Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.</p>Formula:C18H20ClN5O4SPurity:99.84%Color and Shape:SolidMolecular weight:437.9Rubitecan
CAS:<p>Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.</p>Formula:C20H15N3O6Purity:97.54%Color and Shape:Yellow Amorphous PowderMolecular weight:393.35SN-38
CAS:<p>SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).</p>Formula:C22H20N2O5Purity:98% - 99.97%Color and Shape:Light-Yellow SolidMolecular weight:392.4Betulinic acid
CAS:<p>Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.</p>Formula:C30H48O3Purity:99.12% - 99.7%Color and Shape:White Crystalline PowderMolecular weight:456.7Pixantrone dimaleate
CAS:<p>Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.</p>Formula:C25H27N5O10Purity:98.70% - 99.11%Color and Shape:SolidMolecular weight:557.21Genz-644282
CAS:<p>Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.</p>Formula:C22H21N3O5Purity:97.49%Color and Shape:SolidMolecular weight:407.42Suramin Sodium Salt
CAS:<p>Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.</p>Formula:C51H34N6Na6O23S6Purity:97.47% - 99.97%Color and Shape:WhiteMolecular weight:1429.15(S)-10-Hydroxycamptothecin
CAS:<p>(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.</p>Formula:C20H16N2O5Purity:99.09% - 99.81%Color and Shape:SolidMolecular weight:364.35Topotecan
CAS:<p>Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.</p>Formula:C23H23N3O5Purity:96.14% - 98.23%Color and Shape:Light Yellow Needle Crystal Or Crystalline PowderMolecular weight:421.45Bisantrene
CAS:<p>Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.</p>Formula:C22H22N8Purity:96.07% - 98.57%Color and Shape:SolidMolecular weight:398.46Gatifloxacin hydrochloride
CAS:<p>Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.</p>Formula:C19H23ClFN3O4Purity:99.85% - 99.89%Color and Shape:SolidMolecular weight:411.86Berberine hydrogen sulphate
CAS:<p>Berberine hydrogen sulphate, a plant alkaloid, has broad antimicrobial effects on bacteria, fungi, and protozoa.</p>Formula:C20H19NO8SPurity:99% - 99.79%Color and Shape:Yellow Crystals Off-White To Yellow PowderMolecular weight:433.43Belotecan hydrochloride
CAS:Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activityFormula:C25H28ClN3O4Purity:99.63% - ≥95%Color and Shape:SolidMolecular weight:469.96Berberine
CAS:<p>1.</p>Formula:C20H18NO4Purity:95.71% - 99.67%Color and Shape:SolidMolecular weight:336.36Artemisitene
CAS:<p>Artemisitene, an oxidized antimalarial derivative of Artemisinin, stems from precursors like Artemisinin B and Artemisinic acid.</p>Formula:C15H20O5Purity:99.58%Color and Shape:SolidMolecular weight:280.329-amino-CPT
CAS:<p>9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity.</p>Formula:C20H17N3O4Purity:99.13% - 99.82%Color and Shape:Orange-Yellow PowderMolecular weight:363.379-Hydroxycamptothecin
CAS:<p>9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.</p>Formula:C20H16N2O5Purity:98.28%Color and Shape:SolidMolecular weight:364.35Isosteviol
CAS:<p>Isosteviol is a natural sweetener with anti-inflammatory, anti-tumor, glucose-lowering, and other health benefits.</p>Formula:C20H30O3Purity:99.72% - 99.97%Color and Shape:SolidMolecular weight:318.45SW044248
CAS:<p>SW044248 is a noncanonical Top1 inhibitor. It has selective toxicity for NSCLC cells.</p>Formula:C22H23N5O2SPurity:99.56% - 99.87%Color and Shape:SolidMolecular weight:421.52Niranthin
CAS:<p>Niranthin is a potent anti-leishmanial agent, inhibits the relaxation activity of heterodimeric type IB topoisomerase of L.</p>Formula:C24H32O7Purity:99.8%Color and Shape:SolidMolecular weight:432.51Levofloxacin hydrochloride
CAS:<p>Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.</p>Formula:C18H21ClFN3O4Purity:99.78% - 99.98%Color and Shape:SolidMolecular weight:397.8Pirarubicin
CAS:<p>Pirarubicin (Theprubicin), an anthracycline antibiotic, inhibits DNA/RNA synthesis and is used as an antineoplastic.</p>Formula:C32H37NO12Purity:97.80% - 99.15%Color and Shape:Red Crystalline PowderMolecular weight:627.64Indotecan
CAS:<p>Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).</p>Formula:C26H26N2O7Purity:97% - 98%Color and Shape:SolidMolecular weight:478.49Garenoxacin mesylate hydrate
CAS:<p>Garenoxacin mesylate hydrate (Garenoxacin mesylate [USAN]) with potent antimicrobial activity, against common respiratory pathogens, including resistant strains</p>Formula:C23H20F2N2O4·CH4O3S·H2OPurity:99.56%Color and Shape:SolidMolecular weight:540.53Exatecan Mesylate
CAS:<p>Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).</p>Formula:C25H26FN3O7SPurity:97.32% - 99.9%Color and Shape:SolidMolecular weight:531.55Topovale
CAS:<p>Topovale (ARC111) is a potent inhibitor of topoisomerase I.</p>Formula:C23H23N3O5Purity:99.94%Color and Shape:SolidMolecular weight:421.45Nitidine chloride
CAS:1.Formula:C21H18ClNO4Purity:96.59% - 99.55%Color and Shape:SolidMolecular weight:383.82Prulifloxacin
CAS:<p>Prulifloxacin (NM441) is a broad-spectrum fluoroquinolone that inhibits bacterial DNA synthesis by blocking topoisomerase II and IV.</p>Formula:C21H20FN3O6SPurity:99.47%Color and Shape:Yellow Or Slightly Yellow PowerMolecular weight:461.46NU2058
CAS:<p>NU2058 (O(6)-Cyclohexylmethylguanine) is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity.</p>Formula:C12H17N5OPurity:99.34% - 99.92%Color and Shape:SolidMolecular weight:247.3Rabdosiin
CAS:<p>Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.</p>Formula:C36H30O16Purity:98.64% - 99.49%Color and Shape:SolidMolecular weight:718.619-Methoxycamptothecin
CAS:9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.Formula:C21H18N2O5Purity:98.49% - 99.56%Color and Shape:SolidMolecular weight:378.38Mitoxantrone
CAS:<p>Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.</p>Formula:C22H28N4O6Purity:96.29% - 98.74%Color and Shape:Blue PowderMolecular weight:444.48β-Lapachone
CAS:<p>β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.</p>Formula:C15H14O3Purity:99.76% - 99.88%Color and Shape:SolidMolecular weight:242.27Ellipticine hydrochloride
CAS:<p>Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.</p>Formula:C17H15ClN2Purity:97.18%Color and Shape:SolidMolecular weight:282.76Coralyne chloride
CAS:<p>Coralyne chloride is a protoberberine with strong anticancer activity.</p>Formula:C22H22ClNO4Purity:98.88%Color and Shape:SolidMolecular weight:399.87Amsacrine hydrochloride
CAS:<p>Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.</p>Formula:C21H20ClN3O3SPurity:99.05% - 99.92%Color and Shape:SolidMolecular weight:429.92Amonafide
CAS:<p>Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.</p>Formula:C16H17N3O2Purity:99.39%Color and Shape:SolidMolecular weight:283.33Groenlandicine
CAS:<p>Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential as an anti-Alzheimer's agent.</p>Formula:C19H16NO4Purity:98.59% - 99.77%Color and Shape:SolidMolecular weight:322.34Irinotecan
CAS:<p>Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.</p>Formula:C33H38N4O6Purity:98% - 99.92%Color and Shape:SolidMolecular weight:586.68Dxd
CAS:<p>Dxd (OQM5SD32BQ) is a potent DNA topoisomerase I inhibitor (IC50= 0.31 μM). Dxd was used as a conjugate drug for HER2-targeted ADCs. High-Quality, Low-Cost!</p>Formula:C26H24FN3O6Purity:98.21% - ≥98%Color and Shape:SolidMolecular weight:493.48Levofloxacin
CAS:Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.Formula:C18H20FN3O4Purity:98.14% - 99.80%Color and Shape:Off-White To Yellow CrystalsMolecular weight:361.37TAS-103 dihydrochloride
CAS:<p>TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.</p>Formula:C20H21Cl2N3O2Purity:97.78%Color and Shape:SolidMolecular weight:406.31Razoxane
CAS:<p>Razoxane is used as an antimitotic agent with immunosuppressive properties.</p>Formula:C11H16N4O4Purity:99.75%Color and Shape:SolidMolecular weight:268.271,4-Naphthoquinone
CAS:<p>1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.</p>Formula:C10H6O2Purity:99.24% - 99.56%Color and Shape:SolidMolecular weight:158.15Bimolane
CAS:<p>Bimolane is a topoisomerase II inhibitor.</p>Formula:C20H32N6O6Purity:99.13% - 99.29%Color and Shape:SolidMolecular weight:452.5Doxorubicin
CAS:<p>Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.</p>Formula:C27H29NO11Purity:99.31%Color and Shape:Red Crystalline Solid SolidMolecular weight:543.52(±)-10-Hydroxycamptothecin
CAS:<p>(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.</p>Formula:C20H16N2O5Purity:98% - 99.06%Color and Shape:SolidMolecular weight:364.35IndiMitecan
CAS:<p>IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].</p>Formula:C25H21N3O6Purity:98.53%Color and Shape:SoildMolecular weight:459.45Exatecan
CAS:<p>Exatecan (DX-8951f) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL).Exatecan has antitumor activity and may be used in</p>Formula:C24H22FN3O4Purity:99.64% - 99.84%Color and Shape:SolidMolecular weight:435.45PNU-159682
CAS:<p>PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.</p>Formula:C32H35NO13Purity:98.24%Color and Shape:SolidMolecular weight:641.62Camptothecin
CAS:<p>Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.</p>Formula:C20H16N2O4Purity:99.52% - 99.88%Color and Shape:Solid PowderMolecular weight:348.35Ellipticine
CAS:<p>Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast cancer, neuroblastoma, glioblastoma.</p>Formula:C17H14N2Purity:97.26% - 99.88%Color and Shape:SolidMolecular weight:246.31Amsacrine
CAS:<p>Amsacrine (AMSA) (mAMSA) an antineoplastic agent which can intercalate into the DNA of tumor cells.</p>Formula:C21H19N3O3SPurity:99.2%Color and Shape:Yellow Crystalline Powder SolidMolecular weight:393.46Daniquidone
CAS:<p>Daniquidone (Batracylin) is a potent dual inhibitor of DNA topoisomerase I and DNA topoisomerase II with cytotoxic and antiproliferative activity for neoplasms</p>Formula:C15H11N3OPurity:98.39% - 99.52%Color and Shape:SolidMolecular weight:249.27PluriSIn #2
CAS:<p>PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.</p>Formula:C11H8FN3O3Purity:98% - 99.79%Color and Shape:SolidMolecular weight:249.2BNS-22
CAS:<p>BNS-22 is a DNA topoisomerase II (Topo II) inhibitor, induces mitotic abnormalities and exhibits antiproliferative activity against human cancer cells.</p>Formula:C24H25NO5Purity:99.62%Color and Shape:SolidMolecular weight:407.46Exatecan mesylate dihydrate
CAS:<p>Exatecan mesylate dihydrate (DX-8951), a DNA topoisomerase I inhibitor, exhibits an IC50 of 2.2 μM (0.975 μg/mL) and is utilized in cancer research [1] [2] [3].</p>Formula:C25H30FN3O9SPurity:98%Color and Shape:SolidMolecular weight:567.58Aldoxorubicin
CAS:Aldoxorubicin, an albumin-binding prodrug of Doxorubicin, exhibits potent antitumor effects in cancer lines and mouse models.Formula:C37H42N4O13Purity:98%Color and Shape:SolidMolecular weight:750.75Pegamotecan
CAS:<p>Pegamotecan (PEG-camptothecin) is a topoisomerase I (TOP1) inhibitor with anticancer activity, and it is used in the treatment of esophageal, non-small cell</p>Formula:C52H48N6O14Purity:96.40% - 97.83%Color and Shape:SolidMolecular weight:980.984Pyrazoloacridine
CAS:<p>Pyrazoloacridine (PD 115934) binds DNA, inhibits topo I/II, has 1.25 μM IC50 in K562 cells, and exhibits anti-cancer effects.</p>Formula:C19H21N5O3Purity:99.72%Color and Shape:SolidMolecular weight:367.49-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS:<p>9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potential</p>Formula:C22H18ClFN2O4Purity:98%Color and Shape:SolidMolecular weight:428.84Ac-Exatecan
CAS:<p>Ac-Exatecan is acetylation-modified Exatecan.Exatecan (DX-8951) is a DNA topoisomerase I (TOP1) inhibitor with an IC50 value of 2.2 μM and antitumor activity.</p>Formula:C26H24FN3O5Purity:97.09%Color and Shape:SolidMolecular weight:477.48ARN-21934
CAS:<p>ARN-21934 inhibits human topoisomerase II α/β; IC50=2μM; stronger than Etoposide (IC50=120μM) in DNA relaxation.</p>Formula:C21H24N6Purity:99.8%Color and Shape:SolidMolecular weight:360.46NH2-methylpropanamide-Exatecan TFA
CAS:<p>Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.</p>Formula:C30H30F4N4O7Purity:98%Color and Shape:SolidMolecular weight:634.58Trovafloxacin mesylate
CAS:<p>Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).</p>Formula:C21H19F3N4O6SPurity:99.18%Color and Shape:SolidMolecular weight:512.46SDOX
CAS:<p>SDOX, a prodrug, releases Doxorubicin selectively in high-GSH tumor cells, minimizing harm to healthy tissue.</p>Formula:C69H97NO20S2Purity:98%Color and Shape:SolidMolecular weight:1324.63LMP744 hydrochloride
CAS:<p>LMP744 hydrochloride (NSC-706744 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity. </p>Formula:C24H25ClN2O7Purity:99.59% - 99.85%Color and Shape:SolidMolecular weight:488.92Pradofloxacin
CAS:<p>Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.</p>Formula:C21H21FN4O3Purity:98.76%Color and Shape:SolidMolecular weight:396.41Topoisomerase inhibitor 2
CAS:<p>Topoisomerase Inhibitor 2 (18C) is a broad-spectrum bacterial topoisomerase inhibitor effective against multidrug-resistant Gram-negative bacteria [1].</p>Formula:C23H23N5O4Purity:98%Color and Shape:SolidMolecular weight:433.46Topoisomerase I inhibitor 9
CAS:<p>Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value</p>Formula:C23H15Br2FN2Purity:98%Color and Shape:SolidMolecular weight:498.19TH1338
CAS:<p>TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.</p>Formula:C22H21N3O4Purity:98.77%Color and Shape:SolidMolecular weight:391.42Topoisomerase II inhibitor 18
CAS:<p>Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].</p>Formula:C20H21N3OSColor and Shape:SolidMolecular weight:351.47Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Formula:C21H24N4OPurity:98%Color and Shape:SolidMolecular weight:348.44Karenitecin
CAS:<p>Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.</p>Formula:C25H28N2O4SiPurity:98%Color and Shape:SolidMolecular weight:448.59Topoisomerase I/II inhibitor 7
CAS:<p>Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.</p>Formula:C18H13ClN2O3Color and Shape:SolidMolecular weight:340.76Topotecan acetate
CAS:<p>Topotecan acetate is an inhibitor of topoisomerase.</p>Formula:C25H27N3O7Color and Shape:SolidMolecular weight:481.498Edotecarin
CAS:<p>Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).</p>Formula:C29H28N4O11Purity:98%Color and Shape:SolidMolecular weight:608.55Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Formula:C25H25N3O5Purity:98.47%Color and Shape:SolidMolecular weight:447.48
