Phospholipase
Phospholipases are a group of enzymes that hydrolyze phospholipids into fatty acids and other lipophilic substances, playing a critical role in membrane biology and the generation of signaling molecules. Inhibitors of phospholipases are used to study their role in inflammatory diseases, cardiovascular disorders, and neurodegeneration. These inhibitors are also valuable in exploring lipid signaling pathways and their implications in disease mechanisms. At CymitQuimica, we provide a variety of phospholipase inhibitors to support your research in inflammation, lipid metabolism, and cell signaling.
Found 82 products of "Phospholipase"
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Omeprazole
CAS:<p>Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor.</p>Formula:C17H19N3O3SPurity:98.43% - 98.48%Color and Shape:White SolidMolecular weight:345.42Niflumic acid
CAS:<p>Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.</p>Formula:C13H9F3N2O2Purity:99.47%Color and Shape:SolidMolecular weight:282.22Tris(2,4-di-tert-butylphenyl)phosphate
CAS:<p>Tris(2,4-di-tert-butylphenyl)phosphate (TDTBPP) inhibits secretory phospholipase A2 (sPLA2) with anti-inflammatory effect. Cost-effective and quality-assured.</p>Formula:C42H63O4PPurity:99.73%Color and Shape:SolidMolecular weight:662.92Lp-PLA2-IN-1
CAS:<p>Lp-PLA2-IN-1 suppresses Lp-PLA2, aiding in treating atherosclerosis and Alzheimer's.</p>Formula:C21H17F5N4O3Purity:99.60%Color and Shape:SolidMolecular weight:468.38Lansoprazole
CAS:<p>Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON</p>Formula:C16H14F3N3O2SPurity:99.18% - 99.84%Color and Shape:White Crystalline PowderMolecular weight:369.36ML349
CAS:<p>ML349 is an inhibitor of LYPLA2 (IC50: 144 nM). ML349 is an effective and specific acyl protein thioesterase 2 (APT-2) inhibitor (Ki: 120 nM).</p>Formula:C23H22N2O4S2Purity:99.59% - 99.88%Color and Shape:SolidMolecular weight:454.561-Myristoyl-2-Linoleoyl-sn-glycero-3-PC
CAS:<p>1-Myristoyl-2-Linoleoyl-sn-glycero-3-PC is a phospholipid identified in human plasma, characterized by the presence of Myristic acid and Linoleic acid at the sn-1 and sn-2 positions, respectively.</p>Formula:C40H76NO8PColor and Shape:SolidMolecular weight:730.01VU533
CAS:<p>VU533 is a NAPE-PLD activator, EC50=0.30 µM, boosts macrophage activity, potential in cardiometabolic diseases.</p>Formula:C21H22FN3O3S2Purity:99.08%Color and Shape:SolidMolecular weight:447.55AACOCF3
CAS:<p>AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid.</p>Formula:C21H31F3OPurity:99% - 99%Color and Shape:Yellow LiquidMolecular weight:356.47A3373
CAS:<p>A3373 is a novel inhibitor targeting both Phospholipase D1 (PLD1) and Phospholipase D2 (PLD2), demonstrating half maximal inhibitory concentrations (IC50) of</p>Formula:C17H9F7N2OPurity:98%Color and Shape:SoildMolecular weight:390.26Compound 48/80 trihydrochloride
CAS:<p>Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。</p>Formula:C32H48Cl3N3O3Purity:98%Color and Shape:SolidMolecular weight:629.1ASM-IN-3
CAS:<p>ASM-IN-3 (Compound 21b) is a selective acid sphingomyelinase (ASM) inhibitor that can penetrate the blood-brain barrier, with an IC50 of 3.37 μM against purified human ASM. By inhibiting ASM activity in the hippocampus and promoting neurogenesis, ASM-IN-3 alleviates depressive-like behavior in reserpine-induced depressive rats.</p>Formula:C17H13ClN2O4Color and Shape:SolidMolecular weight:344.75BIRM 271
CAS:<p>BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils.</p>Formula:C21H25N3OPurity:99.64%Color and Shape:SoildMolecular weight:335.44SB-435495
CAS:<p>SB-435495 is a compound characterized by its potent, selective, reversible, and non-covalent inhibition of Lp-PLA2, demonstrating an IC50 value of 0.06 nM.</p>Formula:C38H40F4N6O2SPurity:99.07%Color and Shape:SolidMolecular weight:720.82DPTIP hydrochloride
CAS:<p>DPTIP hydrochloride is a potent inhibitor of neutral sphingomyelinase (N-SMase 2) that can cross the blood-brain barrier. It acts as an exosome inhibitor with an IC50 value of 30 nM.</p>Formula:C21H19ClN2O3SColor and Shape:SolidMolecular weight:414.91PLA2-IN-1
<p>PLA2-IN-1 (Compound 7) is a potent and selective inhibitor of phospholipase A (PLA2) with an IC50 value of 1 nM. It effectively inhibits PLA2-induced coagulation disorders in vitro and shows potential for use as an antidote for snake bites caused by cobra venom.</p>Color and Shape:Odour SolidnSMase2-IN-1
<p>nSMase2-IN-1 is an orally active inhibitor of Neutral sphingomyelinase 2 (nSMase2) with a potent IC50 value of 0.13 ± 0.06 μM.</p>Formula:C12H17N5OPurity:98%Color and Shape:SolidMolecular weight:247.3LEI110
CAS:<p>LEI110 inhibits PLA2G16 and HRASLS enzymes, Ki 20 nM, selectively targets related thiol hydrolases.</p>Formula:C25H23F3N2O3Purity:98.66% - 98.8%Color and Shape:SolidMolecular weight:456.46A4333
<p>A4333, a biotinylated derivative of A3373, selectively inhibits Phospholipase D1 (PLD1) while sparing PLD2.</p>Purity:98%Color and Shape:Odour SolidDPTIP
CAS:<p>DPTIP is an effective inhibitor of neutral sphingomyelinase 2 with an IC50 value of 30 nM.</p>Formula:C21H18N2O3SPurity:99.88%Color and Shape:SolidMolecular weight:378.44BMS493
CAS:<p>BMS493 is an inverse agonist of RAR that inhibits retinoic acid-induced differentiation and inhibits the increase in phospholipase A2 activity.</p>Formula:C29H24O2Purity:>99.99%Color and Shape:SolidMolecular weight:404.5Bromoenol lactone
CAS:<p>NeurokininBromoenol lactone ((6E)-Bromoenol lactone) is an iPLA2β and serine protease inhibitor that attenuates nicotine-induced breast cancer cell proliferation.</p>Formula:C16H13BrO2Color and Shape:SolidMolecular weight:317.18PACOCF3
CAS:<p>PACOCF3, a phospholipase A2 inhibitor, hinders Ca2+ signaling with an IC50 of 3.8 μM in renal cells.</p>Formula:C17H31F3OPurity:99.93%Color and Shape:SolidMolecular weight:308.42MJ33 lithium salt
CAS:<p>MJ33 lithium salt is an inhibitor of NADPH oxidase type 2-mediated ROS generation, inhibits PLA2 activity, and can be used to study acute lung injury.</p>Formula:C22H43F3LiO6PPurity:99%Color and Shape:SolidMolecular weight:498.48LEI-401
CAS:<p>LEI-401 is a NAPE-PLD inhibitor.LEI-401 reduces the level of n-acyl ethanolamines in the brain of free-ranging mice and modulates their emotional behaviour.</p>Formula:C24H31N5O2Purity:99.79% - 99.79%Color and Shape:SolidMolecular weight:421.54ML-211
CAS:<p>ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM)</p>Formula:C25H30N4O2Purity:97.07%Color and Shape:SolidMolecular weight:418.53N-(p-amylcinnamoyl) Anthranilic Acid
CAS:<p>N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker.</p>Formula:C21H23NO3Purity:99.35% - 99.67%Color and Shape:SolidMolecular weight:337.41Rhamnetin
CAS:<p>Rhamnetin (beta-Rhamnocitrin), a quercetin derivative found in Coriandrum sativum, has antioxidant and anti-inflammatory activities.</p>Formula:C16H12O7Purity:99.61% - 99.905%Color and Shape:SolidMolecular weight:316.26hnps-PLA Inhibitor
CAS:<p>Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).</p>Formula:C21H21N3O4Purity:99.68%Color and Shape:SolidMolecular weight:379.41Varespladib
CAS:<p>Varespladib (LY315920) inhibits hnsPLA2 effectively (IC50=7 nM), studied for sickle cell, VOC, and acute coronary syndrome.</p>Formula:C21H20N2O5Purity:99.97%Color and Shape:SolidMolecular weight:380.39BAPTA
CAS:<p>BAPTA is a neuroprotective agent in cerebral ischemia, acting as an intercellular Ca2+ chelator.</p>Formula:C22H24N2O10Purity:96.28% - ≥95%Color and Shape:White SolidMolecular weight:476.43Rapanone
CAS:<p>Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.</p>Formula:C19H30O4Purity:99.56%Color and Shape:SolidMolecular weight:322.44U-73343
CAS:<p>U-73343 is an inactive analog of U-73122 and can be used as a negative control. U-73122 dose-dependently inhibits acid secretion irrespective of the stimulant.</p>Formula:C29H42N2O3Purity:99.06%Color and Shape:SolidMolecular weight:466.66Tanshinone I
CAS:<p>Tanshinone I (Tanshinone A), an active principle isolated from the herbal medicine Salvia miltiorrhiza, displays cytotoxicity against tumor cells.</p>Formula:C18H12O3Purity:98.31% - 98.70%Color and Shape:SolidMolecular weight:276.29ML348
CAS:<p>ML348 (GNF-Pf-1127) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).</p>Formula:C18H17ClF3N3O3Purity:99% - 99.88%Color and Shape:SolidMolecular weight:415.79FIPI
CAS:<p>FIPI, a halopemide derivative, strongly blocks PLD1 and PLD2 (IC50s: 25 nM, 20 nM) and hinders PLD-mediated cell activity.</p>Formula:C23H24FN5O2Purity:97.21% - 98.68%Color and Shape:SolidMolecular weight:421.47ML-298
CAS:<p>ML-298 (CID53393915) is a potent, specific inhibitor of Phospholipase D2 (PLD2, IC50 of 355 nM).</p>Formula:C22H23F3N4O2Purity:99.35%Color and Shape:SolidMolecular weight:432.441-Naphthaleneacetic acid
CAS:<p>1-Naphthaleneacetic acid, an auxin-like synthetic plant hormone, boosts rooting in horticulture.</p>Formula:C12H10O2Purity:98.67%Color and Shape:Needles From Water White To Off White CrystalsMolecular weight:186.21ST271
CAS:<p>ST271 is an effective protein tyrosine kinase (PTK) inhibitor.</p>Formula:C16H20N2O2Purity:98.94%Color and Shape:SolidMolecular weight:272.34Darapladib
CAS:<p>Darapladib (SB-480848) is a lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with an IC50 value of 0.25 nM.Cost-effective and quality-assured.</p>Formula:C36H38F4N4O2SPurity:99.82% - >99.99%Color and Shape:SolidMolecular weight:666.77RHC 80267
CAS:<p>RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)</p>Formula:C20H34N4O4Purity:99.54%Color and Shape:White SolidMolecular weight:394.51GW4869
CAS:<p>GW4869 (GW69A) is a selective and non-competitive inhibitor of neutral sphingomyelinase N-SMase (IC50=1 μM).</p>Formula:C30H30Cl2N6O2Purity:98.12% - 98.47%Color and Shape:SolidMolecular weight:577.5RPI-1
CAS:<p>RPI-1 is a competitive, potent ATP-dependent Ret kinase inhibitor.</p>Formula:C17H15NO4Purity:98.91% - ≥95%Color and Shape:SolidMolecular weight:297.311-Linoleoyl Glycerol
CAS:<p>1-Linoleoyl Glycerol (Monolinolein) is fatty acid glycerol that has been isolated from Saururus Chinensis roots.</p>Formula:C21H38O4Purity:98.95% - 99.56%Color and Shape:Less Oil Colourless OilMolecular weight:354.52ONO-RS-082
CAS:<p>ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor. </p>Formula:C21H22ClNO3Purity:99.35%Color and Shape:SolidMolecular weight:371.86AA26-9
CAS:<p>AA26-9 is an effective and broad-spectrum inhibitor of serine hydrolase.</p>Formula:C7H10N4OPurity:99.88%Color and Shape:SolidMolecular weight:166.181-Naphthaleneacetic acid potassium salt
CAS:<p>1-Naphthaleneacetic acid potassium salt (1-NAA Potassium Salt) is a synthetic phytogrowth hormone that promotes plant growth and a PLA2 inhibitor.</p>Formula:C12H9O2·KPurity:97.68%Color and Shape:Off-White To Beige PowderMolecular weight:224.3Difluprednate
CAS:<p>Difluprednate (Myser)(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.</p>Formula:C27H34F2O7Purity:99.23% - 99.86%Color and Shape:SolidMolecular weight:508.55Cambinol
CAS:<p>Cambinol is a SIRT1/2 inhibitor (IC50: 56/59 μM), non-competitive with NAD, weak on SIRT5, and prompts apoptosis in lymphoma cells.</p>Formula:C21H16N2O2SPurity:98.02% - 99.83%Color and Shape:SolidMolecular weight:360.43CAY10594
CAS:<p>CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.</p>Formula:C26H28N4O2Purity:98%Color and Shape:SolidMolecular weight:428.53trans-Benzylideneacetone
CAS:<p>trans-Benzylideneacetone (Acetocinnamone) is used in various synthetic preparations.</p>Formula:C10H10OPurity:97.48%Color and Shape:Light Yellow Low Melting Crystalline MassMolecular weight:146.19Aristolochic acid C
CAS:<p>Aristolochic acid C is a derivative of Aristolochic acid which is a phospholipase A2 inhibitor.</p>Formula:C16H9NO7Purity:99.8%Color and Shape:White PowderMolecular weight:327.25CAY10650
CAS:<p>CAY10650 is an effective inhibitor of cytosolic phospholipase A2α (cPLA2α, IC50: 12 nM).</p>Formula:C28H25NO6Purity:97.33%Color and Shape:SolidMolecular weight:471.5U-73122
CAS:<p>U-73122 (U73122) , an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.</p>Formula:C29H40N2O3Purity:97.50%Color and Shape:Solid Off-WhiteMolecular weight:464.64m-3M3FBS
CAS:<p>m-3M3FBS is a phospholipase C (PLC) activator.</p>Formula:C16H16F3NO2SPurity:99.66%Color and Shape:SolidMolecular weight:343.36Melittin
CAS:<p>Melittin: principal bee venom toxin, 26 amino acids, activates low-weight PLA2, not high-weight PLA2.</p>Formula:C131H229N39O31Purity:98.37% - 99.92%Color and Shape:SolidMolecular weight:2846.46Neomycin sulfate
CAS:<p>Neomycin sulfate (Framycin sulfate) is a broad-spectrum aminoglycoside antibiotic that blocks the synthesis of bacterial proteins in order to exert</p>Formula:C23H46N6O13·3H2SO4Purity:99.4% - 99.88%Color and Shape:Tan PowderMolecular weight:908.87VU0155056
CAS:<p>VU0155056 is a dual PLD1/2 inhibitor with IC50 < 1 µM in cellular assays, inhibits breast cancer cell invasion.</p>Formula:C25H26N4O2Purity:98.6% - 99.15%Color and Shape:SolidMolecular weight:414.5LCL521
CAS:<p>LCL521 inhibits lysosomal acid sphingomyelinase (ASMase).LCL521 is an acid ceramidase (ACDase) inhibitor.</p>Formula:C31H52N4O7Purity:98%Color and Shape:SolidMolecular weight:592.77Omeprazole Sodium
CAS:<p>Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion.</p>Formula:C17H18N3NaO3SPurity:99.84%Color and Shape:Clear In WaterMolecular weight:367.42-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
CAS:<p>2-Decenoylaminoethyl cyclohexylethyl sulfide prevents stress ulcers, stabilizes phospholipase A2 and prostaglandin E2.</p>Formula:C20H37NOSPurity:98%Color and Shape:SolidMolecular weight:339.58ML299
CAS:<p>ML299 (VU0463568) is a dual PLD1/2 inhibitor (PLD1 and PLD2, IC50 of 6 nM, 20 nM, respectively).</p>Formula:C23H26BrFN4O2Purity:98%Color and Shape:SolidMolecular weight:489.38Lp-PLA2-IN-3
CAS:<p>Lp-PLA2-IN-3: Potent oral inhibitor of human Lp-PLA2 with a 14 nM IC50.</p>Formula:C20H13ClF3N3O3SPurity:99.65%Color and Shape:SolidMolecular weight:467.85ASM-IN-1
CAS:<p>ASM-IN-1: Oral acid sphingomyelinase inhibitor, IC50 = 1.5 µM; reduces lipid plaques, plasma ceramide, Ox-LDL.</p>Formula:C16H12BrN3O4Purity:98%Color and Shape:SolidMolecular weight:390.19GK187
CAS:<p>GK187 is a selective and potent Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor, used in the study of neurological disorders.</p>Formula:C14H15F5O2Color and Shape:SolidMolecular weight:310.26Halopemide
CAS:<p>Halopemide is a potent inhibitor of PLD (IC50 = 220 and 310 nM for human PLD1 and PLD2).</p>Formula:C21H22ClFN4O2Purity:96.57%Color and Shape:SolidMolecular weight:416.88Giripladib
CAS:<p>Giripladib (PLA695/PLX-695) blocks radiation-boosted phosphorylation of ERK and Akt in endothelial cells.</p>Formula:C41H36ClF3N2O4SPurity:99.64%Color and Shape:SolidMolecular weight:745.25VU0155069
CAS:<p>VU0155069, a selective PLD1 inhibitor (IC50: 46 nM), halts cancer cell migration in transwell assays.</p>Formula:C26H27ClN4O2Purity:99.5%Color and Shape:SolidMolecular weight:462.97VU0364739
CAS:<p>VU0364739, a selective phospholipase D2 (PLD2) inhibitor with an IC50 of 22 nM, effectively reduces cancer cell proliferation [1].</p>Formula:C26H27FN4O2Purity:98%Color and Shape:SolidMolecular weight:446.52Lp-PLA2-IN-13
CAS:<p>Lp-PLA2-IN-13 (compound 15), a potent Lp-PLA2 inhibitor, holds potential for research in neurodegenerative-related diseases [1].</p>Formula:C22H17F5N4O4Purity:98%Color and Shape:SolidMolecular weight:496.39Lp-PLA2-IN-2
CAS:<p>Lp-PLA2-IN-2 is a selective and potent lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 0f 120 nM for recombinant human Lp-PLA2.</p>Formula:C19H23FN2O4SPurity:98%Color and Shape:SolidMolecular weight:394.46Lp-PLA2-IN-14
CAS:<p>Lp-PLA2-IN-14 (Compound 19), an inhibitor of rhLp-PLA2, exhibits a potent inhibitory effect with a pIC50 value of 8.4.</p>Formula:C16H14F3N3O3Purity:98%Color and Shape:SolidMolecular weight:353.37,7-Dimethyl-(5Z,8Z)-eicosadienoic acid
CAS:<p>7,7-Dimethyl-(5Z,8Z)-eicosadienoic acid (DEDA, 5 μM) significantly impacts the response to βA(25-35) stimulation. It reduces the formation of ROS.</p>Formula:C22H40O2Color and Shape:SolidMolecular weight:336.55Varespladib methyl
CAS:<p>Varespladib methyl (LY333013), a bioavailable prodrug of Varespladib, is a selective group II secretory phospholipase A2 inhibitor.</p>Formula:C22H22N2O5Purity:99.42% - 99.97%Color and Shape:SolidMolecular weight:394.42Ecopladib
CAS:<p>Ecopladib inhibits cPLA2α with IC50 of 0.15 μM (micelles) & 0.11 μM (rat blood).</p>Formula:C39H33Cl3N2O5SPurity:95.15%Color and Shape:SolidMolecular weight:748.11Rilapladib
CAS:<p>Rilapladib (SB 659032) is a selective inhibitor of Lipoprotein-Associated Phospholipase A2(Lp-PLA2, IC50 = 230 pM) and an antagonist of the platelet activating</p>Formula:C40H38F5N3O3SPurity:99.92%Color and Shape:SolidMolecular weight:735.8MAFP
CAS:<p>MAFP (Methyl Arachidonyl Fluorophosphonate) is an effective irreversible inhibitor of anandamide amidase.</p>Formula:C21H36FO2PColor and Shape:SolidMolecular weight:370.48GK420
CAS:<p>GK420 (AVX420) is a potent inhibitor of cytoplasmic phospholipase A2α (cPLA2α), with an XI(50) value of 0.0016. It effectively inhibits the release of arachidonic acid, with an EC50 of 0.09 μM. GK420 plays a significant role in cancer research.</p>Formula:C20H25NO5SColor and Shape:SolidMolecular weight:391.481Ro 23-9358
CAS:<p>Ro 23-9358 is a potent inhibitor of secretory phospholipase A2, exhibiting anti-inflammatory properties.</p>Formula:C30H51NO6Color and Shape:SolidMolecular weight:521.729Lp-PLA2-IN-16
CAS:<p>Lp-PLA2-IN-16 (Example 1) is an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with potential applications in Alzheimer's disease research [1].</p>Formula:C22H17F5N4O3Purity:98%Color and Shape:SolidMolecular weight:480.39Lp-PLA2-IN-12
CAS:<p>Lp-PLA2-IN-12 (compound 19), an Lp-PLA2 inhibitor, is utilized in researching neurodegenerative diseases including Alzheimer's disease (AD), glaucoma, age-</p>Formula:C24H23F2N5O3Purity:98%Color and Shape:SolidMolecular weight:467.47Lp-PLA2-IN-15
CAS:<p>Lp-PLA2-IN-15 (example 2) is an inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2) with potential application in Alzheimer's disease research [1].</p>Formula:C22H17F5N4O3Purity:98%Color and Shape:SolidMolecular weight:480.39
