GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

Show 18 more subcategories

Found 5745 products of "GPCR/G-Protein"

Purity (%)

100

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Angiopeptin TFA
CAS:
- 2478421-60-0
Angiopeptin TFA: somatostatin analogue, sst2/sst5 partial agonist (IC50: 0.26/6.92 nM), suppresses GH & IGF-1, for atherosclerosis research.
Formula:C₅₈H₇₃F₆N₁₁O₁₄S₂
Color and Shape:Solid
Molecular weight:1326.39
Ref: TM-T76042
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Leukotriene B5
CAS:
- 80445-66-5
LTB5, an eicosapentaenoic acid metabolite via 5-LO, has varied bioactivities and enhances bullfrog lung strip contraction.
Formula:C₂₀H₃₀O₄
Color and Shape:Solid
Molecular weight:334.456
Ref: TM-T36423
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Obestatin(rat)
CAS:
- 869705-22-6
Endogenous peptide that suppresses food intake and body weight-gain
Formula:C₁₁₄H₁₇₄N₃₄O₃₁
Purity:98%
Color and Shape:Solid
Molecular weight:2516.81
Ref: TM-TP2279
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Adrenomedullin (16-31), human
CAS:
- 318480-38-5
Adrenomedullin (16-31), human is amino acid residues 16-31 fragment of human adrenomedullin (hADM).
Formula:C₈₂H₁₂₉N₂₅O₂₁S₂
Purity:98%
Color and Shape:Solid
Molecular weight:1865.19
Ref: TM-TP1486
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Ethylpropyltryptamine
CAS:
- 850032-68-7
Ethylpropyltryptamine (EPT) is an orally active novel psychoactive substance. It is predicted to act as a partial agonist of the 5-HT2A receptor.
Formula:C₁₅H₂₂N₂
Color and Shape:Solid
Molecular weight:230.35
Ref: TM-T203137
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TGR5 agonist 1
Compound 18 (TGR5 agonist 1) is a potent agonist of TGR5, exhibiting an EC50 value of 0.31 µM [1].
Formula:C₂₈H₄₈NNaO₆S
Color and Shape:Solid
Molecular weight:549.74
Ref: TM-T74824
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H4R antagonist 3
CAS:
- 1003091-20-0
H4R antagonist 3 is a novel histamine-4 receptor (H4R) antagonist with an EC50 <10 mM.H4R antagonist 3 has potential inflammatory activity for the study of
Formula:C₁₉H₂₁ClN₄S
Purity:98%
Color and Shape:Solid
Molecular weight:372.92
Ref: TM-T77715
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KSK67
CAS:
- 2566715-93-1
KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects on H3 receptors, sigma-1, and sigma-2 receptors, with Ki
Formula:C₂₂H₂₇N₃O₂
Purity:99.11%
Color and Shape:Soild
Molecular weight:365.47
Ref: TM-T77593
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(±)5(6)-EET
CAS:
- 87173-80-6
5(6)-EET is a fully racemic version of the enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.
Formula:C₂₀H₃₂O₃
Color and Shape:Solid
Molecular weight:320.473
Ref: TM-T36070
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Antibiotic Sch 60057
CAS:
- 203061-35-2
Antibiotic Sch 60057 is a useful organic compound for research related to life sciences. The catalog number is T125403 and the CAS number is 203061-35-2.
Formula:C₄₅H₈₄O₆
Color and Shape:Solid
Molecular weight:721.161
Ref: TM-T125403
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4-Hydroxy MET
CAS:
- 77872-41-4
4-Hydroxy MET (4-HO-MET) is a tryptamine-based new psychoactive substance (NPS), structurally similar to the endogenous neurotransmitter serotonin. It has hallucinogenic properties that affect mood, movement, and cognitive functions.
Formula:C₁₃H₁₈N₂O
Color and Shape:Solid
Molecular weight:218.3
Ref: TM-T203151
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Edg-2 receptor inhibitor 1
CAS:
- 1195941-38-8
Edg-2 receptor inhibitor 1 (SAR-100842) is an Edg-2 receptor inhibitor extracted (IC50: <0.1 μM).
Formula:C₂₇H₂₇NO₅
Purity:99.47%
Color and Shape:Solid
Molecular weight:445.51
Ref: TM-T4521
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σ1R-IN-1
σ1R-IN-1 ((R,R)-1a) is an effective σ-1R inhibitor with an IC50 of 110 nM. It shows promising potential for use in research related to neuropsychiatric disorders.
Formula:C₁₅H₂₂N₂
Color and Shape:Solid
Molecular weight:230.35
Ref: TM-T207115
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Tienoxolol FA
Tienoxolol FA, a beta-blocker for treating heart disease, hypertension, and ischemia.
Formula:C₂₂H₃₀N₂O₇S
Purity:97.05% - 98.53%
Color and Shape:Soild
Molecular weight:466.55
Ref: TM-T68161L
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Neurokinin B
CAS:
- 86933-75-7
NKB, a tachykinin peptide, impacts human functions like gonadotropin-releasing hormone secretion.
Formula:C₅₅H₇₉N₁₃O₁₄S₂
Purity:98%
Color and Shape:Solid
Molecular weight:1210.42
Ref: TM-TP1363
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Adenosine 2',5'-diphosphate sodium
CAS:
- 154146-84-6
Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist with non-selective antagonism at recombinant and human platelet P2X1 receptors.
Formula:C₁₀H₁₅N₅NaO₁₀P₂
Color and Shape:Solid
Molecular weight:450.192
Ref: TM-T39025
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Glucagon receptor antagonists-1
CAS:
- 503559-84-0
Glucagon receptor antagonist -1 is a highly effective glucagon receptor antagonist.
Formula:C₂₉H₃₄FNO₂
Purity:98%
Color and Shape:Solid
Molecular weight:447.58
Ref: TM-T11413
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Cholic Acid 7-sulfate
CAS:
- 60320-05-0
Cholic acid 7-sulfate: a cholic acid metabolite with added sulfate at position 7, increased in feces of male mice with specific diets.
Formula:C₂₄H₄₀O₈S
Color and Shape:Solid
Molecular weight:488.64
Ref: TM-T37854
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PAR-4 Agonist Peptide, amide
CAS:
- 352017-71-1
PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).
Formula:C₃₄H₄₈N₈O₇
Purity:98%
Color and Shape:Solid
Molecular weight:680.79
Ref: TM-T7623
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M617
CAS:
- 860790-38-1
Galanin GAL1 agonist, Ki: GAL1 0.23 nM, GAL2 5.71 nM; boosts rat appetite, lessens inflammation pain.
Formula:C₁₁₂H₁₆₁N₂₉O₂₈
Purity:98%
Color and Shape:Solid
Molecular weight:2361.68
Ref: TM-TP1993
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β-CGRP, human
CAS:
- 101462-82-2
β-CGRP, human ,a 37-amino acid peptide,is the beta form of Calcitonin-gene-related peptide (β-CGRP), involved extensively in regulation of the cardiovascular
Formula:C₁₆₂H₂₆₇N₅₁O₄₈S₃
Purity:98%
Color and Shape:Solid
Molecular weight:3793.41
Ref: TM-TP1130
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Spiroglumide
CAS:
- 137795-35-8
Spiroglumide, a CCKB-gastrin antagonist that inhibits dose-dependent pentagastrin-induced acid hypersecretion with an ID50 of 20.1 (8.67-46.4) mg / kg, could be
Formula:C₂₁H₂₆Cl₂N₂O₄
Purity:98.23%
Color and Shape:Soild
Molecular weight:441.35
Ref: TM-T68016
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Orexin A (human, rat, mouse) acetate
Orexin A (human, rat, mouse) acetate (Hypocretin-1 (human, rat, mouse) acetate) is an excitatory neuropeptide with analgesic properties.
Formula:C₁₅₄H₂₄₇N₄₇O₄₆S₄
Color and Shape:Solid
Molecular weight:3621.15
Ref: TM-T73658
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Latanoprost lactone diol
CAS:
- 145667-75-0
Latanoprost lactone diol, a key intermediate for synthesizing Latanoprost (a prostaglandin F2α analogue), lowers IOP by activating FP receptors.
Formula:C₁₈H₂₄O₄
Purity:98%
Color and Shape:White Or Almost White Crystalline Powder
Molecular weight:304.38
Ref: TM-T11821
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YFLLRNP
CAS:
- 149440-16-4
YFLLRNP is a biologically active peptide functioning as a partial agonist of PAR-1, selectively activating the G12/13 signaling pathway.
Formula:C₄₅H₆₇N₁₁O₁₀
Color and Shape:Solid
Molecular weight:922.08
Ref: TM-T80235
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Torososide B
CAS:
- 243835-63-4
Torososide B is an anti-allergic compound that inhibits leukotriene release from calcium ionophore A-stimulated rat peritoneal mast cells.
Formula:C₄₀H₅₂O₂₅
Color and Shape:Solid
Molecular weight:932.83
Ref: TM-T203084
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Methionyl-Lysyl-Bradykinin
CAS:
- 550-19-6
Methionyl-Lysyl-Bradykinin (Met-Lys-Bradykinin), a Bradykinin analogue, is a kinin [1] [2] .
Formula:C₆₁H₉₄N₁₈O₁₃S
Color and Shape:Solid
Molecular weight:1319.58
Ref: TM-T76384
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SBI-810
CAS:
- 1849603-79-7
SBI-810 is a functional selective β-arrestin-biased allosteric modulator of the neurotensin receptor 1 (NTSR1). In the presence of the endogenous ligand neurotensin (NT), SBI-810 regulates NTSR1 signaling through a G protein-specific mechanism. It fully antagonizes NT-induced Gq activation and partially antagonizes NT-induced Gi1 activation, allowing NTSR1 to activate GoA and G12.
Formula:C₂₇H₃₄N₄O₂
Color and Shape:Solid
Molecular weight:446.59
Ref: TM-T203513
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Linzagolix choline
CAS:
- 1321816-57-2
Linzagolix choline is a GnRH antagonist. It can be used to study pain associated with uterine fibroids and endometriosis.
Formula:C₂₇H₂₈F₃N₃O₈S
Purity:99.64%
Color and Shape:Solid
Molecular weight:611.59
Ref: TM-T25742
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25E-NBOMe hydrochloride
CAS:
- 1539266-39-1
25E-NBOMe hydrochloride is a derivative of 2C-E, featuring an N-(2-methoxybenzyl) addition to the amine group, and acts as a selective agonist of the 5-HT2A receptor.
Formula:C₂₀H₂₈ClNO₃
Color and Shape:Solid
Molecular weight:365.89
Ref: TM-T203224
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[8-L-arginine] deaminovasopressin
CAS:
- 25255-33-8
[8-L-arginine] deaminovasopressin (dAVP) is a vasopressin analog [1] .
Formula:C₄₆H₆₄N₁₄O₁₃S₂
Color and Shape:Solid
Molecular weight:1085.22
Ref: TM-T76573
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Tau conotoxin CnVA
CAS:
- 1436463-45-4
Tau conotoxin CnVA, a small peptide found in the venom of Conus consors (cone snail), is a member of the T1 cone snail peptide superfamily. It demonstrates high selectivity for the somatostatin sst3 receptor with a Ki value of 1.5 µM. Tau conotoxin CnVA is unique as the only known toxin interacting with this subfamily of G protein-coupled receptors (GPCR). This compound is useful for research related to diseases associated with the sst3 receptor, such as pancreatic cancer or pituitary adenomas.
Formula:C₇₂H₁₁₆N₂₄O₁₇S₄
Color and Shape:Solid
Molecular weight:1718.1
Ref: TM-TP2735
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BMS-753426
CAS:
- 1004536-52-0
BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .
Formula:C₂₅H₃₃F₃N₆O₂
Color and Shape:Solid
Molecular weight:506.574
Ref: TM-T38397
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5-MeO-MET
CAS:
- 16977-53-0
5-MeO-MET (5-Methoxy-N-methyl-N-ethyltryptamine) is a compound belonging to the 5-methoxytryptamine class. It acts as an agonist for 5-HT1A and 5-HT2A receptors. In mice, 5-MeO-MET inhibits locomotion and has sedative effects.
Formula:C₁₄H₂₀N₂O
Color and Shape:Solid
Molecular weight:232.32
Ref: TM-T203080
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Tetrahydro-β-carboline
CAS:
- 16502-01-5
Compound Fr12161, with CAS No. 16502-01-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr12161 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.
Formula:C₁₁H₁₂N₂
Purity:96.31%
Color and Shape:Tan Solid
Molecular weight:172.2264
Ref: TM-Fr12161
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Eloralintide
CAS:
- 2883634-40-8
Eloralintide (LY 3841136) is an AMYR agonist, anticipated for research in type 2 diabetes and obesity.
Formula:C₂₀₁H₃₁₉N₄₉O₆₅S₂
Color and Shape:Solid
Molecular weight:4526.1
Ref: TM-TP3021
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Δ8-THC-C8
CAS:
- 431041-39-3
Δ8-THC-C8 is a semi-synthetic cannabinoid. It acts as an agonist for the cannabinoid receptor 1 (CB1) with an EC50 value of 13.8 nM.
Formula:C₂₄H₃₆O₂
Color and Shape:Solid
Molecular weight:356.54
Ref: TM-T203219
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25N-NBOMe hydrochloride
CAS:
- 1566571-65-0
25N-NBOMe hydrochloride is a derivative of 2C-N and acts as an agonist for the 5-HT2A and 5-HT2C receptors, with Ki values of 0.144 nM and 1.06 nM, respectively. It has minimal effect on the release of preloaded neurotransmitters from recombinant dopamine, serotonin, and norepinephrine transporters.
Formula:C₁₈H₂₃ClN₂O₅
Color and Shape:Solid
Molecular weight:382.84
Ref: TM-T203235
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PD 144418 oxalate
CAS:
- 1794760-28-3
PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.
Formula:C₂₀H₂₄N₂O₅
Purity:98.76%
Color and Shape:Solid
Molecular weight:372.42
Ref: TM-T39211
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JNJ-10181457 (hydrochloride)
CAS:
- 544707-20-2
JNJ-10181457 (hydrochloride) is a non-imidazole H3 receptor antagonist that is brain-penetrating and selective, increasing NE and acetylcholine concentrations
Formula:C₂₀H₃₀Cl₂N₂O
Color and Shape:Solid
Molecular weight:385.37
Ref: TM-T37220
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FFN246
CAS:
- 2210244-83-8
FFN246, a fluorescent probe, concurrently targets the serotonin transporter (SERT) and vesicular monoamine transporter 2 (VMAT2), exhibiting excitation and
Formula:C₁₅H₁₃FN₂O
Purity:98%
Color and Shape:Solid
Molecular weight:256.27
Ref: TM-T78684
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Xenopus orexin B
CAS:
- 254757-78-3
Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].
Formula:C₁₃₀H₂₁₉N₄₅O₄₀S₂
Color and Shape:Solid
Molecular weight:3116.54
Ref: TM-TP2641
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Oxmetidine FA
Oxmetidine FA is an orally available specific histamine H2 receptor antagonist with antiulcerogenic properties.
Formula:C₂₀H₂₃N₅O₅S
Purity:97.34%
Color and Shape:Soild
Molecular weight:445.49
Ref: TM-T68122L
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Levocarnitine propionate hydrochloride
CAS:
- 119793-66-7
Levocarnitine propionate hydrochloride (ST-261) is used for the treatment of the deterioration of renal function, congestive heart failure, and other diseases.
Formula:C₁₀H₂₀ClNO₄
Purity:90% - 99.77%
Color and Shape:Solid
Molecular weight:253.72
Ref: TM-T1182
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ELA-11(human)
CAS:
- 1784687-32-6
Apelin receptor agonist with high affinity (Ki = 14 nM). Blocks cAMP production and promotes β-arrestin activation; derived from ELA-32.
Formula:C₅₈H₉₀N₁₆O₁₃S₂
Purity:98%
Color and Shape:Solid
Molecular weight:1283.57
Ref: TM-TP1922
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α-CGRP (mouse, rat) TFA
α-CGRP (mouse, rat) TFA, a neuropeptide belonging to the calcitonin gene-related peptide (CGRP) family, is predominantly located at neuromuscular junctions and
Formula:C₁₆₂H₂₆₂N₅₀O₅₂S₂·C₂HF₃O₂
Purity:98%
Color and Shape:Solid
Ref: TM-T78540
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Lys-(Des-Arg9,Leu8)-Bradykinin
CAS:
- 71800-37-8
Lys-(Des-Arg9,Leu8)-Bradykinin is a selective antagonist of the bradykinin B1 receptor [1].
Formula:C₄₇H₇₅N₁₃O₁₁
Purity:98%
Color and Shape:Solid
Molecular weight:998.18
Ref: TM-T80117
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A3AR agonist 1
A3AR Agonist 1 (Compound 12), with a Ki of 25.8 nM, is a potent A3 adenosine receptor (A3AR) agonist that promotes β-arrestin2 recruitment with an effective
Formula:C₂₈H₃₄N₆O₆
Purity:98%
Color and Shape:Solid
Molecular weight:550.61
Ref: TM-T79372
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PACAP (6-38), human, ovine, rat TFA
PACAP (6-38) is a PACAP receptor blocker with IC50s of 30, 600, 40 nM for type I, VIP1, and VIP2 receptors.
Formula:C₁₈₄H₃₀₁N₅₆FO₄₇S
Purity:98%
Color and Shape:Solid
Molecular weight:4138.76
Ref: TM-TP1438
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OXA(17-33)
CAS:
- 343268-91-7
Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.
Formula:C₇₉H₁₂₅N₂₃O₂₂
Purity:98%
Color and Shape:Solid
Molecular weight:1749
Ref: TM-TP1973
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Somatostatin 1-28 acetate
Somatostatin 1-28 acetate circulates in human plasma.
Purity:99.22%
Color and Shape:Soild
Ref: TM-TP2124L
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Nesiritide
CAS:
- 124584-08-3
Nesiritide, recombinant human B-type natriuretic peptide, binds NPR-A/C with Kd 7.3/13 pM.
Formula:C₁₄₃H₂₄₄N₅₀O₄₂S₄
Purity:98%
Color and Shape:Solid
Molecular weight:3464.04
Ref: TM-TP1208
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FGH31
FGH31 (Compound 24), a dopamine D4 agonist, exhibits potent and selective GRK2-dependency with a K i of 1.6 nM and partially activates β-arrestin [1].
Formula:C₃₃H₃₆N₄O₂
Purity:98%
Color and Shape:Solid
Molecular weight:520.66
Ref: TM-T79312
+ Info
MRS7925
MRS7925 (Compound 43) serves as a potent antagonist of the 5-HT2B receptor, with an inhibition constant (Ki) of 17 nM, and is utilized in the study of fibrosis
Formula:C₂₀H₂₆IN₅O₃
Purity:98%
Color and Shape:Solid
Molecular weight:511.36
Ref: TM-T79326
+ Info
Galcanezumab
CAS:
- 1578199-75-3
Galcanezumab: humanized IgG4 antibody that targets CGRP for migraine and cluster headache prevention/treatment.
Purity:> 95%
Color and Shape:Liquid
Molecular weight:144.08 kDa
Ref: TM-T76682
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[Leu13]-Motilin
CAS:
- 59530-69-7
[Leu13]-Motilin (KW-5139) is an analogue of the gastrointestinal hormone motilin that induces concentration-dependent contractions in rabbit gastrointestinal
Formula:C₁₂₁H₁₉₀N₃₄O₃₅
Purity:98%
Color and Shape:Solid
Molecular weight:2681.01
Ref: TM-T78563
+ Info
(+)-OSU 6162
CAS:
- 160777-43-5
(+)-OSU 6162 (Piperidine, 3-[3-(methylsulfonyl)phenyl]-1-propyl-, (3R)-) is an agonist of 5-HT Receptor with anti-Alzheimer and antidepressant activities.
Formula:C₁₅H₂₃NO₂S
Purity:98.19%
Color and Shape:Soild
Molecular weight:281.41
Ref: TM-T60027
+ Info
Conopeptide rho-TIA
CAS:
- 381725-58-2
Conopeptide rho-TIA, a peptide from Conus tulipa venom, acts as a selective, noncompetitive inhibitor at the human α1B-Adrenergic Receptor and as a competitive
Formula:C₁₀₅H₁₆₀N₃₆O₂₁S₄
Purity:98%
Color and Shape:Solid
Molecular weight:2390.88
Ref: TM-T80175
+ Info
[Sar9] Substance P
CAS:
- 77128-75-7
[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.
Formula:C₆₄H₁₀₀N₁₈O₁₃S
Purity:98%
Color and Shape:Solid
Molecular weight:1361.66
Ref: TM-TP1862
+ Info
Minesapride
CAS:
- 1184662-54-1
Minesapride: novel 5-HT4 partial agonist, may treat constipation-predominant IBS.
Formula:C₂₁H₃₁ClN₄O₅
Purity:99.85% - 99.88%
Color and Shape:Solid
Molecular weight:454.95
Ref: TM-T28043L
+ Info
cAC 253 acetate
cAC 253 acetate (TP2135 Free base) is an amylin antagonist. cAC 253 acetate inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM.
Formula:C₁₂₈H₂₀₆N₄₂O₄₂S₂
Purity:98.16% - 99.99%
Color and Shape:Soild
Molecular weight:3069.39
Ref: TM-TP2135L
+ Info
α-CGRP(human)
CAS:
- 90954-53-3
Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.
Formula:C₁₆₃H₂₆₇N₅₁O₄₉S₂
Purity:98%
Color and Shape:Solid
Molecular weight:3789.33
Ref: TM-TP2044
+ Info
PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)
PACAP (6-27) is an antagonist for PACAP receptors with varying IC50s; blocks cAMP in neuroblastoma and breast cancer cells.
Color and Shape:Liquid
Ref: TM-T36427
+ Info
Sigma-1 receptor antagonist 4
Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-induced
Formula:C₂₂H₂₆N₂O
Color and Shape:Solid
Molecular weight:334.45
Ref: TM-T74813
+ Info
Peptide C105Y TFA
Peptide C105Y TFA is a cell-penetrating peptide synthesized based on the amino acid sequence of residues 359-374 of α1-antitrypsin. It enhances the gene expression of DNA nanoparticles.
Formula:C₉₇H₁₄₈N₂₀O₂₃S·xC₂HF₃O₂
Ref: TM-TP3340
+ Info
Methicillin sodium hydrate
CAS:
- 7246-14-2
Methicillin sodium hydrate, a narrow-spectrum antibiotic, combats methicillin-resistant Staphylococcus strains and treats various infections.
Formula:C₁₇H₂₁N₂NaO₇S
Color and Shape:Solid
Molecular weight:420.41
Ref: TM-T73859
+ Info
TAK-448 acetate
CAS:
- 1470374-22-1
TAK-448 acetate (MVT-602 acetate) is a KISS1R agonist, a synthetic peptide similar to kisspeptin.
Formula:C₆₀H₈₄N₁₆O₁₆
Purity:99.88%
Color and Shape:Solid
Molecular weight:1285.41
Ref: TM-TP1093
+ Info
Antibacterial agent 189
Antibacterialagent 189 (compound 3a) is a potent antibacterial agent with high binding affinity to the target proteins OMPA/exo-1,3-β-glucanase. It demonstrates effective antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Candida albicans, and Aspergillus flavus. Additionally, Antibacterialagent 189 exhibits strong binding affinity to the target proteins SMO and SUFU/GLI-1.
Formula:C₃₇H₂₈N₄O
Molecular weight:544.22631
Ref: TM-T209404
+ Info
DSP-1053
CAS:
- 1176326-76-3
Dsp-1053 is a powerful SERT (Ki=1.02 nM) inhibitor with partial 5-HT1A receptor (Ki=5.05 nM) agonizing activity.
Formula:C₂₆H₃₂BrNO₄
Purity:98%
Color and Shape:Solid
Molecular weight:502.44
Ref: TM-T11107
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Tirzepatide
CAS:
- 2023788-19-2
Tirzepatide (LY-3298176) is a dual glucose-dependent polypeptide (GIP) (EC50=0.042 nM) and glucagon-like peptide-1 (GLP-1) (EC50=0.086 nM) receptor agonist.
Formula:C₂₂₅H₃₄₈N₄₈O₆₈
Purity:99.52% - 99.99%
Color and Shape:Solid
Molecular weight:4813.45
Ref: TM-TP1111
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Adrenomedullin (16-31), human TFA
Human adrenomedullin (16-31) TFA, fragment 16-31, binds CGRP1 receptor, raises rat blood pressure, not cats’.
Formula:C₈₄H₁₃₀F₃N₂₅O₂₃S₂
Color and Shape:Solid
Molecular weight:1979.21
Ref: TM-T76011
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Antidepressant agent 4
Antidepressant agent 4: orally active, has antidepressant, anxiolytic, and nootropic effects.
Formula:C₁₉H₃₈ClN₅O₂S
Color and Shape:Solid
Molecular weight:436.06
Ref: TM-T75003
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NPC 567 acetate
NPC 567 acetate is a bradykinin B2 antagonist and can be used in studies about the treatment of allergic airway disease.
Formula:C₆₂H₉₁N₁₉O₁₅
Purity:97.72%
Color and Shape:Solid
Molecular weight:1342.5
Ref: TM-T21060L
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S1PR1 modulator 1
CAS:
- 2328109-05-1
S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6.
Formula:C₂₃H₂₄N₂O₃S
Purity:99.69%
Color and Shape:Solid
Molecular weight:408.51
Ref: TM-T12821
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CB2R probe 1
CAS:
- 2634714-79-5
CB2R Probe 1, a cannabinoid 2 receptor (CB2R) fluorescent probe, exhibits both safety and environmental friendliness, boasting a dissociation constant (K i) of
Formula:C₃₆H₄₂N₄O₄
Color and Shape:Solid
Molecular weight:594.74
Ref: TM-T74604
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Amylin (8-37), human
CAS:
- 135702-23-7
Human-derived Amylin (8-37) is a vasodilator in rat arteries and forms aggregates linked to type II diabetes.
Formula:C₁₃₈H₂₁₆N₄₂O₄₅
Color and Shape:Solid
Molecular weight:3183.495
Ref: TM-T38764
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SYD5115
SYD5115 is an orally active TSH-R antagonist.
Formula:C₂₂H₃₂F₂N₄O₃
Molecular weight:438.24425
Ref: TM-T209589
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Adatanserin hydrochloride
CAS:
- 144966-96-1
Adatanserin hydrochloride (WY50324 hydrochloride) is a 5-HT(1A)/5-HT(2) receptor ligand that is neuroprotective and may be used in the study of depression.
Formula:C₂₁H₃₂ClN₅O
Purity:99.64%
Color and Shape:Solid
Molecular weight:405.96
Ref: TM-T29645
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Donitriptan hydrochloride
CAS:
- 170911-68-9
Donitriptan hydrochloride (Donitriptan monohydrochloride) is a potent, high efficacy agonist of 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively
Formula:C₂₃H₂₆ClN₅O₂
Purity:99.8% - 99.86%
Color and Shape:Solid
Molecular weight:439.94
Ref: TM-T21666
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Lanepitant 2HCl
CAS:
- 170508-05-1
Lanepitant 2HCl is a non-peptide neurokinin-1 receptor antagonist that can be used to study painful neuropathy-like disorders such as migraine.
Formula:C₃₃H₄₇Cl₂N₅O₃
Purity:98.67%
Color and Shape:Solid
Molecular weight:632.66
Ref: TM-T25616
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5-HT2A receptor agonist-5
CAS:
- 2957888-63-8
5-HT2A receptor agonist-5 (compound I-3) is a potent 5-HT2A agonist with a Ki value of 0.017 µM and exhibits antidepressant activity.
Formula:C₂₃H₂₉N₃O
Color and Shape:Solid
Molecular weight:363.5
Ref: TM-T203649
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6α-Prostaglandin I1
CAS:
- 62777-90-6
6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions.
Formula:C₂₀H₃₄O₅
Color and Shape:Solid
Molecular weight:354.487
Ref: TM-T36238
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ORG 2766
CAS:
- 50913-82-1
ORG 2766 is an ACTH 4-9 (H-Met(O)-Glu-His-Phe-D-Lys-Phe-OH) analog and neurotrophic peptide.
Formula:C₄₀H₅₅N₉O₁₁S
Color and Shape:Solid
Molecular weight:869.99
Ref: TM-T33820
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Mini Gastrin I, human
CAS:
- 54405-27-5
Mini Gastrin I, human, is a truncated form of the human gastrin peptide, encompassing amino acids 5-17 of the original sequence.
Formula:C₇₄H₉₉N₁₅O₂₆S
Purity:98%
Color and Shape:Solid
Molecular weight:1646.73
Ref: TM-TP1821
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tBPC
CAS:
- 1942-71-8
Enhances Y4R response to PP, NPY & PYY with EC50 of 0.03, 0.4, 0.5 nM; selective for Y4R over Y1R, Y2R, Y5R.
Formula:C₁₆H₂₄O₂
Color and Shape:Solid
Molecular weight:248.36
Ref: TM-T37528
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GLP-1 moiety from Dulaglutide
GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide which is a glucagon-like peptide 1 receptor (GLP-1) agonist.
Formula:C₁₄₉H₂₂₁N₃₇O₄₉
Purity:98%
Color and Shape:Solid
Molecular weight:3314.62
Ref: TM-TP1316
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EB1002
CAS:
- 2770688-48-5
EB1002 is a selective NK2R agonist that has demonstrated significant enhancements in the expression levels of genes associated with mitochondrial biogenesis (such as PGC-1α) in obese mice. This suggests that EB1002 promotes energy expenditure by enhancing mitochondrial activity. Additionally, EB1002 has improved insulin sensitivity and glucose-lipid metabolism in mice. Therefore, EB1002 holds potential for research into obesity and type 2 diabetes.
Formula:C₇₃H₁₂₄N₁₂O₂₃
Color and Shape:Solid
Molecular weight:1537.83
Ref: TM-T201621
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palm-PrRP31
palm-PrRP31 is a potent dual agonist for GPR10 (EC50=72 pM) and NPFF-R2. It activates downstream signaling pathways by binding to GPR10 and NPFF-R2 receptors, leading to reduced appetite and increased energy expenditure. palm-PrRP31 can be utilized to investigate its mechanism of action in the nervous system, thereby elucidating the complex biological processes involved in the regulation of appetite and energy expenditure.
Formula:C₁₇₆H₂₈₂N₅₆O₄₃S
Molecular weight:3900.1322
Ref: TM-TP3585
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LY 293284
CAS:
- 141318-62-9
LY 293284 is a potent, selective full agonist of 5-HT1A receptor with anxiogenic effects in animal studies.
Formula:C₁₉H₂₆N₂O
Color and Shape:Solid
Molecular weight:298.42
Ref: TM-T27914
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Fpl 14294
CAS:
- 154132-95-3
Fpl 14294 is a novel CCK-8 agonist with effective intranasal anorectic activity in the rat.
Formula:C₄₅H₅₆N₈O₁₃S₃
Purity:98%
Color and Shape:Solid
Molecular weight:1013.17
Ref: TM-T25437
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BMS-604992 dihydrochloride
CAS:
- 1469750-46-6
BMS-604992 dihydrochloride is a selective GHSR agonist with high affinity (Ki=2.3 nM) and potent activity (EC50=0.4 nM), stimulating rodent appetite.
Formula:C₂₄H₃₃Cl₂N₇O₅
Color and Shape:Solid
Molecular weight:570.47
Ref: TM-T38959
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d[Leu4,Lys8]-VP acetate
d[Leu4,Lys8]-VP acetate: Vasopressin V1b agonist. Ki: rat 0.16 nM, human 0.52 nM, mouse 1.38 nM. Low antidiuretic/vasopressor effects.
Formula:C₄₉H₇₁N₁₁O₁₃S₂
Purity:98.86%
Color and Shape:Solid
Molecular weight:1086.28
Ref: TM-TP1927L1
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Conessine hydrobromide
CAS:
- 5913-82-6
Conessine hydrobromide is a naturally occurring steroid alkaloid and has been used in traditional herbal medicine as a treatment for amoebic dysentery.
Formula:C₂₄H₄₁BrN₂
Color and Shape:Solid
Molecular weight:437.51
Ref: TM-T31006
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PZ-128
CAS:
- 371131-16-7
PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.
Formula:C₅₅H₉₉N₁₃O₉
Purity:98%
Color and Shape:Solid
Molecular weight:1086.46
Ref: TM-T28477
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GLP-1R agonist 27
GLP-1R agonist 27 (compound 21) is a potent and orally active GLP-1R agonist. It enhances the accumulation of cyclic adenosine monophosphate (cAMP), reduces blood glucose levels, and decreases food intake. GLP-1R agonist 27 shows potential for research in obesity and type 2 diabetes mellitus (T2DM).
Formula:C₃₂H₃₃N₅O₄Se
Color and Shape:Solid
Molecular weight:630.6
Ref: TM-T204289
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13,14-dihydro-15-keto Prostaglandin F1α
CAS:
- 29044-75-5
13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been reported in the rat stomach.
Formula:C₂₀H₃₆O₅
Color and Shape:Solid
Molecular weight:356.5
Ref: TM-T36148
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Dexchlorpheniramine free base
CAS:
- 25523-97-1
Dexchlorpheniramine Maleate, a histamine receptor antagonist, is used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus.
Formula:C₁₆H₁₉ClN₂
Purity:98%
Color and Shape:Oily Liquid Solid
Molecular weight:274.79
Ref: TM-T0785L
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17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
CAS:
- 1621369-73-0
Prostaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.
Formula:C₂₆H₃₆F₃NO₄
Color and Shape:Solid
Molecular weight:483.572
Ref: TM-T37777
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IRL-1038 acetate
IRL-1038 acetate is a potent ETB endothelin receptor antagonist.
Formula:C₇₀H₉₆N₁₄O₁₇S₂
Purity:97.51%
Color and Shape:Soild
Molecular weight:1469.73
Ref: TM-TP2262L
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8-iso-15-keto Prostaglandin F2α
CAS:
- 191919-01-4
8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans.
Formula:C₂₀H₃₂O₅
Color and Shape:Solid
Molecular weight:352.471
Ref: TM-T36166