GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,024 products)
- Adenosine Receptor(249 products)
- Adrenergic Receptor(3,029 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(159 products)
- CaSR(34 products)
- Cannabinoid Receptor(217 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(443 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(83 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(22 products)
- Glucagon Receptor(195 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(42 products)
- Opioid Receptor(326 products)
- PAFR(14 products)
- PKA(52 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5972 products of "GPCR/G-Protein"
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IMP-1575
CAS:IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.Formula:C19H25N3OSMolecular weight:343.49BI 639667
CAS:BI 639667, an azaindazole-class compound, potently inhibits CCR1 (IC50=1.8 nM in calcium flux assays).Formula:C22H18FN5O3SPurity:99.86%Color and Shape:SolidMolecular weight:451.47MrgprX2 antagonist-6
MrgprX2 antagonist-6 is a potent antiallergic agent with inhibitory effects on mast cell degranulation.Formula:C24H23F3N6O3Color and Shape:SolidMolecular weight:500.47Avitriptan
CAS:Avitriptan is a 5-HT1B/1D receptor agonist with pKi values of 7.44 for 5-HT1Brat, 7.68 for 5-HT1Bhuman, and 8.36 for 5-HT1Dhuman. It can induce contraction in isolated coronary arteries and is used for the treatment of migraines.Formula:C22H30N6O3SMolecular weight:458.577YM-31636 free base
CAS:YM-31636 (free base) is an orally active, potent, and selective agonist of the 5-HT3 receptor with a pKi value of 9.67. This compound induces contraction in isolated guinea pig distal colon and provokes tachycardia in isolated guinea pig right atrium, demonstrating a relative intrinsic activity of about 0.23. YM-31636 (free base) holds potential for research in constipation management.Formula:C14H11N3SColor and Shape:SolidMolecular weight:253.32BMS-986141
CAS:BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614Formula:C27H23N5O5S2Purity:98.43% - 99.26%Color and Shape:SolidMolecular weight:561.63Treprostinil diethanolamine
CAS:<p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>Formula:C27H45NO7Purity:99.86%Color and Shape:SolidMolecular weight:495.65LSN3318839
CAS:<p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>Formula:C26H23Cl2N3O2Purity:99.21%Color and Shape:SolidMolecular weight:480.39PF-07258669
CAS:PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.Formula:C25H27FN6O2Purity:99.9%Color and Shape:SolidMolecular weight:462.52SB-423562
CAS:SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.Formula:C26H32N2O4Purity:99.22%Color and Shape:SolidMolecular weight:436.54Ref: TM-T12846
1mg39.00€5mg85.00€10mg126.00€25mg221.00€50mg338.00€100mg467.00€200mg640.00€1mL*10mM (DMSO)94.00€SB-224289 hydrochloride
CAS:SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.Formula:C32H33ClN4O3Purity:98.99% - 99.96%Color and Shape:SolidMolecular weight:557.08Dersimelagon
CAS:Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.Formula:C36H45F4N3O5Purity:97.35% - 98.23%Color and Shape:SolidMolecular weight:675.75Vofopitant
CAS:Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).Formula:C21H23F3N6OPurity:97.86%Color and Shape:SolidMolecular weight:432.44AZD5462
CAS:AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.Formula:C30H41FN2O6Purity:98.32% - 99.63%Color and Shape:SolidMolecular weight:544.65Vofopitant dihydrochloride
CAS:Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.Formula:C21H25Cl2F3N6OPurity:98.99%Color and Shape:SolidMolecular weight:505.36Ref: TM-T13329L
1mg99.00€5mg235.00€10mg376.00€25mg712.00€50mg1,064.00€100mg1,454.00€500mg2,822.00€1mL*10mM (DMSO)261.00€AZD-5672
CAS:AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.Formula:C32H38F2N2O5S2Purity:98.1%Color and Shape:SolidMolecular weight:632.78Ref: TM-T30260
1mg202.00€5mg459.00€10mg643.00€25mg938.00€50mg1,311.00€100mg1,786.00€1mL*10mM (DMSO)560.00€BQ-788
CAS:BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.Formula:C34H51N5O7Purity:98.81%Color and Shape:SolidMolecular weight:641.8Ref: TM-T10595
1mg137.00€2mg188.00€5mg329.00€10mg472.00€25mg753.00€50mg1,017.00€100mg1,378.00€500mg2,737.00€1mL*10mM (DMSO)360.00€Rolapitant hydrochloride
CAS:Rolapitant HCl is a potent NK1 antagonist, non-CYP3A4 interactive, with anti-emetic effects and a Ki of 0.66 nM.Formula:C25H27ClF6N2O2Purity:98.35% - 99.79%Color and Shape:SolidMolecular weight:536.94Ref: TM-T3724
1mg153.00€5mg365.00€10mg520.00€25mg780.00€50mg1,054.00€100mg1,425.00€200mg1,882.00€1mL*10mM (DMSO)439.00€JMV 2959
CAS:JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).Formula:C30H32N6O2Color and Shape:SolidMolecular weight:508.61ML-290
CAS:ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.Formula:C24H21F3N2O5SColor and Shape:SolidMolecular weight:506.49Beraprost sodium
CAS:Beraprost sodium is a stable and orally active prodrug of PGI2.Formula:C24H29NaO5Color and Shape:SolidMolecular weight:420.481SR 146131
CAS:SR 146131 is a potent and selective agonist of the nonpeptide receptor.Formula:C32H36ClN3O5SPurity:98%Color and Shape:SolidMolecular weight:610.16HOKU-81
CAS:HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.Formula:C12H18ClNO2Color and Shape:SolidMolecular weight:243.737-Desmethyl-agomelatine
CAS:7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.Formula:C14H15NO2Color and Shape:SolidMolecular weight:229.27Pumosetrag Hydrochloride
CAS:Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.Formula:C15H18ClN3O2SPurity:98%Color and Shape:SolidMolecular weight:339.84CYM 9484
CAS:CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.Formula:C27H31N3O3S2Color and Shape:SolidMolecular weight:509.68BIBP3226 TFA
CAS:BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).Formula:C29H32F3N5O5Color and Shape:SolidMolecular weight:587.59SB-399885 hydrochloride
CAS:SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.Formula:C18H22Cl3N3O4SPurity:98%Color and Shape:SolidMolecular weight:482.81Arotinolol
CAS:Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.Formula:C15H21N3O2S3Color and Shape:White SolidMolecular weight:371.54ML-00253764 hydrochloride
CAS:ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).Formula:C18H19BrClFN2OColor and Shape:SolidMolecular weight:413.71SHA 68
CAS:SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.Formula:C26H24FN3O3Purity:98%Color and Shape:SolidMolecular weight:445.49Protease-Activated Receptor-4
CAS:Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.Formula:C33H46N8O7Purity:98%Color and Shape:SolidMolecular weight:666.773-Hydroxybenzylamine
CAS:3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.Formula:C7H9NOColor and Shape:SolidMolecular weight:123.1556-Chloro-5-(2-chloroethyl)indolin-2-one
CAS:6-Chloro-5-(2-chloroethyl)indolin-2-one is a useful organic compound for research related to life sciences. The catalog number is T64862 and the CAS number is 118289-55-7.Formula:C10H9Cl2NOColor and Shape:SolidMolecular weight:230.09TAK-448
CAS:TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.Formula:C58H80N16O14Purity:98%Color and Shape:SolidMolecular weight:1225.36Patecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Purity:98%Color and Shape:LiquidVornorexant
CAS:Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.Formula:C23H22FN7O2Color and Shape:SolidMolecular weight:447.474(R)-(-)-α-Methylhistamine dihydrochloride
CAS:R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.Formula:C6H13Cl2N3Color and Shape:SolidMolecular weight:198.09CRTh2 antagonist 3
CAS:CRTh2 antagonist 3, a potent molecule, activates PDK1 (EC50=2μM, Kd=8.4μM) and may cause cardiovascular inflammation.Formula:C19H20N2O3SPurity:98%Color and Shape:SolidMolecular weight:356.44dapitant
CAS:Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.Formula:C37H39NO4Color and Shape:SolidMolecular weight:561.714-Hydroxyatomoxetine
CAS:4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.Formula:C17H21NO2Purity:98%Color and Shape:SolidMolecular weight:271.35(Rac)-Zevaquenabant
CAS:(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.Formula:C25H21ClF3N5O2SColor and Shape:SolidMolecular weight:547.98N-methyl-2-AI (hydrochloride)
CAS:N-methyl-2-AI (hydrochloride) is a useful organic compound for research related to life sciences. The catalog number is T66396 and the CAS number is 10408-85-2.Formula:C10H14ClNColor and Shape:SolidMolecular weight:183.68BX471 hydrochloride
CAS:BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.Formula:C21H25Cl2FN4O3Purity:98%Color and Shape:SolidMolecular weight:471.35SKF 89748
CAS:SKF 89748 is an agonists of alpha 1-adrenoceptor.Formula:C12H17NOSPurity:98%Color and Shape:SolidMolecular weight:223.33Anti-GLP1R Antibody
<p>Anti-GLP1R Antibody is a human antibody expressed in CHO cells, targeting GLP1R. For isotype controls, refer to Human IgG1 kappa, Isotype Control.</p>Color and Shape:Odour Liquid1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol
CAS:1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol is a useful organic compound for research related to life sciences. The catalog number is T65156 and the CAS number is 24155-42-8.Formula:C11H10Cl2N2OColor and Shape:SolidMolecular weight:257.11Propiram fumarate HCl
CAS:<p>Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.</p>Formula:C16H25N3O·xClHPurity:99.25%Color and Shape:Soild1-Oleoyl Lysophosphatidic Acid
CAS:<p>1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.</p>Formula:C21H41O7PColor and Shape:SolidMolecular weight:436.52Ref: TM-T36907
Discontinued productGoserelin acetate(65807-02-5 Free base)
<p>Goserelin acetate （ICI-118630 acetate） is a naturally occurring decapeptide, a GnRH (gonadotropin releasing hormone) agonist that reduces the production of sex hormones (testosterone and estrogen) for the treatment of prostate cancer, breast cancer and endometriosis.</p>Purity:99.77%Color and Shape:Odour SolidRef: TM-T36918L
Discontinued productDesmethyl cariprazine
CAS:Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).Formula:C20H30Cl2N4OPurity:98%Color and Shape:SolidMolecular weight:413.38BRL 15572
CAS:BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.Formula:C25H27ClN2OColor and Shape:SolidMolecular weight:406.95Amelubant
CAS:Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315 with anti-inflammatory activity[1]. It is a potent, oral, long-acting LTB4 receptor antagonist that negligibly binds to the LTB4 receptor, exhibiting Kis of 221 nM and 230 nM in vital cells and membranes.Formula:C33H34N2O5Purity:98%Color and Shape:SolidMolecular weight:538.634-Hydroxypropranolol hydrochloride
CAS:4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).Formula:C16H22ClNO3Purity:98%Color and Shape:SolidMolecular weight:311.8GSK-3050002
<p>GSK-3050002 (HGS-1035) is a humanized IgG1 antibody that targets and binds to CCL20. It holds potential for inflammation research. For isotype control, refer to Human IgG1 kappa, Isotype Control.</p>Color and Shape:Odour LiquidSarizotan
CAS:Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.Formula:C22H21FN2OColor and Shape:SolidMolecular weight:348.421Picumeterol
CAS:Picumeterol(GR 114297A) is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that can be used to improve lung function and reduce airway hyperreactivity in patients with asthma.Formula:C21H29Cl2N3O2Purity:98%Color and Shape:SolidMolecular weight:426.38TAK-683
CAS:TAK-683: a full KISS1R agonist, IC50=170 pM; a nonapeptide metastin analog with human EC50=0.96 nM, rat EC50=1.6 nM.Formula:C64H83N17O13Purity:98%Color and Shape:SolidMolecular weight:1298.45Canagliflozin-d4
CAS:<p>Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.</p>Formula:C24H25FO5SPurity:98%Color and Shape:SolidMolecular weight:448.542-Methyl-5-HT hydrochloride
CAS:2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.Formula:C11H15ClN2OPurity:98%Color and Shape:SolidMolecular weight:226.7RU 24969 succinate
CAS:<p>RU 24969 succinate, a 5-HT receptor agonist, exhibits K i values of 0.38 nM for 5-HT 1B and 2.5 nM for 5-HT 1A, indicating its affinity towards these receptors. It reduces fluid consumption and enhances forward locomotion. This compound is utilized in neurological disease research.</p>Formula:C18H22N2O5Color and Shape:SolidMolecular weight:346.38Pamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Formula:C23H16O6Purity:99.99%Color and Shape:Fine Yellow PowderMolecular weight:388.37SB251023
CAS:SB251023 is an agonist of β3-adrenoceptor.Formula:C28H34NO6PColor and Shape:SolidMolecular weight:511.55Flumexadol
CAS:Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.Formula:C11H12F3NOPurity:98%Color and Shape:SolidMolecular weight:231.21MEN11467
CAS:MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.Formula:C38H40N4O3Purity:>99.99%Color and Shape:SolidMolecular weight:600.75Neurokinin antagonist 1
CAS:Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.Formula:C38H40N4O3Purity:>99.99%Color and Shape:SolidMolecular weight:600.75GR 218,231
CAS:GR 218,231 is a selective antagonist of D3 dopamine receptor.Formula:C24H33NO3SPurity:98%Color and Shape:SolidMolecular weight:415.59Imetit dihydrobromide
CAS:Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).Formula:C6H12Br2N4SPurity:98%Color and Shape:SolidMolecular weight:332.06AEF0117
CAS:<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Formula:C29H40O3Purity:99.58%Color and Shape:SolidMolecular weight:436.63S1P1 agonist 6
CAS:<p>Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive</p>Formula:C25H26F3NO3Purity:98%Color and Shape:SolidMolecular weight:445.472-MNG
CAS:<p>2-MNG (2-Mercaptonicotinoyl glycine) is a novel melanogenesis inhibitor. 2-MNG inhibits two mechanisms of UV-induced skin pigmentation in vivo.</p>Formula:C8H8N2O3SColor and Shape:LiquidMolecular weight:212.23Dimethandrolone Undecanoate
CAS:Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.Formula:C31H50O3Purity:99.65% - >99.99%Color and Shape:SolidMolecular weight:470.73Ref: TM-T27176
Discontinued product
