
GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(248 products)
- Adrenergic Receptor(2,994 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(154 products)
- CaSR(34 products)
- Cannabinoid Receptor(216 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(23 products)
- Glucagon Receptor(191 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(59 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5964 products of "GPCR/G-Protein"
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Cirazoline (free base)
CAS:Cirazoline: full α1A agonist, partial α1B/D, nonselective α2 antagonist; potential vasoconstrictor.Formula:C13H16N2OColor and Shape:SolidMolecular weight:216.28GSK-269984A
CAS:GSK-269984A is an antagonist of Prostaglandin E2 Receptor 1 (EP1) (pIC50: 7.9).Formula:C20H14Cl2FNNaO3Purity:98%Color and Shape:SolidMolecular weight:429.22ZD 7114 hydrochloride
CAS:β3-adrenoceptor agonistFormula:C22H31ClN2O6Purity:98%Color and Shape:SolidMolecular weight:454.94PNU-96415E
CAS:dopamine D4 and serotonergic 5-HT2A receptor antagonistFormula:C21H27Cl2FN2OPurity:98%Color and Shape:SolidMolecular weight:413.36Adriforant hydrochloride
CAS:Adriforant hydrochloride is an antagonist of histamine H4 receptor.Formula:C13H25Cl3N6Purity:98%Color and Shape:SolidMolecular weight:371.74TMPPAA
CAS:TMPPAA is an allosteric agonist of 5-HT3 receptor.Formula:C15H21NO2Purity:98%Color and Shape:SolidMolecular weight:247.33Bambuterol
CAS:long acting beta-adrenoceptor agonistFormula:C18H29N3O5Purity:98%Color and Shape:Off-White PowderMolecular weight:367.44Landiolol
CAS:Landiolol is used as a highly cardioselective ultra short-acting beta-blocker.Formula:C25H39N3O8Purity:98%Color and Shape:White Crystalline PowderMolecular weight:509.59SR-31747
CAS:SR-31747 blocks cell proliferation by inhibiting sterol isomerase. SR-31747 is a sigma ligand. It has immunosuppressive and anti-inflammatory properties.Formula:C23H35Cl2NPurity:98%Color and Shape:SolidMolecular weight:396.44NBI-27914 hydrochloride
CAS:corticotropin-releasing factor1 (CRF1) receptor antagonistFormula:C18H21Cl5N4Purity:98%Color and Shape:SolidMolecular weight:470.65Protokylol hydrochloride
CAS:Protokylol hydrochloride is a β-adrenergic agonist and bronchodilator, marketed as Asmetil, Caytine, Palison, Ventaire.Formula:C18H22ClNO5Color and Shape:SolidMolecular weight:367.83UK-9040
CAS:UK-9040 inhibits gastric secretory.Formula:C23H31NSPurity:98%Color and Shape:SolidMolecular weight:353.56Butaxamine
CAS:Butaxamine is a beta-2 selective adrenergic antagonist used mostly in animal and tissue experiments to characterize BETA-2 adrenergic receptors.Formula:C15H25NO3Purity:98%Color and Shape:SolidMolecular weight:267.36(1R,1'S,3'R/1R,1'R,3'S)-L-054,264
CAS:somatostatin sst2 receptor agonistFormula:C33H41N5O2Purity:98%Color and Shape:SolidMolecular weight:539.71Apricoxib
CAS:Apricoxib: oral NSAID with antiangiogenic, antineoplastic properties; inhibits COX-2, may reduce tumor growth and angiogenesis.Formula:C19H20N2O3SColor and Shape:SolidMolecular weight:356.44Bifeprunox
CAS:Bifeprunox: potent antipsychotic, partial agonist at D2-like/5-HT1A receptors; treats schizophrenia.Formula:C24H23N3O2Purity:98%Color and Shape:SolidMolecular weight:385.46Protokylol
CAS:Protokylol is a β-adrenergic receptor agonist.Formula:C18H21NO5Purity:98%Color and Shape:SolidMolecular weight:331.36L 741742 hydrochloride
CAS:L 741742 hydrochloride is a selective, high-affinity human D4 receptor antagonist with good oral bioavailability and brain penetration.Formula:C23H26Cl2N2OPurity:99.9%Color and Shape:SolidMolecular weight:417.37VUF 8430
CAS:VUF 8430 is a selective agonist for the H4 receptor.Formula:C4H11N5SPurity:98%Color and Shape:SolidMolecular weight:161.23Bunaprolast
CAS:Bunaprolast (U66858) is a novel and potent leukotriene B4 (LTB4) inhibitor.Bunaprolast exhibits oxidative degradation activity and inhibits lipoxygenase andFormula:C17H20O3Purity:>99.99%Color and Shape:SolidMolecular weight:272.34L-775,606
CAS:L-775,606 is a selective agonist of 5-hydroxytryptamine 1D.Formula:C25H29FN6Purity:98%Color and Shape:SolidMolecular weight:432.54VUF 5681 dihydrobromide
CAS:histamine H3 receptor silent antagonistFormula:C11H21Br2N3Purity:98%Color and Shape:SolidMolecular weight:355.11Verlukast
CAS:Verlukast (MK-0679) is a selective, orally active leukotriene D4 receptor antagonist for use in bronchial asthma research.Formula:C26H27ClN2O3S2Purity:98%Color and Shape:SolidMolecular weight:515.09JNJ-27141491
CAS:JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.Formula:C17H15F2N3O3SPurity:98%Color and Shape:SolidMolecular weight:379.38Metazosin
CAS:Metazosin is an antihypertensive agent that replaces 3H-prazosin from its bond to alpha-1 receptors of the cerebral cortex.Formula:C18H25N5O4Purity:98%Color and Shape:SolidMolecular weight:375.42LY 203647
CAS:LY 203647 is a antagonist of leukotriene D4 and E4 receptor.Formula:C21H30N8O3Purity:98%Color and Shape:SolidMolecular weight:442.51A 61603
CAS:Cixutumumab (IMC-A12) is a humanized IgG monoclonal antibody targeting the IGF1R with anticancer activity.Formula:C14H20BrN3O3SColor and Shape:SolidMolecular weight:390.3DH97
CAS:MT2 melatonin receptor antagonistFormula:C22H26N2OPurity:98%Color and Shape:SolidMolecular weight:334.45A68930
CAS:A 68930 is a dopamine D-1 receptor antagonist. A 68930 inhibits NLRP3 inflammasome activity.Formula:C16H17NO3Color and Shape:SolidMolecular weight:271.31LY 225910
CAS:LY 225910 is a CCK2 receptor antagonist.Formula:C27H24BrN3O2Purity:98%Color and Shape:SolidMolecular weight:502.4MS 245 oxalate
CAS:MS 245 oxalate is a 5-HT6 antagonist.Formula:C21H24N2O7SPurity:98%Color and Shape:SolidMolecular weight:448.49CAY10535
CAS:CAY10535 is a selective TPβ antagonist (IC50 = 99 nM for TPβ vs 1970 nM for TPα), weakly affects platelets (IC50 = 985 nM).Formula:C18H21N3O7SColor and Shape:SolidMolecular weight:423.44N-Salicyloyltryptamine
CAS:N-Salicyloyltryptamine (STP): a tryptamine with anticonvulsant, anti-inflammatory, analgesic effects; inhibits Na+, Ca2+, K+ channels (IC50 34.6 μM).Formula:C17H16N2O2Color and Shape:SolidMolecular weight:280.32SB 235375
CAS:SB 235375 is a potent and selective antagonist of neurokinin-3 receptor with a low central nervous system-penetrant.Formula:C27H24N2O4Purity:98%Color and Shape:SolidMolecular weight:440.49A1AR antagonist 6
CAS:A1AR antagonist 6 (compound 15) is a potent and selective antagonist of A1 adenosine receptor(A1AR) with a pKi of 7.13 and a pIC 50 of 6.38[1].Formula:C17H15N3O2Color and Shape:SolidMolecular weight:293.32SKF-83566 hydrobromide
CAS:D1-like dopamine receptor antagonistFormula:C17H19BrClNOPurity:98%Color and Shape:SolidMolecular weight:368.7Lu AA41063
CAS:Lu AA41063 is a potent and selective antagonist of the hA2A receptor.Formula:C16H17F2N3O2SColor and Shape:SolidMolecular weight:353.39Todralazine
CAS:Todralazine is an anti-hypertensive agent and acts as a β2AR blocker. It also has an antioxidant and free radical scavenging activity.Formula:C11H12N4O2Purity:98%Color and Shape:SolidMolecular weight:232.24Lexipafant
CAS:Lexipafant is a platelet-activating factor (PAF) receptor antagonist.Formula:C23H30N4O4SColor and Shape:SolidMolecular weight:458.57T 82
CAS:T 82 is an antagonist of 5-HT3 and inhibitor of acetylcholinesterase (AChE) and used for the treatment of Alzheimer's Disease.Formula:C56H62N6O8Purity:98%Color and Shape:SolidMolecular weight:947.146L-670,596
CAS:L-670,596 is a thromboxane A2/prostaglandin endoperoxide receptor antagonist.Formula:C22H21F2NO4SPurity:98%Color and Shape:SolidMolecular weight:433.47A2A receptor antagonist 3
CAS:A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist (Ki: 0.4 nM). receptor (Ki: 1467 nM).Formula:C26H26N6O2Color and Shape:SolidMolecular weight:454.52Ro 22-9194
CAS:Ro 22-9194, a class I antiarrhythmic, reduces upstroke velocity and shortens action potential in guinea-pig hearts at ≥10 μM.Formula:C19H27Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:384.35Thioperamide
CAS:histamine H3 and H4 antagonist/inverse agonistFormula:C15H24N4SPurity:98%Color and Shape:White SolidMolecular weight:292.44(Rac)-Upacicalcet
CAS:(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.Formula:C11H14ClN3O6SColor and Shape:SolidMolecular weight:351.76BFE-55
CAS:BFE-55 is derivative of befunolol (a beta-adrenergic partial agonist). BFE-55 interacts with only the high affinity sites in beta-adrenoceptorsFormula:C14H19NO3Purity:98%Color and Shape:SolidMolecular weight:249.31AR-A 2
CAS:AR-A 2, a selective 5-HT1B antagonist; high guinea pig 5-HT1B/1D affinity (Ki: 0.24, 0.47 nM); 10x less for 5-HT1D (Ki: 5 nM).Formula:C27H36N4O2Purity:98%Color and Shape:SolidMolecular weight:448.6NVS-CRF38
CAS:NVS-CRF38 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1).Formula:C19H21N5O2Purity:98%Color and Shape:SolidMolecular weight:351.4SB 206553 hydrochloride
CAS:SB 206553 hydrochloride is a 5-HT2C inverse agonist and a 5-HT2C/5-HT2B receptor antagonist with anxiolytic activity, useful for studying neurological disordersFormula:C17H17ClN4OPurity:99.56%Color and Shape:SolidMolecular weight:328.8Levemopamil HCl
CAS:Levemopamil HCl is used as a calcium channel blocker.Formula:C23H31ClN2Purity:98%Color and Shape:SolidMolecular weight:370.96Alaproclate (hydrochloride)
CAS:Alaproclate, an SSRI, enhances serotonin and SIRT1, hinders NMDA and K+ currents in neurons, and shows antidepressant-like effects in rats.Formula:C13H19Cl2NO2Color and Shape:SolidMolecular weight:292.2γ-Linolenic acid ethyl ester
CAS:γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) is a leukotriene B 4 receptor 4 (LTB 4 ) antagonist which has a potential anti-inflammatory effect[1].Formula:C20H34O2Color and Shape:SolidMolecular weight:306.48Benzatropine
CAS:Benzatropine: Central muscarinic blocker, inhibits dopamine uptake, treats Parkinson's symptoms.Formula:C21H25NOPurity:98%Color and Shape:SolidMolecular weight:307.43(RS)-Butyryltimolol
CAS:(RS)-Butyryltimolol, a racemic prodrug of Timolol, enhances its corneal absorption and acts as a β-adrenergic blocker.Formula:C17H30N4O4SPurity:98%Color and Shape:SolidMolecular weight:386.51Remoxipride
CAS:Remoxipride is an antipsychotic agent. Remoxipride is specific for dopamine D2 receptors.Formula:C16H23BrN2O3Purity:98%Color and Shape:SolidMolecular weight:371.27PF-4479745
CAS:PF-4479745 ia a potent and selective agonist of 5-HT2C receptor.Formula:C17H22N4Purity:98%Color and Shape:SolidMolecular weight:282.38MRS1186
CAS:MRS1186 is an effective and selective antagonist of the human Adenosine A3 receptor (Ki: 7.66 nM).Formula:C16H12ClN5O2Purity:98%Color and Shape:SolidMolecular weight:341.75L-Alprenolol
CAS:L-Alprenolol is a non-selective beta-blocker and a 5-HT1A and 5-HT1B receptor antagonist.Formula:C15H23NO2Purity:98%Color and Shape:SolidMolecular weight:249.35Carcinine
CAS:Carcinine ditrifluoroacetate is a H3 receptor antagonist.Formula:C8H14N4OPurity:98%Color and Shape:SolidMolecular weight:182.22Ro 60-0175 fumarate
CAS:5-HT2 receptor agonistFormula:C15H16ClFN2O4Purity:98%Color and Shape:SolidMolecular weight:342.75MRS2298
CAS:MRS2298, a potent antagonists of the P2Y 1 receptor, has antiaggregatory activity in human platelets.Formula:C10H16ClN5O8P2Purity:98%Color and Shape:SolidMolecular weight:431.66MAT2A-IN-1
CAS:MAT2A-IN-1 suppresses MAT2A, key for MTAP-deficient cancer cell growth; studied for gastric, colon, liver, pancreatic cancers.Formula:C29H28F2N6O4Color and Shape:SolidMolecular weight:562.57GW848687X
CAS:GW848687X, a potent and selective prostaglandin EP1 receptor antagonist, is used for the treatment of inflammatory pain.Formula:C24H18ClF2NO3Purity:98%Color and Shape:SolidMolecular weight:441.85GR 196429
CAS:GR 196429: MT1-selective melatonin receptor agonist; induces sleep, alters circadian rhythm, stimulates melatonin in mice.Formula:C14H18N2O2Purity:98%Color and Shape:SolidMolecular weight:246.3CID1792197
CAS:CID1792197 is a selective agonist of GPR55.Formula:C24H23N3O4S2Purity:98%Color and Shape:SolidMolecular weight:481.59Setastine HCl
CAS:Setastine HCl is a potent antagonist of histamine H1-receptor mediated responses.Formula:C22H29Cl2NOColor and Shape:SolidMolecular weight:394.38PM226
CAS:CB2 agonist with Ki of 12.8 nM; EC50 of 38.67 nM. Negligible CB1 affinity, no GPR55 activity. Anti-inflammatory, neuroprotective, crosses BBB.Formula:C22H31NO3Color and Shape:SolidMolecular weight:357.49L-817,818
CAS:somatostatin sst5 receptor agonistFormula:C33H36N4O3Purity:98%Color and Shape:SolidMolecular weight:536.66threo Ifenprodil hemitartrate
CAS:σ receptor agonist and NR2B subunit-selective NMDA receptor antagonistFormula:C21H27NO2C4H6O6Purity:98%Color and Shape:SolidMolecular weight:400.49Vasopressin V2 receptor antagonist 1
CAS:Vasopressin V2 receptor antagonist 1 (Compound 4g) is a vasopressin V2receptor (V2R) antagonist (Ki: 3.8 nM). dominant polycystic kidney disease (ADPKD).Formula:C33H37ClN4O4Color and Shape:SolidMolecular weight:589.12PA-9
CAS:PA-9 is the first small-molecule PAC1 receptor antagonist.Formula:C17H18N6O2Purity:98%Color and Shape:SolidMolecular weight:338.36MRS1177
CAS:MRS1177 is an effective and selective antagonist of the human Adenosine A3 receptor (hA3AR) (Ki: 0.3 nM).Formula:C20H12ClN5O2Purity:98%Color and Shape:SolidMolecular weight:389.79Vicagrel
CAS:Vicagrel, an oral antiplatelet, boosts aspirin's effect, targeting P2Y12 and fights clots in heart and vessel diseases.Formula:C18H18ClNO4SPurity:98%Color and Shape:SolidMolecular weight:379.86Ibodutant
CAS:Ibodutant is an effective and selective tachykinin NK2 receptor antagonist (pKi: 10.1).Formula:C37H48N4O4SPurity:98%Color and Shape:SolidMolecular weight:644.87S20928
CAS:S20928 is an antagonist of melatonin receptor.Formula:C17H19NOColor and Shape:SolidMolecular weight:253.34DV 7028 hydrochloride
CAS:DV 7028 hydrochloride is a 5-HT2A receptor antagonist.Formula:C21H26ClFN4O3Purity:98%Color and Shape:SolidMolecular weight:436.91hA2A/hCA XII modulator 1
CAS:Potent hA2AAR antagonist & hCA XII inhibitor; Ki: hA2AAR 6.4 nM, hCA XII 6.2 nM. Possible cancer research use.Formula:C24H19N7O4SColor and Shape:SolidMolecular weight:501.52Carbinoxamine
CAS:Carbinoxamine: antihistamine for hay fever, angioedema, rhinitis, mild urticaria, dermatographism, allergic conjunctivitis; an H1-antagonist.Formula:C16H19ClN2OPurity:98%Color and Shape:LiquidMolecular weight:290.79EGIS-7625
CAS:EGIS-7625 is a selective and competitive antagonist of 5-HT2B receptor.Formula:C18H24Cl2N4O2Purity:98%Color and Shape:SolidMolecular weight:399.32GR-203040 HCl
CAS:GR203040 inhibits cyclophosphamide-induced damage in the rat and ferret bladder. GR-203040 is a selective NK1 receptor antagonist.Formula:C20H26Cl2N6OColor and Shape:SolidMolecular weight:437.37HEMADO
CAS:HEMADO is a potent and selective agonist of adenosine A3 receptor (Ki: 1.1 nM at the human A3 subtype).Formula:C17H23N5O4Purity:98%Color and Shape:SolidMolecular weight:361.4PF-592379
CAS:PF-592379 is a potent agonist of dopamine D3 receptor (EC50: 21 nM).Formula:C13H21N3OPurity:98%Color and Shape:SolidMolecular weight:235.33Centanafadine
CAS:Centanafadine inhibits NE/DA transporters and serotonin transporter (IC50: NE=6 nM, DA=38 nM, 5-HT=83 nM).Formula:C15H15NPurity:98%Color and Shape:SolidMolecular weight:209.29UCSF678
CAS:UCSF678: selective 42 nM partial agonist at 5-HT5AR, fewer off-target effects, and lower assay risks than SB-699551.Formula:C15H18N2O2SColor and Shape:SolidMolecular weight:290.38S(-)-Bisoprolol
CAS:S(-)-Bisoprolol, a β1-blocker, may aid in researching hypertension and heart diseases.Formula:C18H31NO4Color and Shape:SolidMolecular weight:325.44Spirendolol
CAS:Spirendolol is an antagonist of β adrenergic receptor.Formula:C21H31NO3Purity:98%Color and Shape:SolidMolecular weight:345.48UP202-56
CAS:UP202-56 is an adenosinergic agonist and is an adenosine analog.Formula:C33H37N7O4Purity:98%Color and Shape:SolidMolecular weight:595.69A331440
CAS:A331440 is an modulator of L-histidine and histamine H3 receptor.Formula:C22H27N3OColor and Shape:SolidMolecular weight:349.47TCS-OX2-29 HCl
CAS:TCS-OX2-29 is a selective orexin-2 receptor antagonist (IC50 = 40 nM), which plays an important role in pain modulation.Formula:C23H32ClN3O3Purity:98%Color and Shape:SolidMolecular weight:433.97(R,R)-Reboxetine mesylate
CAS:(R,R)-Reboxetine mesylate: Antidepressant, high bioavailability, (R,R) enantiomer, selective for noradrenaline, low toxicity.Formula:C20H27NO6SColor and Shape:SolidMolecular weight:409.5AZD5213
CAS:AZD5213: selective human H3 receptor antagonist, pKi 9.3, for sleep/cognition research.Formula:C19H25N3O2Color and Shape:SolidMolecular weight:327.42PF-06256142
CAS:PF-06256142 is a potent and selective orthosteric D1 receptor agonist(D1 EC50=30 nM ).Formula:C21H16N4O2Purity:98%Color and Shape:SolidMolecular weight:356.38MRS 1334
CAS:antagonist for the human adenosine A3 receptorFormula:C31H26N2O6Purity:98%Color and Shape:SolidMolecular weight:522.55SB357134
CAS:SB357134 is a potent, selective and orally active antagonist of 5-HT6 receptor and shows nootropic effects in animal studies.Formula:C17H18Br2FN3O3SPurity:98%Color and Shape:SolidMolecular weight:523.21AChE-IN-14
CAS:AChE-IN-14 inhibits eeAChE, hAChE, eqBuChE (IC50: 0.46-0.48 μM) and binds to H3R (Ki: 159.8 nM), useful for Alzheimer's research.Formula:C28H35NO3Color and Shape:SolidMolecular weight:433.58YQA14
CAS:YQA14 is a selective, high-affinity dopamine D3 receptor antagonist that inhibits cocaine self-administration in rats and mice, opioid addiction research.Formula:C23H27ClN4O3Purity:99.52%Color and Shape:SolidMolecular weight:442.94WIN 62,577
CAS:WIN 62,577 is a allosteric antagonist of mAChR.Formula:C29H31N3OPurity:98%Color and Shape:SolidMolecular weight:437.58LUF6000
CAS:LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR).Formula:C22H20Cl2N4Color and Shape:SolidMolecular weight:411.33Tacitin
CAS:Tacitin (Benzoctamine Hydrochloride) shows sedative and anti-anxiety properties. Tacitin blocks the central postsynaptic serotonin receptors.Formula:C18H20ClNPurity:98%Color and Shape:SolidMolecular weight:285.81
