
GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(248 products)
- Adrenergic Receptor(2,994 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(154 products)
- CaSR(34 products)
- Cannabinoid Receptor(216 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(23 products)
- Glucagon Receptor(191 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(59 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5964 products of "GPCR/G-Protein"
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PA-9
CAS:PA-9 is the first small-molecule PAC1 receptor antagonist.Formula:C17H18N6O2Purity:98%Color and Shape:SolidMolecular weight:338.36Mivazerol
CAS:Mivazerol is an alpha 2-adrenoceptor agonist.Formula:C11H11N3O2Color and Shape:SolidMolecular weight:217.22Vasopressin V2 receptor antagonist 1
CAS:Vasopressin V2 receptor antagonist 1 (Compound 4g) is a vasopressin V2receptor (V2R) antagonist (Ki: 3.8 nM). dominant polycystic kidney disease (ADPKD).Formula:C33H37ClN4O4Color and Shape:SolidMolecular weight:589.125-OxoETE methyl ester
CAS:5-OxoETE methyl ester is a 5-oxoETE ester, an OXER1 agonist with stronger β-arrestin response, EC50 = 1.54 μM.Formula:C21H32O3Color and Shape:SolidMolecular weight:332.48threo Ifenprodil hemitartrate
CAS:σ receptor agonist and NR2B subunit-selective NMDA receptor antagonistFormula:C21H27NO2C4H6O6Purity:98%Color and Shape:SolidMolecular weight:400.49Ethiazide
CAS:Ethiazide is a benzothiadiazine sulfonamide derivative belonging to the class of the thiazide diuretics.Formula:C9H12ClN3O4S2Color and Shape:SolidMolecular weight:325.794-Chloro Trazodone hydrochloride
CAS:4-Chloro Trazodone HCl is a Trazodone isomer, an antidepressant for anxiety disorders.Formula:C19H23Cl2N5OColor and Shape:SolidMolecular weight:408.32PF 10040
CAS:PF 10040 is an antagonist of platelet activating factor (PAF).Formula:C20H24ClNO2Color and Shape:SolidMolecular weight:345.86Noberastine maleate
CAS:Noberastine maleate, a fast-acting furan-derived H1 antagonist, peaks at 4 hours with minimal CNS effects and maximal efficacy at 30 mg/day.Formula:C25H29N5O9Color and Shape:SolidMolecular weight:543.53L-817,818
CAS:somatostatin sst5 receptor agonistFormula:C33H36N4O3Purity:98%Color and Shape:SolidMolecular weight:536.66Fertirelin acetate
CAS:Fertirelin acetate is a gonadotropin-releasing hormone (GnRH) agonist.Formula:C55H74N16O13Color and Shape:SolidMolecular weight:1167.29Oxypertine
CAS:Oxypertine, an indole-derived antipsychotic, treats psychoses like mania, schizophrenia, and severe anxiety, akin to chlorpromazine.Formula:C23H29N3O2Color and Shape:SolidMolecular weight:379.5PM226
CAS:CB2 agonist with Ki of 12.8 nM; EC50 of 38.67 nM. Negligible CB1 affinity, no GPR55 activity. Anti-inflammatory, neuroprotective, crosses BBB.Formula:C22H31NO3Color and Shape:SolidMolecular weight:357.49Anitrazafen
CAS:Anitrazafen is a locally effective anti-inflammatory agent that has been shown to have COX-2 inhibitor activity.Formula:C18H17N3O2Purity:98%Color and Shape:SolidMolecular weight:307.35Usmarapride free base
CAS:Usmarapride free base (SUVN-D4010 free base) is a partial agonist of 5-HT4 receptors, used in Alzheimer's disease research.Formula:C21H29N5O2Purity:99.91% - 99.91%Color and Shape:SolidMolecular weight:383.49Way 100135
CAS:WAY-100135: research drug, phenylpiperazine, potent 5-HT1A antagonist, partial 5-HT1D agonist, minor 5-HT1B activity.Formula:C24H33N3O2Color and Shape:SolidMolecular weight:395.54Tiamenidine hydrochloride
CAS:Tiamenidine hydrochloride is a centrally-acting alpha1 adrenergic receptor antagonist.Formula:C8H11Cl2N3SColor and Shape:SolidMolecular weight:252.16CIA-1 hcl(452087-38-6 Free base)
CAS:CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety ofFormula:C17H20ClN3O2SPurity:99.02%Color and Shape:SolidMolecular weight:365.88Q8 hydrochloride
CAS:Q8 is an antagonist of cysteinyl leukotreine receptor. Q8 inhibits VEGF-independent angiogenesis.Formula:C17H14ClNO2Purity:98%Color and Shape:SolidMolecular weight:299.75Setastine HCl
CAS:Setastine HCl is a potent antagonist of histamine H1-receptor mediated responses.Formula:C22H29Cl2NOColor and Shape:SolidMolecular weight:394.38Clopenthixol
CAS:Clopenthixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.Formula:C22H25ClN2OSColor and Shape:SolidMolecular weight:400.96Paltusotine HCl
CAS:Paltusotine, also known as CRN00808, is a somatostatin receptor agonist.Formula:C27H24Cl2F2N4OColor and Shape:SolidMolecular weight:529.41CID1792197
CAS:CID1792197 is a selective agonist of GPR55.Formula:C24H23N3O4S2Purity:98%Color and Shape:SolidMolecular weight:481.59SC 53116 Hydrochloride
CAS:SC 53116 Hydrochloride is selective agonist of the newly identified serotonin 5-HT4 receptor subtype.Formula:C16H23Cl2N3O2Color and Shape:SolidMolecular weight:360.28Pd 158771
CAS:Pd 158771 is a D2 and 5-HT1A agonist.Formula:C22H31N5Color and Shape:SolidMolecular weight:365.52WRC-0571
CAS:WRC-0571 is a highly potent, selective antagonist of A1 adenosine receptors.Formula:C17H26N6OPurity:98%Color and Shape:SolidMolecular weight:330.43GR 196429
CAS:GR 196429: MT1-selective melatonin receptor agonist; induces sleep, alters circadian rhythm, stimulates melatonin in mice.Formula:C14H18N2O2Purity:98%Color and Shape:SolidMolecular weight:246.3Daledalin
CAS:Daledalin, an unmarketed 1970s antidepressant, is a selective norepinephrine reuptake inhibitor without serotonergic or dopaminergic effects.Formula:C19H24N2Color and Shape:SolidMolecular weight:280.41Fenspiride-d5
CAS:Fenspiride-d5: internal standard for GC/LC-MS quantification, H1 antagonist, NSAID, anti-inflammatory, selective PDE4,5,3 inhibitor.Formula:C15H15D5N2O2Color and Shape:SolidMolecular weight:265.36SGC agonist 2
CAS:SGC agonist 2 is a potent activator for cardiovascular and fibrotic diseases, per patent WO2021219088A1, compound 031.Formula:C23H17F2N7O2Color and Shape:SolidMolecular weight:461.42Sch 33303
CAS:Sch 33303 is an antiallergy agents.Formula:C19H16N2O3Color and Shape:SolidMolecular weight:320.34GW848687X
CAS:GW848687X, a potent and selective prostaglandin EP1 receptor antagonist, is used for the treatment of inflammatory pain.Formula:C24H18ClF2NO3Purity:98%Color and Shape:SolidMolecular weight:441.85SLM6031434 (free base)
CAS:SLM6031434 (free base) is an inhibitor of sphingosine kinase type 2 (SphK2). It consists of pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group.Formula:C22H30F3N5O2Color and Shape:SolidMolecular weight:453.5ChemR23-IN-4
CAS:ChemR23-IN-4 is a potent inhibitor of orally active ChemR23, capable of acting on human ChemR23 (IC50: 17 nM).Formula:C27H26N6O3Color and Shape:SolidMolecular weight:482.53Cetrorelix Acetate
CAS:Cetrorelix Acetate is gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.Formula:C70H92ClN17O14·xC2H4O2Purity:97.96%Color and Shape:SolidMolecular weight:1491.11MAT2A-IN-1
CAS:MAT2A-IN-1 suppresses MAT2A, key for MTAP-deficient cancer cell growth; studied for gastric, colon, liver, pancreatic cancers.Formula:C29H28F2N6O4Color and Shape:SolidMolecular weight:562.57MRS2298
CAS:MRS2298, a potent antagonists of the P2Y 1 receptor, has antiaggregatory activity in human platelets.Formula:C10H16ClN5O8P2Purity:98%Color and Shape:SolidMolecular weight:431.66Ro 60-0175 fumarate
CAS:5-HT2 receptor agonistFormula:C15H16ClFN2O4Purity:98%Color and Shape:SolidMolecular weight:342.75Carcinine
CAS:Carcinine ditrifluoroacetate is a H3 receptor antagonist.Formula:C8H14N4OPurity:98%Color and Shape:SolidMolecular weight:182.22L-Alprenolol
CAS:L-Alprenolol is a non-selective beta-blocker and a 5-HT1A and 5-HT1B receptor antagonist.Formula:C15H23NO2Purity:98%Color and Shape:SolidMolecular weight:249.35MRS1186
CAS:MRS1186 is an effective and selective antagonist of the human Adenosine A3 receptor (Ki: 7.66 nM).Formula:C16H12ClN5O2Purity:98%Color and Shape:SolidMolecular weight:341.75Phenoprolamine Hydrochloride
CAS:Phenoprolamine HCl: α1 blocker with anti-hypertensive, brain, and heart protection; inhibits CYP2D/3A, crosses the blood-brain barrier.Formula:C21H30ClNO3Color and Shape:SolidMolecular weight:379.92PF-4479745
CAS:PF-4479745 ia a potent and selective agonist of 5-HT2C receptor.Formula:C17H22N4Purity:98%Color and Shape:SolidMolecular weight:282.38Remoxipride
CAS:Remoxipride is an antipsychotic agent. Remoxipride is specific for dopamine D2 receptors.Formula:C16H23BrN2O3Purity:98%Color and Shape:SolidMolecular weight:371.27(RS)-Butyryltimolol
CAS:(RS)-Butyryltimolol, a racemic prodrug of Timolol, enhances its corneal absorption and acts as a β-adrenergic blocker.Formula:C17H30N4O4SPurity:98%Color and Shape:SolidMolecular weight:386.51Guanadrel Sulfate
CAS:Guanadrel Sulfate, a postganglionic blocker, is stored in neurons via the norepinephrine pump.Formula:C10H21N3O6SColor and Shape:White To Off-White Crystalline PowderMolecular weight:311.352-Acetylbenzoic acid
CAS:2-Acetylbenzoic acid outperforms 2-propionyloxybenzoic in hindering platelet function and PG synthesis; both similar in blocking PGI2 creation.Formula:C9H8O3Purity:99.62%Color and Shape:Off-White SolidMolecular weight:164.16WAY 629
CAS:WAY 629 is a selective SR-2C agonist that also act as potent 5-HT2C receptor agonists.Formula:C15H18N2Color and Shape:SolidMolecular weight:226.32Benzatropine
CAS:Benzatropine: Central muscarinic blocker, inhibits dopamine uptake, treats Parkinson's symptoms.Formula:C21H25NOPurity:98%Color and Shape:SolidMolecular weight:307.43GAT229
CAS:GAT229 is a CB1 positive modulator, enhancing CB agonist activity without direct activation; influences binding, signaling, and lowers ocular pressure in mice.Formula:C22H18N2O2Color and Shape:SolidMolecular weight:342.39Pargolol
CAS:Pargolol is a beta adrenergic receptor antagonist.Formula:C16H23NO3Color and Shape:SolidMolecular weight:277.36Colterol (free base)
CAS:Colterol: short-acting β2 agonist; Bitolterol prodrug treats asthma, COPD bronchospasm.Formula:C12H19NO3Color and Shape:SolidMolecular weight:225.28BN-81,674
CAS:BN-81,674 is a bioactive chemical.Formula:C30H38N4Color and Shape:SolidMolecular weight:454.65BMY-25271
CAS:BMY-25271 is an antagonist of histamine H2 receptor.Formula:C12H19N5O2S2Purity:98%Color and Shape:SolidMolecular weight:329.44γ-Linolenic acid ethyl ester
CAS:γ-Linolenic acid ethyl ester (Ethyl γ-linolenate) is a leukotriene B 4 receptor 4 (LTB 4 ) antagonist which has a potential anti-inflammatory effect[1].Formula:C20H34O2Color and Shape:SolidMolecular weight:306.48Alaproclate (hydrochloride)
CAS:Alaproclate, an SSRI, enhances serotonin and SIRT1, hinders NMDA and K+ currents in neurons, and shows antidepressant-like effects in rats.Formula:C13H19Cl2NO2Color and Shape:SolidMolecular weight:292.2CP 66713
CAS:CP-66713 is an adenosine A2 receptor antagonist.Formula:C15H10ClN5Color and Shape:SolidMolecular weight:295.73AM-211 sodium
CAS:AM-211 sodium: potent DP2 receptor antagonist, active against allergic inflammation, selective, and orally bioavailable in rats and dogs.Formula:C27H26F3N2NaO4Color and Shape:SolidMolecular weight:522.5Levemopamil HCl
CAS:Levemopamil HCl is used as a calcium channel blocker.Formula:C23H31ClN2Purity:98%Color and Shape:SolidMolecular weight:370.96SB 206553 hydrochloride
CAS:SB 206553 hydrochloride is a 5-HT2C inverse agonist and a 5-HT2C/5-HT2B receptor antagonist with anxiolytic activity, useful for studying neurological disordersFormula:C17H17ClN4OPurity:99.56%Color and Shape:SolidMolecular weight:328.8M-25
CAS:M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.Formula:C23H29N3O2Color and Shape:SolidMolecular weight:379.5NVS-CRF38
CAS:NVS-CRF38 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1).Formula:C19H21N5O2Purity:98%Color and Shape:SolidMolecular weight:351.4AR-A 2
CAS:AR-A 2, a selective 5-HT1B antagonist; high guinea pig 5-HT1B/1D affinity (Ki: 0.24, 0.47 nM); 10x less for 5-HT1D (Ki: 5 nM).Formula:C27H36N4O2Purity:98%Color and Shape:SolidMolecular weight:448.6BFE-55
CAS:BFE-55 is derivative of befunolol (a beta-adrenergic partial agonist). BFE-55 interacts with only the high affinity sites in beta-adrenoceptorsFormula:C14H19NO3Purity:98%Color and Shape:SolidMolecular weight:249.31(Rac)-Upacicalcet
CAS:(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.Formula:C11H14ClN3O6SColor and Shape:SolidMolecular weight:351.76Thioperamide
CAS:histamine H3 and H4 antagonist/inverse agonistFormula:C15H24N4SPurity:98%Color and Shape:White SolidMolecular weight:292.44Y2 Antagonist 36
CAS:Y2 Antagonist 36 is a highly potent, soluble and selective antagonist of NPY Y2.Formula:C27H29ClN4O3Color and Shape:SolidMolecular weight:493Ro 22-9194
CAS:Ro 22-9194, a class I antiarrhythmic, reduces upstroke velocity and shortens action potential in guinea-pig hearts at ≥10 μM.Formula:C19H27Cl2N3OPurity:98%Color and Shape:SolidMolecular weight:384.35A2A receptor antagonist 3
CAS:A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist (Ki: 0.4 nM). receptor (Ki: 1467 nM).Formula:C26H26N6O2Color and Shape:SolidMolecular weight:454.52SMM-189
CAS:SMM-189 is a potent and selective CB2 inverse agonist.Formula:C19H12Cl2O3Color and Shape:SolidMolecular weight:359.2L-670,596
CAS:L-670,596 is a thromboxane A2/prostaglandin endoperoxide receptor antagonist.Formula:C22H21F2NO4SPurity:98%Color and Shape:SolidMolecular weight:433.47T 82
CAS:T 82 is an antagonist of 5-HT3 and inhibitor of acetylcholinesterase (AChE) and used for the treatment of Alzheimer's Disease.Formula:C56H62N6O8Purity:98%Color and Shape:SolidMolecular weight:947.146Lexipafant
CAS:Lexipafant is a platelet-activating factor (PAF) receptor antagonist.Formula:C23H30N4O4SColor and Shape:SolidMolecular weight:458.57Todralazine
CAS:Todralazine is an anti-hypertensive agent and acts as a β2AR blocker. It also has an antioxidant and free radical scavenging activity.Formula:C11H12N4O2Purity:98%Color and Shape:SolidMolecular weight:232.24Lu AA41063
CAS:Lu AA41063 is a potent and selective antagonist of the hA2A receptor.Formula:C16H17F2N3O2SColor and Shape:SolidMolecular weight:353.39SKF-83566 hydrobromide
CAS:D1-like dopamine receptor antagonistFormula:C17H19BrClNOPurity:98%Color and Shape:SolidMolecular weight:368.7A1AR antagonist 6
CAS:A1AR antagonist 6 (compound 15) is a potent and selective antagonist of A1 adenosine receptor(A1AR) with a pKi of 7.13 and a pIC 50 of 6.38[1].Formula:C17H15N3O2Color and Shape:SolidMolecular weight:293.32SB 235375
CAS:SB 235375 is a potent and selective antagonist of neurokinin-3 receptor with a low central nervous system-penetrant.Formula:C27H24N2O4Purity:98%Color and Shape:SolidMolecular weight:440.49N-Salicyloyltryptamine
CAS:N-Salicyloyltryptamine (STP): a tryptamine with anticonvulsant, anti-inflammatory, analgesic effects; inhibits Na+, Ca2+, K+ channels (IC50 34.6 μM).Formula:C17H16N2O2Color and Shape:SolidMolecular weight:280.32CAY10535
CAS:CAY10535 is a selective TPβ antagonist (IC50 = 99 nM for TPβ vs 1970 nM for TPα), weakly affects platelets (IC50 = 985 nM).Formula:C18H21N3O7SColor and Shape:SolidMolecular weight:423.44MS 245 oxalate
CAS:MS 245 oxalate is a 5-HT6 antagonist.Formula:C21H24N2O7SPurity:98%Color and Shape:SolidMolecular weight:448.49LY 225910
CAS:LY 225910 is a CCK2 receptor antagonist.Formula:C27H24BrN3O2Purity:98%Color and Shape:SolidMolecular weight:502.4A68930
CAS:A 68930 is a dopamine D-1 receptor antagonist. A 68930 inhibits NLRP3 inflammasome activity.Formula:C16H17NO3Color and Shape:SolidMolecular weight:271.31DH97
CAS:MT2 melatonin receptor antagonistFormula:C22H26N2OPurity:98%Color and Shape:SolidMolecular weight:334.45A 61603
CAS:Cixutumumab (IMC-A12) is a humanized IgG monoclonal antibody targeting the IGF1R with anticancer activity.Formula:C14H20BrN3O3SColor and Shape:SolidMolecular weight:390.3Bemesetron
CAS:Bemesetron (MDL 72222) is a selective antagonist of 5-HT3 (IC50 = 0.33 nM) with neuroprotective effects.Formula:C15H17Cl2NO2Purity:99.77%Color and Shape:SolidMolecular weight:314.21LY 203647
CAS:LY 203647 is a antagonist of leukotriene D4 and E4 receptor.Formula:C21H30N8O3Purity:98%Color and Shape:SolidMolecular weight:442.51Metazosin
CAS:Metazosin is an antihypertensive agent that replaces 3H-prazosin from its bond to alpha-1 receptors of the cerebral cortex.Formula:C18H25N5O4Purity:98%Color and Shape:SolidMolecular weight:375.42JNJ-27141491
CAS:JNJ-27141491 is a potent, noncompetitive antagonist of human CCR2.Formula:C17H15F2N3O3SPurity:98%Color and Shape:SolidMolecular weight:379.38A 49816
CAS:A 49816 is a high-ceiling diuretic.Formula:C18H17Cl2NO5Color and Shape:SolidMolecular weight:398.24Verlukast
CAS:Verlukast (MK-0679) is a selective, orally active leukotriene D4 receptor antagonist for use in bronchial asthma research.Formula:C26H27ClN2O3S2Purity:98%Color and Shape:SolidMolecular weight:515.09Fallypride
CAS:Fallypride is a potent and selective dopamine D2/D3 receptor antagonist.Formula:C20H29FN2O3Purity:98.97% - >99.99%Color and Shape:SolidMolecular weight:364.45Ref: TM-T70302
1mg359.00€5mg842.00€10mg1,035.00€25mg1,663.00€50mg2,072.00€100mg2,660.00€1mL*10mM (DMSO)677.00€Stresson
CAS:Stresson is a beta-blocking agent bunitrolol.Formula:C14H21ClN2O2Color and Shape:SolidMolecular weight:284.78VUF 5681 dihydrobromide
CAS:histamine H3 receptor silent antagonistFormula:C11H21Br2N3Purity:98%Color and Shape:SolidMolecular weight:355.11TR4161
CAS:TR4161 is a prostaglandin bronchodilator of low tracheobronchial irritancy.Formula:C20H36O4Color and Shape:SolidMolecular weight:340.5L-775,606
CAS:L-775,606 is a selective agonist of 5-hydroxytryptamine 1D.Formula:C25H29FN6Purity:98%Color and Shape:SolidMolecular weight:432.54FK-1052 HCl
CAS:FK-1052 HCl is a serotonin 3 & 4 dual receptor antagonist.Formula:C18H20ClN3OColor and Shape:SolidMolecular weight:329.83Photoregulin1
CAS:Photoregulin1 modulates Nr2e3, slows photoreceptor degeneration in RhoP23H, Pde6brd1 mouse RP models.Formula:C21H23N3O2SColor and Shape:SolidMolecular weight:381.49Savoxepin mesylate
CAS:Savoxepin mesylate, a tetracyclic cyano-dibenzoxepino-azepine derivative, has potent antidopaminergic activity.Formula:C26H30N2O4SPurity:98%Color and Shape:SolidMolecular weight:466.59
