
GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(942 products)
- Adenosine Receptor(242 products)
- Adrenergic Receptor(2,949 products)
- Bombesin Receptor(30 products)
- Bradykinin Receptor(59 products)
- CXCR(149 products)
- CaSR(32 products)
- Cannabinoid Receptor(195 products)
- Dopamine Receptor(410 products)
- Endothelin Receptor(75 products)
- GNRH Receptor(73 products)
- GPCR19(31 products)
- GRK(32 products)
- GTPase(21 products)
- Glucagon Receptor(166 products)
- Hedgehog/Smoothened(45 products)
- Histamine Receptor(359 products)
- LPA Receptor(21 products)
- Melatonin Receptor(24 products)
- OX Receptor(40 products)
- Opioid Receptor(298 products)
- PAFR(11 products)
- PKA(49 products)
- S1P Receptor(17 products)
- SGLT(30 products)
- Sigma receptor(46 products)
Show 18 more subcategories
Found 5378 products of "GPCR/G-Protein"
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AL 8810
CAS:<p>AL-8810 is an 11β-fluoro analog of PGF 2α with selective antagonist effects at the PGF 2α receptor (FP receptor) [1].</p>Formula:C24H31FO4Color and Shape:SolidMolecular weight:402.5APJ receptor agonist 8
CAS:<p>APJ receptor agonist 8 is a small molecule agonist of the APJ receptor, enhancing load-independent cardiac contractility in isolated perfused rat hearts.</p>Formula:C24H27N7O5SPurity:98.31% - 99.60%Color and Shape:SolidMolecular weight:525.58OP-2507
CAS:<p>OP-2507, a prostacyclin agonist, is used potentially for the treatment of hepatic insufficiency and hypertension.</p>Formula:C25H41NO4Purity:98%Color and Shape:SolidMolecular weight:419.65-HT2A/5-HT2C inverse agonist 1
CAS:<p>5-HT2A/5-HT2C inverse agonist 1 serves as a dual and potent inverse agonist for the 5-HT2A and 5-HT2C receptors, with hERG inhibition properties that mitigate cardiovascular risks. Demonstrating significant antipsychotic efficacy in the MK-801-induced mouse model, this compound holds potential for psychosis research.</p>Formula:C24H35N5O2Color and Shape:SolidMolecular weight:425.57MRS2279
CAS:<p>Selective, high affinity competitive antagonist of the P2Y1 receptor</p>Formula:C13H18ClN5O8P2Purity:98%Color and Shape:SolidMolecular weight:469.71Danavorexton
CAS:Danavorexton is an orexin receptor agonist.Formula:C21H32N2O5SColor and Shape:SolidMolecular weight:424.55CM699
CAS:<p>CM699 is an effective dual inhibitor of the dopamine transporter (DAT) and Sigma receptor (σR), with IC50 values of 311 nM and 14.1 nM, respectively.</p>Formula:C24H29N3O2Color and Shape:SolidMolecular weight:391.51CCG258208
CAS:<p>GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).</p>Formula:C24H25FN4O4Purity:98%Color and Shape:SolidMolecular weight:452.48M1069
<p>M1069 is an oral A2A/A2B receptor antagonist, 100x more selective over A1/A3, with antitumor properties by blocking adenosine's immunosuppressive effects.</p>Formula:C25H30N4O8SColor and Shape:SolidMolecular weight:546.59SphK2-IN-1
CAS:<p>SphK2-IN-1 is an SphK2 inhibitor with an IC50 value of 0.359 μM. SphK2-IN-1 can be used to study cancer, inflammation, neurological and cardiovascular diseases.</p>Formula:C23H22ClF3N8OColor and Shape:SolidMolecular weight:518.92Becondogrel
CAS:<p>Becondogrel (2-Oxoclopidogrel) is a metabolite of Clopidogrel. It irreversibly inhibits the P2Y12 receptor, thereby preventing platelet aggregation and thrombosis.</p>Formula:C16H16ClNO3SColor and Shape:SolidMolecular weight:337.821PF-00446687
CAS:PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).Formula:C28H36F2N2O2Purity:98%Color and Shape:SolidMolecular weight:470.595-HT6R/MAO-B modulator 1
<p>5-HT6R/MAO-B modulator 1 blocks 5-HT6R and permanently inhibits MAO-B, protects glial cells, and reverses memory loss.</p>Formula:C33H38N4O3SColor and Shape:SolidMolecular weight:570.74Vofopitant
CAS:<p>Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).</p>Formula:C21H23F3N6OPurity:97.86%Color and Shape:SolidMolecular weight:432.44SB-224289 hydrochloride
CAS:<p>SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.</p>Formula:C32H33ClN4O3Purity:97.82% - 98.99%Color and Shape:SolidMolecular weight:557.08BMS-986141
CAS:<p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>Formula:C27H23N5O5S2Purity:98.43% - 99.26%Color and Shape:SolidMolecular weight:561.63LSN3318839
CAS:<p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>Formula:C26H23Cl2N3O2Purity:99.21%Color and Shape:SolidMolecular weight:480.39Treprostinil diethanolamine
CAS:<p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>Formula:C27H45NO7Purity:99.86%Color and Shape:SolidMolecular weight:495.65PF-07258669
CAS:<p>PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.</p>Formula:C25H27FN6O2Purity:99.9%Color and Shape:SolidMolecular weight:462.52Vofopitant dihydrochloride
CAS:Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.Formula:C21H25Cl2F3N6OPurity:98.99%Color and Shape:SolidMolecular weight:505.36BQ-788
CAS:<p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>Formula:C34H51N5O7Purity:98.81%Color and Shape:SolidMolecular weight:641.8AZD5462
CAS:<p>AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.</p>Formula:C30H41FN2O6Purity:98.32% - 99.63%Color and Shape:SolidMolecular weight:544.65Dersimelagon
CAS:<p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>Formula:C36H45F4N3O5Purity:97.35% - 98.23%Color and Shape:SolidMolecular weight:675.75AZD-5672
CAS:<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Formula:C32H38F2N2O5S2Purity:98.1%Color and Shape:SolidMolecular weight:632.78SB-423562
CAS:<p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>Formula:C26H32N2O4Purity:99.22%Color and Shape:SolidMolecular weight:436.54Rolapitant hydrochloride
CAS:<p>Rolapitant HCl is a potent NK1 antagonist, non-CYP3A4 interactive, with anti-emetic effects and a Ki of 0.66 nM.</p>Formula:C25H27ClF6N2O2Purity:98.35% - 99.79%Color and Shape:SolidMolecular weight:536.94ML-00253764 hydrochloride
CAS:<p>ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).</p>Formula:C18H19BrClFN2OColor and Shape:SolidMolecular weight:413.71(Rac)-Rotigotine hydrochloride
CAS:<p>(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial the 5-HT1A receptor agonist.</p>Formula:C19H26ClNOSColor and Shape:SolidMolecular weight:351.93HOKU-81
CAS:<p>HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.</p>Formula:C12H18ClNO2Color and Shape:SolidMolecular weight:243.73ML-290
CAS:<p>ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.</p>Formula:C24H21F3N2O5SColor and Shape:SolidMolecular weight:506.49SB-399885 hydrochloride
CAS:SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.Formula:C18H22Cl3N3O4SPurity:98%Color and Shape:SolidMolecular weight:482.81Arotinolol
CAS:<p>Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.</p>Formula:C15H21N3O2S3Color and Shape:White SolidMolecular weight:371.54CYM 9484
CAS:CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.Formula:C27H31N3O3S2Color and Shape:SolidMolecular weight:509.68Metipranolol hydrochloride
CAS:<p>Metipranolol hydrochloride is a non-selective β-adrenergic receptor blocking agent.</p>Formula:C17H28ClNO4Purity:98%Color and Shape:SolidMolecular weight:345.86Beraprost sodium
CAS:Beraprost sodium is a stable and orally active prodrug of PGI2.Formula:C24H29NaO5Color and Shape:SolidMolecular weight:420.481JMV 2959
CAS:JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).Formula:C30H32N6O2Color and Shape:SolidMolecular weight:508.61Protease-Activated Receptor-4
CAS:<p>Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.</p>Formula:C33H46N8O7Purity:98%Color and Shape:SolidMolecular weight:666.77Pumosetrag Hydrochloride
CAS:<p>Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.</p>Formula:C15H18ClN3O2SPurity:98%Color and Shape:SolidMolecular weight:339.84SHA 68
CAS:<p>SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.</p>Formula:C26H24FN3O3Purity:98%Color and Shape:SolidMolecular weight:445.49SR 146131
CAS:<p>SR 146131 is a potent and selective agonist of the nonpeptide receptor.</p>Formula:C32H36ClN3O5SPurity:98%Color and Shape:SolidMolecular weight:610.16BIBP3226 TFA
CAS:<p>BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).</p>Formula:C29H32F3N5O5Color and Shape:SolidMolecular weight:587.597-Desmethyl-agomelatine
CAS:<p>7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.</p>Formula:C14H15NO2Color and Shape:SolidMolecular weight:229.27Anti-GLP1R Antibody
<p>Anti-GLP1R Antibody is a human antibody expressed in CHO cells, targeting GLP1R. For isotype controls, refer to Human IgG1 kappa, Isotype Control.</p>Color and Shape:Odour LiquidPicumeterol
CAS:<p>Picumeterol(GR 114297A) is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that can be used to improve lung function and reduce airway hyperreactivity in patients with asthma.</p>Formula:C21H29Cl2N3O2Purity:98%Color and Shape:SolidMolecular weight:426.38TAK-448
CAS:<p>TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.</p>Formula:C58H80N16O14Purity:98%Color and Shape:SolidMolecular weight:1225.36Sarizotan
CAS:<p>Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.</p>Formula:C22H21FN2OColor and Shape:SolidMolecular weight:348.421BRL 15572
CAS:<p>BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.</p>Formula:C25H27ClN2OColor and Shape:SolidMolecular weight:406.95Amelubant
CAS:<p>Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315 with anti-inflammatory activity[1]. It is a potent, oral, long-acting LTB4 receptor antagonist that negligibly binds to the LTB4 receptor, exhibiting Kis of 221 nM and 230 nM in vital cells and membranes.</p>Formula:C33H34N2O5Purity:98%Color and Shape:SolidMolecular weight:538.63dapitant
CAS:<p>Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.</p>Formula:C37H39NO4Color and Shape:SolidMolecular weight:561.71CRTh2 antagonist 3
CAS:<p>CRTh2 antagonist 3, a potent molecule, activates PDK1 (EC50=2μM, Kd=8.4μM) and may cause cardiovascular inflammation.</p>Formula:C19H20N2O3SPurity:98%Color and Shape:SolidMolecular weight:356.444-Hydroxyatomoxetine
CAS:<p>4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.</p>Formula:C17H21NO2Purity:98%Color and Shape:SolidMolecular weight:271.35TAK-683
CAS:<p>TAK-683: a full KISS1R agonist, IC50=170 pM; a nonapeptide metastin analog with human EC50=0.96 nM, rat EC50=1.6 nM.</p>Formula:C64H83N17O13Purity:98%Color and Shape:SolidMolecular weight:1298.45Propiram fumarate HCl
CAS:<p>Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.</p>Formula:C16H25N3O·xClHPurity:99.25%Color and Shape:Soild4-Hydroxypropranolol hydrochloride
CAS:<p>4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).</p>Formula:C16H22ClNO3Purity:98%Color and Shape:SolidMolecular weight:311.8Goserelin acetate(65807-02-5 Free base)
<p>Goserelin acetate (ICI-118630 acetate) is a naturally occurring decapeptide, a GnRH (gonadotropin releasing hormone) agonist that reduces the production of sex hormones (testosterone and estrogen) for the treatment of prostate cancer, breast cancer and endometriosis.</p>Purity:99.77%Color and Shape:Odour SolidRef: TM-T36918L
Discontinued productPatecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Purity:98%Color and Shape:LiquidBX471 hydrochloride
CAS:<p>BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.</p>Formula:C21H25Cl2FN4O3Purity:98%Color and Shape:SolidMolecular weight:471.35(R)-(-)-α-Methylhistamine dihydrochloride
CAS:<p>R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.</p>Formula:C6H13Cl2N3Color and Shape:SolidMolecular weight:198.09GSK-3050002
<p>GSK-3050002 (HGS-1035) is a humanized IgG1 antibody that targets and binds to CCL20. It holds potential for inflammation research. For isotype control, refer to Human IgG1 kappa, Isotype Control.</p>Color and Shape:Odour LiquidDesmethyl cariprazine
CAS:<p>Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).</p>Formula:C20H30Cl2N4OPurity:98%Color and Shape:SolidMolecular weight:413.383-Hydroxybenzylamine
CAS:<p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>Formula:C7H9NOColor and Shape:SolidMolecular weight:123.1551-Oleoyl Lysophosphatidic Acid
CAS:<p>1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.</p>Formula:C21H41O7PColor and Shape:SolidMolecular weight:436.52Ref: TM-T36907
Discontinued productVornorexant
CAS:<p>Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.</p>Formula:C23H22FN7O2Color and Shape:SolidMolecular weight:447.474(Rac)-Zevaquenabant
CAS:<p>(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.</p>Formula:C25H21ClF3N5O2SColor and Shape:SolidMolecular weight:547.98Canagliflozin-d4
CAS:<p>Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.</p>Formula:C24H25FO5SPurity:98%Color and Shape:SolidMolecular weight:448.542-Methyl-5-HT hydrochloride
CAS:2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.Formula:C11H15ClN2OPurity:98%Color and Shape:SolidMolecular weight:226.7Pamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Formula:C23H16O6Purity:99.99%Color and Shape:Fine Yellow PowderMolecular weight:388.37AM-2232
CAS:<p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>Formula:C24H20N2OPurity:99.37%Color and Shape:SolidMolecular weight:352.43MEN11467
CAS:MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.Formula:C38H40N4O3Purity:>99.99%Color and Shape:SolidMolecular weight:600.75Imetit dihydrobromide
CAS:<p>Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).</p>Formula:C6H12Br2N4SPurity:98%Color and Shape:SolidMolecular weight:332.06GR 218,231
CAS:<p>GR 218,231 is a selective antagonist of D3 dopamine receptor.</p>Formula:C24H33NO3SPurity:98%Color and Shape:SolidMolecular weight:415.59Flumexadol
CAS:<p>Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.</p>Formula:C11H12F3NOPurity:98%Color and Shape:SolidMolecular weight:231.21Neurokinin antagonist 1
CAS:<p>Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.</p>Formula:C38H40N4O3Purity:>99.99%Color and Shape:SolidMolecular weight:600.752-Arachidonoylglycerol
CAS:<p>In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand</p>Formula:C23H38O4Purity:95%Color and Shape:LiquidMolecular weight:378.55S1P1 agonist 6
CAS:<p>Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive</p>Formula:C25H26F3NO3Purity:98%Color and Shape:SolidMolecular weight:445.47AEF0117
CAS:<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Formula:C29H40O3Purity:99.58%Color and Shape:SolidMolecular weight:436.632-MNG
CAS:<p>2-MNG (2-Mercaptonicotinoyl glycine) is a novel melanogenesis inhibitor. 2-MNG inhibits two mechanisms of UV-induced skin pigmentation in vivo.</p>Formula:C8H8N2O3SColor and Shape:LiquidMolecular weight:212.23Dimethandrolone Undecanoate
CAS:<p>Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.</p>Formula:C31H50O3Purity:99.65% - >99.99%Color and Shape:SolidMolecular weight:470.73Ref: TM-T27176
Discontinued product

