GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(251 products)
- Adrenergic Receptor(3,025 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(158 products)
- CaSR(34 products)
- Cannabinoid Receptor(218 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(36 products)
- GRK(33 products)
- GTPase(23 products)
- Glucagon Receptor(195 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(327 products)
- PAFR(14 products)
- PKA(60 products)
- S1P Receptor(18 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 6011 products of "GPCR/G-Protein"
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Sigma-1 receptor antagonist 2
CAS:Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).
Formula:C20H26ClN3O2Purity:99.6%Color and Shape:SolidMolecular weight:375.89LTB4 antagonist 3
CAS:Compound 24e, a leukotriene B4 (LTB4) antagonist, exhibits an inhibitory concentration 50 (IC50) of 477 nM and demonstrates anti-inflammatory activity [1].Formula:C29H27NO6Purity:98%Color and Shape:SolidMolecular weight:485.53Bivamelagon hydrochloride
CAS:Bivamelagon hydrochloride is a selective MC4R agonist (EC50=36.5 nM, Ki=65 nM), oral and blood-brain barrier penetration, suitable for obesity and diabetes.Formula:C35H54Cl2N4O4Purity:100%Color and Shape:SolidMolecular weight:665.73YM543 free base
CAS:"YM543 is an effective, oral SGLT2 inhibitor that lowers blood glucose, useful for diabetes research."Formula:C23H24O6Color and Shape:SolidMolecular weight:396.434-hydroxy Nebivolol hydrochloride
CAS:4-Hydroxy Nebivolol, a primary metabolite of Nebivolol, results from the enzymatic hydroxylation of Nebivolol by the cytochrome P450 (CYP) isoform CYP2D6.Formula:C22H25F2NO5HClColor and Shape:SolidMolecular weight:457.915(S)-Fluprostenol
CAS:15(S)-Fluprostenol, an isomer of the FP receptor agonist fluprostenol, serves as a potential active metabolite of 15(S)-fluprostenol isopropyl ester. It can function as an agonist at FP receptors, though with lower potency compared to its 15(R) epimer, fluprostenol.Formula:C23H29F3O6Color and Shape:SolidMolecular weight:458.5NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)
CAS:Compound 40, a cyclic Ape13 analogue and potent APJ agonist (Ki 5.7 nM), shows Gα12-bias and longer half-life.Formula:C49H73N13O11Color and Shape:SolidMolecular weight:1020.18Prostaglandin E2 serinol amide
CAS:Prostaglandin E2 Serinol Amide acts as a weak inhibitor against the hydrolysis of [3H]2-oleoylglycerol, but it is non-hydrolyzable and cannot produce PGE2. Consequently, it is unable to inhibit leukotriene B4 biosynthesis, superoxide production, migration, and the release of antimicrobial peptides [1].Formula:C23H39NO6Color and Shape:SolidMolecular weight:425.566UNC9994
CAS:UNC9994 is a β-arrestin-biased dopamine D₂ receptor agonist (β-arrestin EC50 = 50 nM; Emax = 97%) with robust in vivo antipsychotic drug-like activities.Formula:C21H22Cl2N2OSColor and Shape:SolidMolecular weight:421.38MB-28767
CAS:MB-28767 is an agonist of prostaglandin E2 (PGE2) receptor.Formula:C22H30O5Color and Shape:SolidMolecular weight:374.47GR-127935
CAS:GR-127935 is a potent and selective 5-HT1B/1D receptor antagonist.Formula:C29H31N5O3Color and Shape:SolidMolecular weight:497.59SCH 206272
CAS:SCH 206272 is a potent, orally active antagonist of tachykinin NK(1), NK(2), and NK(3) receptor.Formula:C33H41Cl4N5O4Color and Shape:SolidMolecular weight:713.52KUC-7322
CAS:Ritobegron is used as a selective β3-adrenoceptor agonist and the prodrug of the active compound, KUC-7322.Formula:C21H27NO5Color and Shape:SolidMolecular weight:373.44BMS-763534
CAS:BMS-763534 is a potent antagonist of corticotropin-releasing factor/hormone receptor 1 (CRHR-1).Formula:C18H21ClF2N4O3Color and Shape:SolidMolecular weight:414.83O-Arachidonoyl glycidol
CAS:O-Arachidonoyl glycidol (compound 1), a 2-arachidonoylglycerol (2-AG) analog, effectively inhibits the hydrolysis of cytosolic 2-oleoylglycerol (2-OG) with an IC50 value of 4.5 µM, and also blocks 2-OG and anandamide hydrolysis in membrane fractions with IC50 values of 19 µM and 12 µM, respectively [1].Formula:C23H36O3Color and Shape:SolidMolecular weight:360.53CB-25
CAS:CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cellsFormula:C25H41NO3Purity:98%Color and Shape:SolidMolecular weight:403.6LY320954
CAS:LY320954 is an antagonist of 5-HT2A receptor.Formula:C21H26N4O3Purity:98%Color and Shape:SolidMolecular weight:382.46MK-1421
CAS:MK-1421 is a potent and selective sstr3 antagonist.Formula:C27H24FN9O2Color and Shape:SolidMolecular weight:525.54Vemtoberant
CAS:Vemtoberant is a β3 adrenergic antagonist used in β3-related disorder research like heart failure.Formula:C29H37N3O8S2Color and Shape:SolidMolecular weight:619.75(-)-Isoproterenol hydrochloride
CAS:(-)-Isoproterenol hydrochloride is used as a β-adrenergic receptor agonist in the treatment of bradycardia and as a bronchodilator.Formula:C11H17NO3·CIHColor and Shape:SolidMolecular weight:247.72
