GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(249 products)
- Adrenergic Receptor(3,002 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(154 products)
- CaSR(34 products)
- Cannabinoid Receptor(216 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(23 products)
- Glucagon Receptor(192 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(60 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5966 products of "GPCR/G-Protein"
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15-keto-17-phenyl trinor Prostaglandin F2α
CAS:Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.Formula:C23H30O5Color and Shape:SolidMolecular weight:386.488GLP-1 receptor agonist 9 citrate
GLP-1 receptor agonist 9 citrate is an agonist of GLP-1.
Formula:C38H39ClFN3O12Purity:98.76%Color and Shape:SolidMolecular weight:784.18Prostaglandin J2
CAS:PGJ2, a PGD2 metabolite, is a DP agonist (Ki: 0.9 nM hDP, 6.6 nM hCRTH2), induces cAMP (EC50: 1.2 nM), oxidative stress, neuronal apoptosis, and neurotoxicity.Formula:C20H30O4Color and Shape:SolidMolecular weight:334.45EP3 antagonist 4
CAS:EP3 antagonist 4: hEP inhibitor, Ki = 2 nM, low clearance, high oral AUC, good bioavailability in rats, potential for diabetes research.Formula:C22H20Cl3FN4O3S2Purity:98%Color and Shape:SoildMolecular weight:577.91GLP-1R agonist 16
CAS:Compound 115a, a GLP-1R agonist, effectively activates the GLP-1 receptor with an EC50 of 0.15 nM [1].Formula:C50H58FN10O6PColor and Shape:SolidMolecular weight:945.03KwFwLL-NH2
CAS:KwFwLL-NH2 is a hexapeptide that serves as a ligand for the ghrelin receptor (ghrelin receptor). This compound acts as a specific inverse agonist for the ghrelin receptor, exhibiting moderate potency (EC50=45.6 nM).Formula:C49H66N10O6Color and Shape:SolidMolecular weight:891.11AdTx1
Selective non-competitive α1A adrenoceptor antagonist with Ki of 0.35 nM; inactive on other GPCRs; affects phenylephrine actions.Formula:C310H481N87O100S8Purity:98%Color and Shape:SolidMolecular weight:7283.22Taspoglutide
CAS:Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist(EC50 value of 0.06 nM),and for treatment of type 2 diabetesFormula:C152H232N40O45Purity:98%Color and Shape:SolidMolecular weight:3339.763PACAP (6-38), human, ovine, rat TFA
PACAP (6-38) is a PACAP receptor blocker with IC50s of 30, 600, 40 nM for type I, VIP1, and VIP2 receptors.Formula:C184H301N56FO47SPurity:98%Color and Shape:SolidMolecular weight:4138.76HS014
CAS:Potent MC4 antagonist; Ki: 3.16 nM (MC4), 108 (MC1), 54.4 (MC3), 694 (MC5). Boosts rat appetite, mouse pain, blocks IL-1β Fos in hypothalamus.Formula:C71H94N20O17S2Purity:98%Color and Shape:SolidMolecular weight:1563.77β-CGRP (mouse)
β-CGRP (mouse), a calcitonin gene-related peptide, induces vasodilation and is applicable in research areas including cardiovascular, pro-inflammatory, migraine, and metabolic studies.Formula:C165H265N49O55S2Color and Shape:SolidMolecular weight:3879.29Amitraz
CAS:Amitraz (NSC 324552): white monoclinic crystals, mp 86-87°C, water-insoluble, used as acaricide and in canine demodectic mange.Formula:C19H23N3Purity:99.88%Color and Shape:White/Pale Yellow Crystalline SolidMolecular weight:293.41Mosapride citrate dihydrate
CAS:Mosapride Citrate, a 5-HT4 agonist, boosts gut movement by enhancing acetylcholine release.Formula:C27H35ClFN3O11Purity:98%Color and Shape:SolidMolecular weight:632.04PF-9184
CAS:PF-9184 inhibits human mPGES-1 selectively, with an IC50 of 16.5 nM, and reduces IL-1β-stimulated PGE2 production in vitro.Formula:C21H14Cl2N2O4SPurity:97.43%Color and Shape:SolidMolecular weight:461.32BIIE-0246
CAS:BIIE-0246 is a selective NPY2R antagonist, IC50=15 nM at the rat [125I]PYY3-36 site, reduces NPY-stimulated expression of p-AKT S473 and P-p44/42 MAPK.Formula:C49H57N11O6Purity:98%Color and Shape:SolidMolecular weight:896.05Y1 receptor antagonist 1 formic
H 409-22 isomer formic, a formate salt of Y1 receptor antagonist 1, is an antagonist of the neuropeptide Y1 receptor (neuropeptide Y1 receptor). This compound effectively blocks the actions of the receptor, playing a crucial role in modulating physiological responses.Formula:C29H35N5O5Color and Shape:SolidMolecular weight:533.62Bradykinin (1-6)
CAS:Bradykinin (1-6) is a stable, CPY-cleaved metabolite that triggers pain, induces muscle contractions, and activates NO synthetase.Formula:C30H45N9O8Purity:98%Color and Shape:SolidMolecular weight:659.73Nesiritide acetate
CAS:Nesiritide, a 32-amino acid natriuretic peptide and recombinant form of human brain natriuretic peptide, enhances vasorelaxation ex vivo in porcine hearts from an acute coronary occlusion model when given as a 2 µg/kg bolus dose followed by a 0.01 µg/kg per minute infusion, facilitated by the calcium ionophore A23187. Formulations containing nesiritide have been utilized in managing congestive heart failure.Formula:C143H244N50O42S4C2H4O2Color and Shape:SolidMolecular weight:3524.1Adrenomedullin (1-50), rat
CAS:Rat adrenomedullin (1-50) is a 50-AA peptide; induces arterial vasodilation by activating CGRP1 receptors.Formula:C248H381N77O75S5Purity:98%Color and Shape:SolidMolecular weight:5729.5GEP44
GEP44 is a peptide-biased triple agonist targeting the glucagon-like peptide-1 receptor (GLP-1R), neuropeptide Y1 receptor (Y1-R), and neuropeptide Y2 receptor (Y2-R). It induces GLP-1R-dependent insulin secretion in rat and human islets by offsetting the actions of Y1-R and GLP-1R agonism, controlled by Y1-R antagonists. Additionally, GEP44 enhances glucose uptake in muscle tissue through Y1-R mediation independent of insulin and significantly reduces food intake and body weight in diet-induced obese rat models. GEP44 is utilized in studies related to obesity and type 2 diabetes.Color and Shape:Odour Solid
