GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(993 products)
- Adenosine Receptor(246 products)
- Adrenergic Receptor(3,004 products)
- Bombesin Receptor(33 products)
- Bradykinin Receptor(59 products)
- CXCR(153 products)
- CaSR(33 products)
- Cannabinoid Receptor(212 products)
- Dopamine Receptor(433 products)
- Endothelin Receptor(79 products)
- GNRH Receptor(77 products)
- GPCR19(32 products)
- GRK(32 products)
- GTPase(22 products)
- Glucagon Receptor(182 products)
- Hedgehog/Smoothened(47 products)
- Histamine Receptor(381 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(310 products)
- PAFR(12 products)
- PKA(51 products)
- S1P Receptor(18 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 18 more subcategories
Found 5745 products of "GPCR/G-Protein"
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Burapitant
CAS:<p>Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.</p>Formula:C31H35Cl2F6N3O3Purity:>99.99% - >99.99%Color and Shape:SolidMolecular weight:682.52CB1/2 receptor-1
CAS:CB1/2 receptor-1 (compound 5.3) serves as an agonist for CB1/2 receptors and is utilized in angiogenesis research.Formula:C33H48O2Color and Shape:SolidMolecular weight:476.73MRS2905 trisodium
CAS:<p>MRS2905 (α,β-Methylene-2-thio-UDP) trisodium is a selective P2Y14R agonist with an EC50 of 0.92 nM. It shows no activity on UDP-activated P2Y6 receptors or other P2Y receptors.</p>Formula:C10H13N2Na3O10P2SColor and Shape:SolidMolecular weight:484.199BMS-986104
CAS:BMS-986104 is an effective selective modulator of the S1P1 receptor. It demonstrates efficacy in the mouse EAE model, comparable to that of FTY720. Furthermore, BMS-986104 shows promising remyelination properties in three-dimensional brain cell cultures subjected to lysophosphatidylcholine (LPC)-induced demyelination.Formula:C22H35NOColor and Shape:SolidMolecular weight:329.52RF9 hydrochloride
<p>RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist that acts on hNPFF1R (Ki: 58 nM) and hNPFF2R (Ki: 7 nM).</p>Formula:C26H39ClN6O3Color and Shape:SolidMolecular weight:519.08Merigolix
CAS:Merigolix is a potent gonadotrophin releasing hormone (GnRH) antagonist .Formula:C36H35F7N4O6Color and Shape:SolidMolecular weight:752.68Neladenoson
CAS:Neladenoson is an effective and selective agonist of the Adenosine A1 Receptor (A1R). EGFR-IN-162 shows potential for research in heart failure.Formula:C29H24ClN5O2S2Color and Shape:SolidMolecular weight:574.12GPR183 inverse agonist-1
CAS:GPR183 inverse agonist-1 (Compound 78) is an inverse agonist of GPR183. It inhibits GPR183-mediated Gi activation and β-arrestin2 recruitment while blocking PBMC migration. This compound is utilized in research concerning inflammation, autoimmune, and cancer-related diseases.Formula:C20H20BrN5O2Color and Shape:SolidMolecular weight:442.31Fosrolapitant
CAS:Fosrolapitant is an antagonist of the neurokinin 1 (NK1) receptor.Formula:C27H29F6N2O8PColor and Shape:SolidMolecular weight:654.49Nipradolol
CAS:Nipradolol blocks alpha-1-adrenergic receptors, lowers IOP in rabbits, and reduces NA-induced muscle contraction and dog artery vasodilation.Formula:C15H22N2O6Color and Shape:SolidMolecular weight:326.35Tonapofylline
CAS:Tonapofylline, orally active, selectively blocks A1 adenosine receptor (Ki: 7.4 nM), used in heart failure research.Formula:C22H32N4O4Purity:98.57%Color and Shape:SolidMolecular weight:416.51Revexepride
CAS:Revexepride, a 5-HT4 agonist, may boost CYP3A4, used for treating GERD.Formula:C21H32ClN3O4Purity:98%Color and Shape:SolidMolecular weight:425.95Taprostene
CAS:Taprostene (CG-4203), a stable Prostacyclin analogue, protects endothelium and myocardium post-ischemia in cats, with minimal hemodynamic impact.Formula:C24H30O5Color and Shape:SolidMolecular weight:398.49MRS4833
CAS:MRS4833 (compound 15) is an orally active, potent, competitive antagonist of P2Y14R, exhibiting IC50 values of 5.92 nM for hP2Y14R and 4.8 nM for mP2Y14R. It reduces airway eosinophilia in protease-mediated asthma models and reverses chronic neuropathic pain in mouse CCI models.Formula:C30H24F3NO3Color and Shape:SolidMolecular weight:503.51Rivenprost
CAS:Rivenprost, selective EP4 agonist (Ki: 0.7 nM), promotes bone growth, osteoblast differentiation, and aids wound healing.Formula:C24H34O6SColor and Shape:SolidMolecular weight:450.59Hoe 892
CAS:Hoe 892 is a stable thia-thimo-analogue of prostacyclin and acts as a platelet aggregation inhibitor.Formula:C20H33NO4SColor and Shape:SolidMolecular weight:383.55Histamine H3 antagonist-1
CAS:<p>Compound 10o, a histamine H3 antagonist-1, functions as both a histamine H3 antagonist and a serotonin reuptake inhibitor, making it useful for research in depression [1].</p>Formula:C24H28F3N3O2Color and Shape:SolidMolecular weight:447.49TGR5 Receptor Agonist 3
CAS:TGR5 Receptor Agonist 3 is a GPBAR1 agonist with EC50 of 16.4 nM (hTGR5) & 209 nM (mTGR5), ensures gallbladder safety and reduces filling.Formula:C29H27N3O6Color and Shape:SolidMolecular weight:513.54AM11638
CAS:AM11638 is an endogenous cannabinoid analogue that targets cannabinoid receptors (CB1 and CB2 receptors), exhibiting analgesic properties. It shows potential for research in neurological disorders and inflammation-related diseases.Formula:C27H41NO2Color and Shape:SolidMolecular weight:411.62Rodatristat
CAS:<p>Rodatristat is an effective tryptophan hydroxylase 1 and TPH2 inhibitor (IC50s: 33 nM and 7 nM, respectively).</p>Formula:C27H27ClF3N5O3Purity:98%Color and Shape:SolidMolecular weight:561.98RU 52583
CAS:RU 52583 is an alpha 2-adrenergic receptor antagonist.Formula:C18H20N2Purity:98%Color and Shape:SolidMolecular weight:264.36(S)-Butaprost free acid
CAS:(S)-Butaprost (free acid) is a potent and highly selective EP2 receptor agonist[1].Formula:C23H38O5Color and Shape:SolidMolecular weight:394.54PF-4693627
CAS:PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM).Formula:C26H29Cl2N3O3Purity:98%Color and Shape:SolidMolecular weight:502.43Nolpitantium besilate
CAS:Nolpitantium besilate is a neurokinin-1 receptor antagonist.Formula:C43H50Cl2N2O5SColor and Shape:SolidMolecular weight:777.84Udifitimod
CAS:Udifitimod (BMS-986166) is a potent, selective, and orally active modulator of the S1P1R receptor, showing potential for research in autoimmune diseases.Formula:C25H33NO2Color and Shape:SolidMolecular weight:379.54IMP-1575
CAS:IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.Formula:C19H25N3OSMolecular weight:343.49Osanetant HCl
CAS:Osanetant HCl is the (R)-enantiomer; neurokinin-3 receptor antagonistFormula:C35H42Cl3N3O2Color and Shape:SolidMolecular weight:643.09JKC 302
CAS:JKC 302 is an ET-A receptor antagonist that partially inhibits the contraction of tracheal rings in asthmatic rats induced by ET-1.Formula:C30H42N6O6Color and Shape:SolidMolecular weight:582.69D4R antagonist-1
<p>Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.</p>Formula:C21H25F2NO2Color and Shape:SolidMolecular weight:361.43CB2 receptor antagonist 1
CAS:Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 & 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.Formula:C28H47NO3Color and Shape:SolidMolecular weight:445.68LB-102
CAS:LB-102 is an orally active inhibitor of dopamine D2, D3, and serotonin 5-HT7 receptors, utilized in the study of schizophrenia and other psychiatric disorders.Formula:C18H29N3O4SColor and Shape:SolidMolecular weight:383.51AB-FUBINACA 3-fluorobenzyl isomer
CAS:<p>AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid and an indazole derivative, exhibiting high affinity for central CB1 receptors (Ki= 0.9 nM) and possessing anticonvulsant activity.</p>Formula:C20H21FN4O2Color and Shape:SolidMolecular weight:368.41Y1 receptor antagonist 1
CAS:Y1 receptor antagonist 1 is an antagonist of neuropeptide Y1 receptor.Formula:C28H33N5O3Purity:98.17%Color and Shape:SolidMolecular weight:487.59(±)-Penbutolol
CAS:<p>(±)-Penbutolol ((Rac)-Penbutolol) is the racemic form of Penbutolol. It acts as an orally active β-adrenergic receptor antagonist. (±)-Penbutolol mitigates the tachycardia induced by exercise, reduces the increase in peak expiratory flow rate (PEFR) caused by physical activity, and decreases plasma renin activity (PRA) at rest. The peak plasma concentration of this compound is achieved one hour after oral administration, with a half-life of 4.5 hours, and it is metabolized into active metabolites in the body. This compound is utilized in research related to cardiovascular diseases.</p>Formula:C18H29NO2Color and Shape:SolidMolecular weight:291.43GRK6-IN-5
CAS:<p>GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.</p>Formula:C23H21N3O2Color and Shape:SolidMolecular weight:371.432Mrgx2 antagonist-3
CAS:<p>Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of the MrgX2 receptor, with an IC50 range of 0.042-2.5 nM. It blocks downstream G protein signaling and β-arrestin recruitment, inhibiting Mrgx2 receptor-mediated calcium influx and cell degranulation. Mrgx2 antagonist-3 shows potential for research in inflammation-associated diseases and pruritus, such as chronic urticaria and allergic asthma.</p>Formula:C15H15F2N3OColor and Shape:SolidMolecular weight:291.30MRS2279
CAS:Selective, high affinity competitive antagonist of the P2Y1 receptorFormula:C13H18ClN5O8P2Purity:98%Color and Shape:SolidMolecular weight:469.71L-97-1
CAS:L-97-1 is an antagonist of the adenosine A1 receptor.Formula:C29H38N6O3Purity:98%Color and Shape:SolidMolecular weight:518.65NPRA agonist-11
CAS:NPRA agonist-11 (Example 161) is an NPRA (NPR1) agonist with AC50 values of 1.681 μM and 0.989 μM for human and monkey, respectively. It is applicable in research on cardiovascular and other diseases.Formula:C37H52FN7O2Color and Shape:SolidMolecular weight:645.85AFP-07
CAS:<p>AFP-07 is a highly selective and potent agonist. It was used for the prostacyclin receptor.</p>Formula:C22H29F2NaO5Purity:98%Color and Shape:SolidMolecular weight:434.45Serlopitant
CAS:<p>Serlopitant is a selective antagonist of Neurokinin-1 (NK-1) receptor.</p>Formula:C29H28F7NO2Color and Shape:SolidMolecular weight:555.53F 14679
CAS:<p>F 14679 is a potent 5-HT1A agonist (pKi=10.23) with a maximum Ca2t response similar to 5-HT.</p>Formula:C21H25ClF2N4OPurity:99.09%Color and Shape:SolidMolecular weight:422.9WIN 66306
CAS:WIN 66306: Cyclic heptapeptide, blocks NK1/NK2 receptors, inhibits substance P-triggered contractions in guinea pig ileum.Formula:C41H52N8O9Color and Shape:SolidMolecular weight:800.9GnRH-R antagonist 1
CAS:Compound 21a: Oral GnRH-R antagonist, IC50=0.57 nM, potent against prostate cancer/prevents LH surges.Formula:C31H28F5N7O6SPurity:98%Color and Shape:SolidMolecular weight:721.65APJ receptor agonist 3
CAS:<p>APJ receptor agonist 3 is a highly effective and orally administerable agonist of the APJ receptor, demonstrating a potent EC50 value of 0.027 nM.</p>Formula:C26H29ClN4O5Color and Shape:SolidMolecular weight:512.98GRPR antagonist-2
GRPR antagonist-2 blocks GRPR, kills some cancer cells, effective on HGC-27 (IC50: 0.77 μM) & Pan02 (IC50: 2.5 μM).Formula:C28H32F3N5O4Color and Shape:SolidMolecular weight:559.58Org 274179-0
CAS:<p>Org 274179-0 is an effective allosteric antagonist of the thyroid-stimulating hormone (TSH) receptor, with an IC50 in the nanomolar range. It fully inhibits TSH (and TSI)-mediated activation of the TSH receptor with minimal impact on the efficacy of TSH. This compound can be utilized in studies of Graves' disease (GD).</p>Formula:C28H27F3N2O2Color and Shape:SolidMolecular weight:480.521SGLT1/2-IN-8
CAS:<p>SGLT1/2-IN-8 (compound 8) is a potent and orally active dual inhibitor of SGLT1/2, exhibiting IC50 values of 4 nM and 1 nM, respectively. It shows antihyperglycemic properties, making it suitable for related research.</p>Formula:C22H26O6Color and Shape:SolidMolecular weight:386.438BIIE-0246 HCl
CAS:BIIE-0246: A potent, non-peptide Y2 receptor antagonist; >650-fold more selective than Y1, Y4, Y5.Formula:C49H59Cl2N11O6Color and Shape:SolidMolecular weight:968.97Tixanox sodium
CAS:Tixanox sodium effectively blocks histamine release in the lungs triggered by anti-IgE. It has also been demonstrated that when administered orally, Tixanox sodium can successfully counteract exercise-induced asthma.Formula:C15H9NaO5SColor and Shape:SolidMolecular weight:324.28SSTR5 antagonist 2 hydrochloride
SSTR5 antagonist 2 hydrochloride: potent, oral SSTR5 blocker with potential in type 2 diabetes research.Formula:C32H36ClFN2O5Color and Shape:SolidMolecular weight:583.09Ophiobolin C
CAS:inhibitor of human CCR5 binding to HIV-1 gp120Formula:C25H38O3Purity:98%Color and Shape:SolidMolecular weight:386.57AChE-IN-5
AChE-IN-5: oral, crosses blood-brain barrier, targets AChE/5-HT1A/SERT, potent with 2.29 nM IC50.Formula:C38H45N5OColor and Shape:SolidMolecular weight:587.8CP-608039
CAS:CP-608039 is a selective adenosine A3 receptor agonist for both human A3 and human A1 receptors.Formula:C23H25ClN8O5Color and Shape:SolidMolecular weight:528.95MRS4865
CAS:MRS4865 (compound 7a) serves as a chimeric antagonist for the P2Y14 receptor and an agonist for UDP-glucose, offering protection against neuropathic pain.Formula:C39H39F3N4O7Color and Shape:SolidMolecular weight:732.74Tipelukast
CAS:Tipelukast (KCA 757), an oral drug for asthma research, blocks leukotrienes and fights inflammation and fibrosis.Formula:C29H38O7SPurity:>99.99%Color and Shape:SolidMolecular weight:530.67CCR3 antagonist 2
CAS:CCR3 antagonist2 (example 66) is a CCR3 antagonist useful for researching inflammatory or allergic diseases, particularly those affecting the respiratory tract, such as inflammatory or obstructive airway conditions.Formula:C21H28ClN5O3Color and Shape:SolidMolecular weight:433.93Cicaprost
CAS:<p>Cicaprost (ZK 96480) is an IP agonist with artery relaxing effects; EC50 is 5.8 nM.</p>Formula:C22H30O5Color and Shape:SolidMolecular weight:374.475-HT6/5-HT2AR antagonist-1
Potent 5-HT6/5-HT2A receptors dual antagonist with K i of 11 nM & 39 nM.Formula:C21H26N6SColor and Shape:SolidMolecular weight:394.54GPBAR1-IN-3
CAS:GPBAR1-IN-3 (Compound 14) is both a selective agonist for GPBAR1, with an EC50 value of 0.17 μM, and an antagonist for CysLT1R [1].Formula:C21H23NO2Color and Shape:SolidMolecular weight:321.41AM8936
AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.Formula:C25H33NO3Color and Shape:SolidMolecular weight:395.53Nocloprost
CAS:Nocloprost (SH 475) is a prostaglandin E2 (PGE2) analog, an EP1 and EP3 receptor agonist with local gastric protection and ulcer healing effects.Formula:C22H37ClO4Color and Shape:SolidMolecular weight:400.98M1069
<p>M1069 is an oral A2A/A2B receptor antagonist, 100x more selective over A1/A3, with antitumor properties by blocking adenosine's immunosuppressive effects.</p>Formula:C25H30N4O8SColor and Shape:SolidMolecular weight:546.59DA-302168S
CAS:<p>DA-302168S is an orally active, selective GLP-1R agonist with an EC50 value of 1.32 nM. It promotes insulin secretion and has a hypoglycemic effect. Additionally, DA-302168S reduces food intake. It primarily activates GLP-1R in humans and monkeys, with minimal effect on GLP-1R in rats, mice, and dogs. DA-302168S can be used for research in type 2 diabetes and obesity.</p>Formula:C33H24ClF2N3O5Color and Shape:SolidMolecular weight:616.011LJ-4517
LJ-4517 is an effective A2AAR antagonist (Ki=18.3 nM). LJ-4517 can effectively replace the binding of [3H] ZM241385 at WT A2AAR.Formula:C19H21N5O3SColor and Shape:SolidMolecular weight:399.47(R)-MrgprX2 antagonist-3
CAS:<p>(R)-MrgprX2 antagonist-3 is an antagonist of MrgprX2. It is applicable in the study of inflammatory skin diseases. For more detailed information, please refer to compound E118 in patent document WO2021092240A1.</p>Formula:C16H20FN3O2SMolecular weight:337.41CCR1 antagonist 13
CAS:CCR1 antagonist13 is a selective small molecule antagonist of CCR1.Formula:C25H27ClFN3O4Color and Shape:SolidMolecular weight:487.95AA 497 (Free Base)
CAS:AA 497, a beta-2 agonist, causes relaxation and suppresses Ca spike frequency.Formula:C14H21NO3Purity:98%Color and Shape:SolidMolecular weight:251.32Spns2-IN-3
CAS:Spns2-IN-3 (compound 510) is an SPNS2 inhibitor with an IC50 value of 1.2 μM for hSPNS2. It is applicable in research on autoimmune diseases such as multiple sclerosis (MS) and inflammatory bowel disease (IBD), as well as fibrosis, muscle atrophy, metastasis, acute lung injury, rheumatoid arthritis, colitis, Alzheimer's disease, and other conditions linked to SPNS2 activity.Formula:C25H25F5N4O3Color and Shape:SolidMolecular weight:524.485-HT7R antagonist 3
CAS:Compound 6.4, also known as 5-HT7R antagonist 3, is a selective antagonist of the 5-HT7R with a Ki of 8 nM. It exhibits significantly less affinity towards D2R, 5-HT1AR, and 5-HT2AR with Ki values of 511 nM, 8930 nM, and 5786 nM, respectively. In mice, 5-HT7R antagonist 3 demonstrates anti-depressant and anti-anxiety activities.Formula:C30H33FN4O3Color and Shape:SolidMolecular weight:516.61MF-592
CAS:<p>MF-592: EP4 receptor antagonist, hEP4 IC50 3 nM, hWB IC50 78 nM, great oral PK, rat arthritis ED50 0.1 mg/kg/day, promising for development.</p>Formula:C34H33Cl2N3O6SColor and Shape:SolidMolecular weight:682.61Etoperidone
CAS:Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).Formula:C19H28ClN5OColor and Shape:SolidMolecular weight:377.91UNC10099984A
CAS:UNC10099984A (Compound 6) is a functionally selective ligand for the dopamine D2 receptor, exhibiting a Ki value of 4.6 nM and an EC50 of 6.2 nM for β-arrestin. This compound is useful for research into central nervous system diseases related to the D2 receptor.Formula:C24H29Cl2N3O2Color and Shape:SolidMolecular weight:462.41Pareptide monohydrochloride
CAS:Pareptide monohydrochloride is a metabolically stable analog of melatonin inhibitor (MIF).Formula:C14H27ClN4O3Purity:98%Color and Shape:SolidMolecular weight:334.84Aeruginosin 98-B
CAS:Aeruginosin 98-B, a protease inhibitor, effectively inhibits trypsin, plasmin, and thrombin with IC50 values of 0.6, 7.0, and 10.0 μg/mL, respectively.Formula:C29H46N6O9SColor and Shape:SolidMolecular weight:654.78H-Glu-Thr-OH
CAS:<p>H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).</p>Formula:C9H16N2O6Color and Shape:SolidMolecular weight:248.23PGDM
CAS:PGD2 is involved in allergy, asthma, sleep, temperature regulation, inhibits clotting, and relaxes blood vessels; PGDM, its metabolite, is a biomarker.Formula:C16H24O7Color and Shape:SolidMolecular weight:328.36O-1269
CAS:<p>O-1269 acts as a partial agonist for the cannabinoid receptor 1 (CB1R), with a binding affinity (Ki) of 32 nM. Additionally, it exhibits analgesic properties.</p>Formula:C22H22Cl3N3OColor and Shape:SolidMolecular weight:450.79MRGPRX2 modulator-1
CAS:<p>MRGPRX2 modulator-1 (example 17), a modulator of the mas-related G-protein receptor X2 (MRGPRX2), is employed in studies focused on inflammation, pain, and autoimmune disorders [1].</p>Formula:C20H19F6N5OColor and Shape:SolidMolecular weight:459.39BQ-788
CAS:<p>BQ-788 is an ETB receptor antagonist with potential hypertensive activity that inhibits exogenous ET-1-induced elevation of coronary perfusion pressure.</p>Formula:C34H51N5O7Purity:98.81%Color and Shape:SolidMolecular weight:641.8AZD5462
CAS:<p>AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.</p>Formula:C30H41FN2O6Purity:98.32% - 99.63%Color and Shape:SolidMolecular weight:544.65Vofopitant dihydrochloride
CAS:Vofopitant dihydrochloride (GR 205171A) is a tachykinin NK1 receptor antagonist and a potential compound for the treatment of pathologic vomiting.Formula:C21H25Cl2F3N6OPurity:98.99%Color and Shape:SolidMolecular weight:505.36SB-423562
CAS:SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.Formula:C26H32N2O4Purity:99.22%Color and Shape:SolidMolecular weight:436.54LSN3318839
CAS:<p>LSN3318839 is a potent and orally available glucagon-like peptide-1 receptor (GLP-1R) modulator.LSN3318839 enhances GLP-1R G-protein-coupled signaling and can</p>Formula:C26H23Cl2N3O2Purity:99.21%Color and Shape:SolidMolecular weight:480.39AZD-5672
CAS:<p>AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM.</p>Formula:C32H38F2N2O5S2Purity:98.1%Color and Shape:SolidMolecular weight:632.78PF-07258669
CAS:<p>PF-07258669 is a selective melanocortin 4 receptor (MC4) antagonist used in the study of cachexia and loss of appetite.</p>Formula:C25H27FN6O2Purity:99.9%Color and Shape:SolidMolecular weight:462.52SB-224289 hydrochloride
CAS:<p>SB-224289 hydrochloride (SB-224289A) is a selective antagonist of 5-HT1B receptor, with anxiolytic effect.</p>Formula:C32H33ClN4O3Purity:97.82% - 98.99%Color and Shape:SolidMolecular weight:557.08BMS-986141
CAS:<p>BMS-986141(UDM-003183) is a selective and potent protease-activated receptor-4 (PAR-4) antagonist with oral activity and an IC50 value of 0.4 nM.BMS-98614</p>Formula:C27H23N5O5S2Purity:98.43% - 99.26%Color and Shape:SolidMolecular weight:561.63Treprostinil diethanolamine
CAS:<p>Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1 and IP, with values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1,</p>Formula:C27H45NO7Purity:99.86%Color and Shape:SolidMolecular weight:495.65Dersimelagon
CAS:<p>Dersimelagon (MT-7117) is an orally active, selective melanocortin 1 receptor (MC1R) agonist.Cost-effective and quality-assured.</p>Formula:C36H45F4N3O5Purity:97.35% - 98.23%Color and Shape:SolidMolecular weight:675.75Vofopitant
CAS:Vofopitant (GR 205171) is a potent NK1 receptor antagonist with anxiolytic and antiemetic activity for the study of post-traumatic stress disorder (PTSD).Formula:C21H23F3N6OPurity:97.86%Color and Shape:SolidMolecular weight:432.44Rolapitant hydrochloride
CAS:Rolapitant HCl is a potent NK1 antagonist, non-CYP3A4 interactive, with anti-emetic effects and a Ki of 0.66 nM.Formula:C25H27ClF6N2O2Purity:98.35% - 99.79%Color and Shape:SolidMolecular weight:536.94ML-00253764 hydrochloride
CAS:ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).Formula:C18H19BrClFN2OColor and Shape:SolidMolecular weight:413.71ML-290
CAS:ML-290 is an effective relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes. It shows an EC50 of 94 nM.Formula:C24H21F3N2O5SColor and Shape:SolidMolecular weight:506.49JMV 2959
CAS:JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).Formula:C30H32N6O2Color and Shape:SolidMolecular weight:508.61CYM 9484
CAS:CYM 9484 is a selective and potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.Formula:C27H31N3O3S2Color and Shape:SolidMolecular weight:509.68SB-399885 hydrochloride
CAS:SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.Formula:C18H22Cl3N3O4SPurity:98%Color and Shape:SolidMolecular weight:482.81HOKU-81
CAS:HOKU-81is a new bronchodilator and is one of the metabolites of tulobuterol.Formula:C12H18ClNO2Color and Shape:SolidMolecular weight:243.737-Desmethyl-agomelatine
CAS:7-Desmethyl-agomelatine, a metabolite of Agomelatine, exhibits lower activity than Agomelatine, which functions as a melatonergic (MT1 and MT2) agonist and 5-HT2C antagonist.Formula:C14H15NO2Color and Shape:SolidMolecular weight:229.27BIBP3226 TFA
CAS:BIBP3226 TFA is an effective and selective antagonist of neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor (Kis: 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF).Formula:C29H32F3N5O5Color and Shape:SolidMolecular weight:587.59Beraprost sodium
CAS:Beraprost sodium is a stable and orally active prodrug of PGI2.Formula:C24H29NaO5Color and Shape:SolidMolecular weight:420.481SR 146131
CAS:SR 146131 is a potent and selective agonist of the nonpeptide receptor.Formula:C32H36ClN3O5SPurity:98%Color and Shape:SolidMolecular weight:610.16Pumosetrag Hydrochloride
CAS:Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.Formula:C15H18ClN3O2SPurity:98%Color and Shape:SolidMolecular weight:339.84SHA 68
CAS:SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR) with IC50 values of 22.0 nM for NPSR Asn107 and 23.8 nM for NPSR Ile107.Formula:C26H24FN3O3Purity:98%Color and Shape:SolidMolecular weight:445.49Protease-Activated Receptor-4
CAS:Protease-Activated Receptor-4 (PAR4) is a proteinase-activated receptor-4 agonist used in antiplatelet therapy.Formula:C33H46N8O7Purity:98%Color and Shape:SolidMolecular weight:666.77Arotinolol
CAS:Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand [125I-ICYP] to [5HT1B-serotonergic] receptor sites. It is an antihypertensive agent.Formula:C15H21N3O2S3Color and Shape:White SolidMolecular weight:371.54TAK-683
CAS:TAK-683: a full KISS1R agonist, IC50=170 pM; a nonapeptide metastin analog with human EC50=0.96 nM, rat EC50=1.6 nM.Formula:C64H83N17O13Purity:98%Color and Shape:SolidMolecular weight:1298.45Patecibart
CAS:<p>Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).</p>Purity:98%Color and Shape:Liquid3-Hydroxybenzylamine
CAS:<p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>Formula:C7H9NOColor and Shape:SolidMolecular weight:123.155Propiram fumarate HCl
CAS:<p>Propiram fumarate HClis an orally available Opioid receptors agonist with analgesic activity for the study of musculoskeletal pain.</p>Formula:C16H25N3O·xClHPurity:99.25%Color and Shape:SoildDesmethyl cariprazine
CAS:<p>Desmethyl cariprazine is a Cariprazine active metabolite. Cariprazine, an antipsychotic drug candidate, shows a high affinity for the D3 (Ki: 0.085 nM) and D2 (Ki: 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).</p>Formula:C20H30Cl2N4OPurity:98%Color and Shape:SolidMolecular weight:413.38Sarizotan
CAS:Sarizotan (EMD 128130) is an orally active compound that acts as an agonist for serotonin 5-HT 1A receptors and dopamine receptors, with IC50 values of 6.5 nM for rat 5-HT 1A, 0.1 nM for human 5-HT 1A, 15.1 nM for rat D 2, 17 nM for human D 2, 6.8 nM for human D 3, and 2.4 nM for human D 4.2.Formula:C22H21FN2OColor and Shape:SolidMolecular weight:348.421Goserelin acetate(65807-02-5 Free base)
<p>Goserelin acetate （ICI-118630 acetate） is a naturally occurring decapeptide, a GnRH (gonadotropin releasing hormone) agonist that reduces the production of sex hormones (testosterone and estrogen) for the treatment of prostate cancer, breast cancer and endometriosis.</p>Purity:99.77%Color and Shape:Odour SolidRef: TM-T36918L
Discontinued product1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol
CAS:1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol is a useful organic compound for research related to life sciences. The catalog number is T65156 and the CAS number is 24155-42-8.Formula:C11H10Cl2N2OColor and Shape:SolidMolecular weight:257.114-Hydroxyatomoxetine
CAS:4-Hydroxyatomoxetine, an active metabolite of Atomoxetine, is metabolized by CYP2D6. Atomoxetine is a noradrenaline reuptake inhibitor.Formula:C17H21NO2Purity:98%Color and Shape:SolidMolecular weight:271.35Anti-GLP1R Antibody
<p>Anti-GLP1R Antibody is a human antibody expressed in CHO cells, targeting GLP1R. For isotype controls, refer to Human IgG1 kappa, Isotype Control.</p>Color and Shape:Odour Liquid4-Hydroxypropranolol hydrochloride
CAS:4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors (pA2s: 8.24 and 8.26).Formula:C16H22ClNO3Purity:98%Color and Shape:SolidMolecular weight:311.8(R)-(-)-α-Methylhistamine dihydrochloride
CAS:<p>R(-)-alpha-Methylhistamine 2HCl is an effective and selective agonist of the H3 histamine receptor.</p>Formula:C6H13Cl2N3Color and Shape:SolidMolecular weight:198.09TAK-448
CAS:TAK-448 (MVT-602), a potent KISS1R agonist, IC50: 460 pM, EC50: 632 pM, trialed for Prostate Cancer and Hypogonadism.Formula:C58H80N16O14Purity:98%Color and Shape:SolidMolecular weight:1225.361-Oleoyl Lysophosphatidic Acid
CAS:<p>1-Oleoyl Lysophosphatidic Acid (1-Oleoyl LPA) is a biologically active phospholipid that can be used to study cancer and atherosclerosis.</p>Formula:C21H41O7PColor and Shape:SolidMolecular weight:436.52Ref: TM-T36907
Discontinued productVornorexant
CAS:Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.Formula:C23H22FN7O2Color and Shape:SolidMolecular weight:447.474dapitant
CAS:<p>Dapitant, a non-peptide, selective antagonist of human NKI receptors, is representative of the 7,7,4-triarylperhydroisoindol-4-ols.</p>Formula:C37H39NO4Color and Shape:SolidMolecular weight:561.71CRTh2 antagonist 3
CAS:<p>CRTh2 antagonist 3, a potent molecule, activates PDK1 (EC50=2μM, Kd=8.4μM) and may cause cardiovascular inflammation.</p>Formula:C19H20N2O3SPurity:98%Color and Shape:SolidMolecular weight:356.44BRL 15572
CAS:BRL 15572 is a useful organic compound for research related to life sciences. The catalog number is T64501 and the CAS number is 734517-40-9.Formula:C25H27ClN2OColor and Shape:SolidMolecular weight:406.95(Rac)-Zevaquenabant
CAS:(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.Formula:C25H21ClF3N5O2SColor and Shape:SolidMolecular weight:547.98BX471 hydrochloride
CAS:BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with a Ki of 1 nM for human CCR1, exhibiting 250-fold selectivity over CCR2, CCR5, and CXCR4.Formula:C21H25Cl2FN4O3Purity:98%Color and Shape:SolidMolecular weight:471.35Amelubant
CAS:<p>Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315 with anti-inflammatory activity[1]. It is a potent, oral, long-acting LTB4 receptor antagonist that negligibly binds to the LTB4 receptor, exhibiting Kis of 221 nM and 230 nM in vital cells and membranes.</p>Formula:C33H34N2O5Purity:98%Color and Shape:SolidMolecular weight:538.63SKF 89748
CAS:SKF 89748 is an agonists of alpha 1-adrenoceptor.Formula:C12H17NOSPurity:98%Color and Shape:SolidMolecular weight:223.33GSK-3050002
<p>GSK-3050002 (HGS-1035) is a humanized IgG1 antibody that targets and binds to CCL20. It holds potential for inflammation research. For isotype control, refer to Human IgG1 kappa, Isotype Control.</p>Color and Shape:Odour LiquidPicumeterol
CAS:<p>Picumeterol(GR 114297A) is a potent and selective β2 adrenergic receptor agonist. In vitro and in vivo trials, Picumeterol produced long-lasting airway smooth muscle relaxation. Picumeterol is a pure R enantiomer that can be used to improve lung function and reduce airway hyperreactivity in patients with asthma.</p>Formula:C21H29Cl2N3O2Purity:98%Color and Shape:SolidMolecular weight:426.386-Chloro-5-(2-chloroethyl)indolin-2-one
CAS:6-Chloro-5-(2-chloroethyl)indolin-2-one is a useful organic compound for research related to life sciences. The catalog number is T64862 and the CAS number is 118289-55-7.Formula:C10H9Cl2NOColor and Shape:SolidMolecular weight:230.09Canagliflozin-d4
CAS:<p>Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor.</p>Formula:C24H25FO5SPurity:98%Color and Shape:SolidMolecular weight:448.542-Methyl-5-HT hydrochloride
CAS:2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist with anti-depressive-like effects.Formula:C11H15ClN2OPurity:98%Color and Shape:SolidMolecular weight:226.7Pamoic acid
CAS:<p>Pamoic acid is the orphan G protein-coupled receptor GPR35 agonist. Pamoic acid activates ERK and beta-arrestin2 and causes antinociceptive activity.</p>Formula:C23H16O6Purity:99.99%Color and Shape:Fine Yellow PowderMolecular weight:388.37AM-2232
CAS:<p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>Formula:C24H20N2OPurity:99.37%Color and Shape:SolidMolecular weight:352.43MEN11467
CAS:MEN11467 is a novel, orally available, potent and selective peptidomimetic tachykinin NK 1 receptor antagonist for the study of acute colon cancer.Formula:C38H40N4O3Purity:>99.99%Color and Shape:SolidMolecular weight:600.75Flumexadol
CAS:Flumexadol is a selective 5-HT2C receptor agonist with an affinity (Ki) of 25 nM for the (+)-enantiomer and exhibits 40-fold selectivity over the 5-HT2A receptor. It is an orally active, non-narcotic analgesic.Formula:C11H12F3NOPurity:98%Color and Shape:SolidMolecular weight:231.21SB251023
CAS:SB251023 is an agonist of β3-adrenoceptor.Formula:C28H34NO6PColor and Shape:SolidMolecular weight:511.55GR 218,231
CAS:GR 218,231 is a selective antagonist of D3 dopamine receptor.Formula:C24H33NO3SPurity:98%Color and Shape:SolidMolecular weight:415.59Neurokinin antagonist 1
CAS:<p>Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.</p>Formula:C38H40N4O3Purity:>99.99%Color and Shape:SolidMolecular weight:600.75Imetit dihydrobromide
CAS:Imetit dihydrobromide is a high affinity and effective agonist of histamine H3 and H4 receptors (Ki: 0.3 and 2.7 nM). Imetit mimics the histamine effect in triggering a shape change in eosinophils (EC50: 25 nM).Formula:C6H12Br2N4SPurity:98%Color and Shape:SolidMolecular weight:332.06AEF0117
CAS:<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Formula:C29H40O3Purity:99.58%Color and Shape:SolidMolecular weight:436.63S1P1 agonist 6
CAS:<p>Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive</p>Formula:C25H26F3NO3Purity:98%Color and Shape:SolidMolecular weight:445.47Dimethandrolone Undecanoate
CAS:Dimethandrolone Undecanoate (DMAU) is a novel orally available androgen with progestational activity and is a potential male contraceptive compound.Formula:C31H50O3Purity:99.65% - >99.99%Color and Shape:SolidMolecular weight:470.73Ref: TM-T27176
Discontinued product2-MNG
CAS:<p>2-MNG (2-Mercaptonicotinoyl glycine) is a novel melanogenesis inhibitor. 2-MNG inhibits two mechanisms of UV-induced skin pigmentation in vivo.</p>Formula:C8H8N2O3SColor and Shape:LiquidMolecular weight:212.23
