GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

Show 18 more subcategories

Found 5378 products of "GPCR/G-Protein"

Purity (%)

100

products per page.

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17-TFM-PGF1α
CAS:
- 1027401-98-4
17-TFM-PGF1α (Compound 8) is a saturated prostaglandin analog. It exhibits a high affinity and receptor selectivity for the human prostaglandin F receptor (hFP receptor), with an EC50 of 85 nM.
Formula:C₂₄H₃₅F₃O₅
Color and Shape:Solid
Molecular weight:460.53
Ref: TM-T203103
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BAY-6672
CAS:
- 2247517-53-7
BAY-6672 is, a selective,oral, highly potent human prostaglandin F (FP) receptor antagonist, exerts antifibrotic effects by inhibiting PGF₂α activity.
Formula:C₂₆H₂₇BrClN₃O₃
Purity:99.51%
Color and Shape:Solid
Molecular weight:544.87
Ref: TM-T39760
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Imnopitant dihydrochloride
CAS:
- 290296-52-5
Imnopitant dihydrochloride is a neurokinin NK1 receptor antagonist [1] .
Formula:C₂₈H₃₀Cl₂F₆N₄O
Color and Shape:Solid
Molecular weight:623.46
Ref: TM-T73705
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Utreglutide
CAS:
- 2460862-12-6
Utreglutide is a potent glucagon-like peptide 1 (GLP-1) receptor agonit [1] .
Formula:C₁₉₁H₂₉₈N₄₆O₅₈
Color and Shape:Solid
Molecular weight:4166.67
Ref: TM-T76237
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Substance P (4-11)
CAS:
- 53749-60-3
Substance P (4-11), a C-terminal fragment of Substance P, acts as a highly selective agonist for NK1 receptors, demonstrating specificity in its interaction.
Formula:C₄₆H₆₇N₁₁O₁₀S
Color and Shape:Solid
Molecular weight:966.16
Ref: TM-T76455
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MLGFFQQPKPR-NH2
CAS:
- 1802883-75-5
MLGFFQQPKPR-NH2 is a reversed Substance P peptide. Substance P is a neuropeptide [1] .
Formula:C₆₃H₉₈N₁₈O₁₃S
Color and Shape:Solid
Molecular weight:1347.63
Ref: TM-T76451
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ANQ-11125 TFA
ANQ-11125 TFA is a motilin antagonist with a pKd of 8.24, inhibiting motilide contractions in rabbits.
Formula:C₈₈H₁₂₆F₃N₁₉O₂₃
Color and Shape:Solid
Molecular weight:1875.05
Ref: TM-T75861
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Ecnoglutide
CAS:
- 2459531-73-6
Ecnoglutide (XW003) is a glucagon-like peptide 1 (GLP-1) receptor agonist [1] .
Formula:C₁₉₄H₃₀₄N₄₈O₆₁
Color and Shape:Solid
Molecular weight:4284.76
Ref: TM-T76234
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Neuropeptide Y (18-36) (porcine)
CAS:
- 114495-97-5
"Neuropeptide Y (18-36) (porcine) is a NPY heart receptor blocker, halts I-NPY binding, aids in heart failure research."
Formula:C₁₁₂H₁₇₄N₃₆O₂₇
Color and Shape:Solid
Molecular weight:2456.8
Ref: TM-T76357
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Neuropeptide W-30 (rat)
CAS:
- 383415-90-5
Neuropeptide W-30 (rat) acts as a crucial stress mediator within the central nervous system, influencing the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. It serves as an endogenous ligand for the two related orphan G-protein-coupled receptors (GPCRs), GPR7 and GPR8. NPW-30 binds and activates both GPR7 and GPR8 at comparable effective doses [1] [2] [3].
Formula:C₁₆₅H₂₄₉N₄₉O₃₈S
Color and Shape:Solid
Molecular weight:3559.11
Ref: TM-TP2611
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GLP-1(28-36)amide TFA
GLP-1(28-36)amide TFA, a nonapeptide cleavage product of GLP-1, shows antioxidant properties with anti-diabetic and cardioprotective effects.
Formula:C₅₆H₈₆F₃N₁₅O₁₁
Color and Shape:Solid
Molecular weight:1202.37
Ref: TM-T76191
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BIM-23190 hydrochloride
BIM-23190 hydrochloride, somatostatin analog, SSRT2/5 agonist, Ki: 0.34 nM (SSTR2), 11.1 nM (SSTR5). Used in cancer, acromegaly research.
Color and Shape:Liquid
Ref: TM-T37109
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LH-RH (7-10)
CAS:
- 38482-71-2
LH-RH (7-10), a tetrapeptide, is a key LHRH degradation product found in macrophages and pneumocytes.
Formula:C₁₉H₃₆N₈O₄
Color and Shape:Solid
Molecular weight:440.54
Ref: TM-T76353
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Hemokinin 1, human TFA
Hemokinin-1 is a human TFA and selective NK1 agonist; also activates NK2 & NK3 and induces opioid-independent analgesia.
Formula:C₅₆H₈₅F₃N₁₄O₁₆S
Color and Shape:Solid
Molecular weight:1299.42
Ref: TM-T75840
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(-)-Eseroline fumarate
CAS:
- 70310-73-5
(-)-Eseroline fumarate, a Physostigmine metabolite and AChE inhibitor, triggers cancer cell LDH release and neuronal cell death.
Formula:C₁₇H₂₂N₂O₅
Color and Shape:Solid
Molecular weight:334.37
Ref: TM-T73930
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JNJ-40929837 succinate
CAS:
- 1191044-47-9
JNJ-40929837 succinate is a selective, orally active inhibitor of LTA 4 H (leukotriene A 4 hydrolase). This compound effectively inhibits aminopeptidase activity, leading to the accumulation of Pro-Gly-Pro in serum, and can be utilized in asthma research [1].
Formula:C₂₂H₂₄N₄O₂S·xC₄H₆O₄
Color and Shape:Solid
Ref: TM-T86771
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Human growth hormone-releasing factor TFA
Human growth hormone-releasing factor TFA is a hypothalamic peptide that promotes GH secretion by targeting pituitary GHRHR.
Formula:C₂₁₇H₃₅₉F₃N₇₂O₆₈S
Color and Shape:Solid
Molecular weight:5153.67
Ref: TM-T75713
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AZ7976
CAS:
- 2813866-27-0
AZ7976 (Compound 42), a potent and highly selective agonist for Relaxin Family Peptide Receptor 1 (RXFP1) with a pEC 50 value greater than 10.5, operates through an allosteric mechanism to enhance RXFP1's cAMP signaling, which physiologically elevates heart rate. This property makes AZ7976 a valuable tool in cardiovascular disease research [1].
Formula:C₃₀H₃₃F₇N₂O₆S
Color and Shape:Solid
Molecular weight:682.65
Ref: TM-T85783
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PAR 4 (1-6)
CAS:
- 225779-44-2
PAR 4 (1-6) can be used for relevant research in the life sciences. Its product number is T36293 and CAS number is 225779-44-2.
Formula:C₂₈H₄₁N₇O₉
Color and Shape:Solid
Molecular weight:619.676
Ref: TM-T36293
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BAY-747
CAS:
- 1609342-18-8
BAY-747: oral, brain-penetrant sGC stimulator; improves rat memory, cognition, lowers blood pressure, aids Duchenne muscular dystrophy.
Formula:C₂₂H₂₆F₂N₄O₂
Color and Shape:Solid
Molecular weight:416.46
Ref: TM-T75137
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EP4 receptor antagonist 3
CAS:
- 1207954-34-4
EP4 receptor antagonist 3 from patent WO2010019796 A1 targets EP4 for research on pain, arthritis, and cancer.
Formula:C₂₆H₂₁F₃N₂O₃S
Color and Shape:Solid
Molecular weight:498.52
Ref: TM-T38595
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LY 344864 racemate
CAS:
- 186543-64-6
LY 344864 racemate is a 5-HT1F receptor agonist.
Formula:C₂₁H₂₂FN₃O
Purity:99.75%
Color and Shape:Soild
Molecular weight:351.42
Ref: TM-T2344L
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PACAP (1-27), human, ovine, rat
CAS:
- 127317-03-7
PACAP (1-27) (the N-terminal fragment of PACAP-38) is a novel neuropeptides originally isolated from bovine hypothalamus, also found in humans and rats.
Formula:C₁₄₂H₂₂₄N₄₀O₃₉S
Purity:98%
Color and Shape:Solid
Molecular weight:3147.66
Ref: TM-TP1070
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PF-232798
CAS:
- 849753-15-7
PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.
Formula:C₂₉H₄₀FN₅O₂
Color and Shape:Solid
Molecular weight:509.66
Ref: TM-T28381
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PROTAC(H-PGDS)-8
CAS:
- 2761281-51-8
PROTAC(H-PGDS)-8 is a PROTAC degrader targeting Hematopoietic prostaglandin D synthase (H-PGDS), exhibiting an IC50 of 0.14 μM [1].
Formula:C₄₁H₄₀N₈O₇
Color and Shape:Solid
Molecular weight:756.81
Ref: TM-T84924
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Tamuzimod
CAS:
- 2097854-81-2
Tamuzimod, an effective immunomodulator, exhibits modulatory activity on S1P Receptors with EC50 values below 1 μM [1] [2].
Formula:C₂₁H₁₃Cl₃F₃N₅O₃
Color and Shape:Solid
Molecular weight:546.71
Ref: TM-T74747
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PAR-4 Agonist Peptide, amide
CAS:
- 352017-71-1
PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).
Formula:C₃₄H₄₈N₈O₇
Purity:98%
Color and Shape:Solid
Molecular weight:680.79
Ref: TM-T7623
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Ro60-0175
CAS:
- 169675-08-5
Ro60-0175 is a selective 5-HT2B and 5-HT2C serotonin receptor agonist, often used as fumarate.
Formula:C₁₁H₁₂ClFN₂
Purity:97.09%
Color and Shape:Solid
Molecular weight:226.68
Ref: TM-T39161
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O-Desethyl Dapagliflozin
CAS:
- 864070-37-1
O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM.
Formula:C₁₉H₂₁ClO₆
Purity:98.33%
Color and Shape:Solid
Molecular weight:380.82
Ref: TM-T67849
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[Phe8Ψ(CH-NH)-Arg9]-Bradykinin
CAS:
- 118122-39-7
Selective bradykinin B2 receptor agonist that is resistant to carboxypeptidase cleavage.
Formula:C₅₀H₇₅N₁₅O₁₀
Purity:98%
Color and Shape:Solid
Molecular weight:1046.23
Ref: TM-TP2076
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Upacicalcet HCl
Upacicalcet HCl, a calcium mimetic, reduces blood PTH by targeting parathyroid receptors; treats secondary hyperparathyroidism.
Formula:C₁₁H₁₅Cl₂N₃O₆S
Purity:98.56%
Color and Shape:Soild
Molecular weight:388.22
Ref: TM-T29067L
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SB-408124
CAS:
- 288150-92-5
SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x more selective than OX2.
Formula:C₁₉H₁₈F₂N₄O
Purity:99.81%
Color and Shape:Solid
Molecular weight:356.37
Ref: TM-T6658
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9-deoxy-9-methylene Prostaglandin E2
CAS:
- 61263-32-9
9-deoxy-9-methylene PGE2: stable PGE2 analog with similar effects, less side effects, equal potency in rats, gerbils, primates.
Formula:C₂₁H₃₄O₄
Color and Shape:Solid
Molecular weight:350.499
Ref: TM-T36728
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GLP-1R agonist 20
GLP-1R agonist 20 (Compound I-132) is an agonist of the glucagon-like peptide-1 receptor (GLP-1 receptor), with an EC50 value of 0.0162 nM.
Formula:C₃₁H₃₀Cl₂F₂N₄O₅
Molecular weight:646.15613
Ref: TM-T209770
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Orexin B, rat, mouse
CAS:
- 202801-92-1
Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
Formula:C₁₂₆H₂₁₅N₄₅O₃₄S
Purity:98%
Color and Shape:Solid
Molecular weight:2936.45
Ref: TM-TP1045
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[Sar9] Substance P
CAS:
- 77128-75-7
[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.
Formula:C₆₄H₁₀₀N₁₈O₁₃S
Purity:98%
Color and Shape:Solid
Molecular weight:1361.66
Ref: TM-TP1862
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Bradykinin (1-6)
CAS:
- 23815-88-5
Bradykinin (1-6) is a stable, CPY-cleaved metabolite that triggers pain, induces muscle contractions, and activates NO synthetase.
Formula:C₃₀H₄₅N₉O₈
Purity:98%
Color and Shape:Solid
Molecular weight:659.73
Ref: TM-TP1747
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THX-B
CAS:
- 1372206-64-8
THX-B, a potent non-peptidic p75 NTR antagonist, aids in researching diabetic kidney disease and neurodegenerative and inflammatory disorders.
Formula:C₁₆H₂₄N₆O₄
Color and Shape:Solid
Molecular weight:364.4
Ref: TM-T74097
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Substance P (1-9)
CAS:
- 57468-17-4
Substance P (1-9), a nonapeptide, slows its own inactivation and stimulates neurons.
Formula:C₅₂H₇₇N₁₅O₁₂
Purity:98%
Color and Shape:Solid
Molecular weight:1104.26
Ref: TM-TP1819
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Albiglutide fragment TFA
Albiglutide fragment (GLP-1 (7-36) analog) TFA represents a biologically active segment of Albiglutide, resistant to DPP-4 degradation due to its structure as a
Formula:C₁₄₈H₂₂₄N₄₀O₄₅·xC₂HF₃O₂
Color and Shape:Solid
Ref: TM-T78571
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LSN3160440
CAS:
- 2765539-59-9
LSN3160440 is a GLP-1R allosteric modulator and PPI stabilizer aiding inactive GLP-1 attachment.
Formula:C₂₇H₂₇Cl₂N₃O
Color and Shape:Solid
Molecular weight:480.43
Ref: TM-T75112
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Detomidine carboxylic acid
CAS:
- 115664-39-6
Detomidine carboxylic acid, a urine metabolite of detomidine, is a synthetic α2-agonist, animal analgesic, with cardiac, respiratory, and diuretic effects.
Formula:C₁₂H₁₂N₂O₂
Purity:98%
Color and Shape:Solid
Molecular weight:216.24
Ref: TM-T11010
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MRS2500 tetraammonium
CAS:
- 630103-23-0
Highly potent and selective antagonist of the platelet P2Y1 receptor
Formula:C₁₃H₂₁IN₆O₈P₂
Purity:98%
Color and Shape:Solid
Molecular weight:578.19
Ref: TM-T23023
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Bodilisant
CAS:
- 1416130-06-7
Bodilisant: nanomolar-affinity hH3R ligand, derived from piperidine, with BODIPY fluorophore.
Formula:C₂₇H₃₄BF₂N₃O
Color and Shape:Solid
Molecular weight:465.4
Ref: TM-T25169
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Vicasinabin
CAS:
- 1433361-02-4
Vicasinabin: potent CB2 agonist; researches chronic pain, atherosclerosis, bone mass, neuroinflammation.
Formula:C₁₅H₂₂N₁₀O
Color and Shape:Solid
Molecular weight:358.41
Ref: TM-T38912
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Endolide F
Endolide F (Compound 2) is a proline-containing lactone that serves as a moderate antagonist of the arginine vasopressin V1A receptor.
Formula:C₂₅H₃₂N₄O₆
Molecular weight:484.23218
Ref: TM-TN11172
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GUB03385
GUB03385 is a long-acting PrRP31 analogue and an effective dual agonist for GPR10 (full agonist, EC50: 0.4 nM) and NPFF2R (partial agonist, EC50: 20 nM), with anti-obesity properties.
Formula:C₁₉₈H₃₂₂N₆₀O₅₂S
Molecular weight:4404.41173
Ref: TM-TP3547
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Cagrilintide acetate
.Cagrilintide is a long-acting amylin analog,treat diabetes and obesity by reducing appetite through activation of the AMY3R and calcitonin receptor.
Formula:C₁₉₆H₃₁₆N₅₄O₆₁S₂
Purity:99.88%
Color and Shape:Solid
Molecular weight:4469.06
Ref: TM-T76262L
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Adenosine receptor antagonist 1
CAS:
- 2682930-40-9
A2aR-selective antagonist with IC50 of 0.29 nM; 14x more selective over A2bR.
Formula:C₂₂H₁₅ClFN₇O
Color and Shape:Solid
Molecular weight:447.86
Ref: TM-T40307
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Galanin (1-16), mouse, porcine, rat TFA
Galanin (1-16) agonizes hippocampal receptors; Kd 3 nM. Active on locus coeruleus neurons in mice, pigs, rats.
Formula:C₈₀H₁₁₇F₃N₂₀O₂₃
Purity:98%
Color and Shape:Solid
Molecular weight:1783.9
Ref: TM-TP1317
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15-keto Latanoprost
CAS:
- 135646-98-9
Latanoprost, a PG analog for ocular pressure, metabolizes into 15-keto latanoprost, a less potent variant reducing intraocular pressure and pupil size.
Formula:C₂₆H₃₈O₅
Color and Shape:Solid
Molecular weight:430.58
Ref: TM-T37932
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Neuropeptide Y (13-36), amide, human
CAS:
- 122341-40-6
Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist.
Formula:C₁₃₄H₂₀₇N₄₁O₃₆S
Purity:98%
Color and Shape:Solid
Molecular weight:3000.4
Ref: TM-TP1081
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γ-1-Melanocyte Stimulating Hormone (MSH), amide
γ-1-Melanocyte Stimulating Hormone (MSH), amide, a peptide consisting of 11 amino acids, plays a critical role in regulating sodium (Na+) balance and blood
Formula:C₇₂H₉₇N₂₁O₁₄S
Color and Shape:Solid
Molecular weight:1512.9
Ref: TM-T75971
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ARC 239 dihydrochloride
CAS:
- 55974-42-0
ARC 239 dihydrochloride is a selective α2B adrenoceptor antagonist (pKD values are 8.8, 6.7 and 6.4 at α2B, α2A, and α2D receptors respectively).
Formula:C₂₄H₃₁Cl₂N₃O₃
Purity:99.72%
Color and Shape:Solid
Molecular weight:480.43
Ref: TM-T22033
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S1R agonist 1
CAS:
- 193354-70-0
Compound 6b: Selective S1R agonist, K i = 0.93 nM (S1R), 72 nM (S2R); neuroprotective against ROS, NMDA toxicity.
Formula:C₂₀H₂₅NO
Color and Shape:Solid
Molecular weight:295.42
Ref: TM-T74822
+ Info
FXR/TGR5 agonist 1
CAS:
- 2677689-72-2
FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.
Formula:C₃₁H₃₂ClN₃O₃
Color and Shape:Solid
Molecular weight:530.07
Ref: TM-T40302
+ Info
1-39-Corticotropin (human)(TFA)
ACTH (1-39) human (TFA) is a melanocortin agonist that boosts adrenal CS production and affects the CNS and immune system.
Formula:C₂₀₇H₃₀₈N₅₆O₅₈S·C₂HF₃O₂
Purity:98%
Color and Shape:Solid
Molecular weight:4655.16
Ref: TM-TP1242
+ Info
Donetidine
CAS:
- 99248-32-5
Donetidine is a histamine H2 receptor antagonist used to treat digestive disorders.
Formula:C₂₀H₂₅N₅O₃S
Purity:99.32%
Color and Shape:Solid
Molecular weight:415.51
Ref: TM-T68056
+ Info
Cortistatin 14, human, rat
CAS:
- 193829-96-8
Cortistatin 14: a neuropeptide similar to somatostatin; induces sleep, depresses neuronal activity; found in cortex, hippocampus.
Formula:C₈₁H₁₁₃N₁₉O₁₉S₂
Purity:98%
Color and Shape:Solid
Molecular weight:1721.01
Ref: TM-TP1188
+ Info
BMS-604992 free base
CAS:
- 760944-56-7
BMS-604992 (EX-1314), a selective GHSR agonist, binds strongly (ki=2.3 nM), is orally active, and increases rodent food intake.
Formula:C₂₄H₃₁N₇O₅
Color and Shape:Solid
Molecular weight:497.556
Ref: TM-T40876
+ Info
Peptide C105Y TFA
Peptide C105Y TFA is a cell-penetrating peptide synthesized based on the amino acid sequence of residues 359-374 of α1-antitrypsin. It enhances the gene expression of DNA nanoparticles.
Formula:C₉₇H₁₄₈N₂₀O₂₃S·xC₂HF₃O₂
Ref: TM-TP3340
+ Info
Relaxin H3 (human) TFA
Relaxin H3 (human) (TFA) is a relaxin peptide that exerts antifibrotic effects through the RXFP1 receptor.
Formula:C₂₃₇H₃₇₄N₇₀O₆₉S₆·xC₂HF₃O₂
Ref: TM-TP3503
+ Info
palm11-PrRP31
Palm11-PrRP31 is a lipid-modified analog of the endogenous appetite-suppressing neuropeptide (PrRP). It functions as a potent dual agonist for GPR10 (EC50 = 39 pM) and NPFF-R2. By mimicking the natural activity of PrRP, palm11-PrRP31 binds to these receptors to reduce food intake. It has potential applications as an anti-obesity agent and is useful in studying neuropeptide and receptor interactions.
Formula:C₁₈₁H₂₈₉N₅₅O₄₆S
Molecular weight:4001.16865
Ref: TM-TP3581
+ Info
13,14-dihydro Prostaglandin F2α
CAS:
- 27376-74-5
13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain.
Formula:C₂₀H₃₆O₅
Color and Shape:Solid
Molecular weight:356.503
Ref: TM-T36146
+ Info
A2A/A3 AR antagonist-1
A2A/A3 AR antagonist-1 is a dual fluorescent AR ligand with K i of 90 nM (hA2A) & 31.8 nM (hA3).
Formula:C₅₆H₇₁N₁₅O₁₂S₂
Color and Shape:Solid
Molecular weight:1210.39
Ref: TM-T74606
+ Info
L-796,778 acetate
L-796,778 acetate is a slective somatostatin receptor agonist with IC50 of 24nM for sst3, for sst1, sst2, sst4 and sst5, IC50 is >1000nM.
Formula:C₃₁H₄₄N₆O₉
Purity:98%
Color and Shape:Soild
Molecular weight:644.72
Ref: TM-T32511L
+ Info
Satavaptan
CAS:
- 185913-78-4
Satavaptan is a vasopressin V2 receptor antagonist. Satavaptan improves the control of ascites in cirrhosis.
Formula:C₃₃H₄₅N₃O₈S
Color and Shape:Solid
Molecular weight:643.79
Ref: TM-T28664
+ Info
CB2R/FAAH modulator-3
CAS:
- 2876918-67-9
CB2R/FAAH modulator-3 (compound 27) is a modulator targeting at CB2R and FAAH.
Formula:C₂₂H₃₁NO₂
Purity:99.81%
Color and Shape:Soild
Molecular weight:341.49
Ref: TM-T67747
+ Info
VVZ-149
VVZ-149 is an antagonist of both serotonin receptor 2A (5HT2A) and glycine transporter type 2 (GlyT2), with potential anti-nociceptive activity.
Color and Shape:Solid
Ref: TM-T35087
+ Info
GLP-1R/GIPR agonist-1
GLP-1R/GIPR agonist-1 is a dual receptor agonist for GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). It mimics the action of endogenous hormones GLP-1 and GIP, enhancing insulin secretion while suppressing glucagon release, thus lowering blood sugar. This compound is used in research related to metabolic disorders such as diabetes, obesity, and non-alcoholic steatohepatitis (NASH).
Formula:C₂₂₀H₃₄₂N₅₅O₆₉
Molecular weight:4858.49434
Ref: TM-TP3568
+ Info
α-Helical CRF(9-41)
CAS:
- 90880-23-2
Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).
Formula:C₁₆₆H₂₇₄N₄₆O₅₃S₂
Purity:98%
Color and Shape:Solid
Molecular weight:3827
Ref: TM-TP2048
+ Info
15(S)-HpEPE
CAS:
- 125992-60-1
15(S)-HpEPE, a monohydroperoxy fatty acid, forms when 15-lipoxygenase acts on EPA, with expected biological activities akin to 15(S)-HpETE.
Formula:C₂₀H₃₀O₄
Color and Shape:Solid
Molecular weight:334.456
Ref: TM-T37402
+ Info
Oxyntomodulin
CAS:
- 62340-29-8
GLP-1 analog modulates appetite, boosts metabolism, and curbs gastric acid. Increases cAMP, mildly stimulates glucagon receptor.
Formula:C₁₉₂H₂₉₅N₅₉O₆₀S
Purity:98%
Color and Shape:Solid
Molecular weight:4421.86
Ref: TM-TP1976
+ Info
PEN (rat)
CAS:
- 569364-13-2
PEN (rat) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.
Formula:C₁₀₂H₁₆₉N₂₇O₃₃
Purity:98%
Color and Shape:Solid
Molecular weight:2301.62
Ref: TM-TP1951
+ Info
Cortistatin-14 acetate
Cortistatin-14 acetate, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5).
Formula:C₈₃H₁₁₈N₂₀O₂₀S₂
Purity:98.24% - 99.63%
Color and Shape:Soild
Molecular weight:1780.08
Ref: TM-TP1570L
+ Info
ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate
CAS:
- 2738381-94-5
ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate is a platelet aggregation inhibitor.
Formula:C₂₂H₁₈N₄O₃
Purity:99.86%
Color and Shape:Solid
Molecular weight:386.4
Ref: TM-T9887
+ Info
Metaterol
CAS:
- 3571-71-9
Metaterol is a bioactive chemical.
Formula:C₁₁H₁₇NO₂
Color and Shape:Solid
Molecular weight:195.2582
Ref: TM-T33305
+ Info
20-SOLA
20-SOLA is the first water-soluble 20-HETE antagonist with oral bioavailability. It significantly improves blood pressure changes and kidney damage associated with the streptozotocin (STZ) diabetic mouse model. Additionally, 20-SOLA acts as a GPR75 receptor blocker. This compound is useful in research related to cardiovascular pathology.
Formula:C₃₃H₆₂O₉
Molecular weight:602.43938
Ref: TM-T208783
+ Info
SC 31391
CAS:
- 144730-93-8
SC 31391 is a PGE1 analog.
Formula:C₂₄H₃₂O₆
Color and Shape:Solid
Molecular weight:416.51
Ref: TM-T34550
+ Info
cAC 253 acetate
cAC 253 acetate (TP2135 Free base) is an amylin antagonist. cAC 253 acetate inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM.
Formula:C₁₂₈H₂₀₆N₄₂O₄₂S₂
Purity:98.16% - 99.99%
Color and Shape:Soild
Molecular weight:3069.39
Ref: TM-TP2135L
+ Info
Tocrifluor T1117
CAS:
- 1186195-59-4
Fluorescent form of AM 251, CB1 receptor antagonist
Formula:C₅₆H₅₃Cl₂N₇O₅
Purity:98%
Color and Shape:Solid
Molecular weight:974.97
Ref: TM-T23464
+ Info
L-770644
CAS:
- 173901-95-6
L-770644 is an agonist of B3 adrenergic receptor.
Formula:C₃₀H₃₇N₇O₄S
Color and Shape:Solid
Molecular weight:591.72
Ref: TM-T24377
+ Info
ACTH (1-17)
CAS:
- 7266-47-9
ACTH (1-17), a potent MC1 receptor agonist with a Ki of 0.21 nM, is a variant of corticotropin from the pituitary gland.
Formula:C₉₅H₁₄₅N₂₉O₂₃S
Purity:98%
Color and Shape:Solid
Molecular weight:2093.41
Ref: TM-TP1011
+ Info
GIP/GLP-1 dual receptor agonist-1
CAS:
- 2807481-02-1
Compound 4: GIP/GLP-1 agonist for metabolic/fatty liver disease research.
Color and Shape:Solid
Ref: TM-T75150
+ Info
Somatostatin 1-28 acetate
Somatostatin 1-28 acetate circulates in human plasma.
Purity:99.22%
Color and Shape:Soild
Ref: TM-TP2124L
+ Info
MAO-B-IN-3
MAO-B-IN-3 is a reversible, selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 96 nM and demonstrates affinity for the 5-HT6 receptor with a Ki
Formula:C₂₄H₂₅N₃O₂
Purity:98%
Color and Shape:Solid
Molecular weight:387.47
Ref: TM-T78648
+ Info
Pasireotide
CAS:
- 396091-73-9
Pasireotide (SOM 230) is a cyclohexapeptide, mimicking somatostatin with high affinity for sst1/2/3/4/5 receptors (pKi=8.2/9.0/9.1/<7.0/9.9).
Formula:C₅₈H₆₆N₁₀O₉
Purity:98%
Color and Shape:Solid
Molecular weight:1047.21
Ref: TM-T12370
+ Info
MGV354
MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2].
Formula:C₃₅H₃₇N₅O₃
Purity:98%
Color and Shape:Solid
Molecular weight:575.7
Ref: TM-T12888
+ Info
CYM5442 hydrochloride
CAS:
- 1783987-80-3
CYM 5442 HCl: potent, selective S1P1 agonist (EC50 = 1.35 nM), induces MAPK activation & lymphopenia, brain-penetrant.
Formula:C₂₃H₂₈ClN₃O₄
Color and Shape:Solid
Molecular weight:445.94
Ref: TM-T41144
+ Info
BA 1
CAS:
- 183241-31-8
Potent BB1, BB2, and BB3 agonist; IC50: 0.26, 1.55, 2.52 nM. Boosts glucose transport in myocytes, promotes cancer cell growth in vitro.
Formula:C₅₇H₇₆N₁₄O₁₁
Purity:98%
Color and Shape:Solid
Molecular weight:1133.32
Ref: TM-TP1913
+ Info
PSMA/GRPR ligand 1
PSMA/GRPR ligand 1 (compound 3) is a bispecific ligand with dual targeting capabilities for tumors that express PSMA(+) and GRPR(+).
Color and Shape:Odour Solid
Ref: TM-T206782
+ Info
4-Butyl-α-agarofuran
CAS:
- 272126-07-5
4-Butyl-alpha-agarofuran, a Gharu-wood derivative, is an anxiolytic, antidepressant, and aids neurological research.
Formula:C₁₈H₃₀O
Color and Shape:Solid
Molecular weight:262.43
Ref: TM-T75257
+ Info
L-797,591 hydrochloride
L-797,591 HCl activates SSTR1, boosts p-ERK5 with AG1478, and enhances p38 phosphorylation, reversible by AG1478.
Formula:C₃₈H₅₀ClN₅O₂
Purity:98.65% - >99.99%
Color and Shape:Soild
Molecular weight:644.30
Ref: TM-T27787L
+ Info
Antibacterial agent 189
Antibacterialagent 189 (compound 3a) is a potent antibacterial agent with high binding affinity to the target proteins OMPA/exo-1,3-β-glucanase. It demonstrates effective antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Candida albicans, and Aspergillus flavus. Additionally, Antibacterialagent 189 exhibits strong binding affinity to the target proteins SMO and SUFU/GLI-1.
Formula:C₃₇H₂₈N₄O
Molecular weight:544.22631
Ref: TM-T209404
+ Info
Cetirizine Impurity C dihydrochloride
CAS:
- 2702511-37-1
Cetirizine Impurity C dihydrochloride is a Cetirizine metabolite and long-acting H1-antihistamine.
Formula:C₂₁H₂₇Cl₃N₂O₃
Color and Shape:Solid
Molecular weight:461.81
Ref: TM-T73962
+ Info
Galanin (1-29)(rat, mouse)
CAS:
- 114547-31-8
Non-selective galanin agonist; Ki: GAL1-0.98, GAL2-1.48, GAL3-1.47 nM. Anticonvulsant, stops full seizures in rats.
Formula:C₁₄₁H₂₁₁N₄₃O₄₁
Purity:98%
Color and Shape:White Lyophilized Powder
Molecular weight:3164.499
Ref: TM-TP2028
+ Info
[Pro34]Neuropeptide Y, porcine
CAS:
- 128768-54-7
[Pro34]Neuropeptide Y, porcine functions as a selective agonist for the NPY (Y1) receptor and induces vasoconstriction in the guinea pig's caval vein [1].
Formula:C₁₉₀H₂₈₆N₅₄O₅₆
Color and Shape:Solid
Molecular weight:4222.63
Ref: TM-TP2523
+ Info
Cholic Acid 7-sulfate
CAS:
- 60320-05-0
Cholic acid 7-sulfate: a cholic acid metabolite with added sulfate at position 7, increased in feces of male mice with specific diets.
Formula:C₂₄H₄₀O₈S
Color and Shape:Solid
Molecular weight:488.64
Ref: TM-T37854
+ Info
Antipsychotic agent-2
Compound 11: potent antipsychotic, binds 5-HT1A/2A/2C, D2, H1 receptors; K is 56.6-1140 nM, BBB permeable.
Formula:C₂₂H₂₆FN₅O
Color and Shape:Solid
Molecular weight:395.47
Ref: TM-T74798
+ Info
FR252384
CAS:
- 447405-11-0
FR252384 is an antagonist of the neuropeptide Y-Y5 receptor (IC50: 2.3 nM).
Formula:C₁₈H₁₇N₃
Purity:98%
Color and Shape:Solid
Molecular weight:275.35
Ref: TM-T10514
+ Info
Xenopus orexin B
CAS:
- 254757-78-3
Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].
Formula:C₁₃₀H₂₁₉N₄₅O₄₀S₂
Color and Shape:Solid
Molecular weight:3116.54
Ref: TM-TP2641
+ Info
ONO-8711
CAS:
- 216158-34-8
ONO-8711 is a potent and selective competitive antagonist of EP1 receptor with Kis of 0.6 nM and 1.7 nM for human and mouse EP1, respectively.
Formula:C₂₂H₃₀ClNO₄S
Color and Shape:Solid
Molecular weight:440
Ref: TM-T22125
+ Info
Danshenol B
Danshenol B is a natural product that can be used as a reference standard.
Formula:C₂₂H₂₆O₄
Color and Shape:Solid
Molecular weight:354.446
Ref: TM-T125490
+ Info
GLP-1R agonist 15
CAS:
- 2763621-11-8
GLP-1R agonist 15 (Compound 101) is a GLP-1 receptor agonist [1] .
Formula:C₄₆H₄₇FN₈O₇S
Color and Shape:Solid
Molecular weight:874.98
Ref: TM-T74609
+ Info
GLP-1R agonist 29
GLP-1R agonist 29 (Compound 20) is a GLP-1R agonist that induces hGLP-1R-mediated cAMP stimulation with an EC50 of 0.018 nM. It exhibits favorable pharmacokinetic properties and shows good in vivo exposure, with an AUC0-∞,sc of 77688 ng·h/mL.
Color and Shape:Odour Solid
Ref: TM-T206400
+ Info
GLI1-IN-3
GLI1-IN-3 (Compound 11a) is a triterpenoid-like compound that inhibits Hedgehog signaling in cancer cells with GLI1 overexpression. It suppresses the proliferation of non-small cell lung cancer and prostate cancer cell lines with excessive Hh signaling activation. Additionally, GLI1-IN-3 reduces the expression of GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells.
Color and Shape:Odour Solid
Ref: TM-T206757
+ Info
Pentagastrin meglumine
CAS:
- 57448-84-7
Pentagastrin meglumine is a synthetic pentapeptide that has effects like gastrin when given parenterally.
Formula:C₄₄H₆₆N₈O₁₄S
Color and Shape:Solid
Molecular weight:963.11
Ref: TM-T33916
+ Info
Urocortin II, human TFA
hUcn II, a CRF family member, targets CRF2 receptor, has time-linked stress regulation effects, showing mild motor suppression and delayed anxiolytic action.
Formula:C₁₉₆H₃₄₀F₃N₆₃O₅₆S
Purity:98%
Color and Shape:Solid
Molecular weight:4564.3
Ref: TM-TP1557
+ Info
α-Bulnesene
CAS:
- 3691-11-0
α-Bulnesene, a novel PAF (platelet-activating factor) receptor antagonist, exhibits an IC50 of 17.62 μM. It can be isolated from patchouli. α-Bulnesene inhibits both PAF and arachidonic acid-induced aggregation of rabbit platelets.
Formula:C₁₅H₂₄
Color and Shape:Solid
Molecular weight:204.35
Ref: TM-TN8025
+ Info
Roxatidine
CAS:
- 78273-80-0
Roxatidine, a metabolite of Roxatidine acetate, is a H2-receptor antagonist that prevents ulcers and has anti-inflammatory properties.
Formula:C₁₇H₂₆N₂O₃
Color and Shape:Solid
Molecular weight:306.4
Ref: TM-T74118
+ Info
Cetirizine methyl ester
CAS:
- 83881-46-3
Cetirizine methyl ester is a Cetirizine impurity, a long-acting, oral H1-antihistamine and hydroxyzine metabolite.
Formula:C₂₂H₂₇ClN₂O₃
Color and Shape:Solid
Molecular weight:402.91
Ref: TM-T73933
+ Info
PAR 4 (1-6) (TFA)
PAR 4 (1-6) TFA (GYPGQV TFA), a hexapeptide derived from protease-activated receptor 4 (PAR 4), serves as a specific agonist for PAR 4.
Formula:C₂₈H₄₁N₇O₉·xC₂HF₃O₂
Color and Shape:Solid
Ref: TM-T75904
+ Info
RWJ 676070
CAS:
- 813426-25-4
RWJ 676070 is an antagonist of vasopressin V1A/V2 receptor.
Formula:C₃₀H₂₆ClFN₂O₅
Color and Shape:Solid
Molecular weight:548.99
Ref: TM-T28629
+ Info
Ontazolast
CAS:
- 147432-77-7
Ontazolast: a small-molecule LTB4R antagonist targeting asthma and immune disorders.
Formula:C₂₁H₂₅N₃O
Purity:99.79%
Color and Shape:Soild
Molecular weight:335.44
Ref: TM-T68119
+ Info
FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS is an Exendin-4 peptide derivative.
Color and Shape:Solid
Molecular weight:3692.15
Ref: TM-T75859
+ Info
P4pal10 TFA
P4pal10 TFA, the TFA salt form of P4pal10, serves as an antagonist of the protease-activated receptor 4 (PAR4). This compound inhibits platelet aggregation and thrombin generation induced by tissue factor (TF), exhibiting anticoagulant and antithrombotic activities. Additionally, P4pal10 TFA alleviates carrageenan-induced edema and neutrophil infiltration, and ameliorates damage in rat myocardial ischemia/reperfusion (I/R) models.
Color and Shape:Odour Solid
Ref: TM-TP2784
+ Info
TGR5 agonist 2
TGR5 agonist 2 (compound 19) serves as a highly potent agonist of TGR5, demonstrating an EC50 value of 0.27 µM [1].
Formula:C₂₉H₅₀NNaO₆S
Color and Shape:Solid
Molecular weight:563.77
Ref: TM-T74825
+ Info
HAEGT
CAS:
- 852155-81-8
HAEGT is the first N-terminal 1-5 residues of GLP-1 peptide.
Formula:C₂₀H₃₁N₇O₉
Purity:98%
Color and Shape:Solid
Molecular weight:513.5
Ref: TM-TP1381
+ Info
Clomipramine D3
CAS:
- 136765-29-2
Clomipramine D3 is deuterium-labeled Clomipramine, blocking serotonin, norepinephrine, dopamine transporters (Ki: 0.14, 54, 3 nM).
Formula:C₁₉H₂₃ClN₂
Purity:98%
Color and Shape:Solid
Molecular weight:317.87
Ref: TM-T10842
+ Info
α1A-AR Degrader 9c
CAS:
- 2863635-02-1
α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM.
Formula:C₃₈H₄₃N₁₁O₁₁
Purity:98%
Color and Shape:Solid
Molecular weight:829.82
Ref: TM-T74557
+ Info
Cetirizine Impurity D
CAS:
- 346451-15-8
Cetirizine Impurity D, an antihistamine derivative, acts as a long-lasting H1-receptor antagonist with antiallergic effects.
Formula:C₃₀H₂₈Cl₂N₂
Color and Shape:Solid
Molecular weight:487.46
Ref: TM-T40430
+ Info
13,14-dihydro-15-keto Prostaglandin F1α
CAS:
- 29044-75-5
13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been reported in the rat stomach.
Formula:C₂₀H₃₆O₅
Color and Shape:Solid
Molecular weight:356.5
Ref: TM-T36148
+ Info
CB2R probe 1
CAS:
- 2634714-79-5
CB2R Probe 1, a cannabinoid 2 receptor (CB2R) fluorescent probe, exhibits both safety and environmental friendliness, boasting a dissociation constant (K i) of
Formula:C₃₆H₄₂N₄O₄
Color and Shape:Solid
Molecular weight:594.74
Ref: TM-T74604
+ Info
Benzomalvin B
CAS:
- 157047-97-7
Benzomalvin B, a metabolite from Penicillium, blocks 24% NK1 receptor binding at 100 μg/ml.
Formula:C₂₄H₁₇N₃O₂
Color and Shape:Solid
Molecular weight:379.419
Ref: TM-T38033
+ Info
LAS190792
CAS:
- 1347232-69-2
LAS190792 (AZD8999) is a dual muscarinic antagonist/β2-agonist, pIC50s (M1-M5, β1-β3): 8.9-5.6; used as a bronchodilator.
Formula:C₃₉H₄₃ClN₄O₉S₂
Color and Shape:Solid
Molecular weight:811.36
Ref: TM-T74709
+ Info
MrgprX2 antagonist-5
CAS:
- 2527815-74-1
MrgprX2 antagonist-5 from patent WO2020223255A1 inhibits MrgprX2, useful for inflammatory skin disorder studies.
Formula:C₁₉H₁₃ClF₂N₄O₂S
Color and Shape:Solid
Molecular weight:434.85
Ref: TM-T40176
+ Info
Septide
CAS:
- 79775-19-2
Septide is an NK1 receptor agonist acting at a site distinct from substance P.
Formula:C₃₉H₅₃N₇O₇S
Purity:98%
Color and Shape:Solid
Molecular weight:763.95
Ref: TM-TP2352
+ Info
SR 142948 dihydrochloride
SR 142948 dihydrochloride is a selective oral non-peptide NT antagonist, IC50 <4 nM, with brain penetration and potential for psychiatric research.
Formula:C₃₉H₅₃Cl₂N₅O₆
Color and Shape:Solid
Molecular weight:758.77
Ref: TM-T73677
+ Info
Prolactin Releasing Peptide (1-31), human
CAS:
- 215510-22-8
Human Prolactin Releasing Peptide (1-31) is a potent GPR10 agonist; Ki values are 1.03 nM (human) and 0.33 nM (rat).
Formula:C₁₆₀H₂₅₂N₅₆O₄₂S
Purity:98%
Color and Shape:Solid
Molecular weight:3664.15
Ref: TM-TP1769
+ Info
Tafluprost acid
CAS:
- 209860-88-8
Tafluprost acid is a selective agonist at the prostaglandin F receptor.
Formula:C₂₂H₂₈F₂O₅
Color and Shape:Solid
Molecular weight:410.46
Ref: TM-T20142
+ Info
GI-560192
CAS:
- 301326-41-0
GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.
Formula:C₂₀H₁₆N₂O₂
Purity:99.53%
Color and Shape:Soild
Molecular weight:316.35
Ref: TM-T64351
+ Info
Spantide acetate
Spantide acetate is a selective antagonist of NK1 receptor with Kis of 230 nM and 8150 nM for NK1 and NK2.
Formula:C₇₇H₁₁₂N₂₀O₁₅
Purity:98.9200%
Color and Shape:Solid
Molecular weight:1557.84
Ref: TM-T20413L
+ Info
BQ-123 TFA
BQ-123 TFA: Potent ETA antagonist, IC50 = 7.3 nM, Ki = 25 nM, inhibits ET-1 cell proliferation, lowers rat BP.
Formula:C₃₃H₄₃F₃N₆O₉
Color and Shape:Solid
Molecular weight:724.72
Ref: TM-T73877
+ Info
DSP-1053
CAS:
- 1176326-76-3
Dsp-1053 is a powerful SERT (Ki=1.02 nM) inhibitor with partial 5-HT1A receptor (Ki=5.05 nM) agonizing activity.
Formula:C₂₆H₃₂BrNO₄
Purity:98%
Color and Shape:Solid
Molecular weight:502.44
Ref: TM-T11107
+ Info
PSB 0777 ammonium salt
CAS:
- 2122196-16-9
adenosine A2A receptor full agonist
Formula:C₁₈H₂₄N₆O₇S₂
Purity:98%
Color and Shape:Solid
Molecular weight:500.55
Ref: TM-T23196
+ Info
5-HT7R antagonist 1 free base
CAS:
- 2337008-64-5
5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.
Formula:C₁₄H₁₇ClN₄
Color and Shape:Solid
Molecular weight:276.77
Ref: TM-T39870
+ Info
Brexpiprazole S-oxide D8
CAS:
- 2748605-29-8
Brexpiprazole S-oxide D8 (DM-3411 D8) is a deuterium-labeled metabolite of Brexpiprazole, a partial agonist at 5-HT1A and dopamine receptors.
Formula:C₂₅H₁₉D₈N₃O₃S
Purity:98%
Color and Shape:Solid
Molecular weight:457.61
Ref: TM-T10611
+ Info
PHM-27 (human)
CAS:
- 87403-73-4
Human-derived peptide, VIP/PHM 27 analog, boosts insulin by targeting calcitonin receptor with an EC50 of 11 nM.
Formula:C₁₃₅H₂₁₄N₃₄O₄₀S
Purity:98%
Color and Shape:Solid
Molecular weight:2985.44
Ref: TM-TP1954
+ Info
Hemopressin (human, mouse)
CAS:
- 1314035-51-2
Endogenous peptide, inhibits ep24.15/24.16/ACE with Ki of 27.76/3.43/1.87 μM. Lowers blood pressure, CB1 inverse agonist, reduces pain in vivo.
Formula:C₅₀H₇₉N₁₃O₁₂
Purity:98%
Color and Shape:Solid
Molecular weight:1054.26
Ref: TM-TP1900
+ Info
(S)-V-0219 hydrochloride
(S)-V-0219 hydrochloride, a GLP-1R PAM, triggers calcium in hGLP-1R HEK cells, lowers glucose in mice, and reduces fasting hunger.
Formula:C₂₀H₂₆ClF₃N₄O₂
Color and Shape:Solid
Molecular weight:446.89
Ref: TM-T74265
+ Info
Lys-[Des-Arg9]Bradykinin
CAS:
- 71800-36-7
Selective bradykinin B1 agonist with Ki 0.12 nM; inactive at B2 (>30,000 nM). Lowers blood pressure, more potent than Des-Arg9-Bradykinin.
Formula:C₅₀H₇₃N₁₃O₁₁
Purity:98%
Color and Shape:Solid
Molecular weight:1032.21
Ref: TM-TP1918
+ Info
Isobutyryl-L-carnitine
CAS:
- 25518-49-4
Isobutyryl-L-carnitine is a member of the class of compounds known as acylcarnitines. Isobutyryl-L-carnitine is a product of the acyl-CoA dehydrogenases.
Formula:C₁₁H₂₁NO₄
Purity:98%
Color and Shape:Solid
Molecular weight:231.29
Ref: TM-T19381
+ Info
GLP-1 (9-36) amide
CAS:
- 161748-29-4
GLP-1 (9-36) amide is an antagonist at the human GLP-1 receptor.
Formula:C₁₄₀H₂₁₄N₃₆O₄₃
Purity:97%
Color and Shape:Solid
Molecular weight:3089.41
Ref: TM-TP2252
+ Info
GLP-1(7-37)
CAS:
- 106612-94-6
GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells.
Formula:C₁₅₁H₂₂₈N₄₀O₄₇
Purity:98%
Color and Shape:Solid
Molecular weight:3355.67
Ref: TM-TP1306
+ Info
YM 09538
CAS:
- 70958-86-0
YM 09538 is a biochemical.
Formula:C₁₈H₂₅ClN₂O₅S
Color and Shape:Solid
Molecular weight:416.92
Ref: TM-T35252
+ Info
Dolcanatide
CAS:
- 1092457-65-2
Dolcanatide: oral GC-C agonist with laxative, pain-relief, and anti-inflammatory properties for IBD research.
Formula:C₆₅H₁₀₄N₁₈O₂₆S₄
Color and Shape:Solid
Molecular weight:1681.89
Ref: TM-T76274
+ Info
PACAP-Related Peptide (PRP), human
PRP, human: 29-amino-acid PACAP precursor segment, synthesized for biological/structural research.
Formula:C₁₃₉H₂₂₉N₄₁O₄₂
Purity:98%
Color and Shape:Solid
Molecular weight:3146.57
Ref: TM-TP1850
+ Info
Glucagon-like peptide 1 (1-37), human TFA
Human Glucagon-like peptide 1 (1-37) TFA is a potent GLP-1 receptor agonist derived from proglucagon.
Formula:C₁₈₈H₂₇₆N₅₁F₃O₆₁
Purity:98%
Color and Shape:Solid
Molecular weight:4283.5
Ref: TM-TP1147
+ Info
Neuromedin N
CAS:
- 92169-45-4
Neuromedin N is a neuropeptide derived from the same precursor polypeptide as neurotensin, and with similar but subtly distinct expression and effects.
Formula:C₃₈H₆₃N₇O₈
Purity:98%
Color and Shape:Solid
Molecular weight:745.95
Ref: TM-TP1085
+ Info
Levocarnitine propionate hydrochloride
CAS:
- 119793-66-7
Levocarnitine propionate hydrochloride (ST-261) is used for the treatment of the deterioration of renal function, congestive heart failure, and other diseases.
Formula:C₁₀H₂₀ClNO₄
Purity:90% - 99.77%
Color and Shape:Solid
Molecular weight:253.72
Ref: TM-T1182
+ Info
PD 142893
CAS:
- 143037-36-9
PD 142893 is a functional endothelin-stimulated vasoconstriction antagonist.
Formula:C₅₀H₆₅N₇O₁₀
Purity:98%
Color and Shape:Solid
Molecular weight:924.09
Ref: TM-T25922
+ Info
Hemopressin(rat)
CAS:
- 568588-77-2
Peptide inhibitor for ep24.15, neurolysin & ACE with Ki 27.76, 3.43, 1.87 μM. Lowers blood pressure, modulates CB1 receptor, reduces pain & food intake.
Formula:C₅₃H₇₇N₁₃O₁₂
Purity:98%
Color and Shape:Solid
Molecular weight:1088.27
Ref: TM-TP1901
+ Info
Antidepressant agent 4
Antidepressant agent 4: orally active, has antidepressant, anxiolytic, and nootropic effects.
Formula:C₁₉H₃₈ClN₅O₂S
Color and Shape:Solid
Molecular weight:436.06
Ref: TM-T75003
+ Info
GPR183 antagonist-3
GPR183 antagonist-3 (compound 33) is an orally active GPR183 antagonist with an IC50 value of 8.7 μM. It demonstrates significant in vitro anti-migration and anti-inflammatory activity in monocytes and can alleviate pathological symptoms in experimental colitis induced by dextran sulfate sodium.
Formula:C₂₁H₁₉BrN₄O₂S
Molecular weight:470.04121
Ref: TM-T209316
+ Info
Donitriptan hydrochloride
CAS:
- 170911-68-9
Donitriptan hydrochloride (Donitriptan monohydrochloride) is a potent, high efficacy agonist of 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively
Formula:C₂₃H₂₆ClN₅O₂
Purity:99.8% - 99.86%
Color and Shape:Solid
Molecular weight:439.94
Ref: TM-T21666
+ Info
Guanylin TFA (mouse,rat)
Guanylin (mouse, rat) TFA is a peptide composed of 15 amino acids and acts as an activator of intestinal guanylate cyclase. This compound is utilized in research related to diarrhea.
Formula:C₆₀H₉₀N₁₆O₂₂S₄·xC₂HF₃O₂
Color and Shape:Solid
Molecular weight:1515.71 (free base)
Ref: TM-TP2847
+ Info
PACAP (6-38), human, ovine, rat TFA
PACAP (6-38) is a PACAP receptor blocker with IC50s of 30, 600, 40 nM for type I, VIP1, and VIP2 receptors.
Formula:C₁₈₄H₃₀₁N₅₆FO₄₇S
Purity:98%
Color and Shape:Solid
Molecular weight:4138.76
Ref: TM-TP1438
+ Info
Amitraz
CAS:
- 33089-61-1
Amitraz (NSC 324552): white monoclinic crystals, mp 86-87°C, water-insoluble, used as acaricide and in canine demodectic mange.
Formula:C₁₉H₂₃N₃
Purity:99.88%
Color and Shape:White/Pale Yellow Crystalline Solid
Molecular weight:293.41
Ref: TM-T1632
+ Info
Mosapride citrate dihydrate
CAS:
- 636582-62-2
Mosapride Citrate, a 5-HT4 agonist, boosts gut movement by enhancing acetylcholine release.
Formula:C₂₇H₃₅ClFN₃O₁₁
Purity:98%
Color and Shape:Solid
Molecular weight:632.04
Ref: TM-T6597L
+ Info
KwFwLL-NH2
CAS:
- 942266-38-8
KwFwLL-NH2 is a hexapeptide that serves as a ligand for the ghrelin receptor (ghrelin receptor). This compound acts as a specific inverse agonist for the ghrelin receptor, exhibiting moderate potency (EC50=45.6 nM).
Formula:C₄₉H₆₆N₁₀O₆
Color and Shape:Solid
Molecular weight:891.11
Ref: TM-TP2863
+ Info
Adrenomedullin (1-50), rat
CAS:
- 159964-38-2
Rat adrenomedullin (1-50) is a 50-AA peptide; induces arterial vasodilation by activating CGRP1 receptors.
Formula:C₂₄₈H₃₈₁N₇₇O₇₅S₅
Purity:98%
Color and Shape:Solid
Molecular weight:5729.5
Ref: TM-TP1764
+ Info
β-CGRP (mouse)
β-CGRP (mouse), a calcitonin gene-related peptide, induces vasodilation and is applicable in research areas including cardiovascular, pro-inflammatory, migraine, and metabolic studies.
Formula:C₁₆₅H₂₆₅N₄₉O₅₅S₂
Color and Shape:Solid
Molecular weight:3879.29
Ref: TM-TP2859
+ Info
SGLT1/2-IN-2
CAS:
- 2387812-73-7
SGLT1/2-IN-2 is a chemical compound with robust dual inhibitory properties, exhibiting potent activities against SGLT1 (IC50 = 96 nM) and SGLT2 (IC50 = 1.3 nM).
Formula:C₂₃H₂₆F₂O₇
Color and Shape:Solid
Molecular weight:452.451
Ref: TM-T39966
+ Info
Adenosine receptor agonist 1
Compound 6m, an A3 adenosine receptor (AR) partial agonist, exhibits a K i value of 6.7 nM as an adenosine receptor agonist.
Formula:C₁₂H₁₄ClN₅O₂Se
Color and Shape:Solid
Molecular weight:374.68
Ref: TM-T89890
+ Info
Y1 receptor antagonist 1 formic
H 409-22 isomer formic, a formate salt of Y1 receptor antagonist 1, is an antagonist of the neuropeptide Y1 receptor (neuropeptide Y1 receptor). This compound effectively blocks the actions of the receptor, playing a crucial role in modulating physiological responses.
Formula:C₂₉H₃₅N₅O₅
Color and Shape:Solid
Molecular weight:533.62
Ref: TM-T200259
+ Info
NSC380324
NSC380324 is a P2Y12 receptor antagonist with antiplatelet properties, which can be employed in research on atherosclerotic cardiovascular diseases.
Formula:C₃₁H₂₄N₄O₄
Color and Shape:Solid
Molecular weight:516.55
Ref: TM-T205528
+ Info
Neuropeptide Y (22-36)
CAS:
- 119019-65-7
Neuropeptide Y (22-36) is a 15-amino acid fragment of NPY, which is abundant in the mammalian brain and involved in multiple physiological functions.
Formula:C₈₅H₁₃₉N₂₉O₂₁
Purity:98%
Color and Shape:Solid
Molecular weight:1903.19
Ref: TM-TP1681
+ Info
Motilin, canine
CAS:
- 85490-53-5
Motilin canine, a 22-amino acid peptide, functions as a robust gastrointestinal smooth muscle contraction agonist.
Formula:C₁₂₀H₁₉₄N₃₆O₃₄
Purity:98%
Color and Shape:Solid
Molecular weight:2685.05
Ref: TM-TP1098
+ Info
[18F]-Labeled L-dopa precursor
CAS:
- 1614253-58-5
[18F]-Labeled L-dopa precursor is a precursor for synthesis of 18F-labeled L-dopa[1].
Formula:C₃₅H₃₆N₂O₇
Color and Shape:Solid
Molecular weight:596.67
Ref: TM-T74180
+ Info
des-Gln14-Ghrelin
CAS:
- 293735-04-3
Endogenous rat ghrelin gene variant binds GHS-R1a; strong Ca2+ release (EC50=2.4 nM); boosts GH secretion in vivo.
Formula:C₁₄₂H₂₃₇N₄₃O₄₀
Purity:98%
Color and Shape:Solid
Molecular weight:3186.7
Ref: TM-TP2032
+ Info
2-Furoyl-LIGRLO-amide
CAS:
- 729589-58-6
2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.
Formula:C₃₆H₆₃N₁₁O₈
Purity:98%
Color and Shape:Solid
Molecular weight:777.95
Ref: TM-TP1478
+ Info
Senktide TFA
Senktide TFA is a potent and selective neurokinin 3 (NK3) receptor agonist with an EC50 of 0.5-3 nM, while showing significantly weaker activity on NK1 receptors (EC50=35 µM). It is a promising candidate for research in neurological disorders.
Color and Shape:Odour Solid
Ref: TM-T206656
+ Info
Bamosiran
CAS:
- 1337968-84-9
Bamosiran, a small interfering RNA (siRNA), specifically targets the β-adrenergic receptor 2 to reduce intraocular pressure.
Color and Shape:Solid
Ref: TM-T75155
+ Info
(R)-Preclamol hydrochloride
CAS:
- 89874-80-6
(R)-Preclamol HCl is a dopamine agonist stimulating both auto and postsynaptic receptors.
Formula:C₁₄H₂₂ClNO
Color and Shape:Solid
Molecular weight:255.78
Ref: TM-T73685
+ Info
Alosetron-d3
CAS:
- 1190043-13-0
Alosetron D3 (GR 68755 D3) is a deuterium-labeled Alosetron. Alosetron is an antagonist of 5HT3-receptor.
Formula:C₁₇H₁₈N₄O
Purity:98%
Color and Shape:Solid
Molecular weight:297.37
Ref: TM-T19191
+ Info
Neuropeptide Y(29-64)
CAS:
- 303052-45-1
Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.
Formula:C₁₈₉H₂₈₄N₅₄O₅₈S
Purity:98%
Color and Shape:Solid
Molecular weight:4272.7
Ref: TM-TP1818
+ Info
Phoenixin-14 TFA
Phoenixin-14 TFA (PNX-14 TFA) is an endogenous neuropeptide that can modulate GnRH receptor expression and exerts anxiolytic effects.
Formula:C₇₅H₁₁₀N₁₈O₂₀·xC₂HF₃O₂
Purity:99.11%
Color and Shape:Solid
Molecular weight:1583.78 (free base)
Ref: TM-T81485
+ Info
Thioperamide maleate
CAS:
- 148440-81-7
Thioperamide maleate (MR-12842 maleate) is an effective and selective antagonist of H3 receptor (Ki = 4.3 nM) for inhibition of [3H]histamine synthesis (Ki = 31
Formula:C₁₉H₂₈N₄O₄S
Purity:98.48%
Color and Shape:Solid
Molecular weight:408.52
Ref: TM-T41247
+ Info
19(R)-hydroxy Prostaglandin E1
CAS:
- 64625-55-4
19(R)-hydroxy Prostaglandin E1 is an agonist of EP1 and EP3 receptor subtypes and exhibits contractile activity on smooth muscle and is the major prostaglandin
Formula:C₂₀H₃₄O₆
Color and Shape:Solid
Molecular weight:370.486
Ref: TM-T37778
+ Info
Semaglutide TFA
Semaglutide TFA is a glucagon-like peptide-1 congener that induces weight loss, lowers blood glucose levels and reduces cardiovascular risk in diabetic patients
Formula:C₁₈₉H₂₉₀F₃N₄₅O₆₁
Purity:99.69%
Color and Shape:Solid
Molecular weight:4225.6482
Ref: TM-T12878
+ Info
GLP-1(7-36), amide acetate
CAS:
- 1119517-19-9
GLP-1(7-36), amide acetate is a derivative of GLP-1 peptide , activate the GLP-1 receptor, promote insulin secretion,Type 2 diabetes mellitus and obesity.
Formula:C₁₅₁H₂₃₀N₄₀O₄₇
Purity:99.89%
Color and Shape:Solid
Molecular weight:3357.68
Ref: TM-TP1141
+ Info
SR142948A
CAS:
- 184162-21-8
SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist blocking hypothermia and analgesic effects, NMDA-induced dopamine release.
Formula:C₃₉H₅₂ClN₅O₆
Purity:98%
Color and Shape:Solid
Molecular weight:722.31
Ref: TM-T28845
+ Info
Eloralintide sodium
Eloralintide sodium (LY-3841136 sodium) is an AMYR (amylin receptor) agonist applicable for studying type 2 diabetes and obesity.
Formula:C₂₀₁H₃₁₉N₄₉O₆₅S₂·xNa
Purity:98.66%
Color and Shape:Solid
Molecular weight:4526.1 (free base)
Ref: TM-TP3220
+ Info
S1PR1 modulator 1
CAS:
- 2328109-05-1
S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6.
Formula:C₂₃H₂₄N₂O₃S
Purity:99.69%
Color and Shape:Solid
Molecular weight:408.51
Ref: TM-T12821
+ Info
Pexopiprant
CAS:
- 932708-14-0
Pexopiprant, a potent oral antagonist of the prostaglandin D2 receptor 2 (DP2) with a K i value less than 100nM, is a valuable compound for asthma research.
Formula:C₂₁H₁₇Cl₂F₂NO₄
Color and Shape:Solid
Molecular weight:456.27
Ref: TM-T41073
+ Info
RFRP-3(human)
CAS:
- 311309-27-0
NPFF1 receptor agonist, IC50 0.7 nM, blocks cAMP by forskolin. A GnIH homolog, it inhibits GnRH neuron activity.
Formula:C₄₅H₇₂N₁₄O₁₀
Purity:98%
Color and Shape:Solid
Molecular weight:969.15
Ref: TM-TP1936
+ Info
MM 07
CAS:
- 1876450-21-3
Biased agonist for apelin/G protein pathway, enhances eNOS and cell growth, reduces apoptosis, improves heart function, and dilates vessels.
Formula:C₆₇H₁₀₆N₂₂O₁₄S₃
Purity:98%
Color and Shape:Solid
Molecular weight:1539.9
Ref: TM-TP2000
+ Info
Setmelanotide Acetate(920014-72-8 free base)
CAS:
- 2759937-80-7
Setmelanotide Acetate(920014-72-8 free base) (RM-493 Acetate) is a selective agonist of melanocortin 4 receptor (MC4R)(human and rat MC4R with EC50s of 0.27 nM
Formula:C₅₁H₇₂N₁₈O₁₁S₂
Purity:99.71%
Color and Shape:Solid
Molecular weight:1177.35
Ref: TM-T12882L
+ Info
(S)-Osanetant
CAS:
- 182621-58-5
(S)-Osanetant, an S-enantiomer, is a selective NK3 antagonist with potential for treating schizophrenia and has anxiolytic and antidepressant effects.
Formula:C₃₅H₄₁Cl₂N₃O₂
Color and Shape:Solid
Molecular weight:606.62
Ref: TM-T74413
+ Info
tetranor-PGJM
CAS:
- 1352751-83-7
Tetranor-PGJM is a metabolite of prostaglandin D2 and is associated with the anti-inflammatory effects of curcumin.
Formula:C₁₆H₂₂O₆
Color and Shape:Solid
Molecular weight:310.346
Ref: TM-T38307
+ Info
Antibiotic Sch 60057
CAS:
- 203061-35-2
Antibiotic Sch 60057 is a useful organic compound for research related to life sciences. The catalog number is T125403 and the CAS number is 203061-35-2.
Formula:C₄₅H₈₄O₆
Color and Shape:Solid
Molecular weight:721.161
Ref: TM-T125403
+ Info
[Des-His1,Glu9]-Glucagon amide
CAS:
- 110084-95-2
Glucagon blocker with pA2 of 7.2; no agonist effect. Boosts insulin; prevents glucagon-driven hyperglycemia in rabbits and diabetic rats.
Formula:C₁₄₈H₂₂₁N₄₁O₄₇S
Purity:98%
Color and Shape:Solid
Molecular weight:3358.68
Ref: TM-TP2033
+ Info
5-HT1AR/5-HT6R ligand-1
5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.
Formula:C₂₅H₂₉ClN₄O₂S
Color and Shape:Solid
Molecular weight:485.04
Ref: TM-T205634
+ Info
Mini Gastrin I, human
CAS:
- 54405-27-5
Mini Gastrin I, human, is a truncated form of the human gastrin peptide, encompassing amino acids 5-17 of the original sequence.
Formula:C₇₄H₉₉N₁₅O₂₆S
Purity:98%
Color and Shape:Solid
Molecular weight:1646.73
Ref: TM-TP1821
+ Info
Sarafotoxin S6b
CAS:
- 116303-65-2
non-selective endothelin receptor agonist
Formula:C₁₁₀H₁₆₃N₂₇O₃₄S₅
Purity:98%
Color and Shape:Solid
Molecular weight:2567.96
Ref: TM-TP2290
+ Info
MDL 29913
CAS:
- 135721-56-1
NK2 tachykinin receptor selective antagonist.
Formula:C₄₀H₅₆N₈O₆
Purity:98%
Color and Shape:Solid
Molecular weight:745
Ref: TM-TP1998
+ Info
Conessine hydrobromide
CAS:
- 5913-82-6
Conessine hydrobromide is a naturally occurring steroid alkaloid and has been used in traditional herbal medicine as a treatment for amoebic dysentery.
Formula:C₂₄H₄₁BrN₂
Color and Shape:Solid
Molecular weight:437.51
Ref: TM-T31006
+ Info
Spantide I
CAS:
- 91224-37-2
Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.
Formula:C₇₅H₁₀₈N₂₀O₁₃
Purity:98%
Color and Shape:Solid
Molecular weight:1497.79
Ref: TM-T20413
+ Info
Bim 21009
CAS:
- 106881-54-3
Bim 21009 is an inhibitor of gonadorelin.
Formula:C₇₄H₉₂ClN₁₇O₁₃
Purity:98%
Color and Shape:Solid
Molecular weight:1463.08
Ref: TM-T25154
+ Info
TRAP-6 amide
CAS:
- 141923-40-2
TRAP-6 amide is a PAR-1 thrombin receptor agonist peptide.
Formula:C₃₄H₅₇N₁₁O₈
Color and Shape:Solid
Molecular weight:747.899
Ref: TM-T38852