GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

Show 18 more subcategories

Found 5745 products of "GPCR/G-Protein"

Purity (%)

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Efranarelaxin alfa
CAS:
- 2969217-22-7
Efranarelaxin alfa is an agonist of the relaxin receptor. It shows potential for research in cardiovascular diseases and tissue repair.
Color and Shape:Liquid
Ref: TM-T9901A-865
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JNJ-39933673
CAS:
- 1404307-42-1
JNJ-39933673 is a bio-active chemical.
Formula:C₄₈H₅₄F₂N₂O₁₁
Color and Shape:Solid
Molecular weight:872.96
Ref: TM-T32305
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Anti-TSHR Antibody (M22)
Anti-TSHR Antibody (M22) is a humanized IgG1 monoclonal antibody targeting the thyroid-stimulating hormone receptor (TSHR). This antibody is capable of inhibiting the interaction between TSH and TSHR.
Color and Shape:Odour Liquid
Ref: TM-T9901A-942
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[bAla8]-Neurokinin A(4-10)
CAS:
- 122063-01-8
[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.
Formula:C₃₅H₅₆N₈O₁₀S
Purity:98%
Color and Shape:Solid
Molecular weight:780.94
Ref: TM-TP1100
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α-MSH acetate
α-MSH acetate is an endogenous neuromodulatory peptide derived from POMC and an agonist of MC4R (melanocortin receptor 4).
Purity:99.71%
Color and Shape:Odour Solid
Ref: TM-T7813L
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(R)-Zevaquenabant
(R)-Zevaquenabant ((R)-MRI-1867) is the enantiomer of Zevaquenabant. Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual antagonist of the cannabinoid CB1 receptor and inducible nitric oxide synthase (iNOS). It is beneficial in improving chronic kidney disease (CKD) caused by obesity.
Color and Shape:Odour Solid
Ref: TM-TYD-02102
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Albiglutide Fragment
CAS:
- 782500-75-8
Albiglutide fragment is a 30-amino-acid sequence of modified human GLP-1 (fragment 7-36).
Formula:C₁₄₈H₂₂₄N₄₀O₄₅
Purity:98%
Color and Shape:Solid
Molecular weight:3283.6
Ref: TM-TQ0004
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Blue FPG-A trisodium
CAS:
- 78617-94-4
Blue FPG-A trisodium is a P2X1 & P2Y1 receptor antagonist, IC50: 35.5 μM & 2.6 μM, related to RB2.
Formula:C₂₉H₁₇ClN₇Na₃O₁₁S₃
Color and Shape:Solid
Molecular weight:840.1
Ref: TM-T75347
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Pellotine
CAS:
- 19622-05-0
Pellotine is an alkaloid isolated from Lophophora. It acts as an inverse agonist of the 5-HT7 receptor (5-HT7 receptor), with an EC50 of 291 nM. Pellotine shows strong affinity for the 5-HT1DR and 5-HT6R, with Ki values of 117 nM and 170 nM, respectively. Additionally, Pellotine reduces intracellular cAMP levels, thereby decreasing neuronal excitability and neurotransmitter release.
Formula:C₁₃H₁₉NO₃
Color and Shape:Solid
Molecular weight:237.295
Ref: TM-TN9164
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OXA(17-33) TFA
OXA(17-33) TFA: Potent OX1 agonist, ~23x more selective for OX1 (EC50=8.29nM) than OX2 (187nM).
Formula:C₈₁H₁₂₆F₃N₂₃O₂₄
Color and Shape:Solid
Molecular weight:1863
Ref: TM-T75922
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Dipivefrin
CAS:
- 52365-63-6
Dipivefrin is a prodrug of epinephrine, and is used to treat open-angle glaucoma.
Formula:C₁₉H₂₉NO₅
Color and Shape:Solid
Molecular weight:351.44
Ref: TM-T0103L
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Urotensin I
CAS:
- 83930-33-0
Urotensin I, 41-aa neuropeptide, agonist for human/rat CRF receptors, lowers blood pressure in rats, isolated from white suckers.
Formula:C₂₁₀H₃₄₀N₆₂O₆₇S₂
Purity:98%
Color and Shape:Solid
Molecular weight:4869.46
Ref: TM-TP1199
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Fabesetron
CAS:
- 129300-27-2
Fabesetron (FK1052): oral dual antagonist for 5-HT3/5-HT4 receptors. Aids in managing acute and delayed chemo-induced emesis.
Formula:C₁₈H₁₉N₃O
Color and Shape:Solid
Molecular weight:293.37
Ref: TM-T38692
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Phenoxybenzamine
CAS:
- 59-96-1
Phenoxybenzamine blocks α-1 receptors, potentially reducing neuroinflammation post brain trauma.
Formula:C₁₈H₂₂ClNO
Purity:98%
Color and Shape:Crystals From Petroleum Ether Solid
Molecular weight:303.83
Ref: TM-T1158L
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Cortistatin 29
Cortistatin 29: neuropeptide, relieves neuropathic pain, binds SS receptors (IC50: 2.8-13.7 nM), anti-fibrotic.
Formula:C₁₆₁H₂₄₂N₄₆O₄₁S₂
Color and Shape:Solid
Molecular weight:3539.77
Ref: TM-T76331
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Benzoquinamide hydrochloride
CAS:
- 113-69-9
Benzoquinamide hydrochloride (3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride) is an antiemetic
Formula:C₂₂H₃₃ClN₂O₅
Purity:97.13% - 99.56%
Color and Shape:Solid
Molecular weight:440.96
Ref: TM-T9881
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LAS190792
CAS:
- 1347232-69-2
LAS190792 (AZD8999) is a dual muscarinic antagonist/β2-agonist, pIC50s (M1-M5, β1-β3): 8.9-5.6; used as a bronchodilator.
Formula:C₃₉H₄₃ClN₄O₉S₂
Color and Shape:Solid
Molecular weight:811.36
Ref: TM-T74709
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PZ-128
CAS:
- 371131-16-7
PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.
Formula:C₅₅H₉₉N₁₃O₉
Purity:98%
Color and Shape:Solid
Molecular weight:1086.46
Ref: TM-T28477
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[Leu31,Pro34]-Neuropeptide Y(human,rat)
CAS:
- 132699-73-1
High affinity neuropeptide Y Y1 receptor agonist (Ki = 0.39 nM). Also shows affinity for Y4 and Y5 receptors.
Formula:C₁₈₉H₂₈₄N₅₄O₅₆S
Purity:98%
Color and Shape:Solid
Molecular weight:4241
Ref: TM-TP1985
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GR 94800
CAS:
- 141636-65-9
Potent and selective tachykinin NK2 receptor antagonist
Formula:C₄₉H₆₁N₉O₈
Purity:98%
Color and Shape:Solid
Molecular weight:904.082
Ref: TM-T22811
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GUB03385
GUB03385 is a long-acting PrRP31 analogue and an effective dual agonist for GPR10 (full agonist, EC50: 0.4 nM) and NPFF2R (partial agonist, EC50: 20 nM), with anti-obesity properties.
Formula:C₁₉₈H₃₂₂N₆₀O₅₂S
Molecular weight:4404.41173
Ref: TM-TP3547
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TGR5 agonist 1
Compound 18 (TGR5 agonist 1) is a potent agonist of TGR5, exhibiting an EC50 value of 0.31 µM [1].
Formula:C₂₈H₄₈NNaO₆S
Color and Shape:Solid
Molecular weight:549.74
Ref: TM-T74824
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Imelciment
CAS:
- 2845128-03-0
Imelciment (REGN-9035) is a humanised monoclonal antibody targeting NPR1, which can be used for research into heart failure.
Purity:95%
Color and Shape:Soild
Ref: TM-T9901A-366
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GRK-IN-1
CAS:
- 5423-98-3
4-Amino-5-(bromomethyl)-2-methylpyrimidine used in vitamin B1 analogs and esters synthesis.
Formula:C₆H₁₀Br₃N₃
Color and Shape:Solid
Molecular weight:363.879
Ref: TM-T35723
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Xaliproden
CAS:
- 135354-02-8
Xaliproden is a biochemical.
Formula:C₂₄H₂₂F₃N
Color and Shape:Solid
Molecular weight:381.43
Ref: TM-T35152
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Prostaglandin F1α
CAS:
- 745-62-0
Prostaglandin F1α (PGF1α) is a lipid mediator and an endogenous metabolite of prostacyclin, regulate smooth muscle contraction.
Formula:C₂₀H₃₆O₅
Color and Shape:Solid
Molecular weight:356.5
Ref: TM-T37919
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MK-7246 S enantiomer
MK-7246 S enantiomer is a potent and selective CRTH2 antagonist.
Formula:C₂₁H₂₁FN₂O₄S
Purity:98%
Color and Shape:Solid
Molecular weight:416.47
Ref: TM-T12067
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PSB 0777 ammonium salt
CAS:
- 2122196-16-9
adenosine A2A receptor full agonist
Formula:C₁₈H₂₄N₆O₇S₂
Purity:98%
Color and Shape:Solid
Molecular weight:500.55
Ref: TM-T23196
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Relaxin H3 (human) TFA
Relaxin H3 (human) (TFA) is a relaxin peptide that exerts antifibrotic effects through the RXFP1 receptor.
Formula:C₂₃₇H₃₇₄N₇₀O₆₉S₆·xC₂HF₃O₂
Ref: TM-TP3503
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LP 12 hydrochloride
CAS:
- 1185136-22-4
LP 12 hydrochloride is a selective 5-HT7 receptor agonist (Ki=0.13 nM).
Formula:C₃₂H₄₀ClN₃O
Color and Shape:Solid
Molecular weight:518.14
Ref: TM-T37073
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RC-3095
CAS:
- 138147-78-1
RC-3095, a selective GRPR antagonist, has been shown to have anti-inflammatory properties in different models of inflammation.
Formula:C₅₆H₇₉N₁₅O₉
Purity:98%
Color and Shape:Solid
Molecular weight:1106.32
Ref: TM-TP1470
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TAK-615
CAS:
- 1664335-55-0
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
Formula:C₂₅H₂₂FNO₄
Purity:99.73%
Color and Shape:Solid
Molecular weight:419.44
Ref: TM-T9699
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BPP-2
BPP-2 is a GHSR ligand containing the element F. By labeling BPP-2 with the isotope 18F, a PET probe targeting GHSR can be produced. The binding affinity (Ki) of 18F-BPP-2 for GHSR is 274 nM.
Formula:C₂₇H₂₈FN₅O₂
Molecular weight:473.2227
Ref: TM-T209024
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NPFF2-R ligand 1
NPFF2-R ligand 1 (Compound 16a) is an NPFF2-R ligand with Ki values of 228 nM for NPFF1-R and 27 nM for NPFF2-R, and can be utilized in research on central nervous system-related disorders.
Formula:C₃₂H₄₁N₃O
Molecular weight:483.32496
Ref: TM-T209505
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1,8-Cineole
CAS:
- 470-82-6
Eucalyptol, a natural monoterpenoid and cyclic ether found in eucalyptus species, effectively controls excessive airway mucus secretion and asthma by inhibiting pro-inflammatory cytokines. It serves as an efficacious treatment for non-purulent sinusitis, reducing inflammation and pain when applied topically, and demonstrating leukemic cell-killing capabilities in vitro.
Formula:C₁₀H₁₈O
Purity:97.44% - 97.44%
Color and Shape:Solid
Molecular weight:154.25
Ref: TM-T1714
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GR 64349
CAS:
- 137593-52-3
Potent NK2 agonist, EC50=3.7 nM in rat colon; >1000x selectivity over NK1, >300x over NK3; effective in vivo.
Formula:C₄₂H₆₈N₁₀O₁₁S
Purity:98%
Color and Shape:Solid
Molecular weight:921.12
Ref: TM-TP2023
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4-Chloromethamphetamine hydrochloride
CAS:
- 30572-91-9
4-Chloromethamphetamine hydrochloride is a novel psychoactive substance belonging to the amphetamine class.
Formula:C₁₀H₁₅Cl₂N
Color and Shape:Solid
Molecular weight:220.14
Ref: TM-T203542
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GLP-1 receptor agonist 4
CAS:
- 1187061-62-6
GLP-1 receptor agonist 4 targets GLP-1R, EC50 64.5 nM, potential diabetes treatment research.
Formula:C₅₁H₄₄Cl₂N₄O₆
Purity:98%
Color and Shape:Solid
Molecular weight:879.82
Ref: TM-T11405
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Palmitoyl tetrapeptide-20 TFA
Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide and acts as an agonist of α-MSH. It protects follicular melanocytes by boosting catalase expression and activating melanogenesis.
Formula:C₃₈H₇₀N₆O₈·xC₂HF₃O₂
Ref: TM-TP3504
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(Pro34)-Peptide YY (human)
CAS:
- 179986-93-7
(Pro34)-Peptide YY (human) is a highly Y 1 -selective full agonist of Peptide YY /neuropeptide Y receptors [1] .
Formula:C₁₉₄H₂₉₄N₅₄O₅₆
Color and Shape:Solid
Molecular weight:4278.73
Ref: TM-T76441
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GLP-1R agonist 20
GLP-1R agonist 20 (Compound I-132) is an agonist of the glucagon-like peptide-1 receptor (GLP-1 receptor), with an EC50 value of 0.0162 nM.
Formula:C₃₁H₃₀Cl₂F₂N₄O₅
Molecular weight:646.15613
Ref: TM-T209770
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4-fluoro MBZP
CAS:
- 144734-44-1
4-fluoro MBZP is a novel psychoactive substance in the phenylpiperazine class, utilized for studies on the 5-HT2 receptors in the central nervous system.
Formula:C₁₂H₁₇FN₂
Color and Shape:Solid
Molecular weight:208.28
Ref: TM-T203276
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(+)-Cloprostenol sodium
CAS:
- 62561-03-9
Cloprostenol sodium is a water-soluble PGF2α analog and FP receptor agonist, promoting luteolysis in rats and hamsters.
Formula:C₂₂H₂₈ClNaO₆
Color and Shape:Solid
Molecular weight:446.9
Ref: TM-T29245
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Glucagon-like peptide 1 (1-37), human
CAS:
- 87805-34-3
Human GLP-1 (1-37) is a potent GLP-1 receptor agonist without impact on rat food intake or insulin secretion.
Formula:C₁₈₆H₂₇₅N₅₁O₅₉
Purity:98%
Color and Shape:Solid
Molecular weight:4169.48
Ref: TM-TP1148
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RFRP-1(human)
CAS:
- 311309-25-8
Endogenous NPFF agonist with EC50 of 0.0011 nM (NPFF2) and 29 nM (NPFF1); reduces cardiac function and raises prolactin in rats. GnIH homolog.
Formula:C₆₇H₁₀₁N₁₉O₁₄S
Purity:98%
Color and Shape:Solid
Molecular weight:1428.72
Ref: TM-TP1937
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Haloperidol D4
CAS:
- 1189986-59-1
Haloperidol D4 is deuterium-labeled haloperidol.
Formula:C₂₁H₂₃ClFNO₂
Purity:98%
Color and Shape:Solid
Molecular weight:379.89
Ref: TM-T11535
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(S)-Azelastine hydrochloride
CAS:
- 153408-27-6
(S)-Azelastine HCl, an antihistamine, reduces H1R, M1R, M3R levels and inhibits HNEpC growth.
Formula:C₂₂H₂₅Cl₂N₃O
Purity:98%
Color and Shape:Solid
Molecular weight:418.36
Ref: TM-T21109
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Jmv 176
CAS:
- 119068-32-5
Jmv 176 is a CCK agonist when first given and becomes a cholecystokinin antagonist after 3-4 hours.
Formula:C₅₃H₇₀N₈O₁₅S
Purity:98%
Color and Shape:Solid
Molecular weight:1091.24
Ref: TM-T25550
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5-HT2C agonist-4
CAS:
- 2730085-33-1
Compound 3i, a 5-HT2C agonist-4, acts as an agonist for the 5-HT2C receptor with an EC50 of 5.7 nM. It is capable of reducing locomotor activity in zebrafish larvae.
Formula:C₂₄H₂₅N₅O
Color and Shape:Solid
Molecular weight:399.49
Ref: TM-T203570
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Clozapine N-oxide dihydrochloride
CAS:
- 2250025-93-3
Clozapine N-oxide dihydrochloride is a derivative of Clozapine and an agonist of DREADDs.
Formula:C₁₈H₂₁Cl₃N₄O
Purity:98.11%
Color and Shape:Solid
Molecular weight:415.74
Ref: TM-T72112