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GPCR/G-Protein

GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

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Found 5378 products of "GPCR/G-Protein"

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  • Piperulin A
    Targetmol
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    Piperulin A

    CAS:
    <p>Piperulin A effectively inhibits platelet-activating factor receptor (PAFR) by specifically blocking its binding to isolated rabbit platelet plasma membranes,</p>
    Formula:C23H28O6
    Color and Shape:Solid
    Molecular weight:400.46

    Ref: TM-T79950

  • AR-C126313
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    AR-C126313

    CAS:
    <p>AR-C126313 is a thiouracil derivative.</p>
    Formula:C28H23N7O3S
    Color and Shape:Solid
    Molecular weight:537.59

    Ref: TM-T30120

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    PF-07062119

    <p>PF-07062119 is a humanized immunoglobulin G1 (IgG1) monoclonal antibody designed to target and inhibit GUCY2C.</p>
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-899

  • Upidosin
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    Upidosin

    CAS:
    <p>Upidosin (SB-216469), a uroselective α1 blocker: Ki α1a=0.34 nM, α1b=3.9 nM, α1d=1.5 nM, α2=33.3 nM.</p>
    Formula:C31H33N3O4
    Purity:99.66%
    Color and Shape:Solid
    Molecular weight:511.61

    Ref: TM-T9762

  • Pexopiprant
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    Pexopiprant

    CAS:
    <p>Pexopiprant, a potent oral antagonist of the prostaglandin D2 receptor 2 (DP2) with a K i value less than 100nM, is a valuable compound for asthma research.</p>
    Formula:C21H17Cl2F2NO4
    Color and Shape:Solid
    Molecular weight:456.27

    Ref: TM-T41073

  • Galantide
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    Galantide

    CAS:
    <p>Galantide is a reversible and non-specific antagonist of galanin receptor.</p>
    Formula:C104H151N25O26S
    Purity:98%
    Color and Shape:White Lyophilised Solid
    Molecular weight:2199.53

    Ref: TM-T15368

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    NSC380324

    <p>NSC380324 is a P2Y12 receptor antagonist with antiplatelet properties, which can be employed in research on atherosclerotic cardiovascular diseases.</p>
    Formula:C31H24N4O4
    Color and Shape:Solid
    Molecular weight:516.55

    Ref: TM-T205528

  • Histamine & Melatonin Receptor-Targeted Compound Library
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    Histamine & Melatonin Receptor-Targeted Compound Library

    <p>A unique collection of xnum compounds targeting histaminergic receptor and melatonin receptor for high throughput screening (HTS) and high content screening (HCS</p>
    Color and Shape:Odour Solid

    Ref: TM-L3300

  • SR142948A
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    SR142948A

    CAS:
    <p>SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist blocking hypothermia and analgesic effects, NMDA-induced dopamine release.</p>
    Formula:C39H52ClN5O6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:722.31

    Ref: TM-T28845

  • MGV354
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    MGV354

    <p>MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of &lt;0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2].</p>
    Formula:C35H37N5O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:575.7

    Ref: TM-T12888

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    Cagrilintide acetate

    <p>.Cagrilintide is a long-acting amylin analog,treat diabetes and obesity by reducing appetite through activation of the AMY3R and calcitonin receptor.</p>
    Formula:C196H316N54O61S2
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:4469.06

    Ref: TM-T76262L

  • (Ala13)-Apelin-13
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    (Ala13)-Apelin-13

    CAS:
    (Ala13)-Apelin-13 is a useful organic compound for research related to life sciences. The catalog number is T35374 and the CAS number is 568565-11-7.
    Formula:C63H107N23O16S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1474.75

    Ref: TM-T35374

  • α-Helical CRF(9-41)
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    α-Helical CRF(9-41)

    CAS:
    <p>Corticotropin-releasing factor receptor antagonist (Ki values are 17, 5 and 0.97 at human CRF1, rat CRF2α and mouse CRF2β receptors respectively).</p>
    Formula:C166H274N46O53S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3827

    Ref: TM-TP2048

  • 17-phenyl trinor Prostaglandin E2 ethyl amide
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    17-phenyl trinor Prostaglandin E2 ethyl amide

    CAS:
    <p>17-phenyl trinor PGE2 ethyl amide, an EP1/EP3 agonist (Ki: 14-54 nM), enhances lipid solubility and tissue uptake, is a potent antifertility agent.</p>
    Formula:C25H35NO4
    Color and Shape:Solid
    Molecular weight:413.55

    Ref: TM-T37996

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    5-HT1AR/5-HT6R ligand-1

    <p>5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.</p>
    Formula:C25H29ClN4O2S
    Color and Shape:Solid
    Molecular weight:485.04

    Ref: TM-T205634

  • Hemopressin (human, mouse)
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    Hemopressin (human, mouse)

    CAS:
    <p>Endogenous peptide, inhibits ep24.15/24.16/ACE with Ki of 27.76/3.43/1.87 μM. Lowers blood pressure, CB1 inverse agonist, reduces pain in vivo.</p>
    Formula:C50H79N13O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1054.26

    Ref: TM-TP1900

  • Dehydro Aripiprazole (hydrochloride)
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    Dehydro Aripiprazole (hydrochloride)

    CAS:
    <p>Dehydro aripiprazole, an active atypical antipsychotic metabolite of aripiprazole, is formed by CYP3A4 and CYP2D6.</p>
    Formula:C23H26Cl3N3O2
    Color and Shape:Solid
    Molecular weight:482.83

    Ref: TM-T36664

  • M40
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    M40

    CAS:
    <p>Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat</p>
    Formula:C94H145N23O24
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1981.33

    Ref: TM-TP1992

  • HAEGTFTSD
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    HAEGTFTSD

    CAS:
    <p>HAEGTFTSD is GLP-1's initial segment; GLP-1 (7-36) amide, tied to food intake, stems from preproglucagon in L-cells.</p>
    Formula:C40H57N11O17
    Purity:98%
    Color and Shape:Solid
    Molecular weight:963.94

    Ref: TM-TP1452

  • V-0219 hydrochloride
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    V-0219 hydrochloride

    <p>V-0219 hydrochloride: oral GLP-1R PAM for obesity-linked diabetes study.</p>
    Formula:C20H26ClF3N4O2
    Purity:99.97%
    Color and Shape:Soild
    Molecular weight:446.89

    Ref: TM-T60047L

  • Prostaglandin H1
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    Prostaglandin H1

    CAS:
    <p>Prostaglandin H1 is the cyclooxygenase metabolite of DGLA, a CRTh2 agonist and a precursor of a family of 1 anti-inflammatory prostaglandins.</p>
    Formula:C20H34O5
    Color and Shape:Solid
    Molecular weight:354.487

    Ref: TM-T37328

  • Apelin-36(rat, mouse)
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    Apelin-36(rat, mouse)

    CAS:
    Endogenous APJ agonist from adipocytes; binds APJ tightly, inhibits cAMP, regulates heart function and fluid balance, blocks some HIV strains.
    Formula:C185H304N68O43S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4200.93

    Ref: TM-TP2094

  • α1A-AR Degrader 9c
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    α1A-AR Degrader 9c

    CAS:
    <p>α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM.</p>
    Formula:C38H43N11O11
    Purity:98%
    Color and Shape:Solid
    Molecular weight:829.82

    Ref: TM-T74557

  • LAS190792
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    LAS190792

    CAS:
    <p>LAS190792 (AZD8999) is a dual muscarinic antagonist/β2-agonist, pIC50s (M1-M5, β1-β3): 8.9-5.6; used as a bronchodilator.</p>
    Formula:C39H43ClN4O9S2
    Color and Shape:Solid
    Molecular weight:811.36

    Ref: TM-T74709

  • CRF, bovine
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    CRF, bovine

    CAS:
    CRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.
    Formula:C206H340N60O63S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4697.34

    Ref: TM-TP1191

  • BMS-753426
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    BMS-753426

    CAS:
    <p>BMS-753426 is a potent and orally bioavailable antagonist of CCR2 .</p>
    Formula:C25H33F3N6O2
    Color and Shape:Solid
    Molecular weight:506.574

    Ref: TM-T38397

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    ANXA3 degrader 1

    ANXA3 degrader 1 (Compound 18a5) is a highly selective ANXA3 degrader with activity against cancer cells. It demonstrates significant inhibitory effects in a triple-negative breast cancer (TNBC) tumor xenograft model, with a tumor growth inhibition (TGI) rate of 96%.
    Formula:C30H32N6O2S2
    Color and Shape:Solid
    Molecular weight:572.74

    Ref: TM-T205558

  • CYN 154806
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    CYN 154806

    CAS:
    CYN 154806: potent sst2 antagonist; pIC50: 8.58 (sst2), 5.41 (sst1), 6.07 (sst3), 5.76 (sst4), 6.48 (sst5).
    Formula:C56H68N12O14S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1197.34

    Ref: TM-TP1877

  • NF157
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    NF157

    CAS:
    <p>NF157, a selective P2Y11 antagonist with pKi 7.35, lowers MMP-3/MMP-13, aiding OA treatment; IC50s: P2Y11 463 nM, P2Y1 1811 μM, P2Y2 170 μM.</p>
    Formula:C49H28F2N6Na6O23S6
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1437.1

    Ref: TM-T16291

  • Thioperamide maleate
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    Thioperamide maleate

    CAS:
    <p>Thioperamide maleate (MR-12842 maleate) is an effective and selective antagonist of H3 receptor (Ki = 4.3 nM) for inhibition of [3H]histamine synthesis (Ki = 31</p>
    Formula:C19H28N4O4S
    Purity:98.48%
    Color and Shape:Solid
    Molecular weight:408.52

    Ref: TM-T41247

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    CAP-100

    <p>CAP-100 is a monoclonal antibody targeting CCR7. It neutralizes the ligand binding site and signaling of CCR7. This compound effectively inhibits migration, extravasation, homing, and survival in chronic lymphocytic leukemia (CLL) samples induced by CCR7. CAP-100 can mediate potent tumor cell killing through host immune mechanisms and exhibits favorable toxicity profiles in related hematopoietic cell subsets. It is involved in research on antitumor activity and diseases like chronic lymphocytic leukemia (CLL).</p>
    Color and Shape:Odour Liquid

    Ref: TM-T9901A-961

  • Bombinakinin M
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    Bombinakinin M

    CAS:
    <p>Potent, selective bradykinin receptor agonist 50x stronger than bradykinin, contracts guinea pig ileum muscle at EC50 4.0 nM.</p>
    Formula:C100H159N31O24
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2179.55

    Ref: TM-TP2075

  • Phoenixin-14 TFA
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    Phoenixin-14 TFA

    <p>Phoenixin-14 TFA (PNX-14 TFA) is an endogenous neuropeptide that can modulate GnRH receptor expression and exerts anxiolytic effects.</p>
    Formula:C75H110N18O20·xC2HF3O2
    Purity:99.11%
    Color and Shape:Solid
    Molecular weight:1583.78 (free base)

    Ref: TM-T81485

  • (Ala13)-Apelin-13 acetate
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    (Ala13)-Apelin-13 acetate

    <p>(Ala13)-Apelin-13 acetate, an APJ antagonist, modulates CRF-induced enhanced colonic motility, visceral sensation, and gut barrier.</p>
    Formula:C65H111N23O18S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1534.79

    Ref: TM-T35374L

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    Chemerin-9 (149-157) TFA

    <p>Chemerin-9 (149-157) TFA is a peptide located at positions 149-157 of chemerin-9, acting as a ChemR23/CMKLR1 agonist.</p>
    Formula:C56H67F3N10O15
    Purity:99.77%
    Color and Shape:Solid
    Molecular weight:1177.18

    Ref: TM-TP1435

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    {Val1}-Exendin-3/4

    {Val1}- exendin-3/4 is the first n-terminal 1-28 residue of exendin-4 peptide.
    Formula:NA
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3241.7

    Ref: TM-TP1394

  • Xanthine amine congener trihydrochloride
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    Xanthine amine congener trihydrochloride

    CAS:
    <p>Xanthine amine congener trihydrochloride: potent adenosine antagonist, reverses effects of N6-cyclohexyladenosine on urine, sodium excretion, heart rate.</p>
    Formula:C21H29ClN6O4
    Purity:98.81%
    Color and Shape:Solid
    Molecular weight:464.95

    Ref: TM-T23535L

  • A71378
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    A71378

    CAS:
    <p>A71378 is a high potency, selectivity CCK-A receptors agonist.</p>
    Formula:C48H62N8O13S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:991.12

    Ref: TM-T26484

  • Enuvaptan
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    Enuvaptan

    CAS:
    <p>Enuvaptan is a vasopressin receptor antagonist and has the potential for research into renal and cardiovascular diseases.</p>
    Formula:C21H15ClF6N8O3
    Color and Shape:Solid
    Molecular weight:576.84

    Ref: TM-T39611

  • MCUF-651
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    MCUF-651

    CAS:
    <p>MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.</p>
    Formula:C17H22F2N4OS
    Purity:99.83%
    Color and Shape:Soild
    Molecular weight:368.44

    Ref: TM-T67734

  • Tiaprost
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    Tiaprost

    CAS:
    Tiaprost is a analog of prostaglandin F2α .
    Formula:C20H28O6S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:396.5

    Ref: TM-T17092

  • GLP-1(7-36), amide acetate
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    GLP-1(7-36), amide acetate

    CAS:
    <p>GLP-1(7-36), amide acetate is a derivative of GLP-1 peptide , activate the GLP-1 receptor, promote insulin secretion,Type 2 diabetes mellitus and obesity.</p>
    Formula:C151H230N40O47
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:3357.68

    Ref: TM-TP1141

  • Amylin (8-37), rat
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    Amylin (8-37), rat

    CAS:
    <p>Amylin (8-37), rat, an analog of IAPP, blocks insulin's effects on muscle glucose uptake and glycogen storage.</p>
    Formula:C140H227N43O43
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3200.61

    Ref: TM-TP1233

  • IRL-1620 acetate
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    IRL-1620 acetate

    <p>IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.</p>
    Formula:C88H121N17O29
    Purity:96.64%
    Color and Shape:Solid
    Molecular weight:1881

    Ref: TM-T15595L

  • S1PR1 modulator 1
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    S1PR1 modulator 1

    CAS:
    <p>S1PR1 modulator 1 is a selective inhibitor of S1PR1 with a pIC50 of 7.6.</p>
    Formula:C23H24N2O3S
    Purity:99.69%
    Color and Shape:Solid
    Molecular weight:408.51

    Ref: TM-T12821

  • Cortistatin-14 acetate
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    Cortistatin-14 acetate

    <p>Cortistatin-14 acetate, a neuropeptide have structural similarity to somatostatin-14, binds and exerts its function via the somatostatin receptors (sst1-sst5).</p>
    Formula:C83H118N20O20S2
    Purity:98.24% - 99.63%
    Color and Shape:Soild
    Molecular weight:1780.08

    Ref: TM-TP1570L

  • Donetidine
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    Donetidine

    CAS:
    <p>Donetidine is a histamine H2 receptor antagonist used to treat digestive disorders.</p>
    Formula:C20H25N5O3S
    Purity:99.32%
    Color and Shape:Solid
    Molecular weight:415.51

    Ref: TM-T68056

  • LU AA33810
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    LU AA33810

    CAS:
    <p>LU AA33810 is a neuropeptide Y (NPY) Y5 receptor antagonist.</p>
    Formula:C19H25N3O2S3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:423.62

    Ref: TM-T22935

  • Guanylin(human)
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    Guanylin(human)

    CAS:
    Peptide that activates gut guanylyl cyclase, secreted by GI mucosa, regulates water and electrolytes in gut and kidneys.
    Formula:C58H87N15O21S4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1458.65

    Ref: TM-TP2034

  • I-BOP
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    I-BOP

    CAS:
    <p>I-BOP is an agonist (KD=0.61 nM) at the thromboxane A2 receptor (TP).</p>
    Formula:C23H29IO5
    Color and Shape:Solid
    Molecular weight:512.384

    Ref: TM-T35585