Antibacterial

<p>Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.</p>

<p>Fluconazole (UK-49858) is a triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.</p>

<p>Lysostaphin is an anti-staph compound with 3 enzymes: endopeptidase, glucosamidase, amidase.</p>

<p>Nithiamide (CL-5279) is an orally available antiprotozoan agent used in the treatment of vaginal trichomoniasis.</p>

<p>Tetracycline (Tetracyclin) is a broad-spectrum antibiotic. Tetracycline is commonly used in anti-infective studies. Cost-effective and quality-assured.</p>

<p>Aztreonam (SQ-26,776) is a monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity.</p>

<p>D-Cysteine, a D-isomer, suppresses E. coli growth, forms H2S via D-amino acid oxidase, and protects against cerebellar ataxia.</p>

<p>Phthalylsulfacetamide (Tamid) is a sulfonamide antibiotic used for topical application to the skin and the conjunctiva.</p>

<p>Tilmicosin (EL-870), a macrolide antibiotic, treats bovine and ovine respiratory diseases in animals.</p>

<p>Norethindrone is a potent synthetic hormone used for amenorrhea, uterine bleeding, endometriosis, and contraception.</p>

<p>Meropenem (SM 7338), a broad-spectrum IV antibiotic, treats severe infections but may cause mild liver enzyme elevations or rare cholestatic injury.</p>

<p>NSC-60339: AcrAB-TolC substrate, efflux pump inhibitor, potential cancer drug.</p>

<p>Ampicillin (Aminobenzylpenicillin) is a semi-synthetic penicillin belonging to the β-lactam group of antibiotics.</p>

<p>Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.</p>

<p>Cefpiramide acid (Cefpiramidum) is a third-generation cephalosporin antibiotic.</p>

<p>Sulfanitran is a sulfonamide antibiotic used in the poultry industry.</p>

<p>Ecabet Sodium (TA-2711) is a potential new agent in the management of distal colitis.</p>

<p>Cefiderocol (S-649266) is a new type of siderophore-cephalosporin conjugate with antibacterial activity, inhibiting aerobic gram-negative bacteria.</p>

<p>Econazole ((±)-Econazol) is an imidazole derivative that is commonly used as a topical antifungal agent.</p>

<p>Mafenide hydrochloride (4-Aminomethylbenzenesulfonamide hydrochloride) is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-</p>

<p>Ornidazole (Levo-) (Levornidazole) is the levo-isomer of Ornidazole.</p>

<p>Chlorhexidine dihydrochloride (NSC-185) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.</p>

<p>Bronopol (BNPD): Low-toxicity antimicrobial, highly effective against Gram-negative bacteria.</p>

<p>Sulfamethoxypyridazine (CL 13494) is a sulfanilamide antibacterial agent.</p>

<p>Sulfamethazine sodium (Sulfadimethyldiazine Sodium Salt) salt is a sodium salt form of sulfamethazine, a sulfonamide antibiotic used in the livestock industry.</p>

<p>Ciprofloxacin EP IMpurity A (Fluoroquinolonic Acid) is an antibiotic and antimicrobial agent.</p>

<p>Triclosan (Irgasan) is an antibacterial and antifungal agent.</p>

<p>Ceftazidime (GR20263) is a beta-lactam, cephalosporin antibiotic with bactericidal activity.</p>

<p>NITD-349 is an inhibitor of MmpL3. It shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv.</p>

<p>Benzalkonium chloride: a cationic surfactant, biocide, and phase transfer agent with varied alkyl chains.</p>

<p>Sulfacetamide sodium monohydrate is a sulfonamide antibiotic. It has been investigated for the treatment of rosacea and pityriasis versicolor.</p>

<p>Nifuratel (SAP 113) is a local antiprotozoal and antifungal agent that may also be given orally.</p>

<p>Ceftriaxone sodium hydrate is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.</p>

<p>Cefmenoxime hydrochloride: cephalosporin antibiotic, IV/IM, targets gram-positive/negative bacteria, beta-lactamase resistant, effective, low side effects.</p>

<p>Nepafenac (AHR 9434) is an NSAID that acts as a cyclooxygenase inhibitor.</p>

<p>Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.</p>

<p>Cefazolin sodium, a beta-lactam antibiotic, targets PBPs to disrupt bacterial cell wall synthesis, causing cell lysis.</p>

<p>Oritavancin, a semisynthetic antibiotic for skin infections, approved by FDA on August 6, 2014, targets resistant Gram-positive bacteria.</p>

<p>Julifloricine is an alkaloid isolated from Prosopis juliflora that has antimicrobial activity.</p>

<p>C12-rrw-NH2 (Compound Lip7) is an antimicrobial agent effective against Gram-positive bacteria, particularly demonstrating significant activity against Methicillin-resistant Staphylococcus aureus (MRSA). It induces bacterial cell death by depolarizing the bacterial cell membrane, disrupting membrane integrity, causing nucleic acid and protein leakage, and promoting the generation of Reactive Oxygen Species (ROS). C12-rrw-NH2 is applicable in research focused on developing highly stable antimicrobial peptides.</p>

<p>Ertapenem: injectable carbapenem with broad antimicrobial spectrum, resistant to many beta-lactamases.</p>

<p>Pirlimycin Hydrochloride, a Clindamycin analog, is a semi-synthetic lincosaminide antibiotic.</p>

<p>Napyradiomycin A1, a fungal compound from C. rubra, has antimicrobial effects (MIC 1.56-12.5 μg/ml) and blocks estrogen receptors and mitochondrial enzymes.</p>

<p>8-Methylsulfinyloctyl isothiocyanate: antimicrobial, inhibits plant growth, impairs COX-2 inflammation in macrophages.</p>

<p>N-3-oxo-hexadecanoyl-L-homoserine lactone, a C16 AHL, aids bacterial quorum sensing and primes plant systemic resistance.</p>

<p>Amoxicillin + potassium clavulanate (4:1) is a broad-spectrum, well-absorbed oral antibiotic blocking cell wall synthesis.</p>

<p>Chloramine-T (Chloralone) is a N-chlorinated, and N-deprotonated sulfonamide, used as a biocide and a mild disinfectant.</p>

<p>Nucleocidin, an antitrypanosomal antibiotic, inhibits the transfer of labeled amino acids from S-RNA to protein.</p>

<p>Tellimagrandin II (Eugeniin) is the initial intermediate in the 4 C 1 -glucose derived series of ellagitannins.</p>

<p>FASN-IN-6 (compound 44), a potent fatty acid biosynthesis (FAB) inhibitor, serves as an antibacterial agent, exhibiting minimum inhibitory concentrations (MICs</p>

<p>PF 5081090 has a wide range of applications in life science related research.</p>

<p>Albothricin is a streptothricin antibiotic.</p>

<p>MMV1578877 is an inhibitor of Mycobacterium ulcerans with an IC50 of 0.37 μM. It is applicable in research related to Buruli ulcer (BU).</p>

<p>Eremomycin, an antibiotic, can be used intramuscularly due to low toxicity.</p>

<p>α-Lipomycin is an acyclic polyene antibiotic isolated from the Gram-positive bacterium Streptomyces aureofaciens Tü117.</p>

<p>CysHHC10 is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria.</p>

<p>FtsZ-IN-8: Strong FtsZ inhibitor, blocks bacterial cell division, low resistance risk, minimal toxicity to mammalian cells.</p>

<p>SF2312 ammonium is the ammonium salt of SF2312, a phosphonate antibiotic and enolase inhibitor derived from the actinomycete Micromonospora and active under</p>

<p>Pectin, a plant cell wall derived heteropolysaccharide, forms nanoparticles for delivery and acts as an antimicrobial adsorbent.</p>

<p>Monogalactosyl diglyceride is a key lipid in photosynthesis and myelin, also boosting PKCα in oligodendrocytes.</p>

<p>2,5-Dimethylcyclohexa-2,5-diene-1,4-dione inhibits the viability of HL60 and K562 cells and exhibits antibacterial and anticancer properties.</p>

<p>Metallo-β-lactamase-IN-11 (compound 5f), a potent inhibitor of Metallo-β-lactamases (MBLs), demonstrates efficacy against the bacterial metallophyllactamase</p>

<p>Helvolic acid, an antibiotic derived from Xylaria sp., exhibits effectiveness against Gram-positive bacteria.</p>

<p>Rose Bengal is a photosensitizer effective against microbial cells. In the presence of light and oxygen, it inhibits the growth of yeast cells and other microorganisms, sometimes leading to their death. Rose Bengal can also limit bacterial growth, restrict the colony size of filamentous fungi, and suppress the growth of "spreading fungi" such as Rhizopus and Trichoderma.</p>

<p>Ibericin, an anthraquinone from Prismatomeris filamentosa roots, exhibits antibacterial effects on Gram-positive and Gram-negative bacteria.</p>

<p>Antibacterial agent 43 from patent WO2013030735A1 shows strong activity against infections and has research potential.</p>

<p>Gepotidacin S enantiomer is an S enantionmer of gepotidacin.</p>

<p>4-Ethoxycoumarin has antimicrobial activity.</p>

<p>Showdomycin is an antibiotic with antineoplastic activity.</p>

<p>UCM53 has a wide range of applications in life science related research.</p>

<p>Psammaplin A: marine-derived, inhibits HDAC/DNA methyltransferases, strong DAC1 blocker (IC50=0.9nM), antimicrobial against Gram-positive bacteria, anticancer.</p>

<p>Dicloxacillin Sodium (BRL1702 Sodium) is a β-lactamase resistant penicillin similar to oxacillin and it has activity against gram-positive/negative bacteria.</p>

<p>Fobrepodacin (SPR720) is an orally active and potent phosphate prodrug of SPR719 (VXc-486). Fobrepodacin has potent bactericidal activities in vivo.</p>

<p>Antimicrobial agent-39 (Compound 8i) is an antibiotic that targets the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It disrupts bacterial cell membranes, causing leakage of cellular contents and demonstrating broad-spectrum antibacterial activity. Additionally, Antimicrobial agent-39 targets organic cation transporters (OCT) and accumulates in infected kidneys, improving pyelonephritis in mouse models.</p>

<p>Psicofuranine: a nucleoside antibiotic inhibiting GMP synthase and P. falciparum growth with an IC50 of 0.3 mM.</p>

<p>Antibacterial agent 150 (compound 5g) exhibits potent activity against a wide range of bacteria, including both Gram-positive and Gram-negative species, with</p>

<p>Verruculogen, a toxin from Penicillium/Aspergillus, blocks Ca2+-K+ channels and halts mammalian M phase.</p>

<p>Polyunsaturated anacardic acid diene from cashew shells fights MRSA, S. mutans, and S. mansoni; inhibits soybean lipoxygenase-1.</p>

<p>Ro-23-9424, a cephalosporin with fleroxacin at 3' and aminothiazolylmethoxyimino at 7, exhibits strong broad-spectrum antibacterial effects.</p>

<p>N-3-oxo-pentanoyl-L-Homoserine lactone is a quorum sensing inhibitor for E. coli at 230 nM and activates V. fischeri luminescence at 20-200 nM.</p>

<p>KU13 is an inhibitor of non-tuberculous mycobacteria (NTM), demonstrating minimum inhibitory concentrations (MIC) of 0.032-8 μg/mL against Mycobacterium and 2 μg/mL against E. coli. It is applicable in research focused on anti-infective treatments.</p>

<p>EATC, a tetracycline byproduct, combats Pseudomonas to E. coli with MIC50s of 0.75-16 mg/L.</p>

<p>Olaquindox can be used in relevant research in the life sciences. Its product number is T2779 and CAS number is 23696-28-8.</p>

<p>Cyclacillin (Wy-4508), an oral aminopenicillin, fights many gram-positive/negative bacteria.</p>

<p>Nv-CATH, an antibacterial peptide derived from frogs, exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria, and significantly</p>

<p>PMAP-23 is an antimicrobial peptide (AMP) with biological activity, derived from porcine myeloid cells.</p>

<p>β-Lactamase-IN-5, a β-lactamase inhibitor isolated from compound 720, holds significant potential for studying bacterial infections.</p>

<p>SC 28538, a 5-nitroimidazole, matches metronidazole in potency against multiple pathogens in vitro.</p>

<p>Aerocyanidin is an antibiotic (antibiotic) that contains an isonitrile group and is primarily effective against Gram-positive bacteria.</p>

<p>Mycobactin P is one of iron(III) chelating compounds produced by most species of Mycobacteria which act as growth factors.</p>

<p>Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.</p>

<p>Framycetin is an aminoglycoside antibiotic and it also inhibits hammerhead ribozyme (Ki: 13.5 μM).</p>

<p>Galloyl-bis-HHDP glucose (HeT), an ellagitannin, exhibits phytoprotective effects against Pseudomonas viridiflava [1].</p>

<p>SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.</p>

<p>Amoxycillin arginine salt is a bioactive chemical.</p>

<p>Omadacycline: an aminomethylcycline antibiotic, cidal against four Streptococcus pneumoniae strains.</p>

<p>Thiotropocin is an antibiotic.</p>

<p>FPI-1523 inhibits β-lactamase (Kd: CTX-M-15 = 4 nM, OXA-48 = 34 nM), blocks PBP2 (IC50 = 3.2 μM), and has strong antimicrobial effects.</p>

<p>MBL-IN-1 (compound 41), a β-Lactamase inhibitor, exhibits an IC50 range of 0.10 to 25.85 µM and is utilized in the study of bacterial infections [1].</p>

<p>Lipid X is a monosaccharide precursor of E coli lipid A.</p>

<p>Antibacterial Agent 33 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Maximin 15, an antimicrobial peptide originating from toad brain, exhibits activity against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis, with</p>

<p>Cefatrizine inhibits eEF-2 kinase, affecting apoptosis, autophagy, and ER stress in cancers.</p>

<p>Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.</p>