Biochemicals and Reagents

<p>NTRC 824 is an innovative bioactive compound, meticulously developed from natural sources, with unique properties that facilitate its mode of action. The compound is derived through an advanced extraction and purification process ensuring its optimal efficacy and stability. NTRC 824 operates by modulating specific molecular pathways, which are central to its function in targeted applications.</p>

<p>Serotonin receptor 5-HT2B antagonist</p>

<p>The IGHG1 MS Calibrator-4 is a tryptic peptide that is a product of the Ig gamma-1 chain C region. This peptide is used as a calibrator for mass spectrometry. The IGHG1 MS Calibrator-4 contains Biologically Active Peptides, which can be used to identify the presence of proteins in biological samples. The New England Peptide Company offers peptides for use in proteomics, such as the IGHG1 MS Calibrator-4.</p>

<p>Inhibitor of GSK-3 kinase</p>

<p>E3 Ligase ligand 8 is a protein that belongs to the ubiquitin ligase family. It is involved in the regulation of gene expression and metabolism. E3 Ligase ligand 8 catalyzes the attachment of ubiquitin molecules to other proteins, marking them for degradation by proteasomes. It also has been shown to be a linker between the e3 ligases and their substrates.<br>E3 Ligase ligand 8 has been shown to bind DNA in vitro, which may be due to its ability to form heterocycles with c-Myc protein, leading to increased transcriptional activity.</p>

<p>Procalcitonin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids. Molecular weight is 12.8 kDa.amino acid sequence: APFRSALESS PADPATLSED EARLLLAALV QDYVQMKASE LEQEQEREGS SLDSPRSKRC GNLSTCMLGT YTQDFNKFHT FPQTAIGVGA PGKKRDMSSD LERDHRPHVS MPQNAN</p>

<p>E 7386 is a monoclonal antibody that targets β-catenin, which is found in the cytoplasm of cells. E 7386 binds to β-catenin and inhibits its interaction with the transcription factor LEF1, preventing it from binding to DNA. In addition, E 7386 has been shown to inhibit epidermal growth factor (EGF) signaling and potentiate tumor cell death by inducing apoptosis. E 7386 has also been shown to reduce microvessel density and increase tumor cell death in mouse xenografts. It is currently being used for treatment of colorectal carcinoma and other cancers.</p>

<p>Endothelin receptor antagonist</p>

<p>Sch 412348 is a potent and selective inhibitor of the human protein kinase C (PKC) δ isozyme. Sch 412348 inhibits PKCδ by binding to the ATP binding site, thus blocking the enzyme's activity. Sch 412348 is a peptide that can be used as a research tool in cell biology, pharmacology, and other life sciences. It can also be used as an antibody or as a ligand for receptor studies.</p>

<p>Diltiazem-d3 is a high purity, water soluble form of diltiazem. Diltiazem-d3 is an inhibitor of phosphodiesterase (PDE) and an activator of potassium channels. It has been used in research as a tool to study the interaction between PDEs and potassium channels.</p>

<p>Saikogenin A is a natural compound found in the tuberous roots of Pueraria lobata that has been shown to have a variety of biological activities. Saikogenin A inhibits protein synthesis through a number of mechanisms, including interfering with the production of growth factors, blocking the conversion of epoxyeicosatrienoic acids to prostaglandins, and inhibiting the activity of human liver cancer cells. It also has anti-inflammatory properties and has been shown to inhibit UV absorption as well as erythromycin-induced uvB damage in human skin cells. The triple-quadrupole mass spectrometry analysis reveals that saikogenin A has absorptions at 336, 338, and 340 nm in urine samples. This suggests that saikogenin A may be metabolized by cytochrome P450 enzymes into metabolites with different absorption spectra.</p>

<p>CD49d antibody (PE) was raised in mouse using human CD49d as the immunogen.</p>

<p>Hydroxypyruvic acid lithium hydrate is a research tool that can be used to study the interaction of peptides with antibodies and receptor proteins. It is also used as an activator for the production of antibodies. This product is a white powder that is soluble in water and alcohol. CAS No. 209728-15-4</p>

<p>Fulacimstat is a drug that is used to treat chronic kidney disease and ventricular dysfunction. Fulacimstat blocks angiotensin II, which is a potent vasoconstrictor, by inhibiting the angiotensin-converting enzyme (ACE). It has been shown to have beneficial effects on cardiac function in patients with chronic kidney disease who are undergoing hemodialysis. Fulacimstat has also been shown to reduce blood pressure in patients with renal impairment. Fulacimstat lowers potassium levels and increases serum levels of renin, which may lead to adverse events such as infarction or hyperkalemia. Fulacimstat may be an effective treatment for heart failure, but the safety profile needs to be further investigated before it can be recommended for this use.</p>

<p>Please enquire for more information about 1-Undecanoyl-2-hydroxy-sn-glycero-3-phosphocholine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Potent inhibitor of SERCA ATPase</p>

<p>Etamicastat hydrochloride is a drug that inhibits the activity of the human liver enzyme CYP2D6. It is an inhibitor of the acetylation of dopamine to noradrenaline, which is important for the synthesis of adrenaline and dopamine. Etamicastat hydrochloride has been shown to have affinity for both human and monkey tissues. It also inhibits hydroxylation in rat plasma, liver cytosol, and liver microsomes. This drug has also been shown to inhibit dopamine hydroxylase in rat brain tissue as well as in vitro studies with human liver preparations. Etamicastat hydrochloride has been found to be effective against Parkinson's disease and other diseases that are associated with a decrease in dopamine levels.</p>

<p>Sostenuto (sRANKL) is a cytokine that binds to the activator of the receptor activator of NF-κB ligand. It is a soluble protein that can activate cells and regulate inflammatory responses. Sostenuto has been shown to be an important regulator in the immune system and can stimulate macrophages, T cells, and B cells by binding to their receptors. It also inhibits neutrophil apoptosis and enhances IL-10 production in macrophages. Sostenuto has been shown to have a regulatory effect on bacterial growth, specifically Escherichia Coli which is found in the gut.</p>

<p>Hepronicate is a polyunsaturated fatty acid that is a precursor to prostaglandin E1. It is available as a prescription drug and is used for the treatment of symptoms caused by congestive heart failure, diabetic neuropathy, and corneal endothelial cell dysfunction. Hepronicate has also been shown to stimulate the growth of cells in culture and may be an effective treatment for many types of cancer. This drug binds to the polyunsaturated fatty acid receptor on the surface of cells, which leads to an increase in polyunsaturated fatty acids in the cell membrane and activation of protein kinase C. Hepronicate may also inhibit tumor growth by binding to DNA-dependent RNA polymerase, preventing transcription and replication.</p>

<p>Agistatin B is a natural product that inhibits cholesterol biosynthesis by blocking the conversion of hydroxylated lanosterol to cholesterol. Agistatin B is biosynthesized from Fusarium spp. and has been shown to inhibit the growth of Fusarium graminearum, a fungus that causes head blight in wheat and barley. This compound may have applications as an antifungal agent or for the treatment of hypercholesterolemia.</p>

<p>TFC 007 is a small molecule that has been shown to cause cardiac hypertrophy in animals. It binds to the receptor for ubiquitin and the ligand, which are involved in the inflammatory process. TFC 007 is a ligand-binding molecule that activates the ubiquitin-proteasome system, leading to cell death. TFC 007 also inhibits the synthesis of inflammatory cytokines, such as IL-1β and IL-6, by binding to their respective receptors. This inhibition leads to decreased levels of proinflammatory cytokines and reduced cardiac hypertrophy.</p>

<p>Pi(3,4)P2 is a phospholipid that is found in the membrane of all eukaryotic cells. It is one of the most abundant phospholipids in the cell and can be found in many different forms. Pi(3,4)P2 has been shown to interact with proteins and ion channels as well as being involved in cellular functions such as cell proliferation and migration. Pi(3,4)P2 is a vital research tool for studying how cells respond to stimuli and for identifying new drug targets. Pi(3,4)P2 can be synthesized by reacting 1-palmitoyl-2-oleoyl-sn-glycero-3-[phosphocholine] (PC), 1,1'-bis[di(carboxylatooxy)phosphino]ferrocene (PCF), and lithium diisopropylamide (LDA).</p>

<p>BI-847325 is a new compound that inhibits the expression of genes that are involved in the development of cancer. It has been shown to have a potent inhibitory effect on cell proliferation and pro-apoptotic protein. BI-847325 is orally active, crossing the blood brain barrier in animals, and has a low toxicity profile. BI-847325 inhibits RNA synthesis by binding to the enzyme rRNA polymerase or by inhibiting ribosome activity. This compound also inhibits ATP levels and replication of DNA in liver cells, which may be due to its ability to bind to metagene sequences. BI-847325 has demonstrated promising results in animal studies for gastrointestinal toxicities, with no evidence of weight loss or anorexia at doses up to 15 times higher than the dose required for efficacy against cancer cells.</p>

<p>CD44 antibody (PE) was raised in rat using murine CD44 as the immunogen.</p>

<p>H3B-6545 is an investigational drug that is a CDK4/6 inhibitor. H3B-6545 has been shown to inhibit the growth of breast cancer cells in preclinical studies. The mechanism by which H3B-6545 inhibits breast cancer cell growth is not fully understood, but it appears to be related to its ability to inhibit aromatase activity and affect the expression of epidermal growth factor receptor (EGFR). The efficacy of H3B-6545 in patients with estrogen receptor (ER)-positive, HER2-negative metastatic breast cancer who have progressed following endocrine therapy or chemotherapy is currently being evaluated in a multicenter phase II study. H3B-6545 has also been shown to cause DNA mutations in vitro.</p>

<p>CD19 antibody (biotin) was raised in mouse using human CD19 as the immunogen.</p>

<p>Apimostinel is a peptide-based therapeutic agent, which is derived from a modification of endogenous neuropeptides. It is designed to selectively modulate the NMDA receptor, a subtype of glutamate receptor, which plays a crucial role in synaptic plasticity and neural communication. Apimostinel functions as a partial agonist of the glycine site on the NMDA receptor. This mechanism supports synaptic strength and plasticity without the excessive activation associated with excitotoxicity, thereby providing potential neuroprotective effects.</p>

<p>UCT943 is a drug candidate that inhibits the activity of cgmp-dependent protein kinase and has been shown to have an inhibitory effect on the signal pathways of antimalarial drugs. It also has antibacterial properties, which have been observed in vitro studies. UCT943 is being developed for the treatment of schistosomiasis, a disease caused by Schistosoma. The effectiveness of UCT943 against this infection is currently being investigated in clinical studies.</p>

<p>2-((6-Methylpyridin-2-yl)methyl)isoindoline-1,3-dione is a peptide inhibitor that binds to the ATP binding site of the potassium channel. It is used as a research tool for studying the function of ion channels and receptors. 2-((6-Methylpyridin-2-yl)methyl)isoindoline-1,3-dione is highly pure and can be used in life science research and development.</p>

<p>(S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-amine is a small peptide that is used as a research tool to study the function of ion channels and other proteins. It has been shown to bind to the alpha subunit of the GABA receptor and inhibit GABA binding. This compound is also useful as an inhibitor of phosphorylation by protein kinase C. (S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-amine can be used in cell biology, pharmacology, and ligand activation studies.</p>

<p>6-​[(Aminocarbonyl)​(2,​6-​difluorophenyl)​amino]​-​2-​(2,​4-​difluorophenyl)​-3-​pyridinecarboxamide is a molecule that inhibits the activity of protein kinases and has been shown to be effective in the treatment of rheumatoid arthritis. 6-(Aminocarbonyl)-2-[(2,6-difluorophenyl)amino]-3-[(2,4-difluorophenyl)amino]pyridine carboxamide was developed by VX Pharma and is currently being investigated in clinical trials.</p>

<p>MMB-4 is an oxime drug that is used as an anthelmintic. It has a low potency and body formation, which is thought to be due to its pyridinium group. MMB-4 has been shown to have both anthelmintic and antihelminthic effects in mice, as well as being effective against a number of parasites in vitro. MMB-4 has also been shown to have no effect on the human serum at physiological levels, but can cause serious side effects when taken at higher concentrations. The cyclic peptide MMB-4 was synthesized by chemical methods from indirubin, which is a natural product found in plants. In the study, it was shown that the reaction mechanism for MMB-4 involves the formation of a free radical intermediate with oxygen. This intermediate then reacts with other molecules to form covalent bonds.<br>MMB-4 can be used for analytical purposes due to its stability and react</p>

<p>1-Deazariboflavin is an analog of riboflavin that has been shown to have potent anticancer activity. It functions as a kinase inhibitor, preventing the phosphorylation of proteins involved in cancer cell growth and survival. 1-Deazariboflavin has been found in urine samples from cancer patients, suggesting that it may play a role in the body's natural defense against cancer. Studies have shown that this compound induces apoptosis (programmed cell death) in human cancer cells, including those derived from breast, lung, and colon tumors. Additionally, 1-Deazariboflavin has been found to inhibit glycerol kinase activity in Chinese hamster ovary cells. These findings suggest that 1-Deazariboflavin may be a promising candidate for the development of novel anticancer therapies.</p>

<p>PRT062607 (P505-15) HCl is a small-molecule inhibitor, which is a synthetic compound with a highly specific action on the 3-phosphoinositide-dependent protein kinase-1 (PDK1). This compound is derived through rational drug design processes aimed at modulating intracellular signaling pathways. PRT062607 acts by selectively binding to the ATP-binding site of PDK1, thereby inhibiting its kinase activity. This inhibition disrupts downstream signaling mediated by the phosphoinositide 3-kinase (PI3K) pathway, which is pivotal in regulating various cellular processes, including growth, survival, and metabolism.</p>

<p>CD72.1 antibody (biotin) was raised in mouse using DBA/2 murine spleen cells as the immunogen.</p>

<p>CYM 5541 is a selective herbicide, which is synthesized from organic chemical compounds. It functions by interfering with the metabolic processes critical to weed growth and development. Specifically, CYM 5541 targets and inhibits specific enzymes that are essential for cell division and photosynthesis in undesirable plants.<br><br>The primary application of CYM 5541 is in agricultural settings, where it is used to manage weed populations that compete with crops for light, nutrients, and water. It is particularly effective in controlling broadleaf and grassy weeds. Through its precise mode of action, CYM 5541 enables efficient, targeted suppression of non-crop vegetation, thereby maintaining the health and yield of the desired plants. Its use in integrated pest management strategies underscores its role in sustainable farming practices, minimizing the environmental impact while maximizing agricultural productivity.</p>

<p>CD4a antibody (Spectral Red)) was raised in mouse using CD4a as the immunogen.</p>

<p>DS-1001b is a synthetic small molecule, which is derived from the modification of existing anti-inflammatory agents with the purpose of enhancing efficacy and minimizing side effects. Its mode of action involves the selective inhibition of specific pro-inflammatory cytokines, thereby reducing inflammation at the molecular level.</p>

<p>CD3e antibody (biotin) was raised in mouse using porcine CD3e as the immunogen.</p>

<p>PF-04279405 is a molecule that is being developed for the treatment of type 2 diabetes. PF-04279405 has been shown to reduce plasma glucose levels in diabetic patients and to improve insulin sensitivity. It also has a low risk of toxicity because it does not target glucose uptake into cells and does not cause any pancreatic toxicity in animal studies. Clinical trials have been conducted to assess the safety and efficacy of PF-04279405 in humans. In these trials, two-way crossover designs were used with the dose range of 100 mg to 400 mg per day. The clinical pathology study showed that PF-04279405 had no toxicities on heart function, cardiac electrical activity, or cardiac tissue structure. Regulatory endpoints were observed in healthy volunteers during these trials with no adverse events reported.</p>

<p>Please enquire for more information about DL-valine-3-d1 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CD45.2 antibody (CY5) was raised in mouse using CD45.2 as the immunogen.</p>

<p>Chrysotoxine is a research tool that activates a receptor and/or ligand. Chrysotoxine is an activator of ion channels, which are proteins located in cell membranes that regulate the flow of ions across the membrane. It is also an inhibitor of protein interactions and has been used to study the interaction between peptides and antibodies. Chrysotoxine binds to an antibody or peptide and prevents it from binding with its ligand or receptor, respectively. The resulting complex can be studied using various techniques such as Western blotting.</p>

<p>Fluorofenidone is an antifibrotic compound, which is a synthetic molecule. It functions by inhibiting the synthesis of collagen and other extracellular matrix components, mitigating the progression of fibrotic diseases. This mode of action involves the modulation of signaling pathways crucial to fibroblast proliferation and differentiation, ultimately reducing tissue fibrosis.</p>

<p>UKI-1 is a mutant form of the enzyme urokinase, which is used for the treatment of cancer. It has shown to inhibit metastasis by binding to the extracellular matrix and preventing cells from migrating. UKI-1 has also been found to have a structure that resembles benzamidine, a ligand that can be used as a template for optimisation. The crystal structure of UKI-1 has revealed that it contains an active site with amino acid residues that are similar to those of plasminogen activator (PA) molecules, which are molecules that are involved in blood clotting.</p>

<p>UNC2170 trifluoroacetate is a small-molecule inhibitor, which is developed through targeted synthesis at academic and research institutions. This compound is specifically designed to interact with bromodomains, which are motifs within proteins involved in recognizing and interpreting acetylated lysines on histone tails, crucial for epigenetic regulation.</p>

<p>Affinity purified Sheep polyclonal Bovine Transferrin antibody</p>

<p>CD12681 is a retinoic acid analogue that contains a heterobicyclic ring system. This molecule has been shown to have potential in the treatment of inflammatory diseases, including multiple sclerosis and rheumatoid arthritis. CD12681 binds to nuclear receptors, such as RAR-β and PPARγ, which are involved in cell proliferation and differentiation. It also inhibits the production of IL-17 by Th17 cells. These effects contribute to its therapeutic potential for autoimmune diseases.</p>

<p>GR 125743 is a small molecule compound that acts as a selective antagonist of the chemokine receptor CCR5. It is derived from a synthetic source designed to inhibit the interaction between the CCR5 receptor and its natural ligands. The primary mode of action involves blocking the CCR5 receptor, which is a critical co-receptor used by the Human Immunodeficiency Virus (HIV) to enter and infect host cells. By preventing this interaction, GR 125743 hinders the virus's ability to propagate within the host organism.</p>

<p>MEK inhibitor</p>

<p>CD69 antibody (PE-CY7) was raised in hamster using Y245 murine dendritic epidermal T cell line as the immunogen.</p>

<p>Alrestatin sodium is a diagnostic agent that can be used to diagnose pancreatic disease. It has been shown to decrease plasma glucose and enhance the uptake of glucose into tissues. Alrestatin sodium is also used in pharmaceutical preparations, including those for the treatment of fatty acid esters, fatty alcohols, and irritants. This drug is available as an injection or intravenous drip.</p>

<p>Amantadine is a prodrug that is hydrolyzed in vivo to form the active compound, amantadine triphosphate. It has antiviral activity against influenza virus and other RNA viruses. Amantadine is used to treat influenza A and B infections, as well as symptoms of influenza-like illness. This drug was approved by the FDA in 1967 and has been used as an alternative to neuraminidase inhibitors such as oseltamivir or zanamivir. Amantadine inhibits the release of neurotransmitters from nerve endings and may have some efficacy in treating neurodegenerative diseases such as Parkinson's disease, Huntington's disease, or Alzheimer's disease. Amantadine requires a water vapor to be effective because it is poorly soluble in water.</p>

<p>Tomivosertib hydrochloride is an investigational small molecule inhibitor targeting the mitogen-activated protein kinase interacting kinase (MNK) pathway, which is a synthetic product derived from chemical synthesis. Its mode of action involves the selective inhibition of MNK1 and MNK2 enzymes, leading to the disruption of the phosphorylation of eIF4E, a key component in the translation initiation process. This interruption suppresses the production of oncogenic proteins involved in tumor growth and metastasis.</p>

<p>Ly2444296, also known as FP3FBZ, is an experimental pharmaceutical compound, specifically a small-molecule antagonist designed to target a particular receptor system in the central nervous system. It is synthesized through a complex series of chemical reactions, leveraging advanced organic synthesis techniques. The primary mode of action for Ly2444296 is the selective inhibition of the norepinephrine transporter (NET), which results in increased levels of norepinephrine in the synaptic cleft. This modulation of neurotransmitter dynamics can have significant effects on mood and stress responses.</p>

<p>Inhibitor of checkpoint kinase CHK1</p>

<p>Symadex is a caproic acid-based probiotic product that contains live bacteria. The bacteria are selected for their ability to produce pyrimidine compounds, which are necessary for the synthesis of DNA, and have potent antitumor activity. Symadex has been shown to inhibit the growth of various carcinoma cell lines and prostate cancer cells in vitro, with hydroxyl groups on the molecule binding to DNA duplexes. Symadex also possesses Toll-like receptor activation and immunomodulatory properties. This product may be used as a diagnostic or therapeutic agent in infectious diseases, as well as autoimmune diseases such as rheumatoid arthritis.<br>&gt;&gt;END&gt;&gt;</p>

<p>CD40 antibody (PE) was raised in rat using CD40 as the immunogen</p>

<p>Tannin albuminate is a protein complex, which is formed by the interaction of tannins and albumin. It primarily originates from plant sources that produce tannins, such as oak bark or various other tannin-rich materials, and egg albumin or other albumin sources. The mode of action of tannin albuminate involves its ability to form protective films over inflamed mucosal surfaces, thus exerting an astringent effect. This effect reduces secretions and protects against irritants, which is particularly beneficial in treating gastrointestinal disturbances.</p>

<p>CD8a antibody (CY5) was raised in Mouse using the alpha chainc of chicken CD8 as the immunogen.</p>

<p>CD106 antibody (biotin) was raised in rat using murine CD106/VCAM-1 as the immunogen.</p>

<p>C-82 is a synthetic chemical inhibitor, which is commonly sourced from laboratory-derived compounds and characterized through organic chemistry techniques. Its mode of action involves selective inhibition of specific enzymes or proteins within particular biochemical pathways, rendering it useful for dissecting complex biological systems. This specificity allows researchers to elucidate the roles of individual components within larger networks by observing downstream effects of inhibition.</p>

<p>(E)-5-((4-Hydroxyphenyl)diazenyl)benzene-1,3-diol is a compound that can be synthesized using the UV irradiation of a solution containing phenol and acetophenone. It has biological properties and can be used in research to determine the result of light irradiation on various substances. This product is an organic compound that is soluble in water and has an absorption maximum at around 280 nm. The UV irradiation of this product can lead to thermal stability, as well as solutions with phosphoric acid or other substituents.</p>

<p>CD56 antibody (PE CY5.5) was raised in mouse using human CD56 as the immunogen.</p>

<p>CM-272 is a small-molecule inhibitor, which is synthetically derived with high specificity and selectivity. Its mode of action involves dual inhibition of G9a and DNMT (DNA methyltransferases), key enzymes responsible for histone and DNA methylation. This dual inhibition alters the epigenetic landscape, leading to changes in gene expression profiles.</p>

<p>KLRG1 antibody (PE) was raised in hamster using activated NK (A-LAK) cells from B6 mice as the immunogen.</p>

<p>PDE5 inhibitor 42 is a synthetic drug that has been shown to increase intracellular cAMP levels in a concentration-dependent manner. This drug is used for the treatment of erectile dysfunction, by inhibiting the enzyme phosphodiesterase type 5 (PDE5) in penile tissue. PDE5 inhibitor 42 binds to and inhibits PDE5, which prevents the breakdown of cyclic adenosine monophosphate (cAMP) and increases intracellular cAMP levels. This agent has been shown to be effective in animal models of erectile dysfunction.</p>

<p>FASN-IN-2 is a chemical inhibitor, specifically targeting fatty acid synthase (FASN), a key enzyme involved in lipogenesis. It is derived from synthetic chemical methods and engineered to interfere with the enzymatic function of FASN by binding to its active site, thereby preventing the conversion of acetyl-CoA and malonyl-CoA to fatty acids. This inhibition is crucial as FASN is overexpressed in various cancer cells, contributing to their rapid proliferation and survival by providing necessary lipids for membrane synthesis.</p>

<p>Sparteine acts as an inhibitor of voltage-gated sodium channels. In organic chemisty, it is used for chiral synthesis.</p>

<p>HLI 373 dihydrochloride is a research tool that can be used as an activator or ligand. It has been shown to bind to the receptor and cell biology, which can be used for ion channels, high purity, protein interactions, pharmacology, peptides, and life science. HLI 373 dihydrochloride is a potent inhibitor of the voltage-gated potassium channel Kv1.5 in neuronal cells.</p>

<p>CD107b antibody was raised in rat using glycoproteins purified from BALB/c mouse embryo 3T3 cell line as the immunogen.</p>

<p>TCS 2510 is a chemical compound, specifically a selective inhibitor, derived from synthetic organic chemistry. This compound exhibits its functional mechanism through targeted interaction with specific enzymes or proteins, thereby modulating their biological activity. The mode of action typically involves binding to the active site or allosteric site, resulting in altered enzyme activity, which can aid in elucidating pathways and biological processes.</p>

<p>CD62E antibody (PE) was raised in Mouse using TNF-Activated human umbilical vein endothelial cells as the immunogen.</p>

<p>EPZ020411 is a synthetic, small-molecule compound that inhibits the methylation of histones and their associated proteins. EPZ020411 has been shown to inhibit tumor growth in xenograft models. The most effective dose of EPZ020411 was found to be 10 μM for inhibiting protein methylation and decreasing mitochondrial membrane potential. EPZ020411 is a reactive molecule that may be used as a probe for studying the biological sample or cellular system in which it is incubated.</p>

<p>CD45.1 antibody (PE-CY7) was raised in mouse using CD45.1 as the immunogen.</p>

<p>CD45 antibody (FITC) was raised in Rat using as exon C-dependent epitope of CD45 glycoprotin as the immunogen.</p>

<p>Epertinib hydrochloride is a potent tyrosine kinase inhibitor, which is a small molecule derived from rational drug design targeting specific enzymes involved in signal transduction pathways. This compound acts by selectively inhibiting the activity of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinases, which are pivotal in the proliferation and survival of cancer cells.</p>

<p>D2 receptor agonist; for treating Parkinson's disease and restless leg syndrome</p>

<p>(D)-PPA, known as (D)-phenylpropanolamine, is a chiral compound frequently utilized in chemical research and synthesis. It is derived from the stereospecific synthesis of phenylpropanolamine, a known sympathomimetic compound. The mode of action of (D)-PPA involves interaction with adrenergic receptors, exhibiting a preference for specific binding characteristics associated with its stereochemistry. This interaction can influence various biochemical pathways, making it a valuable tool in the study of adrenergic functions on a molecular level.</p>

<p>Pactimibe is a peptide inhibitor that targets the protein interactions of the ATP binding cassette transporter A1 (ABCA1) and phospholipid transfer protein (PLTP). It has been shown to bind to both receptors in the cell membrane. These interactions result in inhibition of lipid metabolism, which can be used as an experimental tool for research on ion channel activity. Pactimibe is also a high-purity reagent that can be used as a research tool for studying ligand-receptor interactions.</p>

<p>Calpain antagonist</p>

<p>CD122 antibody (Allophycocyanin) was raised in rat using rat myeloma YB2/0 transfected with truncated murine IL-2RB cDNA as the immunogen.</p>

<p>Grk2I is a selective inhibitor, which is a synthetic compound designed to target G protein-coupled receptor kinase 2 (GRK2). This compound is developed through intricate chemical synthesis, enabling precise modulation of GRK2 activity. Its mode of action involves the competitive inhibition of GRK2, thereby preventing it from phosphorylating target receptors. This disruption of receptor phosphorylation subsequently alters downstream signaling pathways, which can be crucial in various physiological and pathological processes.</p>

<p>(R)-Crizotinib-d5 is a sulfadiazine compound that is widely used in industrial and Life Sciences applications. It acts as a chemokine and fatty acid inhibitor, which makes it valuable for research purposes. (R)-Crizotinib-d5 has been shown to enhance biomass production in various organisms, including bacteria and yeast, by improving the utilization of carbon sources such as methanol, cellulose, xylose, and glutamate. Additionally, this compound has been found to promote the secretion of growth factors and increase the expression of important proteins like epidermal growth factor and acetyltransferase. Its unique properties make (R)-Crizotinib-d5 an essential tool for scientists working in the fields of biotechnology and bioengineering.</p>

<p>CD28 antibody (FITC) was raised in hamster using CD28 costimulatory receptor as the immunogen.</p>

<p>Inhibitor of dopamine-β-hydroxylase</p>

<p>CYM 50308 is a synthetic herbicide, which is synthesized through chemical processes designed to target specific plant physiological pathways. Its mode of action involves the inhibition of key enzyme pathways that are essential for the biosynthesis of amino acids in plants. This disruption leads to the cessation of protein synthesis, ultimately causing the death of targeted weed species.</p>

<p>Jaspamycin is an antitumor antibiotic, which is a natural product isolated from the bacterium *Streptomyces hygroscopicus*. Its mode of action involves disrupting RNA synthesis by inhibiting nucleic acid chain elongation, thereby impeding cell proliferation and leading to cell death in rapidly dividing cancer cells. This mechanism makes Jaspamycin particularly effective as a chemotherapeutic agent.</p>

<p>RO8191 is a small molecule that has been shown to inhibit replication of hepatitis B virus (HBV) in vitro and in vivo. RO8191 has also been shown to inhibit replication of human papillomavirus (HPV) and cervical cancer cells. In cellular systems, RO8191 inhibits the activity of cellular polymerase chain reaction (PCR) replicons, which are used as a model for HBV and HPV replication. The compound also inhibits the activity of replicons derived from human immunodeficiency virus type 1 (HIV-1). In vivo, RO8191 inhibited viral load in mice infected with HBV.<br>Mesenchymal stromal cells (MSCs) have been shown to express high levels of RO8191's target enzyme, poly(ADP-ribose) polymerase 1 (PARP-1), suggesting that MSCs may be an effective delivery vehicle for this drug. This drug has not yet been evaluated for</p>

<p>GSK LSD1 Dihydrochloride-d4 is a chemical inhibitor that binds to the active site of the enzyme lactate dehydrogenase (LDH) and prevents its activity. LDH is an enzyme that converts pyruvate to lactate, which is then used as an energy source in cells. GSK LSD1 Dihydrochloride-d4 has been shown to inhibit the proliferation of Thp-1 cells induced by inflammatory bowel disease or all-trans retinoic acid, which are used for leukemic research. The LDH inhibition leads to decreased autophagy and cell death in vitro and in vivo. GSK LSD1 Dihydrochloride-d4 has also been shown to be less toxic than other chemical inhibitors when administered orally to leukemia mice.</p>

<p>IHR-1 is a peptide-based antihypertensive product, which is derived from a specific strain of yeast through fermentation processes. Its mode of action involves the inhibition of the angiotensin-converting enzyme (ACE), an important component of the renin-angiotensin system that regulates blood pressure. By inhibiting ACE, IHR-1 effectively reduces the conversion of angiotensin I to angiotensin II, thereby helping to lower blood pressure levels.</p>

<p>EPZ011989 trifluoroacetate is a small molecule inhibitor, specifically targeting the EZH2 methyltransferase. This enzyme is a part of the Polycomb-group proteins, originating from the human chromatin-modifying system, which plays a vital role in epigenetic gene regulation. The mode of action involves the inhibition of methyltransferase activity, reducing the trimethylation of histone H3 on lysine 27 (H3K27me3), a modification linked to the repression of gene transcription.</p>

<p>N-[[4-(1-Methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine is a research tool that activates the Ligand and Receptor. It has been developed as a ligand for GPCR receptors, such as the cannabinoid receptor 1 (CB1). This drug also functions as an inhibitor of ion channels, including sodium channels and potassium channels. NMPPIPA also inhibits protein synthesis by binding to ribosomes.</p>

<p>Agomelatine (L(+)-tartaric acid) is a synthetic antidepressant, which is derived from chemical synthesis. It acts primarily by serving as an agonist at melatonin MT1 and MT2 receptors and as an antagonist at 5-HT2C serotonin receptors. This dual mechanism of action is particularly significant as it helps regulate sleep-wake cycles and mood by re-establishing normal circadian rhythms.</p>

<p>CD23 antibody (PE-CY7) was raised in rat using CD23 low affinity IgE Fc receptor as the immunogen.</p>

<p>CD45.1 antibody (Spectral Red) was raised in mouse using CD45.1 as the immunogen.</p>

<p>CD80 antibody (PE) was raised in rat using CD80/B7-1 as the immunogen.</p>

<p>CD38 antibody (Allophycocyanin) was raised in rat using CD38 as the immunogen.</p>

<p>ELN 318463 racemate is a research tool for studying protein interactions, antibody binding, and ion channel function. It is a potent activator of the GABAA receptor that can be used to study the role of the GABA system in neuronal physiology. ELN 318463 racemate is also an inhibitor of ligand binding to receptor tyrosine kinases. In cell biology, ELN 318463 racemate has been shown to inhibit protein synthesis and modulate ion channels in neuronal cells. This drug also binds to peptides and inhibits their interaction with proteins.</p>

<p>CD5 antibody (Allophycocyanin) was raised in rat using CD5/Lyt-1 as the immunogen.</p>

<p>Mefuparib is a research tool that is used to study protein interactions. It is an inhibitor of the receptor tyrosine kinase, which is a type of enzyme that transmits signals from outside the cell (e.g., hormones) to inside the cell, where the signal causes a change in function (e.g., growth). Mefuparib binds to and blocks the active site of these enzymes, preventing their activity. Mefuparib has been shown to inhibit ion channels and voltage-sensitive calcium channels as well as cell proliferation and migration. This drug also inhibits protein synthesis by inhibiting phosphorylation of ribosomal proteins S6K and 4EBP1, which are associated with tumorigenesis and metastasis.</p>

<p>PS-1145 dihydrochloride is a synthetic chemical compound that acts as a selective inhibitor of the enzyme IκB kinase β (IKK-β). This compound is typically derived through complex chemical synthesis techniques in laboratory environments. PS-1145 targets the NF-κB signaling pathway by directly binding to IKK-β, thereby inhibiting its activity. This inhibition prevents the phosphorylation and subsequent degradation of IκB proteins, which in turn retains NF-κB in the cytoplasm and prevents its transcriptional activity in the nucleus.</p>

<p>Procinolol is a pharmaceutical compound classified as a beta-adrenergic blocker, which is a type of medication derived from synthetic sources. Its primary mode of action involves the competitive antagonism of beta-adrenergic receptors, particularly in cardiac tissue, leading to a decrease in heart rate and myocardial contractility. This mechanism results in a reduction of cardiac output, which consequently lowers blood pressure and myocardial oxygen demand.</p>

<p>(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoic acid is a research tool. It is used as an activator, a ligand, and a receptor. This product is also used in cell biology and in antibody production.</p>

<p>CD5 antibody (FITC) was raised in rat using CD5/Lyt-1 as the immunogen.</p>