Metabolismo

<p>OGT inhibitor 4a is an O-linked n-acetylglucosaminyltransferase (OGT) inhibitor with anticancer activity for the study of autoimmune and neurological disorders.</p>

<p>Potent, reversible, non-toxic MPO inhibitor; reduces stroke damage &amp; study aid for bronchial dysplasia.</p>

<p>PEP 3 CHA: a carbohydrate metabolite with cytoprotection and antioxidant properties; cell membrane permeable.</p>

<p>N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.</p>

<p>JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM).</p>

<p>SGN-2FF is an oral fucosyltransferase inhibitor with antitumor activity.</p>

<p>Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.</p>

<p>Praziquantel (Droncit) is an anthelmintic that paralyzes worms by increasing calcium in muscle cells, causing tegument damage and immune response.</p>

<p>LG-100064 is an agonist of retinoid-X-receptor (RXR)(EC50s of 330 nM, 200 nM, and 260 nM for RXRα, RXRβ and RXRγ)</p>

<p>ML390 exerts its potent differentiation effect on multiple leukemia models.</p>

<p>Clarithromycin (A-56268), a macrolide antibiotic, inhibits Cytochrome P450 3A4 and P-Glycoprotein.</p>

<p>CVT-10216 inhibits ALDH2 (IC50: 29 nM) and ALDH-1 (IC50: 1.3 μM), reducing alcohol intake and anxiety in rats.</p>

<p>Abiraterone Acetate (CB7630) is an androstene derivative that inhibits steroid 17-alpha-hydroxylase and is used as an antineoplastic agent.</p>

<p>Moclobemide (Ro111163) is a reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.</p>

<p>DPA-714: a TSPO ligand (Ki=7 nM) with a fluorine atom for PET imaging of inflammation and brain tumors.</p>

<p>Chlormethiazole hydrochloride is an anticonvulsant and sedative. It also has neuroprotective.</p>

<p>PFB-FDGlu, a cell-permeable GCase substrate, is cleaved to emit fluorescein, used to assess GCase activity in live cells via flow cytometry.</p>

<p>6-Aminocaproic acid (EACA) is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.</p>

<p>Diethylcarbamazine citrate treats filariasis, targeting W. bancrofti and L. loa by inhibiting arachidonic acid in microfilaria.</p>

<p>Sucralose (Trichlorosucrose), an artificial sweetener, is not degraded by the body, so it is noncaloric.</p>

<p>1,2-Dipalmitoyl-sn-glycerol 3-phosphate sodium, a phosphatidic acid, is a human endogenous metabolite.</p>

<p>BAMB-4 inhibits ITPKA, impeding lung tumor cell metastasis, with an IC50 of 37 μM.</p>

<p>CBR-5884: active PHGDH inhibitor, IC50=33μM, disrupts serine synthesis, selectively targets high-serine cancers.</p>

<p>Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.</p>

<p>GSK-7975A is a potent and orally available inhibitor of CRAC channel.</p>

<p>Imidacloprid-urea, a byproduct of imidacloprid, may alter its environmental behavior by competing for soil binding sites.</p>

<p>Nampt-IN-5 is a potent and orally active inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) .</p>

<p>LY2183240 inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM).</p>

<p>GV-58 agonizes N/P-Q-type Ca2+ channels (EC50: 7.21/8.81 μM) with 20x less inhibition on CDK kinases.</p>

<p>Ranolazine 2HCl, an antianginal, treats arrhythmia by inhibiting sodium current without changing blood pressure or heart rate.</p>

<p>Cecropin B acetate activates NF-κB, inhibits CYP3A29, disrupts PXR/RXR-α-DNA binding, and has potent antimicrobial properties.</p>

<p>L-Tyrosine ((S)-Tyrosine) is a naturally occurring tyrosine and is synthesized in vivo from L-phenylalanine, considered a non-essential amino acid.</p>

<p>(±)-N-3-Benzylnirvanol is a racemic mixture of (+)-N-3-Benzylnirvanol and (-) -n-3-Benzylnirvanoll.</p>

<p>Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.</p>

<p>N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.</p>

<p>Managlinat dialanetil (MB06322) is an orally available fructose 1,6-bisphosphatase (FBPase) inhibitor with hypoglycaemic activity for type 2 diabetes.</p>

<p>Naringinase, with α-L-rhamnosidase and β-D-glucosidase activities, transforms steroids, antibiotics, and glycosides.</p>

<p>GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).</p>

<p>T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Vasopressin acetate: cyclic nonapeptide synthesized in the hypothalamus, functions as a neurotransmitter via G protein-coupled receptors.</p>

<p>P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.</p>

<p>Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties.</p>

<p>TNO155 inhibits SHP2 enzyme with an IC50 of 0.011 μM, potentially aiding cancer treatment.</p>

<p>Cefdinir (FK-482), a semi-synthetic third-gen cephalosporin antibiotic, treats ear, sinus, throat, and skin infections.</p>

<p>Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.</p>

<p>OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) is a selective and metabolically stable anandamide cellular uptake (ACU)</p>

<p>Hyaluronic acid sodium (MW 40 kDa) is a low molecule of sodium hyaluronate that penetrates into the dermis and promotes skin metabolism.</p>

<p>Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat 25-OH-D protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat 25-OH-D. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat 25-OH-D in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.</p>

<p>Denifanstat (FASN-IN-2) is a FASN inhibitor with selective and oral activity. Denifanstat has been used in studies of steatohepatitis. Cost effective and quality assured.</p>

<p>(S)-(+)-N-3-Benzylnirvanol is a cytochrome P450 CYP2C19 inhibitor with a ki value of 82.5μM for CYP2C9 and 0.25μM for CYP2C19.Cost-effective and quality-assured.</p>

<p>NAMPT Activator-1, EC50: 3.3-3.7 µM, specific niacinamide phosphotransferase stimulant, shields cells, potential neuroprotectant.</p>

<p>Hyaluronic acid sodium (MW 300 kDa) is a medium molecule sodium hyaluronate that penetrates into the dermis and stimulates skin metabolism.</p>

<p>Hyaluronic acid sodium (MW 10 kDa) is a low molecular sodium hyaluronate with stabilizing and restorative properties, which can slow down skin aging and promote the proliferation and differentiation of epidermal cells.</p>

<p>Topiramate (RWJ 17021) is a unique antiseizure medication that is used in the treatment of partial and generalized seizures.</p>

<p>Hyaluronic acid sodium (MW 2,000,000 kDa) is a high molecular hyaluronic acid sodium, with moisturizing effect, can form a thin layer on the surface of the skin, can slow down the evaporation of water from the surface of the skin.</p>

<p>Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potential</p>

<p>Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.</p>

<p>Topiroxostat (FYX-051) is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.</p>

<p>Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity.</p>

<p>Clevidipine (Clevidipine butyrate) is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood</p>

<p>Sulfameter (Sulfametoxydiazine) is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.</p>

<p>Gamibetal (4-Amino-3-hydroxybutyric Acid) is used as a chiral reagent in the synthesis of antiepileptic and hypotensive drug GABOB and analogues.</p>

<p>ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).</p>

<p>Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.</p>

<p>Liarozole dihydrochloride inhibits CYP450, estrogen, androgen synthesis; an oral drug for prostate cancer/skin disorders.</p>

<p>Emicizumab (ACE 910), a humanized antibody, mimics factor VIII, treating and preventing hemophilia A.</p>

<p>Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate), an active metabolites of norgestimate, is a steroidal progestin used in contraceptive patches.</p>

<p>Cotinine (NIH-10498) is an alkaloid found in tobacco and is also the predominant metabolite of nicotine.</p>

<p>SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.</p>

<p>Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.</p>

<p>Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.</p>

<p>Ca2+ channel agonist 1 activates N-type Ca2+ channels and inhibits Cdk2 (EC50: 14.23 μM/3.34 μM) for motor nerve issues.</p>

<p>Ipriflavone (Osteofix) (Osteofix) is a feed additive and a catabolic agent. It is used to inhibit bone resorption.</p>

<p>Procodazole (2-Benzimidazolepropionic acid) is a non-specific active immunoprotective agent against viral and bacterial infections.</p>

<p>PF-06424439 methanesulfonate: oral, potent, selective DGAT2 inhibitor (IC50=14 nM), noncompetitive, slowly reversible.</p>

<p>Fenclonine (CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin.</p>

<p>Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.</p>

<p>Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is a dione-type anticonvulsant with antiepileptic activity.</p>

<p>Vitamin K (Kephton) has blood coagulation action and is important for coagulation factors, matrix-Gla protein, and osteocalcin.</p>

<p>H-Lys(Tfa)-OH is an inhibitor of L-lysine cyclodeaminase.</p>

<p>MK-0941: an oral glucokinase activator for type 2 diabetes with potent glucose-lowering effects.</p>

<p>Telotristat ethyl (LX1606) is a orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.</p>

<p>Ferulic acid 4-O-sulfate (Ferulic acid 4-sulfate) relaxes arterioles and lowers blood pressure in mice.</p>

<p>Mafenide hydrochloride (4-Aminomethylbenzenesulfonamide hydrochloride) is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-</p>

<p>Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.</p>

<p>Actarit (4-acetylaminophenylacetic acid) is an anti-inflammatory drug.</p>

<p>Carbadox, an antibacterial for swine dysentery and growth promotion, is banned in the UK due to carcinogen and mutagen risks.</p>

<p>MK 0434 is a steroid 5α-reductase inhibitor and hormone antagonist associated with a significant reduction in DHT.</p>

<p>Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Cost-effective and quality-assured.</p>

<p>Pitavastatin lactone, a major human metabolite, potently inhibits HMG-CoA reductase with minimal hepatic microsome metabolism.</p>

<p>HIF-PHD-IN-3 is a hiPSC-CM cardioprotective scaffold with potential inhibitory effects on HIF-PHD, regulates heme oxygenase-1, and can be used to study anaemia.</p>

<p>BAY-2402234: a selective DHODH inhibitor targeting myeloid cancers with low-nanomolar potency.</p>

<p>Mildronate dihydrate is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.</p>

<p>EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).</p>

<p>Etofibrate is a combination of clofibrate and niacin, used to treat hyperlipemia.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent and specific inhibitor of TPH[1].</p>