Metabolismo

<p>Desmethylene Paroxetine hydrochloride is a non-conjugated metabolite of Paroxetine, a catechol intermediate.</p>

<p>JTV-519 Formate is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA).</p>

<p>SHO1122147 (Compound 7m) disrupts the mitochondrial electron transport chain, demonstrating mitochondrial uncoupling activity (EC50=3.6 μM). It increases the cellular oxygen consumption rate (OCR=69%) and enhances cellular respiration. Additionally, SHO1122147 is orally active and can be utilized in research related to obesity and metabolic dysfunction-associated steatohepatitis (MASH).</p>

<p>Zaragozic acid D inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.</p>

<p>LDHA-IN-8, an inhibitor, inhibits the proliferation of pancreatic and lung cancer cells, decreasing the intracellular lactate content and increasing ROS levels.</p>

<p>DSPE-PEG2000-LyP-1 is a PEG compound composed of DSPE and a nine-residue peptide (LyP-1). LyP-1 specifically targets tumor-associated lymphatic vessels and macrophages.</p>

<p>α-Glucosidase-IN-78 (Compound 12m) is a reversible competitive inhibitor of α-glucosidase (α-glucosidase) with an IC50 of 6.0 μM. Due to its blood sugar-lowering properties, α-Glucosidase-IN-78 is applicable in diabetes research.</p>

<p>9(R)-HODE cholesteryl ester, from atherosclerotic lesions, may form enzymatically or by lipid peroxidation; used as a chiral analysis standard.</p>

<p>Coproporphyrin III is a derivative of porphyrin.</p>

<p>Mitochondrial inhibitor 49 (respiration-IN-1 hydrobromide, IC50=8.8 mg/mL) from US20110301180A1 reduces platelet respiration.</p>

<p>hCAII/IX-IN-1 (compound 4o) is a potent inhibitor of hCAII and hCAIX, with Ki values of 7.4 nM and 7.0 nM, respectively. It plays a significant role in cancer research.</p>

<p>L-Lysine, sulfite (2:1) is a drug/ therapeutic agent.</p>

<p>2-Hydroxy atorvastatin lactone, a metabolite of Atorvastatin, is an orally active HMG-CoA reductase inhibitor that efficiently reduces blood lipids [1][2].</p>

<p>Pyrrophenone selectively and reversibly inhibits cPLA2 (IC50=4.2 nM), blocks AA, PGE2, and LTC4 production in cells, and is less effective on other PLA2s.</p>

<p>DSPE-PEG2000-TAASGVRSMH is a PEG compound composed of DSPE and TAASGVRSMH. This compound exhibits strong affinity for the NG2 proteoglycan on PC membranes. DSPE-PEG2000-TAASGVRSMH can be utilized for drug delivery.</p>

<p>hCAII/XII-IN-1 (compound 4l) is a potent inhibitor of hCAXII and hCAII, with Ki values of 8.4 nM and 9.4 nM, respectively. It plays a significant role in cancer research.</p>

<p>4-Hydroxy Atorvastatin calcium salt is metabolised by cytochrome P450 CYP3A4 and has antimicrobial and anti-microbial activity.</p>

<p>MAGL-IN-21 (Compound (S)-6) is a selective inhibitor of monoacylglycerol lipase (MAGL) with an IC50 of 1.59 nM.</p>

<p>Endogenous metabolite in urine, 1-O-Hexadecyl-2-O-docosahexaenoyl-sn-glycero-3-phosphorylcholine, linked to obesity research.</p>

<p>Cetirizine 3-chloro impurity is an impurity of Cetirizine 3-chloro [1] .</p>

<p>5-(3-Hydroxyphenyl)-5-phenylhydantoin is a bioactive chemical.</p>

<p>MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].</p>

<p>GOase, a type II copper enzyme from fungus, oxidizes alcohols to aldehydes and reduces O2 to H2O2.</p>

<p>Chaetosemin J, antifungal, inhibits Botrytis, Alternaria, Magnaporthe, Gibberella; MIC 12.5-25 μM.</p>

<p>H-Arg-Lys-OH TFA is a dipeptide formed from L-arginyl and L-lysine residues [1] .</p>

<p>IGUANA-1 is a highly efficient and selective ALDH1B1 inhibitor that inhibits the growth of colorectal cancer cells and colorectal cancer cell-derived organoids.</p>

<p>Sphingomyelin phosphodiesterase, a hydrolase, converts sphingomyelin into phosphocholine and ceramide, affecting cellular processes and cholesterol metabolism.</p>

<p>FUT8-IN-1 (Compound 37) is an inhibitor of α-1,6-fucosyltransferase (FUT8), with a dissociation constant (KD) of 49 nM and an IC50 around 50 µM. In the presence of FUT8, FUT8-IN-1 forms a highly active naphthoquinone imine intermediate, thereby inhibiting FUT8's enzymatic activity.</p>

<p>ND-011992: Quinazoline inhibitor of E. coli respiratory enzymes; IC50s: 0.12-2.47 μM; potential tuberculosis research.</p>

<p>QXG-6442 is a molecular glue degrader targeting CK1α, demonstrating a degradation potency with a DC50 of 5.7 nM and a Dmax of 90%. In the MOLM-14 cell line, QXG-6442 induces antiproliferative effects.</p>

<p>Xanthine Oxidase-IN-9 (also known as Icarisids E or Compound 2) effectively inhibits xanthine oxidase (XOD) with an IC50 value of 31.81 μM [1].</p>

<p>Captopril EP Impurity E, an ACE inhibitor with antihypertensive properties, has an IC50 of 0.025 μM.</p>

<p>Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] .</p>

<p>CK1δ/CK1ε ligand-1 is a ligand of CK1δ/CK1ε and can serve as a target protein ligand for the synthesis of the CK1 PROTAC degrader AH078.</p>

<p>Corynecin IV is a metabolite similar to chloramphenicol, originally isolated from corynebacteria.</p>

<p>LysoFos Glycerol 14 is a useful organic compound for research related to life sciences. The catalog number is TF0117 and the CAS number is 326495-21-0.</p>

<p>Viridicatin is a natural product for research related to life sciences. The catalog number is T38335 and the CAS number is 129-24-8.</p>

<p>Compound 14, a &lt;1 μM 5-lipoxygenase inhibitor, researches inflammation, cancer, stroke, Alzheimer's.</p>

<p>Pegevongitide acts as an agonist of the angiopoietin-1 receptor.</p>

<p>MTHFD2-IN-2 (compound 13) serves as a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].</p>

<p>1-Amino-1-deoxy-D-fructose is an amino sugar causing DNA damage at pyrimidine sites, found in elevated levels in diabetics.</p>

<p>Daclatasvir Impurity C is an impurity found in Daclatasvir, a robust inhibitor of the HCV NS5A protein [1].</p>

<p>RORγ agonist 1 is a highly potent and orally bioavailable compound that activates the RORγ receptor.</p>

<p>2-Aminoflubendazole, a metabolite of benzimidazoles (BZ), belongs to a class of drugs effective against fungi, protozoa, and helminths.</p>

ASP8477 is a potent and selective FAAH inhibitor. It increases anandamide levels in the brain when administered orally. In rat models of neuropathic and osteoarthritic pain, ASP8477 demonstrates significant efficacy without causing motor coordination issues. A single oral dose of ASP8477 improves thermal hyperalgesia and cold allodynia in rats with chronic constriction nerve injury. Moreover, ASP8477 restores the decreased muscle pressure threshold in a myalgia model induced by reserpine. Research indicates that ASP8477 possesses analgesic effects effective for alleviating neuropathic and functional pain, making its pharmacological properties suitable for chronic pain treatment.

<p>Ganoderenic acid K, from Ganoderma lucidum, inhibits HMG-CoA reductase with an IC50 of 16.5 μM.</p>

<p>Alfacalcidol-D6 is a deuterated Alfacalcidol. Alfacalcidol is a non-selective VDR activator medication.</p>

Creatine Kinase (CPK/CK), Bovine Heart (CK, CPK, Creatine Phosphokinase), is a biological material or organic compound suitable for use in life sciences research.

<p>3,5,6,7,8,4′-hexamethoxyflavone is a natural product for research related to life sciences. The catalog number is TN7114 and the CAS number is 34170-18-8.</p>

<p>Guignardone J, a secondary metabolite, is isolated from the endophytic fungus Phyllosticta capitalensis [1].</p>

Aspartate Aminotransferase, Human is a biocatalyst and serves as a pivotal enzyme in new biotechnology. Enzyme engineering aims to improve the reaction kinetics, substrate specificity, and activity under extreme conditions (such as low or high pH). By introducing stimuli-responsive modifications to these enzymes, the dynamic regulation of activity can also be achieved.

<p>Arginase (L-Arginine amidinase) is a key hydrolytic enzyme in the urea cycle, which hydrolyzes L-arginine into urea and L-ornithine.</p>

Benzoyl coenzyme A (sodium) is the sodium salt form of Benzoyl coenzyme A. It is a derivative of coenzyme A (CoA), where the thiol group of CoA is linked to a benzoyl group. This compound serves as a substrate in acyl transfer reactions, playing a role in catalysis. Benzoyl coenzyme A (sodium) is a versatile metabolic intermediate used in studies exploring enzyme substrate specificity, metabolic regulation, and drug metabolism.

<p>13-epi-12-oxo PDA is a lipoxygenase derivative of α-linolenic acid in green plant leaves, often isomerizing during extraction and storage.</p>

M145724 ((3Z,6E)-1-N-Methylalbonoursin) is a metabolite that can be extracted from Streptomyces albus.

Dimethylpropiothetin hydrochloride (s,s-Dimethyl-β-propionic acid thetine) represents the hydrochloride variant of dimethylpropiothetin. This compound is extractable from marine algae and serves as a precursor to dimethylsulfide (DMS). Additionally, it plays a role in the osmoregulation processes within Hymenomonas carterae.

<p>Formate dehydrogenase, found in all life forms, converts formate to CO2 and is categorized by metal content for research.</p>

Beta-Galactose dehydrogenase converts galactose to galactonolactone, reducing NAD to fluorescent NADH; useful in galactose measurement.

WAY-615145 is a compound that activates glucokinase.

<p>D-Amino acid oxidase enzyme metabolizes and detoxifies exogenous D-amino acids, regulating D-serine in the brain.</p>

<p>Gliorosein is a biohcemical.</p>

<p>Ferulic acid acyl-β-D-glucoside, a metabolite of Ferulic Acid, is a novel inhibitor of fibroblast growth factor receptor 1 (FGFR1).</p>

<p>SAHH, an enzyme, reversibly converts SAH into adenosine and L-homocysteine, and may predict HBV-LC outcomes.</p>

<p>2-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol is a triglyceride.</p>

<p>Nepetalactone is found in the plant Nepeta parnassica and has high mosquito repellency properties.</p>

<p>Galactokinase (BiGalK), a phosphotransferase, catalyzes the ATP-dependent phosphorylation of α-D-galactose to galactose 1-phosphate [1].</p>

<p>Tuna AI is an inhibitor of the angiotensin-converting enzyme. Tuna AI is a bioactive chemical.</p>

<p>Glycidamide is a carcinogen and metabolite of acrylamide that induces DNA adduct formation and mutations.</p>

<p>16(S)-HETE, a CYP450 byproduct of arachidonic acid, inhibits kidney tubule ATPase by 60% at 2 μM upon angiotensin II trigger.</p>

<p>CstII (ST8Sia VI), an alpha-2,8-sialyltransferase, catalyzes α2,8 oligo/polysialic acid chain elongation. Used in biochemical research.</p>

<p>PKR activator 4 (example 7A), a potent activator of pyruvate kinase R (PKR), holds promise for blood disorder research [1].</p>

<p>Thymus peptide C, a hormonal drug derived from the thymus glands of young calves, acts as a substitute for the physiological functions of the thymus.</p>

<p>Omfiloctocog alfa (SCT-800) is a recombinant FVIII for Hemophilia A research.</p>

<p>β-N-Acetylhexosaminidase is an exoglycosidase that catalyzes the hydrolysis of terminal non-reducing β-N-acetylgalactosamine and glucosamine residues in</p>

<p>Kidney sodium transport is partly controlled by 17-HETE, a CYP450 metabolite of arachidonic acid, with the (S) enantiomer inhibiting ATPase at 2 μM.</p>

<p>MU1742 is a probe for CK1δ and CK1ε protein kinases [1] .</p>

<p>Piliformic acid: a fungal metabolite, cytotoxic to BC-1 cells (IC50=5μg/ml), fights L. braziliensis (IC50=78.5μM) &amp; C. gloeosporioides (MIC=292μM).</p>

<p>Daclatasvir Impurity B, a noted impurity of the antiviral agent Daclatasvir, acts as a potent inhibitor of the HCV NS5A protein [1].</p>

<p>Myxochelin A from A. disciformis fights Gram-positive bacteria, inhibits 5-LO with IC50 of 1.9 μM, and is cytotoxic to colon cancer cells.</p>

<p>isomer-CM 352 is a metalase inhibitor that can be used to slow brain damage.</p>

<p>Casein Kinase Substrates 3 is a substrate of casein kinase.</p>

<p>Canadensolide is an antifungal metabolite of Penicillium canadense .</p>

<p>(-)-OPC-51803 is an antidiuretic hormone V2 receptor agonist used in the treatment of nocturia and urinary incontinence.</p>

<p>SBI993, a SBI-477 analog, confirms MondoA gene action in vivo and lowers muscle TAG and liver fat.</p>

<p>SMS2-IN-1: potent SMS2 inhibitor; IC50: 6.5 nM, Kd: 37 nM; 150x selectivity over SMS1.</p>

<p>Simvastatin Acyl-β-D-glucuronide, a metabolite formed from Simvastatin, acts as a competitive inhibitor of HMG-CoA reductase, showcasing a potent Ki of 0.2 nM.</p>

<p>OGP, a natural 14-mer serum peptide at μM levels, is crucial for osteogenic response to bone injury.</p>

<p>Kyotorphin is a Morphine-like dipeptide.</p>

<p>6-Keto Cholestanol is a useful organic compound for research related to life sciences. The catalog number is T126283 and the CAS number is 1175-06-0.</p>

<p>1-thio-β-D-Glucose is an analog of β-D-glucose in which sulfur replaces the hydroxyl group at the one position.</p>

<p>Linoleoyl-L-carnitine, a natural acylcarnitine, rises in mouse liver post high-dose isoniazid (200 mg/kg).</p>

<p>(±)10(11)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid .</p>

<p>Acetic acid, 2-[4-[(2-ethyl-3-benzofuranyl)carbonyl]phenoxy]- is a compound used for antiviral activity determinations.</p>

<p>"Cyclohexanoyl CoA (CHCoA) activates CHC in R. palustris, converts to hippuric acid in guinea pig liver."</p>

<p>(R)-2-Hydroxyoleic acid (R)-2-OHOA, an orally active, R-enantiomer fatty acid, modulates membrane lipids and shows antitumor properties.</p>

<p>Estriol 3-β-D-glucuronide is a metabolite of estriol .</p>

<p>Microginin 527, a compound found in Microcystis, is an inhibitor of protein phosphatase, ACE, and leucine aminopeptidase.</p>

<p>PDE4-IN-4 is a compound acting as both a potent M3 antagonist (p IC 50 = 10.2) and a PDE4 inhibitor (p IC 50 = 8.8), designed for inhalation-based treatment of</p>

<p>Glucose 1-dehydrogenase, an enzyme, transforms glucose and NAD(P) into NAD(P)H and gluconic acid.</p>

<p>Suberylglycine is an acyl glycine that is a normally minor metabolite of fatty acid.</p>