Metabolismo

<p>Catestatin acetate is a non-competitive antagonist of nAChR and inhibits catecholamine release.</p>

<p>E 6080 HCl is a 5-lipoxygenase inhibitor and can be used to study bronchial diseases.</p>

<p>24, 25-Dihydroxy VD3 is closely related to 1,25-dihydroxy vitamin D3, the active form of vitamin D3.</p>

<p>Antiproliferative agent-13 is a compound with antiproliferative activity.</p>

<p>MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.</p>

<p>α-Hydroxytamoxifen is a metabolite of tamoxifen. It reacts with DNA and causes the formation of DNA adducts.</p>

<p>CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiological</p>

<p>hCA/VEGFR-2-IN-4 (compound 15b), an indolinylbenzenesulfonamide, serves as a potential dual inhibitor targeting cancer-related human carbonic anhydrases hCA IX/</p>

<p>CAIR, an E. coli metabolite, helps identify its PurE active site and aids in fungal purine synthesis.</p>

<p>WVSAV is a ligand for the PDZ2 domain (tyrosine phosphatase) with a dissociation constant (Kd) of 111 μM. It is utilized in studies of protein-ligand interactions.</p>

<p>(±)-Equol 4’-sulfate is a gut-mediated phase II metabolite of the isoflavonoid phytoestrogen (±)-equol .[1] It has been used as a standard for the</p>

<p>Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K i of 0.6 nM [1] .</p>

<p>FITC-GW3965: Fluorescent LXRβ agonist; FITC replaces trifluoromethyl in GW3965; used to probe LXRβ function.</p>

<p>Methylcardol triene, a phenolic compound present in cashew nut shell liquid, demonstrates α-glucosidase inhibition (IC50= 39.6 µM) and exhibits schistosomicidal properties by eliminating 100% of adult S. mansoni worms within 24 hours at 100 and 200 µM concentrations. Moreover, it serves as a precursor for synthesizing mono- and bis-benzoxazines.</p>

<p>CYP4A11/CYP4F2-IN-2: Potent oral inhibitor of CYP4A11 &amp; CYP4F2 (IC50: 140 &amp; 40 nM), potential kidney disease treatment.</p>

<p>PDE enzyme hydrolyzes cyclic nucleotides, regulates signal transduction, and varies in type (PDE1-PDE11) with disease research potential.</p>

<p>Propiverine N-oxide is the primary metabolite of propiverine hydrochloride, and it influences bladder contraction and saliva secretion in miniature pigs.</p>

<p>DPPS is a negatively charged diacyl-phospholipid used to create cationic vesicles and liposomes.</p>

<p>Ingenol disoxate (LEO43204) is a compound for treating actinic keratosis, a natural Euphorbia peplus extract.</p>

<p>LH1513 is a dioxalate salt derivative of l-lysine that inhibits CaOx crystallization more effectively than citrate and pyruvate. It shows potential preventive activity in hyperoxaluria models and effectively prevents urinary CaOx crystal formation in Agxt knockout mice. AGXT-1 is a mitochondrial protein involved in metabolic processes.</p>

<p>GOase, a type II copper enzyme from fungus, oxidizes alcohols to aldehydes and reduces O2 to H2O2.</p>

<p>GLUT inhibitor-1: oral, targets GLUT1/3 (IC50: 242/179 nM), for cancer/autoimmune research.</p>

<p>DSPE-PEG1000-CGKRK is a PEG compound composed of DSPE and the cell-penetrating peptide (CGKRK). It is utilized for drug delivery.</p>

<p>DSPE-PEG1000-WYRGRL consists of DSPE and a cartilage-targeting peptide (WYRGRL) as a PEG compound. WYRGRL is a type II collagen-targeting peptide that can bind to type II collagen α1. DSPE-PEG1000-WYRGRL is suitable for drug delivery applications.</p>

<p>Bendroflumethiazide (Naturetin) is a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)</p>

<p>L-Glutamic acid ammonium is an excitatory neurotransmitter.</p>

<p>N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.</p>

<p>Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.</p>

<p>Biotin (Vitamin B7) sodium aids in metabolism, cell growth, fatty acid synthesis, and gluconeogenesis.</p>

<p>DSPE-PEG2000-TAASGVRSMH is a PEG compound composed of DSPE and TAASGVRSMH. This compound exhibits strong affinity for the NG2 proteoglycan on PC membranes. DSPE-PEG2000-TAASGVRSMH can be utilized for drug delivery.</p>

<p>Echinocandin B: a cyclic hexapeptide from A. nidulans, inhibits fungal cell wall synthesis by blocking beta-1,3-glucan.</p>

<p>Aclimostat (ZGN-1061) is a MetAP2 inhibitor with strong preclinical results, improving obesity-related metrics and gene expression.</p>

<p>ZD-2138: Selective 5-LOX inhibitor, eases allergen-induced asthma attacks and airway constriction in guinea pigs.</p>

3-Hydroxyanisole has inhibitory activity against MAO-A (IC50 = 24 ± 2.8 μM) and can be used to study neurological and psychiatric diseases.

<p>HIF-PHD-IN-4 (Compound 13) is an orally active PHD2 inhibitor with an IC50 of 100 nM. At a dose of 2 mg/kg, it effectively enhances G-CSF-induced mobilization of hematopoietic stem cells in mice. HIF-PHD-IN-4 is suitable for research in the oncology field.</p>

<p>RMC-4630 (SHP2-IN-7) is an inhibitor of SHP2.</p>

<p>Cystocholic acid is a metabolite of bile acids, possessing antimicrobial potential.</p>

<p>Picornain 3C, a protease in picornaviruses, cleaves Gln-Gly bonds in poliovirus polyproteins and similar sites in others.</p>

<p>GS-493: Specific SHP2 inhibitor, very potent (IC50=71 nM), 29x affinity vs. SHP1, 45x vs. PTP1B; hinders cancer cell growth/movement.</p>

<p>Carboxylesterase-IN-1, a pesticide inhibits carboxylesterase at 50 μg/mL, akin to triphenyl phosphate.</p>

<p>Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).</p>

<p>(±)13(14)-DiHDPA is a metabolite of docosahexaenoic acid that is produced via oxidation by cytochrome P450 epoxygenases.</p>

<p>SHO1122147 (Compound 7m) disrupts the mitochondrial electron transport chain, demonstrating mitochondrial uncoupling activity (EC50=3.6 μM). It increases the cellular oxygen consumption rate (OCR=69%) and enhances cellular respiration. Additionally, SHO1122147 is orally active and can be utilized in research related to obesity and metabolic dysfunction-associated steatohepatitis (MASH).</p>

<p>Ritonavir metabolite is a Ritonavir metabolite, which is a inhibitor of HIV protease.</p>

<p>AV22-149 (compound 22) is an inhibitor of Carbonic Anhydrase .</p>

<p>DMPS-Na is an arsenicolytic agent with toxicity that can be used to study cell membranes.</p>

<p>DSPE-PEG1000-ANG is a PEG compound composed of DSPE and a dual-targeting ligand (Angiopep-2, ANG). ANG demonstrates high LRP1 binding efficiency and has been utilized for targeting glioma delivery. DSPE-PEG1000-ANG is suitable for drug delivery applications.</p>

<p>DSPE-PEG1000-TAT is a PEG compound composed of DSPE and the cell-penetrating peptide (TAT) peptide. It can be utilized for drug delivery.</p>

<p>2-Methylnicotinamide is an endogenous metabolite of nicotinamide and can be used for related research in the life sciences.</p>

<p>CAIX/CAXII-IN-4 (Compound 7h) is an inhibitor of carbonic anhydrase (CA) that binds to CAIX, CA XII, and CAII with Ki values of 1.324 μM, 0.435 μM, and 3.035 μM, respectively. This compound exhibits broad-spectrum anti-tumor activity and inhibits the proliferation of central nervous system tumor cells U251, with a GI50 of 0.361 μM.</p>

<p>DSPE-PEG2000-NYZL1 is a PEG compound composed of DSPE and NYZL1. NYZL1 has the ability to specifically bind to bladder cancer tissues and cells. DSPE-PEG2000-NYZL1 is suitable for drug delivery applications.</p>

<p>Antibacterial agent 132 showed antimicrobial activity against C.</p>

<p>Rubratoxin A is a classical mycotoxin used as a PP2A-specific inhibitor.</p>

Compound 6C, a PROTAC degrader, targets CYP1B1 with IC50s (95.1 nM CYP1B1, 9838.6 nM CYP1A2) for prostate cancer research.

<p>Ilexsaponin B2 is a natural product for research related to life sciences. The catalog number is TJS0502 and the CAS number is 108906-69-0.</p>

<p>2,4-Dimethylquinoline is a potential CYP1A2 inhibitor , and it also exhibits weak inhibitory activity against CYP2A5, CYP2A6, and CYP2B6.</p>

Ppack trifluoroacetate: Peptide, inhibits thrombin, prevents clotting (Ki: 0.24 nM), used in anticoagulation & thrombin research.

<p>Adenosine deaminase is an enzyme that catalyzes the irreversible deamination of 2'-deoxyadenosine and adenosine to 2'-deoxyinosine and inosine, respectively.</p>

<p>PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells.</p>

α-Glucosidase-IN-75 (compound 13) is an inhibitor of α-glucosidase, exhibiting an IC50 value of 3.81 μM. It is employed in the study of cardiovascular diseases induced by high glucose levels.

Guanosine triphosphate tritris (GTP tritris) serves as a crucial enhancer in myocyte differentiation, playing an essential role in regulating miRNA-muscle regulatory factors. It promotes the release of exosomes rich in guanine and guanine-derived molecules, and is considered an activation precursor for RNA synthesis. In mitochondrial functionality, GTP is involved in the entry of proteins into the matrix, which is vital for various regulatory pathways. It initiates peptide synthesis by facilitating the binding of formylmethionine-tRNA to the ribosome, and aids in polypeptide chain elongation. Additionally, GTP acts as a carrier for phosphates and pyrophosphates, channeling chemical energy into specific biosynthetic pathways. It activates signal transduction G proteins, regulates cellular processes such as proliferation and differentiation, and its hydrolysis by small GTPases (including Ras and Rho) is indispensable for both proliferation and apoptosis. Furthermore, the small GTPase Rab assists in vesicle docking, fusion, and formation. Beyond signal transduction, GTP is also an energy-rich precursor in the biosynthesis of DNA and RNA enzymes.

<p>DSPE-PEG1000-R8 is a PEG compound composed of DSPE and the cell-penetrating peptide (R8). It is applicable for drug delivery.</p>

<p>Vitamin K5, a photosensitizer &amp; antimicrobial, inhibits PKM2, PKM1 &amp; PKL, induces apoptosis in colon cells, and preserves food &amp; medicine.</p>

<p>Cell-penetrating peptide</p>

<p>N-Demethylerythromycin A, a metabolite of erythromycin from S. erythreus, may contaminate its preparations.</p>

<p>Obeversen is a DGAT-2 synthesis reducer [1] .</p>

<p>IDO1/TDO-IN-7 (Compound 43b), an isochinoline derivative, functions as a potent dual inhibitor of IDO1/TDO with IC50 values of 0.31 μM and 0.08 μM, respectively. Demonstrating favorable pharmacokinetics and strong antitumor efficacy in the B16-F10 tumor model, this compound also exhibits low toxicity.</p>

<p>hCAIX-IN-19 is a sulfonamide inhibitor with an inhibition constant (KI) of 6.2 nM for hCAIX, exhibiting significant selectivity towards hCAIX over hCAI (hCA I/</p>

<p>BuChE-IN-15, a chemical compound, exhibits potent inhibitory activity with IC50 values of 81 nM and 400 nM, respectively. It also demonstrates good blood-brain barrier permeability and neuroprotective properties, making it suitable for research in Alzheimer's disease.</p>

<p>Z-Asp(OBzl)-OH (N-Cbz-L-Aspartic acid 4-benzyl ester) is an aspartic acid derivative.</p>

<p>DSPE-PEG2000-LyP-1 is a PEG compound composed of DSPE and a nine-residue peptide (LyP-1). LyP-1 specifically targets tumor-associated lymphatic vessels and macrophages.</p>

<p>Amidepsine A is a natural product for research related to life sciences. The catalog number is T22187 and the CAS number is 169181-28-6.</p>

<p>BAY-588 is an inactive control probe of BAY-876 which is an inhibitor of GLUT1.</p>

<p>Bam 12P acetate is the putative enkephalin precursor in bovine adrenal, pituitary, and hypothalamus.</p>

<p>7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium, a cap analog, is utilized in the synthesis of mRNA cap analogues[1].</p>

<p>CHEMBL1276927 (N-(3-(1H-benzo[d]imidazol-2-yl)phenyl)-3-methylbenzamide) shows antibacterial and antiparasitic activities against Chlamydia pneumoniae and</p>

<p>Mitochondrial inhibitor 49 (respiration-IN-1 hydrobromide, IC50=8.8 mg/mL) from US20110301180A1 reduces platelet respiration.</p>

<p>Cytochrome P450 derivatives act as vasodilators. Blocking sEH, their inactivator, may treat hypertension. S-NEPC measures sEH activity.</p>

<p>Ercalcidiol is a metabolite of vitamin D2 and can be used in monitoring vitamin D therapy.</p>

<p>DSPE-PEG1000-CCK8 is a PEG compound composed of DSPE and Cholecystokinin-8 (CCK8). Cholecystokinin-8 exhibits peptide activity that regulates gallbladder contraction and the functions of the digestive system. DSPE-PEG1000-CCK8 can be utilized for drug delivery.</p>

<p>5-Formylcytosine (5FC) is a rare mammalian DNA base aiding in demethylation, altering helix structure, and affecting RNA polymerase II activity.</p>

<p>Aschantin is a useful organic compound for research related to life sciences. The catalog number is T126072 and the CAS number is 13060-15-6.</p>

<p>Pyrrophenone selectively and reversibly inhibits cPLA2 (IC50=4.2 nM), blocks AA, PGE2, and LTC4 production in cells, and is less effective on other PLA2s.</p>

<p>H-Arg-Lys-OH TFA is a dipeptide formed from L-arginyl and L-lysine residues [1] .</p>

<p>DSPE-PEG5000-KAA is a PEG compound composed of DSPE and the CKAAKNK (KAA) peptide. The CKAAKNK peptide specifically targets the tumor vasculature of RIP-Tag2 transgenic mice. DSPE-PEG5000-KAA can be utilized for drug delivery purposes.</p>

<p>Archangelicin is a useful organic compound for research related to life sciences. The catalog number is T125179 and the CAS number is 2607-56-9.</p>

<p>FP-biotin: organophosphorus toxicant for biomarker discovery, targets FAAH, ABHD6, MAG-lipase in plasma via avidin-bead purification.</p>

<p>Eflucimibe (L0081), an ACAT inhibitor, treats cardiovascular, endocrine, and metabolic diseases, and helps in atherosclerosis and hyperlipidemia research.</p>

<p>Chaetosemin J, antifungal, inhibits Botrytis, Alternaria, Magnaporthe, Gibberella; MIC 12.5-25 μM.</p>

<p>Relzomostat inhibits MetAP2, with research potential for obesity and type 2 diabetes.</p>

Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).

<p>Oxytetracycline calcium is a tetracycline antibiotic effective against Gram-negative and Gram-positive bacteria, inhibits protein synthesis, and fights HSV-1.</p>

<p>Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.</p>

<p>A unique collection of xnum endogenous metabolism-related compounds for research in endogenous metabolism-related diseases and drug screening.</p>

<p>13-cis-Retinyl palmitate in corn flakes is 75% as active as all-trans form.</p>

<p>Biotin-Vitamin B12, a biotinylated form, is crucial for brain, nervous system function, and blood formation.</p>

<p>AM6701 is a novel highly potent inhibitor of human alpha/beta hydrolase domain 6 (habhd6)</p>

<p>FUT8-IN-1 (Compound 37) is an inhibitor of α-1,6-fucosyltransferase (FUT8), with a dissociation constant (KD) of 49 nM and an IC50 around 50 µM. In the presence of FUT8, FUT8-IN-1 forms a highly active naphthoquinone imine intermediate, thereby inhibiting FUT8's enzymatic activity.</p>

<p>N-Desmethyl Sildenafil (UK-103,320) (Desmethylsildenafil) is a prominent metabolite of Sildenafil, a potent inhibitor of phosphodiesterase type 5 (PDE5).</p>

<p>MTB-9655 inhibits ACSS2 with 3.8 nM IC50, useful in research of viral, metabolic, neuropsychiatric diseases, inflammation, and cancer.</p>