Metabolismo

<p>Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.</p>

<p>Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).</p>

<p>Chlorindione (chlophenadione) is a vitamin K antagonist, a potent anticoagulant compound.</p>

<p>6-Aminocaproic acid (EACA) is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.</p>

<p>N-(1-Adamantyl)acetamide is used as intermediates for synthesis of amantadine hydrochloride.</p>

D-Carnitine hydrochloride ((S)-Carnitine Hydrochloride), a constituent of striated muscle and liver, is used in the treatment of hyperlipoproteinemias.

<p>Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity.</p>

<p>Muraglitazar (BMS-298585) is a PPAR α/γ dual agonist for the treatment of type 2 diabetes and associated dyslipidemia.</p>

<p>N-Desmethyl-Apalutamide is a less potent antagonist of the androgen receptor, is an active Apalutamide metabolite.</p>

<p>VU0359595 (ML-270) is a selective PLD1 inhibitor with 3.7 nM IC50; &gt;1700x more selective over PLD2, for cancer/diabetes/neurodegenerative research.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat PⅠNP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PⅠNP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat PⅠNP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Fenofibrate (Lipanthyl) is a PPARα agonist. Fenofibrate inhibits cytochrome P450 isoforms. Fenofibrate exhibits antihyperlipidemic activity. Cost-effective and quality-assured.</p>

<p>Amlodipine Besylate(Amlodipine benzenesulfonate) is a long-lasting calcium channel blocker.</p>

<p>Cotinine (NIH-10498) is an alkaloid found in tobacco and is also the predominant metabolite of nicotine.</p>

<p>5-R-Rivaroxaban is the (R)-enantiomer of Rivaroxaban, a potent FXa inhibitor with IC50 0.7 nM and Ki 0.4 nM.</p>

<p>XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).</p>

<p>Eliglustat hemitartrate (Genz-112638) , with an IC50 of 24 nM, is a specific, potent, oral active glucocerebral glycosidase inhibitor.</p>

<p>Afalanine (N-Acetyl-DL-phenylalanine) is a kind of Amino Acids and Derivatives.</p>

<p>ACT-678689 (Compound Example 1.53.4) (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1].</p>