Metabolismo

<p>Octanoyl Coenzyme A (sodium salt) inhibits citrate synthase and glutamate dehydrogenase with an IC50 of 0.4–1.6 mM.</p>

<p>D-3, a phosphorpeptide, is an efficient, simple, and specific iPSC-eliminating agent.</p>

<p>GSK-3β/CK-1δ-IN-1 (8d) is a dual inhibitor of GSK-3β and CK-1δ that can cross the blood-brain barrier, with IC50 values of 0.77 μM and 0.57 μM, respectively. GSK-3β/CK-1δ-IN-1 (8d) is applicable in neuroblastoma research.</p>

<p>3-chloro-4-sulfonyl-Benzonitrile inhibits hHSD1/mHSD1, IC50: 16nM/10nM.</p>

<p>SY-640, an acetamide derivative, strongly protects the liver and lessens Propionibacterium acnes and lipopolysaccharide-induced damage in mice.</p>

<p>CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively.</p>

<p>Abz-Ser-Pro-3-nitro-Tyr is the substrate of ACE2 (angiotensin-converting enzyme-2) [1] .</p>

<p>IPH5201 is a human IgG1 monoclonal antibody (mAb) targeting ENTPD1/CD39. It enhances the accumulation of immunostimulatory ATP released by tumor cells undergoing combination chemotherapy (CT) and reduces the levels of immunosuppressive adenosine (Ado) in the tumor microenvironment (TME). IPH5201 is useful for research on antitumor immunity. Recommended isotype control: Human IgG1 kappa, Isotype Control.</p>

Compound 2058-74-4, with CAS No. 2058-74-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 2058-74-4 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>

<p>H-Met-Val-OH is a dipeptide inhibiting FMO1 and FMO3 and promoting neurite outgrowth, relevant for neuroregenerative and enzymatic modulation studies.</p>

<p>FZQ-21 (Compound 70P) is an inhibitor of the water-soluble epoxide hydrolase (sEH), with an IC50 value of 4 nM. The IC50 for inhibiting human sEH is 1.5 nM, which is comparable to that of EC5026 (1.7 nM). FZQ-21 is utilized in sepsis research.</p>

<p>FABP4-IN-3 (Compound C3) is a highly selective inhibitor of FABP4, with an inhibition constant (Ki) of 25 ± 3 nM for FABP4 and a Ki of 15.03 μM for FABP3, showcasing a selectivity factor of 601 times over FABP3. It also demonstrates metabolic stability and potent anti-inflammatory activity in cells, making it a promising candidate for research in metabolic disorders, cardiac dysfunction, and inflammation-related diseases.</p>

<p>Photo-DL-lysine is a photo-reactive amino acid based on DL-lysine used to capture proteins that are post-translationally modified by lysine binding.</p>

<p>α-Amylase/α-Glucosidase-IN-12 (compound 10k) is a dual inhibitor targeting α-glucosidase and α-amylase, with IC50 values of 34.52 nM and 24.62 nM, respectively. This inhibitor is designed based on [triazolo[4,3-b][1,2,4]triazine and holds potential for diabetes research.</p>

<p>α-Glucosidase-IN-44 (compound IT4) is an α-glucosidase inhibitor with an IC50 value of 2.35 μM. This compound is orally active and has the ability to reduce fasting blood glucose levels in diabetic mice.</p>

<p>PROTACNAMPT Degrader-1 is an effective NAMPT-targeting PROTAC with a DC50 value of 217 nM. It exhibits antiproliferative activity, with an IC50 value of 0.12 μM against A2780 cells.</p>

<p>ST6Sialyltransferase5 (EC:2.4.3.3, ST6GALNAC5, SIAT7E, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5) transfers sialic acid to N-acetylgalactosamine (GalNAc) residues. It may serve as a biomarker in cervical screening samples.</p>

<p>NAMPTactivator-7 (Compound 232) is an activator of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of less than 0.5 μM. It effectively stimulates NAMPT in U2OS cells, demonstrating a cellular EC50 of less than 0.5 μM.</p>

<p>Fmoc-Cys-Asp10 (TFA) is a non-releasable oligopeptide linker involved in synthesizing releasable oligopeptide linkers. These releasable linkers are used to deliver drugs to fracture-targeting oligopeptides, thereby reducing the healing time of fractured femurs.</p>

<p>α-Glucosidase-IN-46 is a potent inhibitor of α-glucosidase, with an IC50 of 26.0 μM. This compound is applicable in the research of Type 2 diabetes.</p>

<p>LYP-8 is a potent NAMPT degrader that achieves a maximum degradation rate of 97% in NAMPT within SKOV-3 cells at a concentration of 0.5 μM. LYP-8 also demonstrates anticancer activity both in vitro and in vivo.</p>

<p>HumanFactor VIIa is a vitamin K-dependent serine protease involved in the blood coagulation process. It has the ability to activate coagulation factor X, which in turn converts prothrombin into thrombin, leading to the transformation of fibrinogen into fibrin and resulting in the formation of blood clots. HumanFactor VIIa holds potential for improving hemophilia.</p>

<p>α-Glucosidase-IN-57 (Compound 10c) is a competitive, orally active α-glucosidase inhibitor with an IC50 of 0.180 μM and a Ki of 0.15 μM. It effectively reduces fasting and overall blood glucose levels in mice, making it suitable for antidiabetic research.</p>

<p>Thalifendine chloride is a metabolite of berberine,the methoxy group at the C-10 position undergoes demethylation by CYP51. cytotoxicity against P-388 cells.</p>

<p>Speract, a peptide from sea urchin eggs, regulates sperm motility and stimulates sperm mitochondrial metabolism.</p>

<p>Creatine-d3 is an isotopically labeled version of creatine. Creatine is an endogenous amino acid metabolite that plays a crucial role in cellular energy, particularly within muscles and the brain.</p>

<p>RORγt inverse agonist 33 (compound (R)-D4) is an orally bioavailable RORγt inverse agonist with an IC50 of 21 nM, playing a significant role in rheumatoid arthritis research.</p>

<p>CK2-IN-13 (compound 12c) is a potent inhibitor of CK2, with an IC50 value of 5.8 nM, playing a significant role in cancer research.</p>

<p>α-Glucosidase-IN-83 (compound I-1) is a potent inhibitor of α-glucosidase, demonstrating an IC50 of 1.49 μg/mL. This compound effectively reduces blood glucose levels in vivo.</p>

<p>MAGL-IN-21 (Compound (S)-6) is a selective inhibitor of monoacylglycerol lipase (MAGL) with an IC50 of 1.59 nM.</p>

<p>Calcium Channel antagonist 4 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM).</p>

<p>L 645164 is an inhibitor of hydroxymethylglutaryl-CoA reductase.</p>

<p>FTI-2148 diTFA inhibits FT-1 and GGT-1 with IC50s of 1.4 nM and 1.7 μM; a RAS-mimetic compound.</p>

<p>Cy3-PEG-DSPE (MW 3400) is a PEG phospholipid that incorporates Cy3 dye, utilized for labeling proteins/nucleic acids and in fluorescence microscopy. It can self-assemble in aqueous solutions to form micelles/lipid bilayers, and is employed in the creation of liposomes or nanoparticles for delivering nutrients such as mRNA or DNA vaccines.</p>

<p>α-Amylase/α-Glucosidase-IN-18 (Compound 9g) is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 49.17 nM and 10.71 nM, respectively. It is suitable for research related to type 2 diabetes.</p>

<p>Corynecin IV is a metabolite similar to chloramphenicol, originally isolated from corynebacteria.</p>

<p>C18:1 Ceramide (d18:1/18:1(9Z)) is a ceramide, and C18:1-Ceramide levels are elevated in overweight and insulin-resistant , advanced ovarian cancer.</p>

ASP8477 is a potent and selective FAAH inhibitor. It increases anandamide levels in the brain when administered orally. In rat models of neuropathic and osteoarthritic pain, ASP8477 demonstrates significant efficacy without causing motor coordination issues. A single oral dose of ASP8477 improves thermal hyperalgesia and cold allodynia in rats with chronic constriction nerve injury. Moreover, ASP8477 restores the decreased muscle pressure threshold in a myalgia model induced by reserpine. Research indicates that ASP8477 possesses analgesic effects effective for alleviating neuropathic and functional pain, making its pharmacological properties suitable for chronic pain treatment.

Creatine Kinase (CPK/CK), Bovine Heart (CK, CPK, Creatine Phosphokinase), is a biological material or organic compound suitable for use in life sciences research.

M145724 ((3Z,6E)-1-N-Methylalbonoursin) is a metabolite that can be extracted from Streptomyces albus.

<p>Largazole is a potent and selective histone deacetylase (HDAC) inhibitor and antiproliferative agent from Symploca.</p>

Mannose 6-phosphate (M6P) features a type I integral membrane receptor.

<p>Probestin is an aminopeptidase M inhibitor, isolated from Streptomyces azureus MH663-2F6.</p>

<p>Spaglumic acid acetate (Isospaglumic acid acetate) is a neuropeptide found in millimolar concentrations in brain.</p>

<p>C22 Galactosylceramide, a CNS sphingolipid, rises in mouse spinal cord on a methionine-restricted diet, found in Alzheimer's hippocampus.</p>

<p>AY 9944 dihydrochloride is a intermediate.</p>

<p>COMT-IN-2 (compound 9) is the most potent inhibitor of COMT, exhibiting selective inhibition for brain (IC50=24 nM) and liver (IC50=81 nM) MB-COMT compared to the liver S-COMT isoform (IC50=620 nM).</p>

<p>Fexarene is a non-steroidal FXR agonist.</p>

<p>Acremin F is a useful organic compound for research related to life sciences. The catalog number is T124074 and the CAS number is 863480-61-9.</p>

<p>Myxochelin A from A. disciformis fights Gram-positive bacteria, inhibits 5-LO with IC50 of 1.9 μM, and is cytotoxic to colon cancer cells.</p>

<p>SLC7A11-IN-3 (Compound 42711_11) acts as an inhibitor of SLC7A11.</p>

<p>Folitixorin calcium is an antineoplastic enhancing agent.</p>

<p>isomer-CM 352 is a metalase inhibitor that can be used to slow brain damage.</p>

<p>Casein Kinase Substrates 3 is a substrate of casein kinase.</p>

Bupirimate, a systemic fungicide for powdery mildew in roses and apples, belongs to pyrimidines.

<p>IFB-088 acetate targets PPP1R15A-related diseases, including cancers and protein misfolding disorders.</p>

<p>(-)-OPC-51803 is an antidiuretic hormone V2 receptor agonist used in the treatment of nocturia and urinary incontinence.</p>

<p>ACTH (18-39), or Corticotropin-like Peptide, boosts insulin, amylase, and protein secretion dose-dependently.</p>

<p>LY 135114 is a metabolite of LY 195448, which is a phenethanolamine with anti-tumour activity.</p>

<p>Perfluorobutane is a gas that is colorless.</p>

<p>Sucunamostat (SCO-792) hydrochloride is an orally active, reversible inhibitor of enteropeptidase, displaying inhibition constants (IC50) of 4.6 nM for rat</p>

<p>trans-Hydroxy Glimepiride, an active sulfonylurea glimepiride metabolite, is primarily synthesized in the liver by CYP2C9.</p>

<p>(±)10(11)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid .</p>

<p>Acetic acid, 2-[4-[(2-ethyl-3-benzofuranyl)carbonyl]phenoxy]- is a compound used for antiviral activity determinations.</p>

<p>Ninopterin is an experimental antineoplastic and folic acid analog.</p>

<p>Generates rapid acidifications down to pH 2</p>

<p>5,7-Dichloropyrazolo[1,5-a]pyrimidine (fragment 5) is an inhibitor of the enzyme phosphodiesterase 10A (PDE10A) with a Ki value of 24 μM. This compound can be employed in research related to schizophrenia.</p>

<p>Benzoic acid (Standard) is a standard substance for quantitative analysis.Benzoic acid (Dracylic acid) is an aromatic alcohol and common additive.</p>

<p>Betulinditosylate is a derivative of Betulin, which functions as an SREBP inhibitor.</p>

<p>MCI-INI-3 is a selective competitive inhibitor of human ALDH1A3, with a Ki value of 0.55 μM for ALDH1A3 and 78.2 μM for ALDH1A1. It inhibits retinoic acid biosynthesis and can reduce the viability of glioblastoma cells GSC-83 and GSC-326.</p>

<p>(R)-SCH 42495, less potent enantiomer of NEP inhibitor SCH 42495, has oral antihypertensive action.</p>

<p>Propionylcarnitine (Propionyl carnitine) is a widely used dietary supplement that has been associated with glaucoma and does it ruptu</p>

<p>DCG04: a mannose-6-phosphate receptor ligand, fluorescent cysteine cathepsin probe for endolysosomal targeting.</p>

<p>SHP2-IN-34 (compound A8) is a phenylurea SHP2 inhibitor with anti-cancer properties. It significantly suppresses tumor growth in CT26 mouse models.</p>

<p>Rubratoxin B is a mycotoxin that causes hypoglycemia and fatty liver and has exhibited anticancer activity.</p>

<p>1,3-Dipalmitoleoyl-rac-glycerol: a diacylglycerol inhibiting yeast α-glucosidase over rat's (IC50s: 4.45 vs 9326.5 μM). Used to study membrane potentials.</p>

<p>Meproscillarin is a glycoside with high bioavailability (about 70%) and an elimination independent of renal function.</p>

<p>(Iso)-Dehydroemetine (Dehydroisoemetine, (+/-)-) is a compound with antispasmolytic effect on smooth muscle.</p>

<p>YF704 (compound 4w), a selective allosteric inhibitor of SHP2, exhibits antiproliferative effects and induces apoptosis in cancer cells with an IC50 of 0.25 μM.</p>

<p>Reticulol is an isocoumarin derivative produced by certain species of Streptomyces.</p>

<p>MAGL-IN-11 (compound 29) is a selective, reversible inhibitor of monoacylglycerol lipase (MAGL), with potential in researching inflammation, cancer, and</p>

<p>α-Glucosidase-IN-25 (Compound (R)-8k) serves as a competitive inhibitor for α-glucosidase, demonstrating an inhibitory concentration 50 (IC50) of 1.19μM, making</p>

<p>Compound 5, DDC 3′-O-β-D-glucuronide, is a drug metabolite with properties that inhibit the fibrillization and oligomerization of Aβ42, suggesting its potential</p>

<p>Asperglaucid A: a phthalide-like compound with strong antibacterial effects against Pseudomonas syringae pv actinidae and Bacillus cereus; MIC: 6.25 μM.</p>

<p>ent-Prostaglandin F2α is the enantiomer of PGF2α and is found in urine.</p>

<p>Pyrindolol, a S. alboverticillatus metabolite, inhibits bovine β-galactosidase at 2 μg/ml in acid; not effective on other species' enzymes.</p>

<p>Aeruginosin B is a biochemical.</p>

<p>DSPE-PEG2000-CSTSMLKAC is a PEG compound composed of DSPE and CSTSMLKAC. CSTSMLKAC can mediate phage selective homing to ischemic heart tissue. DSPE-PEG2000-CSTSMLKAC is suitable for drug delivery.</p>

<p>ω-Conotoxin MVIIA is a potent, selective inhibitor of Ca_v2.2, exhibiting an IC_50 of 0.33 μM in the SH-SY5Y fluorimetric hCa_v2.2 assay [1].</p>

<p>Inostamycin A, a anticancer bacterial metabolite isolated from Streptomyces, is a selective inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase.</p>

<p>LYP-IN-1 is a potent, selective inhibitor of lymphoid-specific tyrosine phosphatase useful for studying autoimmune disorders and immune signaling.</p>

<p>D-Fructose 1-phosphate disodium salt, a derivative of fructose, serves as a crucial intermediate in glucose metabolism.</p>

<p>5-Methoxyresorcinol (Flamenol) is a chemical intermediate.</p>

<p>Adenosine 3',5'-diphosphate sodium inhibits hydroxysteroid sulfotransferases and studies SULT kinetics/structure.</p>

<p>Calcium Channel antagonist5 (compound 32) is a calcium channel antagonist with a pIC50 of 5.50.</p>

<p>PPARγ agonist16 (Compound 4G) is a PPARγ agonist that competitively binds to the ligand-binding domain (LBD) of PPARγ with an IC50 of 1790 nM. It reduces ear swelling in mouse models and exhibits antihyperglycemic activity in mice with Streptozotocin-induced diabetes.</p>

<p>(-)-Dihydroguaiaretic acid is a useful organic compound for research related to life sciences and the catalog number is T126154.</p>

<p>β-Cryptoxanthin is isolated from Satsuma mandarin orange with an anti-stress effect. It is an oxygenated carotenoid and an antioxidant.</p>

<p>Larsucosterol sodium: a liver-derived cholesterol byproduct; modulates lipid synthesis, inflammation, and cell death regulation.</p>

<p>(±)-CBCQ, an oxidation product of cannabidiol, exhibits an EC50 value of 14.7 μM for the activation of peroxisome proliferator-activated receptor γ (PPAR-γ).</p>

<p>LXQ-87 is an orally administered, non-competitive inhibitor of PTP1B with an IC50 of 1.061 μM, demonstrating hypoglycemic activity. It alleviates insulin resistance and enhances cellular glucose uptake, making it useful for type 2 diabetes research.</p>

<p>E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.</p>

<p>5-Aminoisotonitazene is a metabolite of the synthetic opioid analgesic agent, Isotonitazene, found in urine.</p>

<p>11,12-DiHETrE: Endogenous P450 eicosanoid, used in preterm labor study and NAFL/NASH differentiation.</p>

<p>5-(3',4'-Dihydroxyphenyl)-γ-valerolactone is a metabolic byproduct of gut microbiota processing of (-)-Epicatechin. [5-(3',4'-Dihydroxyphenyl)-γ-valerolactone] exhibits antioxidant properties.</p>