Metabolismo
Os inibidores do metabolismo são compostos que interferem nas vias metabólicas, alterando a produção e utilização de energia dentro das células. Esses inibidores são usados para estudar a regulação do metabolismo, o papel das vias metabólicas em doenças como o câncer e o diabetes, e para desenvolver novas estratégias terapêuticas. Os inibidores do metabolismo podem direcionar várias enzimas e processos envolvidos na glicólise, na oxidação de ácidos graxos e em outras funções metabólicas. Na CymitQuimica, oferecemos uma ampla gama de inibidores do metabolismo de alta qualidade para apoiar sua pesquisa em bioquímica, distúrbios metabólicos e desenvolvimento de medicamentos.
Subcategorias de "Metabolismo"
- AhR(41 produtos)
- Aminopeptidase(67 produtos)
- CETP(18 produtos)
- Anidrase carbónica(177 produtos)
- Caseína quinase(130 produtos)
- DHFR(32 produtos)
- Descarboxilase(4 produtos)
- Desidrogenase(267 produtos)
- FAAH(63 produtos)
- FXR(58 produtos)
- Factor Xa(80 produtos)
- Sintase de Ácidos graxos(32 produtos)
- Ferroptose(215 produtos)
- GR(3 produtos)
- GSNOR(3 produtos)
- Glucoquinase(53 produtos)
- HIF/HIF Prolil-Hidroxilase(142 produtos)
- HMG-CoA Reductase(32 produtos)
- Hidroxilase(30 produtos)
- IDO(82 produtos)
- LDL(8 produtos)
- Lipase(96 produtos)
- Lipídio(59 produtos)
- Lipoxigenase(124 produtos)
- MAO(87 produtos)
- MPO(2 produtos)
- NAMPT(36 produtos)
- P450(6 produtos)
- PAI-1(25 produtos)
- PDE(165 produtos)
- PED(1 produtos)
- PKM(15 produtos)
- PPAR(164 produtos)
- Fosfolipase(82 produtos)
- ROR(42 produtos)
- Receptor de Retinóide(29 produtos)
- SGK(11 produtos)
- Tiorredoxina(12 produtos)
- Transferase(30 produtos)
- Tansportador(42 produtos)
- UGT(4 produtos)
- Inibidores de Xantina Oxidase (XO)(9 produtos)
Exibir 34 mais subcategorias
Foram encontrados 8597 produtos de "Metabolismo"
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CAII-IN-3
<p>CAII-IN-3, a thiosemicarbazone, potently inhibits CA-II with an IC50 of 13.4 μM.</p>Fórmula:C18H18F2N4SCor e Forma:SolidPeso molecular:360.42TAK-915
CAS:<p>TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.</p>Fórmula:C19H18F4N4O5Pureza:98%Cor e Forma:SolidPeso molecular:458.36D-Citrulline
CAS:<p>D-Citrulline (H-D-Cit-OH), a stereoisomer of L-citrulline, effectively reduces cardiac contractile dysfunction caused by polymorphonuclear leukocyte (PMN) in isolated perfused rat hearts undergoing ischemia/reperfusion. This protective effect is mediated through a non-NO-mediated mechanism.</p>Fórmula:C6H13N3O3Cor e Forma:SolidPeso molecular:175.19GlcCer (d18:1/18:0)
CAS:<p>GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a sphingolipid with potential applications in research on Parkinson's disease and Lewy body dementia.</p>Fórmula:C42H81NO8Cor e Forma:SolidPeso molecular:728.094Glucosylceramide synthase-IN-3
<p>Glucosylceramide synthase-IN-3 (BZ1) is a potent, brain-accessible, oral GCS inhibitor with a 16 nM IC50, relevant for Gaucher's disease study.</p>Fórmula:C21H20FN3O3Cor e Forma:SolidPeso molecular:381.4HIF-1/2α-IN-1
<p>HIF-1/2α-IN-1, an orally active compound, functions as an inhibitor of HIF-2α.</p>Fórmula:C17H16N6O4Cor e Forma:SolidPeso molecular:368.35CYP2C9/CYP2C19-IN-1
<p>CYP2C9/CYP2C19-IN-1 is a potent inhibitor of CYP2C9/CYP2C19 without liver toxicity or genotoxicity and can be used to study Zika virus (ZIKV) infection.</p>Fórmula:C27H28N2O6SCor e Forma:SolidPeso molecular:508.59Complex III-IN-1
<p>Complex III-IN-1 inhibits complex III, has antifungal properties, and an EC50 of 18.53 mg/L against S. sclerotiorum.</p>Fórmula:C14H20ClNO2S2Cor e Forma:SolidPeso molecular:333.9AChE/hCA I-IN-1
CAS:<p>AChE/hCA I-IN-1 (Compound L3) is an inhibitor of acetylcholinesterase (AChE) and carbonic anhydrase (CA), effectively inhibiting AChE, hCA I, and hCA II with IC50 values of 302 nM, 265 nM, and 283 nM, respectively.</p>Fórmula:C13H9BrNNaO4SCor e Forma:SolidPeso molecular:378.174Mutant IDH1-IN-3
CAS:<p>Mutant IDH1-IN-3 (Compound 1) is a selective allosteric inhibitor targeting the mutant isocitrate dehydrogenase 1 (IDH1), with an IC50 of 13 nM for R132HIDH1. It effectively suppresses the production of D-2-hydroxyglutarate (2HG) in cells and is applicable for research in oncology.</p>Fórmula:C22H30N4OCor e Forma:SolidPeso molecular:366.5HIF-1α-IN-5
<p>HIF-1α-IN-5 is an inhibitor of HIF-1α with an IC 50 value of 24 nM in HEK293T cells that also inhibits the activity of MAO-A.</p>Fórmula:C16H15N3O2Cor e Forma:SolidPeso molecular:281.31Benfooxythiamine
CAS:<p>Benfooxythiamine is a transketolase (TKT) inhibitor that suppresses SARS-CoV-2 replication and enhances the activity of the glycolysis inhibitor 2DG. It exhibits antiviral properties.</p>Fórmula:C19H22N3O7PSCor e Forma:SolidPeso molecular:467.433DDO-3733
CAS:<p>DDO-3733 is a conformational activator of Protein Phosphatase 5 (PP5) that functions independently of TRP, facilitating the dephosphorylation of downstream substrates.</p>Fórmula:C10H6F2N2OSCor e Forma:SolidPeso molecular:240.23BMS-185354
CAS:<p>BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM, offering potential for cancer research.</p>Fórmula:C26H27NO3Cor e Forma:SolidPeso molecular:401.497Miaosporone A
<p>Miaosporone A: angucyclic quinone, cytotoxic to MCF-7, NCI-H187, Vero cells; anti-TB and anti-malaria with IC50 of 2.4 μM, 2.5 μM.</p>Fórmula:C19H18O5Cor e Forma:SolidPeso molecular:326.34Etiocholanolone glucuronide
CAS:<p>Etiocholanolone glucuronide (Etio-G) is a metabolite of Etiocholanolone, produced through the catalysis by UDP glucuronosyltransferase in the liver. Etiocholanolone glucuronide shows potential for research in metabolic-related diseases.</p>Fórmula:C25H38O8Cor e Forma:SolidPeso molecular:466.564Propofol sulfate sodium
CAS:<p>Propofolsulfate (sodium) is a metabolite of Propofol.</p>Fórmula:C12H17NaO4SCor e Forma:SolidPeso molecular:280.316CP 524515
CAS:<p>CP 524515 is a potent inhibitor of cholesterol ester transfer protein (CETP), which results in increased levels of high-density lipoprotein cholesterol.</p>Fórmula:C27H27F9N2O4Cor e Forma:SolidPeso molecular:614.5Vimirogant hydrochloride
<p>Vimirogant (VTP-43742) HCl: Oral, selective RORγt inhibitor (IC50: 17 nM, Ki: 3.5 nM), >1000x selectivity over RORα/β, targets Th17, not Th1/2/Treg.</p>Fórmula:C27H36ClF3N4O3SCor e Forma:SolidPeso molecular:588.21487α-Hydroxy alprazolam
CAS:<p>α-Hydroxy alprazolam (U 40125), the primary metabolite of α-Hydroxy alprazolam, possesses pharmacological activity accounting for 60% of that of Alprazolam.</p>Fórmula:C17H13ClN4OCor e Forma:SolidPeso molecular:324.76GSK 366
CAS:<p>GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).</p>Fórmula:C17H16ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:361.78DPM-1003
CAS:<p>DPM-1003 is an allosteric inhibitor of PTP1B, targeting the non-catalytic, disordered C-terminal segment of the PTP1B protein, and has shown beneficial effects in reducing pulmonary inflammation in mice.</p>Fórmula:C35H57N3O3Cor e Forma:SolidPeso molecular:567.845Quinapril
CAS:<p>Quinapril is an orally active, non-peptide, and non-thiol angiotensin-converting enzyme (ACE) inhibitor. It primarily blocks the conversion of angiotensin I to angiotensin II in both plasma and tissues. Upon enzymatic hydrolysis, Quinapril is converted into the pharmacologically active Quinaprilat and is effective in hypertension models.</p>Fórmula:C25H30N2O5Cor e Forma:SolidPeso molecular:438.516hCAII-IN-4
CAS:<p>hCAII-IN-4 (Compound 12j) is a potent inhibitor of human carbonic anhydrase II (hCA II), exhibiting an inhibitory concentration (IC50) of 7.78 μM.</p>Fórmula:C31H23NO9Cor e Forma:SolidPeso molecular:553.52FTI-2148
CAS:<p>FTI-2148 blocks RAS-related FT-1 & GGT-1; IC50: 1.4 nM & 1.7 μM.</p>Fórmula:C24H28N4O3SPureza:98%Cor e Forma:SolidPeso molecular:452.57DC360
CAS:<p>DC360 is a synthetic analog of all-trans retinoic acid (ATRA) that can induce the expression of RARβ. It is useful for studies characterizing the retinoic acid signaling pathway.</p>Fórmula:C23H23NO2Cor e Forma:SolidPeso molecular:345.434Monoamine oxidase/Aromatase-IN-1
<p>Compound 2q: Dual MAO/aromatase inhibitor; IC50: 39 nM (MAO-B), 31 nM (aromatase). Useful in neurological/breast cancer research.</p>Fórmula:C19H19N3O3SCor e Forma:SolidPeso molecular:369.44Zaragozic acid C
CAS:<p>Zaragozic acid C is an effective inhibitor of squalene synthase.</p>Fórmula:C40H50O14Pureza:98%Cor e Forma:SolidPeso molecular:754.821-Stearoyl-sn-glycerol 3-phosphate sodium
CAS:<p>1-Stearoyl-sn-glycerol 3-phosphate sodium, a biologically active phospholipid, plays a crucial role in regulating cell motility, proliferation, invasion, survival, and the production of growth factors through interactions with G protein-coupled receptors (GPCR). Synthesized during the formation of membrane phospholipids, this compound typically has a low plasma concentration (approximately 100nM) and originates from various cell types, including activated platelets, epithelial cells, leukocytes, neuronal cells, and tumor cells. Its distinctive structure features stearic acid at the sn-1 position and a hydroxyl group at the sn-2 position.</p>Fórmula:C21H42NaO7PCor e Forma:SolidPeso molecular:460.52CYP1B1-IN-2
<p>CYP1B1-IN-2 (compound 9j) is a highly potent and selective inhibitor of CYP1B1, a cytochrome P450 enzyme. It exhibits an IC50 value of 0.52 nM [1].</p>Fórmula:C20H11F3O2Cor e Forma:SolidPeso molecular:340.3hCA XII/II/IX-IN-1
<p>hCA XII/II/IX-IN-1 inhibits hCA I/II/IX/XII (IC50: 2.6, 0.004, 0.005, 0.001 μM) with anticancer properties.</p>Fórmula:C25H34N4O7SCor e Forma:SolidPeso molecular:534.63NTPDase-IN-1
<p>NTPDase-IN-1 selectively inhibits NTPDases 1, 2, 8 with IC50 of 0.05, 0.23, 0.54 μM. Non-competitive, K m 21 μM, used in cancer, immune, infection research.</p>Fórmula:C18H25N3OS2Cor e Forma:SolidPeso molecular:363.54LDHA-IN-5
CAS:<p>LDHA-IN-5 is a novel and potent inhibitor targeting both glycolate oxidase (GO) and lactate dehydrogenase A (LDHA), designed for the treatment of primary</p>Fórmula:C27H22FN7O6S3Cor e Forma:SolidPeso molecular:655.7FXIa-IN-6
CAS:<p>FXIa-IN-6: Potent, selective FXIa inhibitor (Ki=0.3 nM); strong PK with high oral bioavailability, low clearance preclinically.</p>Fórmula:C31H29ClF2N4O4Cor e Forma:SolidPeso molecular:595.04EB-0150
<p>EB-0150 inhibits ER α-Glu I/II (IC50: 0.73/0.0337 μM), is an N-substituted valerian with antiviral effects, and has drug discovery potential.</p>Fórmula:C19H30N6O7Cor e Forma:SolidPeso molecular:454.48α-Glucosidase-IN-14
<p>α-Glucosidase-IN-14 is a potent inhibitor of α-glucosidase (IC50: 5.22 μM).</p>Fórmula:C24H27N5O4S2Cor e Forma:SolidPeso molecular:513.63BT-114143
CAS:<p>BT-114143 is a plasminogen activator inhibitor with an IC50 of 8.42 μM. It is applicable in research related to hemorrhagic diseases caused by excessive fibrinolysis, including traumatic bleeding, severe menorrhagia, postpartum hemorrhage, and complications of hemophilia.</p>Fórmula:C8H11N2O3PCor e Forma:SolidPeso molecular:214.158Anticancer agent 78
<p>Anticancer agent 78: anti-aromatase (IC50=0.9 μM), cytotoxic, potential in breast cancer research.</p>Fórmula:C19H14BrNO4Cor e Forma:SolidPeso molecular:400.22PF-06795071
CAS:<p>PF-06795071 is an effective and selective covalent inhibitor of MAGL (IC50: 3 nM).</p>Fórmula:C18H17F4N3O3Pureza:98%Cor e Forma:SolidPeso molecular:399.34Casein kinase 1δ-IN-30
CAS:<p>Casein kinase1δ-IN-30 (Compound 581) is an inhibitor of casein kinase 1δ (CK1δ). It can be utilized in research related to neurodegenerative diseases.</p>Fórmula:C18H15BrN6O2SCor e Forma:SolidPeso molecular:459.32Dopaminechrome
CAS:<p>Dopaminechrome (DACHR) is an oxidation product of dopamine that promotes the generation of H2O2 at mitochondrial complex I in the brain in a concentration- and respiration-dependent manner. It possesses neurotoxic properties and can be utilized in Parkinson's disease research.</p>Fórmula:C8H7NO2Cor e Forma:SolidPeso molecular:149.147SDX-7539
CAS:<p>SDX-7539 is a selective MetAP2 inhibitor that inhibits the proliferation of HUVEC, with an IC50 of 120 μM. It has demonstrated antitumor activity in xenografted NSCLC in athymic nude mice.</p>Fórmula:C23H38N2O5Peso molecular:422.56Magnesium ionophore III
CAS:<p>Magnesium ionophore III (ETH 4030) is an ion carrier that regulates intracellular magnesium ion concentrations. It enhances cellular functions and metabolic activities by increasing the permeability of cell membranes to magnesium ions. Additionally, Magnesium ionophore III is utilized in research to explore the significance of magnesium ions in biological processes and their impact on cellular physiology.</p>Fórmula:C30H58N4O4Cor e Forma:SolidPeso molecular:538.81Homomoschatoline
CAS:<p>Homomoschatoline is an antibacterial isolated from Artabotrys crassifolius.</p>Fórmula:C19H15NO4Pureza:98%Cor e Forma:SolidPeso molecular:321.33Carbonic anhydrase inhibitor 17
CAS:<p>Carbonic anhydrase inhibitor 17 (compound 7c) is a pyrazine-based sulfonamide that acts as a carbonic anhydrase II inhibitor, with an IC50 value of 0.63 nM.</p>Fórmula:C18H15ClN4O3S2Peso molecular:434.92Phospho-L-arginine
CAS:<p>Phospho-L-arginine is a derivative of arginine.</p>Fórmula:C6H15N4O5PPeso molecular:254.18MRS4458
CAS:<p>MRS4458 is an effective inhibitor of the P2Y14 Receptor.</p>Fórmula:C24H20F3N5O3SPureza:98%Cor e Forma:SolidPeso molecular:515.51Nomelidine
CAS:<p>Nomelidine, the active N-demethylated metabolite of zimelidine, has been used as an antidepressant and analgesic.</p>Fórmula:C15H15BrN2Pureza:98%Cor e Forma:SolidPeso molecular:303.20LRAT-IN-1
CAS:<p>LRAT-IN-1 (compound 1) is an inhibitor of lecithin retinol acyltransferase (LRAT) with an IC50 value of 21.1 μM. This compound works by inhibiting the esterification of retinol to form retinyl esters, thereby increasing the availability of retinol in the skin to deliver anti-aging benefits. LRAT-IN-1 is under investigation for its potential use as an anti-aging ingredient in cosmetics.</p>Fórmula:C27H47N5O5S2Cor e Forma:SolidPeso molecular:585.82EpoY
CAS:<p>EpoY (SD-142) is an irreversible inhibitor of the primary brain microtubule-associated tyrosine carboxypeptidase (TCP), a complex formed by vasohibin-1 (VASH1) and small vasohibin-binding protein (SVBP). By inhibiting TCP with an IC50 value of approximately 500 nM, EpoY effectively reduces the levels of detyrosinated α-tubulin, which is crucial for microtubule dynamics and neuronal differentiation. This inhibition results in significant differentiation defects and is linked to potential issues related to cancer and cardiomyopathy.</p>Fórmula:C15H17NO7Cor e Forma:SolidPeso molecular:323.30
