Caspase
Caspase inhibitors are compounds that block the activity of caspases, a family of proteases that are central executors of apoptosis. Caspases cleave specific substrates within the cell to trigger the apoptotic process, leading to programmed cell death. Caspase inhibitors are used to study the mechanisms of apoptosis, as well as to prevent unwanted cell death in various research models. These inhibitors are also explored in therapeutic contexts to protect cells from apoptosis in diseases such as neurodegeneration. At CymitQuimica, we offer a wide range of high-quality caspase inhibitors to support your research in apoptosis, cell death, and related fields.
Found 125 products of "Caspase"
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Aspirin
CAS:<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>Formula:C9H8O4Purity:99.78% - 99.91%Color and Shape:White Solid CrystallineMolecular weight:180.16Q-VD-OPH
CAS:<p>Q-VD-OPh is an irreversible caspase inhibitor with an IC50 value of 48 nM against caspase-7 and between 25 and 400 nM against caspase-1, 3, 8, 9, 10, 12.</p>Formula:C26H25F2N3O6Purity:97.8% - 98.95%Color and Shape:SolidMolecular weight:513.5Thiabendazole
CAS:<p>Thiabendazole (2-(4-Thiazolyl)benzimidazole) is a benzimidazole derivative with anthelminthic property.</p>Formula:C10H7N3SPurity:99.14%Color and Shape:Light Yellow PowderMolecular weight:201.25Fenbufen
CAS:<p>Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis.</p>Formula:C16H14O3Purity:98.35% - 98.46%Color and Shape:White SolidMolecular weight:254.28Diclofenac sodium
CAS:<p>Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions.</p>Formula:C14H10Cl2NNaO2Purity:98.21% - 99.73%Color and Shape:White Or Off-White PowderMolecular weight:318.13Ac-FLTD-CMK
CAS:<p>Ac-FLTD-CMK, an abscisicin D derivative, selectively inhibits inflammatory caspases-1, -4, and -11 (IC50: 46.7 nM, 1.49 μM, 329 nM) but not caspase-3.</p>Formula:C26H37ClN4O8Purity:95.17%Color and Shape:SolidMolecular weight:569.05Dehydrocorydaline chloride
CAS:<p>Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.</p>Formula:C22H24ClNO4Purity:99.53%Color and Shape:SolidMolecular weight:401.88Ac-YVAD-CMK
CAS:<p>Ac-YVAD-CMK: Irreversible Caspase-1 inhibitor; halts pyroptosis, IL-1β/IL-18; neuroprotective and anti-inflammatory.</p>Formula:C24H33ClN4O8Purity:97.08% - 99.909%Color and Shape:SolidMolecular weight:540.99Lacidipine
CAS:<p>Lacidipine (SN-305) is a slow-acting, long-duration lipophilic dihydropyridine calcium blocker that prevents reflex tachycardia and lowers blood pressure.</p>Formula:C26H33NO6Purity:99.98%Color and Shape:White-To-Off-White Crystalline SolidMolecular weight:455.54Diclofenac diethylamine
CAS:<p>Diclofenac Diethylamine, a non-selective COX inhibitor, is utilized as a nonsteroidal anti-inflammatory drug (NSAID).</p>Formula:C18H22Cl2N2O2Purity:99.81% - 99.87%Color and Shape:SolidMolecular weight:369.29Diclofenac
CAS:<p>Diclofenac: a nonsteroidal compound inhibiting COX-1 and COX-2, reducing pro-inflammatory prostaglandins.</p>Formula:C14H11Cl2NO2Purity:99.69% - 99.97%Color and Shape:Crystals From Ether-Petroleum Ether SolidMolecular weight:296.15Terfenadine
CAS:<p>Terfenadine, metabolized to fexofenadine by CYP3A4, is a non-sedative antihistamine targeting H1 receptors.</p>Formula:C32H41NO2Purity:98.76% - 99.75%Color and Shape:SolidMolecular weight:471.67ML-9
CAS:<p>ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively.</p>Formula:C15H18Cl2N2O2SPurity:99.69%Color and Shape:Crystalline SolidMolecular weight:361.29Oxidopamine hydrochloride
CAS:<p>Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) is an neurotransmitter dopamine antagonist.</p>Formula:C8H12ClNO3Purity:98.34% - 99.85%Color and Shape:Physical Description Beige Solid (Ntp 1992)Molecular weight:205.64Oxidopamine hydrobromide
CAS:<p>Oxidopamine hydrobromide (6-OHDA hydrobromide) is a neurotransmitter dopamine antagonist.</p>Formula:C8H12BrNO3Purity:98.22% - 99.88%Color and Shape:Beige To Brown Fine Crystalline PowderMolecular weight:250.09Crustecdysone
CAS:<p>Crustecdysone (Hydroxyecdysone) is a steroid hormone that regulates the processes of molting or ecdysis in insects.</p>Formula:C27H44O7Purity:99.06% - 99.67%Color and Shape:Canary Yellow Fine PowderMolecular weight:480.63Caspase-3 activator 2
<p>Caspase-3 Activator 2 (Compound 2f) is a caspase 3 activator with cytotoxic effects on HL-60 and K562 cells, exhibiting IC 50 values of 33.52 μM and 76.90 μM,</p>Purity:98%Color and Shape:Odour SolidZ-VDVA-(DL-Asp)-FMK
CAS:<p>Z-VDVA-(DL-Asp)-FMK is a derivative compound of Z-VDVAD-FMK specifically designed as an inhibitor targeting caspase-2.</p>Formula:C32H46FN5O11Color and Shape:SolidMolecular weight:695.742PQ401
CAS:<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Formula:C18H16ClN3O2Purity:99.77%Color and Shape:SolidMolecular weight:341.79Protease Inhibitor Library
<p>A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;</p>Color and Shape:Odour SolidBOC-D-FMK
CAS:<p>Boc-D-FMK is an irreversible, cell-permeable, and broad-spectrum caspase inhibitor and inhibits apoptosis stimulated by TNF-α (IC50: 39 μM).</p>Formula:C11H18FNO5Purity:97.02%Color and Shape:SolidMolecular weight:263.26(Iso)-Z-VAD(OMe)-FMK
CAS:<p>(Iso)-Z-VAD(OMe)-FMK is an isomer of Z-VAD(OMe)-FMK, which is a pan-caspase inhibitor with irreversible properties. Z-VAD(OMe)-FMK is also an inhibitor UCHL1.</p>Formula:C22H30FN3O7Purity:97.10%Color and Shape:SoildMolecular weight:467.49Apoptosis Compound Library
<p>A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;</p>Color and Shape:Odour SolidSanggenon G
CAS:<p>Sanggenon G inhibits XIAP by binding its BIR3 domain; affinity is 34.26 μM, boosting caspase activation.</p>Formula:C40H38O11Color and Shape:SolidMolecular weight:694.72Sarglaroids F
<p>Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+</p>Formula:C38H44O12Purity:98%Color and Shape:SolidMolecular weight:692.75TNF-α-IN-11
<p>TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor exhibiting a dissociation constant (K D) of 12.06 μM.</p>Formula:C24H26N2O5Color and Shape:SolidMolecular weight:422.47Ac-VDVAD-CHO TFA
<p>Ac-VDVAD-CHO (TFA) is a caspase-2/3 inhibitor with IC50 values of 46 nM and 15 nM, respectively.</p>Color and Shape:Odour SolidAc-Trp-Glu-His-Asp-Aldehyde
CAS:<p>Ac-Trp-Glu-His-Asp-Aldehyde is a powerful and selective inhibitor of caspase-1, demonstrating a K_i value of 56 pM [1] [2].</p>Formula:C28H33N7O9Color and Shape:SolidMolecular weight:611.6IRF1-IN-2
CAS:<p>IRF1-IN-2 is a small molecule IRF1 inhibitor that suppresses pyroptosis, protecting against radiation-induced skin damage.</p>Formula:C18H20N2O4SPurity:99.85%Color and Shape:SolidMolecular weight:360.43Ac-LEHD-AMC
CAS:<p>Ac-LEHD-AMC, a fluorogenic caspase-9 substrate, releases fluorescent AMC upon cleavage, aiding caspase-9 activity measurement.</p>Formula:C33H41N7O11Color and Shape:SolidMolecular weight:711.729Reproxalap
CAS:<p>Reproxalap (NS-2) is a dry eye treatment that neutralizes aldehydes like malondialdehyde.</p>Formula:C12H13ClN2OPurity:99.4% - 99.97%Color and Shape:SolidMolecular weight:236.7Ac-LEVD-CHO
CAS:<p>Ac-LEVD-CHO, a caspase-4 inhibitor, is a peptide with the sequence Ac-Leu-Glu-Val-Asp-al [1].</p>Formula:C22H36N4O9Color and Shape:SolidMolecular weight:500.54Boc-Asp(OBzl)-CMK
CAS:<p>Boc-Asp(OBzl)-CMK, an inhibitor of IL-1 converting enzyme (ICE, caspase1), prevents the death of CHP100 neuroblastoma cells and inhibits IL-1β release induced by the viral coat protein [1].</p>Formula:C17H22ClNO5Color and Shape:SolidMolecular weight:355.81δ-secretase inhibitor 11
CAS:<p>δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.</p>Formula:C10H12N4O2Purity:99.84%Color and Shape:SolidMolecular weight:220.23Pralnacasan
CAS:<p>Pralnacasan blocks IL-18, IL-1β, IFN-γ. It’s a potent oral enzyme inhibitor with use in arthritis therapy (Ki: 1.4 nM).</p>Formula:C26H29N5O7Purity:98%Color and Shape:SolidMolecular weight:523.54Z-WEHD-FMK
CAS:<p>Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).</p>Formula:C37H42FN7O10Purity:98%Color and Shape:SolidMolecular weight:763.78Ac-IEPD-AFC
CAS:<p>Ac-IEPD-AFC (IEPD) is a fluorescent substrate for granzyme B and can be used to measure granzyme B activity.</p>Formula:C32H38F3N5O11Purity:99.16%Color and Shape:SolidMolecular weight:725.67IRF1-IN-1
CAS:<p>IRF1-IN-1 (Compound I-2) is an IRF1 inhibitor , inhibiting the cleavage of Caspase 1, GSDMD, IL-1, and PARP1,protecting against skin inflammatory damage.</p>Formula:C22H24N4O4SPurity:99.88%Color and Shape:SolidMolecular weight:440.52AKN-028
CAS:<p>AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.</p>Formula:C17H14N6Purity:99.88%Color and Shape:SolidMolecular weight:302.33TD1092
<p>TD1092, a pan-IAP degrader, activates caspase 3/7, induces apoptosis in cancer cells, inhibits NF-κB, and is used in cancer research.</p>Formula:C55H70N8O9Color and Shape:SolidMolecular weight:987.19MX1013
CAS:<p>MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.</p>Formula:C18H23FN2O6Color and Shape:SolidMolecular weight:382.39Almorexant hydrochloride
CAS:<p>Almorexant hydrochloride (ACT 078573 hydrochloride) is a dual orexin receptor antagonist that induces apoptosis and can be used to study sleep disorders.</p>Formula:C29H32ClF3N2O3Purity:99.85%Color and Shape:SolidMolecular weight:549.02J22352
CAS:<p>J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in</p>Formula:C24H21N3O4Color and Shape:SolidMolecular weight:415.44EF24
CAS:<p>EF24 treatment boosts caspase 3/9 activity, hinders MEK1/ERK phosphorylation, and exhibits strong anti-tumor effects in OSCC by deactivating MAPK/ERK.</p>Formula:C19H15F2NOPurity:99.71%Color and Shape:SolidMolecular weight:311.33PAC-1
CAS:<p>PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer and Thoracic Cancers.</p>Formula:C23H28N4O2Purity:96.78% - 99.77%Color and Shape:SolidMolecular weight:392.49Ivachtin
CAS:<p>Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining</p>Formula:C20H21N3O7SPurity:99.74%Color and Shape:SolidMolecular weight:447.46Penicillic acid
CAS:<p>Penicillic acid, a mycotoxin from Aspergillus/Penicillium, blocks Fas ligand apoptosis and is cytotoxic to rat lung macrophages.</p>Formula:C8H10O4Purity:98%Color and Shape:Needles From Petroleum Ether Slight Yellow PowderMolecular weight:170.16Guggulsterone
CAS:<p>Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.</p>Formula:C21H28O2Purity:99.4% - 99.8%Color and Shape:Light Yellow PowderMolecular weight:312.455,7,4'-Trimethoxyflavone
CAS:<p>5,7,4'-Trimethoxyflavone (4',5,7-Trimethoxyflavone) is isolated from Kaempferia parviflora (KP) which is a medicinal plant from Thailand.</p>Formula:C18H16O5Purity:97.53%Color and Shape:SolidMolecular weight:312.32Chelidonic acid
CAS:<p>Chelidonic acid, in Chelidonium majus, acts as an analgesic, antimicrobial, CNS sedative, and has anti-inflammatory properties.</p>Formula:C7H4O6Purity:99.03%Color and Shape:SolidMolecular weight:184.1Almorexant
CAS:<p>Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.</p>Formula:C29H31F3N2O3Purity:97.75% - 98.02%Color and Shape:SolidMolecular weight:512.56Asperosaponin VI
CAS:<p>Asperosaponin VI, from Dipsacus asper rhizome, treats back pain, hematoma, and fractures.</p>Formula:C47H76O18Purity:97.15% - 99.79%Color and Shape:SolidMolecular weight:929.1Z-IETD-FMK
CAS:<p>Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective caspase 8 inhibitor, which has cell permeable.</p>Formula:C30H43FN4O11Purity:95% - 99.81%Color and Shape:SolidMolecular weight:654.68Ginsenoside Rh2
CAS:<p>Ginsenoside Rh2 (20(S)-Ginsenoside Rh2), an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.</p>Formula:C36H62O8Purity:99.20% - 99.76%Color and Shape:White PowderMolecular weight:622.872-HBA
CAS:<p>2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.</p>Formula:C17H14O3Purity:99.76%Color and Shape:SolidMolecular weight:266.29Ac-DEVD-AMC
CAS:<p>Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .</p>Formula:C30H37N5O13Purity:98.20%Color and Shape:White PowderMolecular weight:675.64KEA1-97
CAS:<p>Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M).</p>Formula:C15H9Cl2FN4Purity:97.07%Color and Shape:SolidMolecular weight:335.16Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Z-VAD(OMe)-FMK
CAS:<p>View and buy Z-VAD(OMe)-FMK from TargetMol.Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor.Cited in 10 publications.</p>Formula:C22H30FN3O7Purity:95.92% - 99.71%Color and Shape:SolidMolecular weight:467.49Ac-DEVD-CHO acetate
<p>Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.</p>Formula:C22H34N4O13Purity:98.54%Color and Shape:SolidMolecular weight:562.52PHYTOSPHINGOSINE
CAS:<p>Phytosphingosine: anticancer phospholipid; triggers apoptosis in cancer cells via caspase 8 activation and Bax translocation.</p>Formula:C18H39NO3Purity:99.81%Color and Shape:SolidMolecular weight:317.51TC11
CAS:<p>TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis</p>Formula:C20H22N2O2Purity:97.86%Color and Shape:SolidMolecular weight:322.4Belnacasan
CAS:<p>Belnacasan (VX-765) is an orally active IL-converting enzyme/caspase-1 inhibitor.</p>Formula:C24H33ClN4O6Purity:96.53% - 99.5%Color and Shape:SolidMolecular weight:508.99Sesamolin
CAS:<p>Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.</p>Formula:C20H18O7Purity:98.77% - 99.04%Color and Shape:SolidMolecular weight:370.35Wedelolactone
CAS:<p>Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.</p>Formula:C16H10O7Purity:98.07% - 99.87%Color and Shape:SolidMolecular weight:314.25PI-1840
CAS:<p>PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.</p>Formula:C22H26N4O3Purity:98.82%Color and Shape:SolidMolecular weight:394.47Dehydrocorydaline
CAS:<p>1.</p>Formula:C22H24NO4Purity:99.84%Color and Shape:SolidMolecular weight:366.43Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Formula:C9H6O4Purity:97.47% - 99.8%Color and Shape:SolidMolecular weight:178.14Ac-DEVD-pNA
CAS:<p>Ac-DEVD-pNA is the preferred peptidic substrate for caspase-3.</p>Formula:C26H34N6O13Purity:>99.99%Color and Shape:WhiteMolecular weight:638.58Z-YVAD-FMK
CAS:<p>AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.</p>Formula:C31H39FN4O9Purity:98.00%Color and Shape:SolidMolecular weight:630.66Emricasan
CAS:<p>Emricasan (IDN-6556) is a pan-caspase inhibitor with irreversible properties.</p>Formula:C26H27F4N3O7Purity:98.13% - 99%Color and Shape:SolidMolecular weight:569.5Z-FA-FMK
CAS:<p>Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.</p>Formula:C21H23FN2O4Purity:98.84% - 99.68%Color and Shape:SolidMolecular weight:386.42Dihydrocapsaicin
CAS:<p>Dihydrocapsaicin, similar to capsaicin, is an irritant found in Capsicum, used in "pure" capsaicin products at about 10%, activates VR1, and is an antioxidant.</p>Formula:C18H29NO3Purity:99.61% - ≥95%Color and Shape:White CrystalMolecular weight:307.43Aristolactam I
CAS:<p>Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway.</p>Formula:C17H11NO4Purity:98.98% - 99.63%Color and Shape:SolidMolecular weight:293.27Ossirene
CAS:<p>Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.</p>Formula:C2H4Cl3O2Te·H4NPurity:≥98%Color and Shape:SolidMolecular weight:312.05Tauroursodeoxycholate
CAS:<p>Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.</p>Formula:C26H45NO6SPurity:98.77% - 99.93%Color and Shape:White SolidMolecular weight:499.7Senkyunolide I
CAS:<p>1. Senkyunolide I has neuroprotective effect, associated with its anti-oxidation and anti-apoptosis properties.</p>Formula:C12H16O4Purity:99.73% - 99.88%Color and Shape:SolidMolecular weight:224.25Diclofenac Potassium
CAS:<p>Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.</p>Formula:C14H10Cl2KNO2Purity:99.51%Color and Shape:White To Yellowish Crystalline PowderMolecular weight:334.24CASP3 Activator 1541
CAS:<p>CASP3 Activator 1541 is an activator of the proenzyme forms of caspase-3, and induces cell death.</p>Formula:C24H17N3O4Purity:98.84%Color and Shape:SolidMolecular weight:411.41L67
CAS:<p>L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).</p>Formula:C16H14Br2N4O4Purity:98.34% - 99.56%Color and Shape:SolidMolecular weight:486.11Phenoxodiol
CAS:<p>Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)</p>Formula:C15H12O3Purity:98.07%Color and Shape:SolidMolecular weight:240.25AVN-944
CAS:<p>AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.</p>Formula:C25H27N5O5Purity:99.07% - ≥95%Color and Shape:SolidMolecular weight:477.51Taurodeoxycholic acid sodium hydrate
CAS:<p>Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.</p>Formula:C26H46NNaO7SPurity:99.95%Color and Shape:SolidMolecular weight:539.705,7-Dihydroxychromone
CAS:<p>1.</p>Formula:C9H6O4Purity:99.76% - ≥95%Color and Shape:SolidMolecular weight:178.14Boc-Asp(OMe)-fluoromethyl ketone
CAS:<p>Boc-Asp(OMe)-FMK is a broad-spectrum caspase inhibitor that blocks Fas-mediated processes without affecting IL-8 chemotaxis.</p>Formula:C11H18FNO5Purity:≥98%Color and Shape:SolidMolecular weight:263.26Tauroursodeoxycholate sodium
CAS:<p>Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.</p>Formula:C26H44NNaO6SPurity:97.90%Color and Shape:SolidMolecular weight:521.69Z-VAD-FMK
CAS:<p>Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases.Z-VAD-FMK binds to activated caspases and inhibits apoptosis.Z-VAD-FMK does not</p>Formula:C21H28FN3O7Purity:98.24% - 99.79%Color and Shape:SolidMolecular weight:453.46(E/Z)-Necrosulfonamide
CAS:<p>(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.</p>Formula:C18H15N5O6S2Purity:97.62% - 98%Color and Shape:SolidMolecular weight:461.47Lobaplatin
CAS:<p>Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe.</p>Formula:C9H18N2O3PtPurity:98.00%Color and Shape:SolidMolecular weight:397.33Z-DEVD-FMK
CAS:<p>Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7,</p>Formula:C30H41FN4O12Purity:96.19% - 99.69%Color and Shape:SolidMolecular weight:668.66Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Formula:C19H24O5Purity:96.66%Color and Shape:SolidMolecular weight:332.39Dehydrocorydaline nitrate
CAS:<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Formula:C22H24N2O7Purity:99.79% - 99.92%Color and Shape:SolidMolecular weight:428.44Dehydrotrametenolic acid
CAS:<p>Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in</p>Formula:C31H48O3Purity:98%Color and Shape:SolidMolecular weight:468.71Limonin glucoside
CAS:<p>Limonin glucoside: a citrus compound, blocks HIV/HTLV-1, triggers cancer cell death, kills Aedes larvae.</p>Formula:C32H42O14Color and Shape:SolidMolecular weight:650.674Caspase-3-IN-1
CAS:<p>Caspase-3-IN-1 is a potent inhibitor of Caspase-3 (IC50: 14.5 nM).</p>Formula:C26H25N3O6SColor and Shape:SolidMolecular weight:507.56Tigilanol tiglate
CAS:<p>Tigilanol tiglate (EBC-46) is a PKC/C1 domain activator. Tigilanol tiglate induces immunogenic cell death and tumour regression.</p>Formula:C30H42O10Purity:98%Color and Shape:SolidMolecular weight:562.65Anisperimus
CAS:<p>Anisperimus (LF 15-0195) is an immunosuppressant that prevents CNS autoimmunity by promoting the development of regulatory CD4 T cells expressing Foxp3.</p>Formula:C18H39N7O3Purity:98.10%Color and Shape:SolidMolecular weight:401.55AD-2646
CAS:<p>AD-2646 has antidepressant activity and inhibits 2-deoxy-D-glucose (2-DG)-induced gastric acid secretion.</p>Formula:C23H40N2O4Color and Shape:SolidMolecular weight:408.57ZYZ-488
CAS:<p>ZYZ-488 is an Apoptosis protease activating factor-1 (Apaf-1) inhibitor, which suppresses the activation of procaspase-9 and procaspase-3.</p>Formula:C20H29N3O11Purity:99.04%Color and Shape:SolidMolecular weight:487.46Caspase-9 Inhibitor III
CAS:<p>Caspase-9 Inhibitor III (Ac-LEHD-cmk) blocks caspase-9, protects against ischemic heart damage.</p>Formula:C24H35ClN6O9Color and Shape:SolidMolecular weight:587.02p-nitro-Pifithrin-α
CAS:<p>p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor.</p>Formula:C15H16BrN3O3SColor and Shape:SolidMolecular weight:398.27SDZ 224-015
CAS:<p>SDZ 224-015 is an inhibitor of interleukin-1β (IL-1β) converting enzyme and caspase-1 with anti-COVID-19 and anti-inflammatory activity.</p>Formula:C30H35Cl2N3O9Purity:95.49% - 95.49%Color and Shape:SolidMolecular weight:652.52VRT-043198
CAS:<p>VRT-043198, a VX-765 metabolite, is a potent ICE/caspase-1 inhibitor, crossing the blood-brain barrier with K i of 0.8/0.6 nM.</p>Formula:C22H29ClN4O6Color and Shape:SolidMolecular weight:480.94QM31
CAS:<p>QM31 is a selective Apaf-1 inhibitor(inbitita formation of the apoptosome with IC50 of 7.9μM).</p>Formula:C39H38Cl4N4O4Purity:98%Color and Shape:SolidMolecular weight:768.56N1,N11-Diethylnorspermine
CAS:<p>DENSPM: potent anticancer, spurs polyamine breakdown, triggers cytochrome c release and caspase 3, kills GBM via SSAT & H2O2.</p>Formula:C13H32N4Color and Shape:SolidMolecular weight:244.42GRI977143
CAS:<p>GRI977143: selective LPA2 agonist (EC50=3.3μM), blocks caspases 3/7/8/9, limits DNA fragmentation.</p>Formula:C22H17NO4SPurity:98.07%Color and Shape:SolidMolecular weight:391.44OT-82
CAS:<p>OT-82 is a NAMPT inhibitor with anticancer activity and cytotoxicity and is used in the study of leukemias.</p>Formula:C26H21FN4OPurity:98.91% - 99.315%Color and Shape:SolidMolecular weight:424.47ML132
CAS:<p>ML132 is an effective and selective inhibitor of caspase 1 (IC50: 0.316 nM).</p>Formula:C22H28ClN5O5Color and Shape:SolidMolecular weight:477.94CZL55
CAS:<p>CZL55 is a potent caspase-1 inhibitor with an IC50 value of 0.024 μM.CZL55 has low cytotoxicity and can be used in the study of febrile seizures (FS).</p>Formula:C20H22N2O6Purity:98.19%Color and Shape:SolidMolecular weight:386.4NLRP3 agonist 1
CAS:<p>Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.</p>Formula:C15H16N6Purity:99.01%Color and Shape:SolidMolecular weight:280.33M190S
CAS:<p>M109S is a novel small molecule that shields cells from mitochondria-dependent apoptosis, demonstrating effectiveness both in vitro and in vivo.</p>Formula:C21H21N5O2Purity:98%Color and Shape:SolidMolecular weight:375.42Ac-YVAD-pNA
CAS:<p>Ac-YVAD-pNA, a specific substrate for Caspase-1, serves to detect Caspase-1 activity, a crucial mediator of inflammatory processes [1] [2].</p>Formula:C29H36N6O10Color and Shape:SolidMolecular weight:628.639GDC-2394
CAS:<p>GDC-2394: Oral, selective NLRP3 inhibitor; blocks IL-1β (human 0.4μM, mouse 0.1μM), spares NLRC4.</p>Formula:C20H25N5O4SColor and Shape:SolidMolecular weight:431.51CIL62
CAS:<p>CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].</p>Formula:C23H26O5Purity:97.07%Color and Shape:SolidMolecular weight:382.45EP1013
CAS:<p>EP1013 is a broad-spectrum selective inhibitor of Caspase used in the study of type 1 diabetes.</p>Formula:C18H23FN2O6Purity:98%Color and Shape:SolidMolecular weight:382.38M867
CAS:<p>M867 is a selective, reversible caspase-3 inhibitor, possessing an IC50 of 1.4 nM and a Ki value of 0.7 nM, demonstrating anti-apoptotic activity [1].</p>Formula:C27H43N7O6Purity:98%Color and Shape:SolidMolecular weight:561.67Ac-VAD-CHO
CAS:<p>Ac-Val-Ala-Asp-CHO (Ac-VAD-CHO) serves as a pan-caspase inhibitor and preserves mitochondrial membrane potential (MMP) while preventing the release of</p>Formula:C14H23N3O6Purity:98%Color and Shape:SolidMolecular weight:329.35Z-YVAD-CMK
CAS:<p>Z-YVAD-CMK is an inhibitor of both caspase-1 and caspase-3, as referenced in [1].</p>Formula:C30H37ClN4O9Purity:98%Color and Shape:SolidMolecular weight:633.09ZIF-8
CAS:<p>ZIF-8 is an anticancer agent that can inherently trigger pyroptosis through a caspase-1/gasdermin D (GSDMD)-dependent pathway.</p>Formula:C4H6N2ZnColor and Shape:SolidMolecular weight:147.513Caspase-3-IN-2
CAS:<p>Caspase-3-IN-2 (Compound 4d) acts as an inhibitor of α-Chymotrypsin. It also exhibits inhibitory activity against HIV protease and caspase 3, with inhibition rates of 57% and 51% respectively at a concentration of 100 μM.</p>Formula:C10H6ClNO5Color and Shape:SolidMolecular weight:255.611N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride
CAS:<p>N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride (TLCK hydrochloride) is an irreversible serine protease inhibitor that functions by alkylating the histidine residue at the active site, thus inhibiting trypsin and trypsin-like proteases. It effectively inhibits caspase-3, caspase-6, and caspase-7 with IC50 values of 12.0, 54.5, and 19.3 μM, respectively. Additionally, N-a-Tosyl-L-lysinyl-chloromethylketone hydrochloride induces apoptosis in HL-60 cells and prevents the reduction of mitochondrial transmembrane potential during the apoptosis process.</p>Formula:C14H22Cl2N2O3SMolecular weight:369.31M826
<p>M826, a non-peptide, potent, selective, and reversible caspase-3 inhibitor, exhibits an IC50 of 0.005 μM and demonstrates strong anti-apoptotic activity in</p>Formula:C28H45N7O6Purity:98%Color and Shape:SolidMolecular weight:575.7Ac-DMLD-CMK
CAS:<p>Ac-DMLD-CMK is a peptide designed to target the caspase3-Gsdme signaling pathway in mice. It specifically inhibits the activation of caspase 3 and Gsdme, preventing the cleavage of Gsdme by caspase 3, which reduces pyroptosis. This process helps alleviate damage to renal tubular epithelial cells and decrease the secretion of inflammatory cytokines. Ac-DMLD-CMK can lower serum creatinine and blood urea nitrogen levels in mice induced by Cisplatin, thereby mitigating the progression of renal dysfunction. It holds potential for research into chemotherapy-induced nephrotoxicity.</p>Formula:C22H35ClN4O9SColor and Shape:SolidMolecular weight:567.053(2R,3S)-Emricasan
CAS:<p>(2R,3S)-Emricasan ((2R,3S)-PF 03491390) is an isomer of Emricasan. This compound acts as an orally effective irreversible pan-caspase inhibitor. (2R,3S)-Emricasan inhibits the increase in caspase-3 activity induced by Zika virus (ZIKV) and protects human cortical neural progenitor cells.</p>Formula:C26H27F4N3O7Color and Shape:SolidMolecular weight:569.5Z-VA-DL-D-FMK
CAS:<p>Z-VA-DL-D-FMK (Z-VA-DL-D(OH)-FMK) acts as an inhibitor of caspases. It irreversibly binds to caspases, enhancing the sensitivity to TNF-α and stimulating HIV replication in infected T cells ACH-2.</p>Formula:C21H28FN3O7Color and Shape:SolidMolecular weight:453.46
