Immunology and Inflammation

Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CD248. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CD248. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human CD248, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human CD248 in the samples is then determined by comparing the OD of the samples to the standard curve.

Azobenzene, an aryl azo compound with a N=N bond between two phenyl rings, represents a broad molecule class.

IL-15-IN-1 is a selective and potent Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells (IC50: 0.8 μM).

Ac2-26 ammonium is an N-terminal derivative peptide of Annexin-A1 (AnxA1) with anti-inflammatory activity.

TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.

Methylthiouracil (NSC-193526) is a thiourea antithyroid agent that inhibits the synthesis of thyroid hormone, and it is used to treat hyperthyroidism.

Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE.

APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM

BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members.

iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) is a potent nitric oxide synthase (NOS) inhibitor that inhibits the NADPH oxidase activity of nNOS.

Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings.

BAY-985: potent oral TBK1/IKKε inhibitor; IC50s: TBK1 (2/30 nM), IKKε (2 nM); has antitumor properties.

Naphazoline hydrochloride (Naphazoline HCl) is an adrenergic vasoconstrictor agent used as a decongestant.

α-Lipoic Acid, a sulfur-containing octanoic acid derivative, is biosynthesized from linoleic acid and used in dietary supplements.

Atazanavir sulfate, an azapeptide HIV-protease inhibitor, treats HIV/AIDS alongside other anti-HIV drugs.

Valdecoxib (SC 65872), an NSAID, treats osteoarthritis, rheumatoid arthritis, and menstrual pain. Not for NSAID allergies.

Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.

Anifrolumab（MEDI-546） is a potent type I interferon (IFN) receptor antagonist, a human monoclonal antibody that targets IFN.Anifrolumab inhibits the activity of

Guaiacol, a flavorant precursor, has medicinal uses and serves as an oxygen indicator turning yellow-brown at 470 nm.

S-Nitroso-N-acetyl-DL-penicillamine (SNAP) acts as a stable inhibitor of platelet aggregation, is a nitric oxide donor and .

Theralizumab (TGN1412) is a monoclonal antibody for treating leukemia and arthritis by stimulating T cells.

Tildrakizumab (SCH 900222) is a humanized antibody against IL-23, with a 136 pM Kd, used for psoriasis research.

Talacotuzumab, an IgG1 monoclonal antibody, blocks IL-3/CD123 and boosts ADCC, targeting AML with high CD123 affinity.

Xanthone (Xanthenone) is currently used as ovicide for codling moth eggs and as a larvicide.

Spesolimab (BI 655130) is an antibody targeting IL-36 receptor, key in immunity, for systemic pustular psoriasis and dermatitis studies.

Tremelimumab, a CTLA-4 blocker, is used with Durvalumab to treat solid tumors like liver and lung cancer.

Telazorlimab (GBR-830) is a humanized monoclonal antibody that targets the OX40 co-stimulatory receptor on activated T cells.

Tesidolumab, a fully human IgG1/λ anti-C5 monoclonal antibody, inhibits crovalimab and C5, preventing membrane attack complex formation.

Liranaftate (Piritetrate) is a thiocarbamate and squalene epoxidase inhibitor with antifungal activity.

Ravulizumab (ALXN1210) is a humanized antibody for blocking complement activation, treating PNH, aHUS, and myasthenia gravis.

Ordesekimab (AMG 714) is a human anti-IL-15 IgG1 κ monoclonal antibody for studying NRCD.

Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.

Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central

Sifalimumab (MEDI-545), a monoclonal antibody, inhibits IFNα to treat moderate-severe SLE.

Lidocaine, an amide local anesthetic, reduces pain and inflammation by dampening ICAM-1, cytokines, and neutrophil influx.

Diclofenac Amide is used as a intermediates of Diclofenac.

Fezakinumab: a monoclonal antibody targeting IL-22; used in researching psoriasis, arthritis, dermatitis.

Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.

DPPH (2,2-Diphenyl-1-picrylhydrazyl) is a stable radical that can be used to measure the free radical scavenging activity. Cost effective and quality assured.

Salsalate (Sasapyrine) is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic

Sodium laureth sulfate is an anionic surfactant known for strong cleaning, wetting, emulsifying, dispersing, and foaming abilities.

Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.

"BPK-29 hydrochloride targets NR0B1, altering C274 and hinders KEAP1-mutant cancer cell growth."

GNF351: Full AHR antagonist, inhibits DRE-dependent/independent activity, low toxicity, binds AHR (IC50: 62 nM).

CU-CPT22: first TLR1/2 complex probe, binds at TLR1/2 interface (IC50=0.58μM), inhibits Pam3CSK4 binding (Ki=0.41μM).

IMD-0560 is a novel inhibitor of IκB kinase β.

4-Aminosalicylic acid (para-aminosalicylic acid) is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.

Indomethacin (Indomethacin) is a inhibitor of COX1 and COX2. Indomethacin is a non-steroidal anti-inflammatory agent. Cost-effective and quality-assured.

Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.

LR-90, an AGE inhibitor, aids in diabetic research by limiting inflammation in human monocytes.

SN50 acetate is a cell permeable inhibitor of NF-κB translocation.

Carboxyebselen (HOOC-Ebs) is an endothelial nitric oxide synthase (eNOS) inhibitor that is potent and selective.

Brodalumab (AMG 827), a human IgG2 monoclonal antibody, inhibits IL-17R, treating psoriasis.

Risankizumab (BI 655066) is a monoclonal antibody for psoriasis, targeting IL-23, with high affinity (Kd <10 pM) and an IC50 of 2 pM.

AB-680 is a highly potent, reversible, and selective inhibitor of CD73 (an ectonucleotidase, Ki: 4.9 pM for hCD73) with anti-tumor activity, displays >10,000-

Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.

4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice.

Enoblituzumab is a humanized IgG1 κmab monoclonal antibody that recognizes human B7-H3 protein and can be used to study solid tumors such as non-small cell lung

Antipyrine, an analgesic/antipyretic, used orally or as ear drops, tests liver enzyme response to diseases/drugs.

DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.

Amatuximab is a chimeric humanized IgG1/k antibody targeting MSLN with antitumor effects for solid tumors.

Ketorolac tromethamine salt (Ketorolac tris salt) non-selective inhibits the enzymes cyclooxygenase 1 (COX-1) and COX-2with anti-inflammatory, analgesic, and