Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1424 products of "Autophagy"
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Nicardipine hydrochloride
CAS:<p>Nicardipine hydrochloride is a potent calcium channel blocker used to dilate cerebral and coronary vessels.</p>Formula:C26H30ClN3O6Purity:99.58% - 99.89%Color and Shape:Yellow SolidMolecular weight:515.99Lapatinib Ditosylate
CAS:<p>Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).</p>Formula:C29H26ClFN4O4S·2C7H8O3SPurity:99.41%Color and Shape:Yellow SolidMolecular weight:925.46AKOS037652256
CAS:<p>AKOS037652256 modulates TRPML, treating TRPML-linked diseases like lysosomal disorders, muscular dystrophy, neurodegeneration, and oxidative stress.</p>Formula:C24H26ClFN4O4S2Purity:98.81%Color and Shape:SolidMolecular weight:553.07Fendiline hydrochloride
CAS:<p>Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel.</p>Formula:C23H26ClNPurity:98.76% - 99.75%Color and Shape:SolidMolecular weight:351.91NBDHEX
CAS:<p>NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1).</p>Formula:C12H15N3O4SPurity:97.38%Color and Shape:SolidMolecular weight:297.33Fluvastatin sodium
CAS:<p>Fluvastatin sodium (Fluvastatin sodium salt), a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), is a commonly used cholesterol</p>Formula:C24H25FNNaO4Purity:98.54% - 99.56%Color and Shape:Light Yellow Solid PowderMolecular weight:433.45Silmitasertib sodium salt
CAS:<p>Silmitasertib sodium salt (CX-4945 sodium salt) is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).</p>Formula:C19H11ClN3NaO2Purity:99.49% - 99.62%Color and Shape:SolidMolecular weight:371.75Reserpine
CAS:<p>Reserpine, an alkaloid from Rauwolfia roots, depletes neurotransmitters, used in treating hypertension and psychosis, but side effects restrict use.</p>Formula:C33H40N2O9Purity:98.85% - 99.81%Color and Shape:White Or Pale Buff To Slightly Yellowish Powder With A Bitter Taste (Ntp 1992)Molecular weight:608.68BIX 02565
CAS:<p>BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).</p>Formula:C26H30N6O2Purity:97.44% - 99.7%Color and Shape:SolidMolecular weight:458.56Carboplatin
CAS:<p>Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor.</p>Formula:C6H12N2O4PtPurity:98% - 99.72%Color and Shape:White Crystalline PowderMolecular weight:371.25Irinotecan Hydrochloride
CAS:<p>Irinotecan HCl, a camptothecin derivative prodrug, becomes active metabolite SN-38, inhibiting topoisomerase I to trigger apoptosis.</p>Formula:C33H39ClN4O6Purity:98% - 99.94%Color and Shape:Yellow Crystalline PowderMolecular weight:623.14Loperamide hydrochloride
CAS:<p>Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.</p>Formula:C29H34Cl2N2O2Purity:99.91% - >99.99%Color and Shape:Crystals Practically Insoluble In WaterMolecular weight:513.50Dihydroartemisinin
CAS:<p>Dihydroartemisinin (Artenimol) is an antimalarial drug. High-Quality, Low-Cost!</p>Formula:C15H24O5Purity:98% - 99.41%Color and Shape:White SolidMolecular weight:284.35Simvastatin
CAS:<p>Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity.</p>Formula:C25H38O5Purity:98.54% - 99.13%Color and Shape:SolidMolecular weight:418.57Hesperetin
CAS:<p>Hesperetin belongs to the flavanone class of flavonoids.</p>Formula:C16H14O6Purity:98.45% - 99.27%Color and Shape:SolidMolecular weight:302.28Iohexol
CAS:<p>Iohexol, a contrast agent, has an osmolality of 322-844 mOsm/kg, 1.1-3 times blood plasma's.</p>Formula:C19H26I3N3O9Purity:99.61% - 99.89%Color and Shape:White To Off-White Solid PowderMolecular weight:821.14Matrine
CAS:<p>Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.</p>Formula:C15H24N2OPurity:97.16% - >99.99%Color and Shape:SolidMolecular weight:248.36Paclitaxel
CAS:<p>Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer.</p>Formula:C47H51NO14Purity:98% - 99.92%Color and Shape:White PowderMolecular weight:853.91Procainamide hydrochloride
CAS:<p>Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog</p>Formula:C13H21N3O·HClPurity:99.83% - 99.97%Color and Shape:White To Slightly Yellow PowderMolecular weight:271.79Gimeracil
CAS:<p>Gimeracil (Gimestat) is a competitive, reversible inhibitor of dihydropyrimidine dehydrogenase.</p>Formula:C5H4ClNO2Purity:99.80%Color and Shape:SolidMolecular weight:145.54Sulfamerazine
CAS:<p>Sulfamerazine (RP2632), a long-acting antibacterial, blocks dihydrofolic acid synthesis by competing with PABA.</p>Formula:C11H12N4O2SPurity:99.78%Color and Shape:White Or Yellowish Crystalline PowderMolecular weight:264.30Pravastatin sodium
CAS:<p>Pravastatin sodium (CS-514 (sodium)), an HMG-CoA reductase inhibitor, inhibits sterol synthesis with IC50 of 5.6 μM.</p>Formula:C23H35NaO7Purity:97.14%Color and Shape:White Crystalline PowderMolecular weight:446.52Raloxifene hydrochloride
CAS:<p>Raloxifene HCl treats postmenopausal osteoporosis, acts as estrogen on bone/cholesterol, and blocks it in breast/uterus.</p>Formula:C28H28ClNO4SPurity:98% - 99.97%Color and Shape:Light Yellow SolidMolecular weight:510.044Sulfisoxazole
CAS:<p>Sulfisoxazole: a short-acting antibacterial targeting gram-positive/negative bacteria and inhibits breast cancer exosome by affecting endothelin receptor A.</p>Formula:C11H13N3O3SPurity:99.87% - 99.98%Color and Shape:White To Cream PowderMolecular weight:267.30Penfluridol
CAS:<p>Penfluridol (TLP-607) is a highly potent antipsychotic.</p>Formula:C28H27ClF5NOPurity:98.9% - 99.87%Color and Shape:Off-White To White Crystalline PowderMolecular weight:523.97Megestrol acetate
CAS:<p>Megestrol acetate (BDH1298) is an oral progestogen with anti-androgenic properties, used for endometrial and breast cancer, anorexia, and cachexia.</p>Formula:C24H32O4Purity:99.46% - 99.78%Color and Shape:Crystalline SolidMolecular weight:384.51Naringin
CAS:<p>Naringin: flavanone glycoside with blood lipid-reducing, antioxidant, anticancer properties, inhibits cytochrome P450.</p>Formula:C27H32O14Purity:99.23%Color and Shape:Beige Creamish Powder Solid Solid Particulate/PowderMolecular weight:580.53Triclosan
CAS:<p>Triclosan (Irgasan) is an antibacterial and antifungal agent.</p>Formula:C12H7Cl3O2Purity:99.63%Color and Shape:White Solid CrystallineMolecular weight:289.54Metformin hydrochloride
CAS:<p>Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) is an AMPK activator. Metformin is used in type 2 diabetes research. Cost-effective and quality-assured.</p>Formula:C4H12ClN5Purity:97.53% - 99.97%Color and Shape:White Or Almost White Crystals Solid CrystallineMolecular weight:165.63Deferoxamine Mesylate
CAS:<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>Formula:C26H52N6O11SPurity:94.68% - 99.8%Color and Shape:SolidMolecular weight:656.79Norepinephrine bitartrate monohydrate
CAS:<p>Norepinephrine bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.</p>Formula:C8H11NO3·C4H6O6·H2OPurity:97.88% - ≥95%Color and Shape:SolidMolecular weight:337.28Nimodipine
CAS:<p>Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.</p>Formula:C21H26N2O7Purity:99.64% - 99.79%Color and Shape:SolidMolecular weight:418.44Lamotrigine
CAS:<p>Lamotrigine (BW430C) is an Anti-epileptic Agent and Mood Stabilizer.</p>Formula:C9H7Cl2N5Purity:99.76% - 99.95%Color and Shape:White To Pale Cream-Colored Powder Crystals From Isopropanol SolidMolecular weight:256.09Clotrimazole
CAS:<p>Clotrimazole (FB 5097), an imidazole derivative with a broad spectrum of antimycotic activity, inhibits biosynthesis of the sterol ergostol.</p>Formula:C22H17ClN2Purity:99.89%Color and Shape:Crystals SolidMolecular weight:344.84Erlotinib
CAS:<p>Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.</p>Formula:C22H23N3O4Purity:98.19% - 99.98%Color and Shape:White To Off-White PowderMolecular weight:393.44Albendazole
CAS:<p>Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.</p>Formula:C12H15N3O2SPurity:98.21% - 98.76%Color and Shape:Colorless Crystals SolidMolecular weight:265.33Rhein
CAS:<p>Rhein (NSC 38629) is an anthraquinone compound extracted from Polygonaceae Rheum Officinale with anti-inflammation and antitumor activities.</p>Formula:C15H8O6Purity:99.04%Color and Shape:Physical Description Yellow Needles (From Methanol) Or Yellow-Brown Powder (Ntp 1992)Molecular weight:284.226-Mercaptopurine
CAS:<p>6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties.</p>Formula:C5H4N4SPurity:99.53% - 99.63%Color and Shape:Yellow Crystalline Powder SolidMolecular weight:152.18Pregnenolone
CAS:<p>Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.</p>Formula:C21H32O2Purity:99.5% - >99.99%Color and Shape:SolidMolecular weight:316.48Sodium salicylate
CAS:<p>Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.</p>Formula:C7H5NaO3Purity:99.36% - 99.92%Color and Shape:White Solid AmorphousMolecular weight:160.11Naproxen
CAS:<p>Naproxen ((S)-Naproxen) is a propionic acid derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic</p>Formula:C14H14O3Purity:99.6% - 99.89%Color and Shape:Crystals From Acetone-Hexane SolidMolecular weight:230.26Irinotecan hydrochloride trihydrate
CAS:<p>Irinotecan hydrochloride trihydrate (CPT-11 HCl Trihydrate) keeps DNA from unwinding by inhibiting topoisomerase 1.</p>Formula:C33H45ClN4O9Purity:98.22% - >99.99%Color and Shape:Pale Yellow To Yellow Crystalline PowderMolecular weight:677.18Pemetrexed
CAS:<p>Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).</p>Formula:C20H21N5O6Purity:98.1% - 99.92%Color and Shape:Similar To White PowderMolecular weight:427.41Sophocarpine monohydrate
CAS:<p>Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.</p>Formula:C15H22N2OPurity:99.55%Color and Shape:SolidMolecular weight:246.35Motixafortide TFA(664334-36-5,Free)
<p>Motixafortide TFA is a CXCR4 antagonist with ~1 nM IC50, promoting AML apoptosis by modulating miR-15a/16-1 and downregulating ERK and BCL-2.</p>Formula:C99H145F4N33O21S2Purity:>99.99%Color and Shape:SolidMolecular weight:2273.54GCN2iB
CAS:<p>GCN2iB is an ATP-competitive inhibitor of serine/threonine protein kinase, stress-responsive kinase (GCN2).Cost-effective and quality-assured.</p>Formula:C18H12ClF2N5O3SPurity:99.08%Color and Shape:SolidMolecular weight:451.83Rutin
CAS:<p>Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and</p>Formula:C27H30O16Purity:95.66% - 97.19%Color and Shape:SolidMolecular weight:610.52CXCR7 antagonist-1
CAS:<p>CXCR7 antagonist-1 is a specific antagonist of the binding of the SDF-1 chemokine or I-TAC to the chemokine receptor CXCR7.</p>Formula:C21H19FN6OPurity:99.93%Color and Shape:SolidMolecular weight:390.41Bosutinib
CAS:<p>Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.</p>Formula:C26H29Cl2N5O3Purity:98.98% - 99.9%Color and Shape:Yellowish-Orange Or Pink To Brownish Solid Solid PowderMolecular weight:530.45Triflupromazine hydrochloride
CAS:<p>Triflupromazine hydrochloride (Fluopromazine hydrochloride), an antipsychotic medication, is Dopamine D1/D2 receptor antagonists.</p>Formula:C18H20ClF3N2SPurity:99.76% - 99.82%Color and Shape:CrystalsMolecular weight:388.88Monacolin J
CAS:<p>Monacolin J (Antibiotic MB 530A) is a cholesterol biosynthesis inhibitor.</p>Formula:C19H28O4Purity:98.06%Color and Shape:SolidMolecular weight:320.42LY2510924 acetate(1088715-84-7 free base)
<p>Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.</p>Formula:C64H91N13O13Purity:97.32%Color and Shape:SolidMolecular weight:1250.49AMG 487
CAS:<p>AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.</p>Formula:C32H28F3N5O4Purity:99.82% - 99.89%Color and Shape:SolidMolecular weight:603.59VUF11207 fumarate
CAS:<p>VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).</p>Formula:C31H39FN2O8Purity:97.98%Color and Shape:SolidMolecular weight:586.65Dexamethasone
CAS:<p>Dexamethasone: a glucocorticoid agonist; modulates IL receptors; reduces inflammatory miRNA-155 exosomes in macrophage responses.</p>Formula:C22H29FO5Purity:98% - 99.91%Color and Shape:Crystals From Ether (Ntp 1992)Molecular weight:392.46Salicylic acid
CAS:<p>Salicylic acid (2-Hydroxybenzoic acid), a natural compound extracted from Willow bark, is an anti-inflammatory inhibitor of activity cyclooxygenase.</p>Formula:C7H6O3Purity:98.04% - 98.83%Color and Shape:White Solid PowderMolecular weight:138.12VUF-11222
CAS:<p>VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).</p>Formula:C25H31BrINPurity:99.82%Color and Shape:SolidMolecular weight:552.33ITIC
CAS:<p>"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."</p>Formula:C94H82N4O2S4Purity:98%Color and Shape:SolidMolecular weight:1427.96vMIP-II (1-21) TFA
<p>vMIP-II (1-21) (NT21MP) TFA (TFA is a potent inhibitor of CXCR4. This compound interacts broadly with CC and CXC chemokine receptors. Furthermore, vMIP-II (1-21) TFA inhibits CXCR4 by competing for binding sites with 125I-SDF-1R, exhibiting an IC50 value of 190 nM.</p>Color and Shape:Odour SolidBalixafortide
CAS:<p>Balixafortide (POL6326), a potent CXCR4 blocker with IC50 < 10 nM, mobilizes HSPCs and is anti-cancer, 1000x more selective than CXCR7.</p>Formula:C84H118N24O21S2Purity:98%Color and Shape:SolidMolecular weight:1864.14ITIC-4F
CAS:<p>ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.</p>Formula:C94H78F4N4O2S4Purity:98%Color and Shape:SolidMolecular weight:1499.92Autophagy Compound Library
<p>A unique collection of 1248 compounds with defined autophagy-inducing or -inhibitory activity for research in autophagy, high throughput screening (HTS) and</p>Color and Shape:Odour SolidCalmodulin-Dependent Protein Kinase II (290-309)
CAS:<p>Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II</p>Formula:C103H185N31O24SPurity:98%Color and Shape:SolidMolecular weight:2273.83Balixafortide TFA (1051366-32-5 free base)
<p>Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.</p>Formula:C82H113N22F3O23S2Purity:98%Color and Shape:SolidMolecular weight:1896.054-Amino-D-phenylalanine
CAS:<p>4-Amino-D-phenylalanine ([D-Phe(4-NH2)]) is a cyclic pentapeptide that inhibits the binding of CXCL12 to CXCR4 in FC131, with an IC50 value of 0.1 μM.</p>Formula:C9H12N2O2Color and Shape:SolidMolecular weight:180.2EB-42486
CAS:<p>EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.</p>Formula:C22H22N8OPurity:99.53%Color and Shape:SolidMolecular weight:414.46Tat-beclin 1 acetate
<p>Tat-beclin 1 acetate is a potent inducer of autophagy and interacts with the negative regulator of autophagy, GAPR-1.</p>Purity:99.44%Color and Shape:SoildAutophagy-IN-6
<p>Autophagy-IN-6 (compound 1u) is an inhibitor of lysosomal autophagy that induces the accumulation of the LC3-II protein. Additionally, it exhibits antiproliferative activity.</p>Formula:C28H43N3O3Color and Shape:SolidMolecular weight:469.66TC14012 TFA
<p>TC14012 TFA is a peptide-mimetic CXCR4 antagonist and CXCR7 agonist that promotes the recruitment of β-arrestin by CXCR7 .</p>Formula:C92H141F3N34O21S2Purity:96.31%Color and Shape:SolidMolecular weight:2180.44Schisandrin A
CAS:<p>Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM</p>Formula:C24H32O6Purity:99.21% - 99.901%Color and Shape:SolidMolecular weight:416.51ALA-A2 peptide
<p>ALA-A2, a cancer peptide found in α-lactalbumin, selectively kills cancer cells by inducing autophagy (Autophagy). It possesses cell-penetrating properties, allowing it to enter cells effectively without relying on membrane solubilization effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. This peptide shows promise for research in cancer treatment and autophagy regulation.</p>Formula:C67H111N21O19SColor and Shape:SolidMolecular weight:1546.79Sulfadiazine
CAS:<p>Sulfadiazine, a short-acting sulfonamide, blocks bacterial folic acid synthesis; used with pyrimethamine to treat toxoplasmosis in AIDS, newborns.</p>Formula:C10H10N4O2SPurity:99.32%Color and Shape:White To Slightly Yellow Crystalline PowderMolecular weight:250.28AChE-IN-80
<p>AChE-IN-80 (Compound 1) is an inhibitor of acetylcholinesterase (AChE). It suppresses inflammation and reactive oxygen species (ROS) production in cultured neurons and microglia, induces autophagy, and prevents the spread of beta-amyloid (Aβ) fibrils. AChE-IN-80 exhibits antioxidant activity and neuroprotective effects, making it valuable for Alzheimer's disease research.</p>Formula:C11H14N2O2SColor and Shape:SolidMolecular weight:238.306Chromomycin A2
CAS:<p>Chromomycin A2, from marine actinomycetes, halts B. subtilis and various cancer cells; promotes autophagy in melanoma.</p>Formula:C59H86O26Color and Shape:SolidMolecular weight:1211.3DOTA-CXCR4-L
<p>DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancer</p>Formula:C58H78N16O14Purity:98%Color and Shape:SolidMolecular weight:1223.34PBA-1105 TFA
<p>PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. This compound selectively binds to the exposed hydrophobic regions of misfolded proteins, promoting their degradation through the autophagy (autophagy) pathway. Additionally, PBA-1105 TFA enhances the autophagic flux of Ub-bound aggregates.</p>Formula:C41H49F3N2O8Color and Shape:SolidMolecular weight:754.832Fasudil
CAS:<p>Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.</p>Formula:C14H17N3O2SPurity:99.79% - 99.84%Color and Shape:SolidMolecular weight:291.37MRT67307
CAS:<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Formula:C26H36N6O2Purity:99.25% - 99.84%Color and Shape:SolidMolecular weight:464.6ML-SA5
CAS:<p>ML-SA5 is a MCOLN1 agonist that blocks autophagic flux by disrupting fusion between autophagosomes and lysosomes.Cost-effective and quality-assured.</p>Formula:C19H24ClN3O4S2Purity:99.16% - >99.99%Color and Shape:SoildMolecular weight:457.99Elaiophylin
CAS:<p>Elaiophylin exhibits anti-Plasmodium falciparum and anti-Trypanosoma brucei activity; IC50: 0.36 μM & 0.45 μM, respectively.</p>Formula:C54H88O18Purity:98%Color and Shape:SolidMolecular weight:1025.27Rimantadine
CAS:<p>Rimantadine (1-Rimantadine) (Flumadine) is an anti-influenza virus drug for T. brucei with IC50 of 7 μM.</p>Formula:C12H21NPurity:98%Color and Shape:SolidMolecular weight:179.3Ezurpimtrostat
CAS:<p>Ezurpimtrostat targets fibrosis, cancer, autophagy, CTSB, CTSL, CTSD. (From patent WO2020048694 A1)</p>Formula:C25H31ClN4Color and Shape:SolidMolecular weight:423.0Cyclic MKEY
CAS:<p>MKEY peptide inhibits CXCL4-CCL5, reduces atherosclerosis and aneurysm, neuroinflammatory effects unknown.</p>Formula:C113H174N28O34S2Purity:98%Color and Shape:SolidMolecular weight:2532.89SJFα
CAS:<p>SJFα (SJF alpha) degrades p38α and p38δ and can be used in cancer research.</p>Formula:C59H67F2N7O11SPurity:95.25%Color and Shape:SolidMolecular weight:1120.27TH152
CAS:<p>TH152 is a general reversible ligand for LC3/GABARAP with a dissociation constant (KD) of 2 µM. LC3/GABARAP is a protein associated with autophagy.</p>Formula:C22H23ClN4O4S2Color and Shape:SolidMolecular weight:507.03Diquat dibromide
CAS:<p>Diquat dibromide is a water-soluble herbicide that causes rapid and profound systemic toxicity.Diquat dibromide induces acute kidney injury with high lethality.</p>Formula:C12H12Br2N2Purity:97.11% - 99%Color and Shape:SolidMolecular weight:344.05CXCR7 modulator 1
CAS:<p>CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.</p>Formula:C48H57F2N7O7SPurity:98%Color and Shape:SolidMolecular weight:914.07PTX80
CAS:<p>PTX80 is an antagonist of p62, with an IC50 value of 31.18 nM. It has been shown to reduce tumor volume in a HCT116 colorectal cancer mouse xenograft model.</p>Formula:C26H26N4O3SColor and Shape:SolidMolecular weight:474.58CXCL-CXCR1/2-IN-1
CAS:<p>CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.</p>Formula:C14H8Cl2N4O3SPurity:99.4%Color and Shape:SoildMolecular weight:383.21ATG16L1 stabilizer-1
<p>ATG16L1 stabilizer-1 (compound A3B) is an FKBP12-independent stabilizer of ATG16L1 that enhances cellular autophagy (Autophagy). Regardless of the presence of FKBP12, it has an inhibitory EC50 value of 12.1 μM for ATG16L1. When used alone, ATG16L1 stabilizer-1 can induce GFP-LC3 puncta formation, with an EC50 value of 12.0 μM.</p>Formula:C45H62N14O5SColor and Shape:SolidMolecular weight:911.13OsMo
<p>OsMo is a lysosomal-targeting hNEU1 inhibitor utilized in the study of myocardial injury.</p>Color and Shape:Odour SolidBOLD-100 free base
CAS:<p>BOLD-100 (NKP-1339/IT-139) is a ruthenium anticancer agent that inhibits GRP78 and disrupts ER homeostasis, affecting lysosome function and autophagy.</p>Formula:C14H12Cl4N4RuColor and Shape:SolidMolecular weight:479.15NI-0801
<p>NI-0801 (Anti-CXCL10 / IP-1) is a CHO-expressed humanized monoclonal antibody targeting CXCL10/IP-10 for the study of vitiligo and biliary cirrhosis.</p>Purity:97.9% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.4% (SEC-HPLC)Color and Shape:Odour LiquidMito-fisetin mF3
<p>Mito-fisetin mF3 (compund mito-fisetin mF3) is a potent anticancer and anti-aging therapeutic agent that targets mitochondria.</p>Formula:C52H42IO7PColor and Shape:SolidMolecular weight:936.76XL01126
<p>XL01126 degrades LRRK2 (DC50: 14 nM G2019S, 32 nM WT), crosses the blood-brain barrier, aiding Parkinson's studies.</p>Formula:C50H64ClFN10O6S2Color and Shape:SolidMolecular weight:1019.69Salinomycin sodium salt
CAS:<p>Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.</p>Formula:C42H69NaO11Purity:98.76% - 99.11%Color and Shape:White Or Light Yellow Crystalline Powder With Special SmelMolecular weight:772.98BVT173187
CAS:<p>BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.</p>Formula:C14H10Cl3NO2Color and Shape:SolidMolecular weight:330.59SJFδ
CAS:<p>SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].</p>Formula:C62H63F2N7O12SPurity:98%Color and Shape:SolidMolecular weight:1168.27Retinoic acid-d5
CAS:<p>Retinoic acid-d5: deuterium-labeled, natural RAR agonist (IC50: 14 nM), affects cell growth and development, inhibits Nrf2.</p>Formula:C20H28O2Purity:98%Color and Shape:SoildMolecular weight:305.47CZC-54252 hydrochloride
CAS:<p>CZC-54252 hydrochloride: selective LRRK2 inhibitor; IC50 = 1.85/1.28 nM (wild-type/G2019S); neuroprotective; EC50 = 1 nM for G2019S injury.</p>Formula:C22H26Cl2N6O4SPurity:98.21%Color and Shape:SolidMolecular weight:541.45SG31
<p>SG31 is a potent activator of autophagy, exerting its effects through the AMPK/ULK1-dependent pathway.</p>Formula:C26H37N6O8PColor and Shape:SolidMolecular weight:592.58Pantoprazole Sodium Hydrate
CAS:<p>Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus</p>Formula:C16H14F2N3NaO4SH2OPurity:98.32%Color and Shape:SolidMolecular weight:432.37CXM102
<p>CXM102 is an activator of autophagy. This compound induces autophagy in aged BMSCs, rejuvenating them and promoting their preferential differentiation into osteoblasts. CXM102 enhances the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. In middle-aged male mice, it stimulates bone anabolic metabolism, reduces marrow adipocytes, delays bone loss, lowers serum inflammation levels, reduces organ fibrosis, and extends lifespan.</p>Formula:C28H27NO3Color and Shape:SolidMolecular weight:425.52MLCK inhibitor peptide 18
CAS:<p>Myosin light chain kinase inhibitor; IC50=50 nM; 4000x more selective over CaM kinase II; no PKA inhibition; cell-permeable.</p>Formula:C60H105N23O11Purity:98%Color and Shape:SolidMolecular weight:1324.64Autophagy/REV-ERB-IN-1 hydrochloride
<p>Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual inhibitor of autophagy and REV-ERB with anticancer properties. It enhances the efficacy of autophagy blockade and increases cytotoxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) is applicable in melanoma research.</p>Formula:C24H32Cl2F2N2Molecular weight:456.19106(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), consisting of Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit the CRBN protein and serves as a crucial intermediate for synthesizing complete PROTAC molecules.</p>Formula:C27H32N8O5Molecular weight:548.24957Indomethacin-D4
CAS:<p>Indomethacin-D4 is a deuterium labeled Indomethacin.</p>Formula:C19H16ClNO4Purity:98%Color and Shape:SolidMolecular weight:361.81ALX 40-4C
CAS:<p>ALX40-4C is a small peptide inhibitor of the chemokine receptor CXCR4 that can inhibit X4 strains of HIV-1.</p>Formula:C56H113N37O10Purity:98%Color and Shape:SolidMolecular weight:1464.74PDEδ autophagic degrader 1
<p>PDEδ autophagic degrader 1 (compound 12c) is an autophagosome-tethering compound (ATTEC) and a potent autophagic degrader of PDEδ. This compound effectively reduces PDEδ protein levels through lysosome-mediated autophagy without affecting PDEδ mRNA expression. Additionally, PDEδ autophagic degrader 1 inhibits the growth of KRAS mutant pancreatic cancer cells.</p>Formula:C41H42Br2IN7O5Molecular weight:997.06589(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate combining an E3 ligase ligand with a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. This compound functions as a Cereblon ligand, recruiting the CRBN protein and serving as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C29H36N8O6Molecular weight:592.27578CXCL8 (54-72)
<p>CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.</p>Formula:C107H173N33O30Molecular weight:2400.30261(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is an E3 ligase ligand-linker conjugate (E3LigaseLigand-Linker Conjugates) composed of thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of CRBN protein, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C33H42N8O7Molecular weight:662.31765(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
<p>(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C30H39N5O6Molecular weight:565.29003Atorvastatin Sodium
CAS:<p>Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors on</p>Formula:C33H34FN2NaO5Purity:99.88% - >99.99%Color and Shape:SolidMolecular weight:580.63CCR7 antagonist 1
<p>CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.</p>Formula:C13H22N6OSMolecular weight:310.15758RCP168
<p>RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.</p>Formula:C365H585N105O95S5Molecular weight:8119.27766ALX 40-4C Trifluoroacetate
<p>Alx40-4C trifluoroacetate inhibits CXCR4 and is an APJ antagonist with IC50 of 2.9M.</p>Formula:C58H114F3N37O12Purity:98%Color and Shape:SolidMolecular weight:1578.76PF-06835375
CAS:<p>PF-06835375 is a humanized IgG1 antibody that selectively targets CXCR5 expressed on B cells, Tfh cells, and circulating Tfh-like cells (cTfh). It is applicable for research into systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).</p>Color and Shape:LiquidAntitumor agent-133
<p>Antitumor agent-133 (compound 4d) is a bis-santine derivative that demonstrates activity against Huh1 (IC50 = 17.13 μM) and Huh7 (IC50 = 8.27 μM). It induces autophagy and inhibits tumor growth by modulating the levels of the LC3BII, ATG5, and p62 proteins.</p>Formula:C27H24Br2N4O8Molecular weight:689.99609ATRA-biotin
CAS:<p>ATRA-biotin is a biotin-conjugated form of all-trans retinoic acid (ATRA). It is utilized for the purpose of tracking ATRA within cells or specific tissues.</p>Formula:C36H55N3O4SColor and Shape:SolidMolecular weight:625.91Tigecycline hydrate
CAS:<p>Tigecycline hydrate: broad-spectrum, glycylcycline antibiotic, bacteriostatic, inhibits protein synthesis, effective against resistant bacteria.</p>Formula:C29H39N5O8·xH2OColor and Shape:SolidSyntide 2
CAS:<p>Syntide-2 is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 µM).</p>Formula:C68H122N20O18Purity:98%Color and Shape:Lyophilized SolidMolecular weight:1507.82(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc
<p>(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. This compound serves as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C31H41N5O6Molecular weight:579.30568AUTAC1
CAS:<p>AUTAC1 is a MetAP2-targeted autophagy-mediated degradator (AUTAC) that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.</p>Formula:C44H63FN8O11SPurity:99.45% - 99.45%Color and Shape:SolidMolecular weight:931.08Cabergoline
CAS:<p>Cabergoline (FCE-21336), an ergot-derived dopamine D2-like agonist, targets D2/D3/5-HT2B, normalizes prolactin, controls pituitary tumors.</p>Formula:C26H37N5O2Purity:97.69% - 99.86%Color and Shape:White Crystalline SolidMolecular weight:451.6MRL828
<p>MRL828 is a compound that combines a Tau pathology-binding ligand with a guanine group modified by ATTEC technology, allowing it to selectively target aggregated tau proteins for clearance via the autophagy-lysosome pathway (ALP). MRL828 reduces intracellular Tau aggregates and facilitates the secretion of Tau.</p>Formula:C46H51FN14O5SColor and Shape:SolidMolecular weight:930.38716Biotin-16-UTP
CAS:<p>Biotin-16-UTP serves as an efficient substrate for RNA polymerase, capable of substituting UTP in vitro transcription reactions to facilitate RNA labeling [1].</p>Formula:C32H48Li4N7O19P3SColor and Shape:SolidMolecular weight:987.51Indole-3-Glyoxylyl Chloride
CAS:<p>Indole-3-glyoxylyl chloride (3-Indoleglyoxylyl chloride) can be used in chemical synthesis, such as bisindolylmaleimide.</p>Formula:C10H6ClNO2Purity:99.72%Color and Shape:Yellow To Orange Powder Or CrystalsMolecular weight:207.61LC3B recruiter 2
CAS:<p>LC3B recruiter 2 (34R) is an LC3B recruiting agent incorporated into the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), with a direct binding affinity for LC3B. It connects via a linker to the CDK9 inhibitor SNS-032, creating an ATTEC capable of targeting and degrading the CDK9 and Cyclin T1 complex, while also inhibiting them. Consequently, LC3B recruiter 2 exerts its function through an LC3B-dependent autophagy-lysosome pathway, interfering with the cancer cell cycle progression, thereby demonstrating antitumor activity.</p>Formula:C10H9ClN2O2Color and Shape:SolidMolecular weight:224.644Polyphyllin G
CAS:<p>Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.</p>Formula:C51H84O22Purity:98%Color and Shape:SolidMolecular weight:1049.21Autophagy agonist-1
<p>Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1/S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.</p>Formula:C33H41N3O5Color and Shape:SolidMolecular weight:559.7H1k
<p>H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that downregulates the expression of cell cycle protein B1.</p>Formula:C27H22N2OPurity:98.13%Color and Shape:SoildMolecular weight:390.48Acetyl coenzyme A
CAS:<p>Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways in the tricarboxylic acid cycle, fatty acid synthesis</p>Formula:C23H38N7O17P3SColor and Shape:SolidMolecular weight:809.57Fumagilin-105
CAS:<p>Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.</p>Formula:C46H60N2O9Color and Shape:SolidMolecular weight:784.98Autocamtide 2
CAS:<p>Autocamtide-2: Selective peptide for CaMKII, a CAMK Ser/Thr kinase.</p>Formula:C65H118N22O20Purity:98%Color and Shape:White PowderMolecular weight:1527.77DB1113
CAS:<p>DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.</p>Formula:C59H68F3N13O6SColor and Shape:SolidMolecular weight:1144.31SQA1
CAS:<p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>Formula:C22H26N4O5Color and Shape:SolidMolecular weight:426.47TRAF6 peptide
CAS:<p>TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.</p>Formula:C145H238N34O44Color and Shape:SolidMolecular weight:3161.64Microcolin H
CAS:<p>Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].</p>Formula:C38H63N5O9Color and Shape:SolidMolecular weight:733.93PBA-1105b
CAS:<p>PBA-1105b, a longer PEGylated derivative of PBA-1105, is an autophagy-targeting chimeric compound (AUTOTAC) that can induce self-oligomerization of p62. It enhances the autophagic flux of Ub-bound aggregates.</p>Formula:C47H64N2O10Color and Shape:SolidMolecular weight:817.02YTK-105
CAS:<p>YTK-105 is a ligand targeting autophagy that binds to p62.</p>Formula:C16H19NO2Purity:98.31%Color and Shape:SoildMolecular weight:257.33Ch55-O-C3-NH2
CAS:<p>Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR.</p>Formula:C27H35NO4Purity:98%Color and Shape:SolidMolecular weight:437.57LC3in-C42
<p>LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.</p>Color and Shape:Odour SolidN6-Isopentenyladenosine
CAS:<p>N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.</p>Formula:C15H21N5O4Purity:97.13% - 99.69%Color and Shape:SolidMolecular weight:335.36Bacilotetrin C analogue
<p>Bacilotetrin C analogue is a variant of Bacilotetrin C. It exhibits cytotoxicity against the triple-negative breast cancer cell line MDA-MB-231, with an IC50 of 0.48 μM. This compound induces autophagy (autophagy) in tumor cells and possesses antitumor activity.</p>Formula:C44H76N6O10Color and Shape:SolidMolecular weight:849.11Deoxy-thalidomide-Pip-C-PIP-boc
CAS:<p>Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.</p>Formula:C28H39N5O5Color and Shape:SolidMolecular weight:525.64Beclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Color and Shape:Odour SolidPF-543
CAS:<p>PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.</p>Formula:C27H31NO4SPurity:99.02%Color and Shape:SolidMolecular weight:465.6Dusquetide TFA
<p>Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.</p>Formula:C27H48F3N9O7Color and Shape:SolidMolecular weight:667.72HDAC6-IN-58
<p>HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM for HDAC6 and 7374.5 nM for HDAC1. It enhances tubulin acetylation, exhibits antiproliferative effects, and induces autophagy (autophagy).</p>Color and Shape:Odour SolidFDW028
CAS:<p>FDW028 is a FUT8 inhibitor with antitumor activity that works by promoting B7-H3 lysosomal degradation through defucosylation and CMA pathways.</p>Formula:C22H24N6OPurity:98.73% - 99.55%Color and Shape:SoildMolecular weight:388.47cGMP-HTL
<p>cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.</p>Formula:C31H51ClN7O14PSColor and Shape:SolidMolecular weight:844.27Peptide R
CAS:<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Formula:C39H59N13O8S2Color and Shape:SolidMolecular weight:902.1Flavopiridol
CAS:<p>Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.</p>Formula:C21H20ClNO5Purity:97.74% - 99.86%Color and Shape:SolidMolecular weight:401.84STO-609 acetate
CAS:<p>STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for the</p>Formula:C19H10N2O3·C2H4O2Purity:99.75%Color and Shape:SolidMolecular weight:374.35Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Formula:C115H145ClN18O31S2Zn2Color and Shape:SolidMolecular weight:2505.83Cy5.5-SE (DIPEA)
<p>Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.</p>Formula:C53H66N4O16S4Color and Shape:SolidMolecular weight:1143.37Corydalmine hydrochloride
CAS:<p>Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.</p>Formula:C20H24ClNO4Color and Shape:SolidMolecular weight:377.86Fe-TMPyP
CAS:<p>Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.</p>Formula:C44H36Cl5FeN8Color and Shape:SolidMolecular weight:909.92Insecticidal agent 364
CAS:<p>Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.</p>Formula:C23H18N4O3SPurity:99.81%Color and Shape:SolidMolecular weight:430.48Manzamine A hydrochloride
CAS:<p>Manzamine A hydrochloride: oral beta-carboline inhibiting GSK-3β & CDK-5; blocks autophagy in cancer; antimalarial; fights HSV-1.</p>Formula:C36H45ClN4OColor and Shape:SolidMolecular weight:585.23CXCR4-IN-3
<p>CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).</p>Biotin-11-dCTP
<p>Biotin-11-dCTP is a fluorescent dye for DNA labeling [1] .</p>Formula:C28H43Li3N7O16P3SColor and Shape:SolidMolecular weight:879.49MRT 67307 dihydrochloride
CAS:<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Formula:C26H38Cl2N6O2Purity:99.75%Color and Shape:SoildMolecular weight:537.53(S)-Sitagliptin phosphate
CAS:<p>(S)-Sitagliptin phosphate, less active enantiomer, is a potent DPP4 inhibitor with an IC50 of 19 nM.</p>Formula:C16H18F6N5O5PColor and Shape:SolidMolecular weight:505.314Autophagy/REV-ERB-IN-1
<p>Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.</p>Formula:C24H30F2N2Molecular weight:384.23771Clionamine B
CAS:<p>Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.</p>Formula:C27H45NO3Color and Shape:SolidMolecular weight:431.65Tigecycline mesylate
CAS:<p>Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>Formula:C30H43N5O11SPurity:98%Color and Shape:SolidMolecular weight:681.75Hoechst 33342 analog trihydrochloride
CAS:<p>Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating the</p>Formula:C32H38Cl3N7Color and Shape:SolidMolecular weight:627.05Erlotinib-13C6
CAS:<p>Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.</p>Formula:C22H23N3O4Color and Shape:SolidMolecular weight:399.397D-CopA3
CAS:<p>D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.</p>Formula:C96H184N30O18S2Color and Shape:SolidMolecular weight:2110.81Desethylamiodarone hydrochloride
CAS:<p>Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.</p>Formula:C23H26ClI2NO3Purity:98%Color and Shape:SolidMolecular weight:653.72G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Formula:C27H31IN2O3Color and Shape:SolidMolecular weight:558.45Autocamtide 2, amide
<p>Autocamtide-2, an amide, is a selective CaMKII substrate for CAMK family assays at 100 μM.</p>Formula:C65H119N23O19Purity:98%Color and Shape:SolidMolecular weight:1526.79p62-ZZ Ligand-Linker Conjugate 1
CAS:<p>p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.</p>Formula:C31H42N2O6Color and Shape:SolidMolecular weight:538.68Tetramethylrhodamine-dUTP
<p>Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .</p>Formula:C43H52N6O19P3Color and Shape:SolidMolecular weight:1049.82Acridine homodimer
CAS:<p>Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.</p>Formula:C38H42Cl2N6O2Color and Shape:SolidMolecular weight:685.69AZD4721
CAS:<p>AZD4721, an oral CXCR2 antagonist, may be researched for treating inflammation.</p>Formula:C19H25FN4O5S2Color and Shape:SolidMolecular weight:472.55PHTPP-1304
CAS:<p>PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.</p>Formula:C51H50F6N4O7Color and Shape:SolidMolecular weight:944.96Cyanine 5 Tyramide methyl indole
<p>Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.</p>Formula:C40H47N3O8S2Color and Shape:SolidMolecular weight:761.95Nictide
CAS:<p>Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.</p>Formula:C123H193N45O28Color and Shape:SolidMolecular weight:2750.13Tigecycline hydrochloride
CAS:<p>Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>Formula:C29H40ClN5O8Purity:98%Color and Shape:SolidMolecular weight:622.11Valproic acid sodium salt
CAS:<p>Sodium valproate is an anti-epileptic, boosting brain GABA levels and possibly affecting potassium channels for membrane stability.</p>Formula:C8H15NaO2Purity:98.43% - 99.78%Color and Shape:White PowderMolecular weight:166.2RK-682 (calcium salt)
CAS:<p>RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.</p>Formula:C42H74CaO10Color and Shape:SolidMolecular weight:779.122Desethyl chloroquine
CAS:<p>Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.</p>Formula:C16H22ClN3Purity:99.56%Color and Shape:SolidMolecular weight:291.82TSPO Ligand-Linker Conjugates 1
<p>TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.</p>Formula:C32H55N3O10SColor and Shape:SolidMolecular weight:673.86NAMPT degrader-1
<p>Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.</p>Formula:C56H68ClN9O5S2Color and Shape:SolidMolecular weight:1046.78CX4338
CAS:<p>CX4338 is a CXCL8-mediated chemotaxis inhibitor.</p>Formula:C22H24N2OSColor and Shape:SolidMolecular weight:364.50CXCR4 antagonist 1
CAS:<p>CXCR4 antagonist 1 is a potent inhibitor of the CXCR4 receptor, with notable anti-HIV activity.</p>Formula:C27H43N7Color and Shape:SolidMolecular weight:465.69BRD4 degrader-5
<p>BRD4 degrader-5 (Compound 23) is a protein degrader utilizing a hydrophobic tag (HyTag) that targets BRD4 for degradation through endoplasmic reticulum stress and the autophagy-lysosome pathway (DC50 = 24.7 μM). It also inhibits the proliferation of 4T1 cancer cells, with an IC50 of 20.6 μM.</p>Formula:C35H42ClN7O2SColor and Shape:SolidMolecular weight:660.27DMTr-4'-CF3-5-Me-U-CED phosphoramidite
<p>DMTr-4'-CF3-5-Me-U-CED is a dye for oligonucleotide labeling in RNA research.</p>Formula:C42H50F3N4O8PColor and Shape:SolidMolecular weight:826.84SHP2-IN-35
<p>SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.</p>Formula:C34H32FeO6Color and Shape:SolidMolecular weight:592.46MeCY5-NHS ester triethylamine
<p>MeCY5-NHS ester (potassium) is a reactive dye optimized for labeling proteins and nucleic acids [1].</p>Formula:C42H56N4O10S2Color and Shape:SolidMolecular weight:841.04(3R,5S)-Fluvastatin
CAS:<p>(3R,5S)-Fluvastatin, a synthetic HMG-CoA reductase inhibitor (IC50: 8 nM), activates Nrf2 for antioxidant defense.</p>Formula:C24H26FNO4Color and Shape:SolidMolecular weight:411.47KRH-3955 hydrochloride
CAS:<p>KRH-3955 hydrochloride is an orally available CXCR4 blocker with IC50 of 0.61 nM and EC50 of 0.3-1.0 nM against X4 HIV-1.</p>Formula:C28H48Cl3N7Color and Shape:SolidMolecular weight:589.09MW-150 hydrochloride
CAS:<p>MW-150 hydrochloride is a selective p38α MAPK inhibitor with a 101 nM Ki, offering good CNS penetration and oral bioavailability.</p>Formula:C24H24ClN5Color and Shape:SolidMolecular weight:417.93Chlorotris(triphenylphosphine)copper
CAS:<p>Chlorotris (triphenylphosphine) copper (CuCl(TPP)₃) is a metal complex that targets DNA. Through non-covalent interactions of its copper (I) center, such as groove-binding, it affects DNA function and exhibits inhibitory activity against bacteria, fungi, and tumor cells. Chlorotris (triphenylphosphine) copper holds potential for research as an antimicrobial, antitumor, and antioxidant agent.</p>Formula:C54H45ClCuP3Color and Shape:SolidMolecular weight:885.86Hexidium iodide
CAS:<p>Hexidium iodide fluoresces, stains mammalian cells & gram-positive bacteria, and binds to DNA with EDTA. Excitation/emission: ~518/600 nm.</p>Formula:C25H28IN3Color and Shape:SolidMolecular weight:497.424Desfluoro-ezetimibe
CAS:<p>Desfluoro-ezetimibe: a defluorinated ezetimibe impurity; a stable, potent cholesterol blocker and Nrf2 activator.</p>Formula:C24H22FNO3Purity:98%Color and Shape:SolidMolecular weight:391.43Cytochalasin E
CAS:<p>Cytochalasin E, from Aspergillus, disrupts actin, inhibits angiogenesis, and halts tumor growth.</p>Formula:C28H33NO7Purity:98%Color and Shape:Crystals From Acetone-Hexane White PowderMolecular weight:495.56
