GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

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Found 5378 products of "GPCR/G-Protein"

Purity (%)

100

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MrgprX2 antagonist-5
CAS:
- 2527815-74-1
MrgprX2 antagonist-5 from patent WO2020223255A1 inhibits MrgprX2, useful for inflammatory skin disorder studies.
Formula:C₁₉H₁₃ClF₂N₄O₂S
Color and Shape:Solid
Molecular weight:434.85
Ref: TM-T40176
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S1H
S1H is an analog of human growth hormone (hGH) and acts as an antagonist to the human growth hormone receptor (hGHR). It inhibits the interaction between hGH and hGHR and prevents the phosphorylation of STAT5 in cells treated with hGH.
Formula:C₉₄H₁₄₁N₂₃O₂₇
Molecular weight:2024.03673
Ref: TM-TP3539
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Dopamine D2 receptor agonist-2
CAS:
- 1610591-93-9
Dopamine D2 receptor agonist-2 (Dopamine D2 Receptor) is a ligand targeting the dopamine D2 receptor.
Formula:C₂₅H₃₁Cl₂N₅OS
Purity:98.93%
Color and Shape:Soild
Molecular weight:520.52
Ref: TM-T60075
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Azido-FTY720
CAS:
- 881914-35-8
Azido-FTY720 (azido-Fingolimod) is an analogue of FTY720, with an azido group for click chemistry reactions. FTY720 is an orally available S1P1R modulator .
Formula:C₁₉H₃₂N₄O₂
Color and Shape:Solid
Molecular weight:348.49
Ref: TM-T37548
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IRL-1038
CAS:
- 144602-02-8
ETB endothelin receptor antagonist
Formula:C₆₈H₉₂N₁₄O₁₅S₂
Purity:98%
Color and Shape:Solid
Molecular weight:1409.67
Ref: TM-TP2262
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Prazobind
CAS:
- 107021-36-3
Prazobind is a prazosinoid substance that blocks insulin stimulation of IP1 (inositol phosphate) accumulation and is an effective α1 adrenoceptor blocker.
Formula:C₂₃H₂₇N₅O₃
Color and Shape:Solid
Molecular weight:421.501
Ref: TM-T35581
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NF546
CAS:
- 1006028-37-0
NF546 is a selective agonist of non-nucleotide P2Y11(pEC50 of 6.27).
Formula:C₄₇H₄₄N₆Na₄O₁₇P₄
Purity:98%
Color and Shape:Solid
Molecular weight:1180.74
Ref: TM-T12217
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Nebokitug
Nebokitug is a humanized IgG1κ antibody targeting CCL24, with HumanIgG1kappa, Isotype Control serving as its corresponding isotype control.
Color and Shape:Odour Liquid
Ref: TM-T9901A-472
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Cortagine
Potent CRF1 agonist, EC50 = 0.18 nM in rats. Exhibits in vivo anxiolytic and antidepressant effects; reduces mouse defensive behavior.
Formula:C₁₉₂H₃₂₃N₅₅O₆₃S
Purity:98%
Color and Shape:Solid
Molecular weight:4442.06
Ref: TM-TP2067
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Nafetolol
CAS:
- 42050-23-7
Nafetolol (K 5407) is a biochemical reagent that can be used to synthesize other compounds.
Formula:C₁₉H₂₉NO₃
Purity:98.91%
Color and Shape:Solid
Molecular weight:319.44
Ref: TM-T33581
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Abediterol napadisylate
CAS:
- 1044516-17-7
Abediterol napadisylate is a novel long-acting β2-agonist in persistent asthma that is efficacy, safe, and tolerable.
Formula:C₆₀H₆₈F₄N₄O₁₄S₂
Purity:98%
Color and Shape:Solid
Molecular weight:1209.32
Ref: TM-T24995
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Vapiprost
CAS:
- 85505-64-2
Vapiprost is an antagonist of the thromboxane receptor and a prostaglandin receptor.
Formula:C₃₀H₃₉NO₄
Purity:98%
Color and Shape:Solid
Molecular weight:477.64
Ref: TM-T24931
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K41498
CAS:
- 434938-41-7
Potent CRF2α/β antagonist; Ki: 0.66/0.62 nM, weak for CRF1 (425 nM). Blocks sauvagine in hCRF2 cells and urocortin hypotension in rats.
Formula:C₁₆₂H₂₇₆N₄₈O₄₆
Purity:98%
Color and Shape:Solid
Molecular weight:3632.26
Ref: TM-TP2009
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α-MSH acetate
α-MSH acetate is an endogenous neuromodulatory peptide derived from POMC and an agonist of MC4R (melanocortin receptor 4).
Purity:99.71%
Color and Shape:Odour Solid
Ref: TM-T7813L
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PSB-22269
PSB-22269 is identified as a GPR17 antagonist with a Ki value of 8.91 nM. It exhibits significant inhibitory effects in cAMP and G protein activation assays. Molecular docking studies indicate that the binding site of PSB-22269 includes positively charged arginine residues and a hydrophobic pocket. PSB-22269 promotes myelin regeneration strategies, offering potential for multiple sclerosis research.
Formula:C₂₆H₂₁NO₆
Color and Shape:Solid
Molecular weight:443.45
Ref: TM-T203177
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L 366811
CAS:
- 127819-95-8
L 366811 is a potent oxytocin antagonist.
Formula:C₄₃H₅₆N₈O₆
Color and Shape:Solid
Molecular weight:780.95
Ref: TM-T24291
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Albiglutide Fragment
CAS:
- 782500-75-8
Albiglutide fragment is a 30-amino-acid sequence of modified human GLP-1 (fragment 7-36).
Formula:C₁₄₈H₂₂₄N₄₀O₄₅
Purity:98%
Color and Shape:Solid
Molecular weight:3283.6
Ref: TM-TQ0004
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[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide
CAS:
- 313988-89-5
Potent, selective NPY Y5 receptor agonist; IC50: 0.24 nM (Y5), >500 nM (Y2), 530 nM (Y1), 51 nM (Y4); Ki: 0.1-0.15 nM (Y5); increases food intake in vivo.
Formula:C₁₈₃H₂₈₁N₅₇O₅₄S₂
Purity:98%
Color and Shape:Solid
Molecular weight:4207.67
Ref: TM-TP1963
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Acrinor
CAS:
- 8004-31-7
Acrinor is a adrenergic beta receptor agonist.
Formula:C₃₅H₄₆Cl₂N₁₀O₈
Purity:98%
Color and Shape:Solid
Molecular weight:805.72
Ref: TM-T25003
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ADTN
CAS:
- 53463-78-8
ADTN is an agonist of the dopamine receptor.
Formula:C₁₀H₁₃NO₂
Purity:98%
Color and Shape:Solid
Molecular weight:179.22
Ref: TM-T23643
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VU0453379
CAS:
- 1638646-27-1
VU0453379 is a highly selective and central nervous system penetrant positive allosteric modulator of glucagon-like peptide-1R (EC50: 1.3 μM).
Formula:C₂₆H₃₄N₄O₂
Purity:98%
Color and Shape:Solid
Molecular weight:434.57
Ref: TM-T17242
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FR190997
CAS:
- 193344-25-1
FR190997 is an agonist of bradykinin B2 receptor.
Formula:C₃₇H₃₃Cl₂N₅O₅
Color and Shape:Solid
Molecular weight:698.59
Ref: TM-T27377
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TGR5 agonist 6
CAS:
- 2925211-47-6
Compound 22b, also known as TGR5 agonist 6, is a non-systemic, intestine-targeted TGR5 agonist that demonstrates significant and sustained blood glucose-lowering effects with an acceptable safety profile.
Formula:C₄₂H₄₈Cl₂N₆O₆
Color and Shape:Solid
Molecular weight:803.77
Ref: TM-T200705
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GLP-1R Antagonist 1
CAS:
- 488097-06-9
GLP-1R Antagonist 1 is an orally active, CNS penetrant and non-competitive glucagon-like peptide 1 receptor (GLP-1R) antagonist (IC50: 650 nM).
Formula:C₁₆H₁₁ClF₆N₄O₂
Purity:99.84%
Color and Shape:Solid
Molecular weight:440.73
Ref: TM-T15387
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INCB3344 R-isomer
INCB3344 is a potent CCR2 antagonist. INCB3344 R-isomer is the R-isomer of INCB3344.
Formula:C₂₉H₃₄F₃N₃O₆
Purity:98%
Color and Shape:Solid
Molecular weight:577.59
Ref: TM-T11650
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Metaraminol
CAS:
- 54-49-9
Metaraminol is a sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors.
Formula:C₉H₁₃NO₂
Color and Shape:Solid
Molecular weight:167.21
Ref: TM-T0279L
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Cagrilintide acetate
.Cagrilintide is a long-acting amylin analog,treat diabetes and obesity by reducing appetite through activation of the AMY3R and calcitonin receptor.
Formula:C₁₉₆H₃₁₆N₅₄O₆₁S₂
Purity:99.88%
Color and Shape:Solid
Molecular weight:4469.06
Ref: TM-T76262L
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Hemokinin 1, human
CAS:
- 491851-53-7
Endogenous P-like compound, NK1 receptor agonist; IC50: NK1-1.8 nM, NK3-370 nM, NK2-480 nM; boosts B-cell growth, antiapoptotic, lowers blood pressure in vivo.
Formula:C₅₄H₈₄N₁₄O₁₄S
Purity:98%
Color and Shape:Solid
Molecular weight:1185.4
Ref: TM-TP1899
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2-Furoyl-LIGRLO-amide
CAS:
- 729589-58-6
2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.
Formula:C₃₆H₆₃N₁₁O₈
Purity:98%
Color and Shape:Solid
Molecular weight:777.95
Ref: TM-TP1478
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Hemokinin 1 (mouse)
CAS:
- 208041-90-1
Hemokinin 1 (mouse) is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.
Formula:C₆₁H₁₀₀N₂₂O₁₅S
Purity:98%
Color and Shape:White Powder
Molecular weight:1413.65
Ref: TM-TP1772
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Clotizolam
CAS:
- 54123-06-7
Clotizolam is a thienotriazolodiazepine derivative with PAF antagonistic properties, exhibiting sedative, anxiolytic, anticonvulsant, and muscle relaxant effects.
Formula:C₁₅H₁₀Cl₂N₄S
Color and Shape:Solid
Molecular weight:349.24
Ref: TM-T203541
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Ro 25-1553
CAS:
- 159427-08-4
Ro 25-1553 is a 31-amino acid analog of vasoactive intestinal peptide (VIP) that functions as an agonist for the VIP2 receptor (VPAC2 receptor). In guinea pig models, Ro 25-1553 exhibits bronchodilator effects on tracheal smooth muscle contraction induced by neural stimuli or Carbachol.
Formula:C₁₆₀H₂₅₈N₄₆O₄₆
Color and Shape:Solid
Molecular weight:3562.04
Ref: TM-T203230
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Detomidine carboxylic acid
CAS:
- 115664-39-6
Detomidine carboxylic acid, a urine metabolite of detomidine, is a synthetic α2-agonist, animal analgesic, with cardiac, respiratory, and diuretic effects.
Formula:C₁₂H₁₂N₂O₂
Purity:98%
Color and Shape:Solid
Molecular weight:216.24
Ref: TM-T11010
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O-2172
CAS:
- 521062-92-0
O-2172 is a carbocyclic analogue serving as an inhibitor of dopamine transporter (DAT), exhibiting IC50 values of 47 nM for DAT and 7000 nM for the serotonin transporter (SERT).
Formula:C₁₄H₁₆Cl₂O₂
Color and Shape:Solid
Molecular weight:287.18
Ref: TM-T203629
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P2Y14 antagonist 1
P2Y14 antagonist 1 (compound 45) is a highly selective and orally active P2Y14 receptor antagonist with an IC50 value of 0.70 nM. It demonstrates significant anti-inflammatory effects by effectively reducing pulmonary infiltration of immune cells and inflammatory responses through the inhibition of the NLRP3 signaling pathway. P2Y14 antagonist 1 is suitable for studying acute lung injury.
Formula:C₂₄H₂₁N₃O₃
Color and Shape:Solid
Molecular weight:399.442
Ref: TM-T205734
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5-hydroxy Propranolol
CAS:
- 81907-82-6
5-hydroxy Propranolol, a propranolol metabolite, is formed in the liver via P450 2D6.
Formula:C₁₆H₂₁NO₃
Color and Shape:Solid
Molecular weight:275.348
Ref: TM-T36237
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Apigenin 6,8-di-C-α-L-arabinopyranoside
CAS:
- 73140-47-3
Apigenin 6,8-di-C-alpha-L-arabinopyranoside is a useful organic compound for research related to life sciences.
Formula:C₂₅H₂₆O₁₃
Color and Shape:Solid
Molecular weight:534.47
Ref: TM-T124311
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Thiothixene
CAS:
- 5591-45-7
Thiothixene has a wide range of applications in life science related research.
Formula:C₂₃H₂₉N₃O₂S₂
Color and Shape:Solid
Molecular weight:443.62
Ref: TM-T38200
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Neuropeptide Y (human)
CAS:
- 90880-35-6
Neuropeptide Y (29-64), amide, human is a biologically active 36-amino acid peptide.
Formula:C₁₈₉H₂₈₅N₅₅O₅₇S
Purity:98%
Color and Shape:Solid
Molecular weight:4271.68
Ref: TM-TP1140
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AR-C126313
CAS:
- 216657-60-2
AR-C126313 is a thiouracil derivative.
Formula:C₂₈H₂₃N₇O₃S
Color and Shape:Solid
Molecular weight:537.59
Ref: TM-T30120
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[Ala1,3,11,15]-Endothelin
CAS:
- 121204-87-3
Selective ETB endothelin receptor agonist (IC50 values are 0.33 and 2200 nM for displacing [125I]-ET-1 from ETB and ETA receptors respectively).
Formula:C₁₀₉H₁₆₃N₂₅O₃₂S
Purity:98%
Color and Shape:Solid
Molecular weight:2368
Ref: TM-TP2099
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Survodutide
CAS:
- 2805997-46-8
Survodutide (BI 456906) is a dual agonist of glucagon and glucagon-like peptide 1 (GLP-1) receptor (GLP Receptor) that reduces body weight in HbA1c16 diabetes.
Formula:C₁₉₂H₂₈₉N₄₇O₆₁
Purity:99.83%
Color and Shape:Solid
Molecular weight:4229.0957
Ref: TM-T76559
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Upidosin
CAS:
- 152735-23-4
Upidosin (SB-216469), a uroselective α1 blocker: Ki α1a=0.34 nM, α1b=3.9 nM, α1d=1.5 nM, α2=33.3 nM.
Formula:C₃₁H₃₃N₃O₄
Purity:99.66%
Color and Shape:Solid
Molecular weight:511.61
Ref: TM-T9762
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Gemeprost
CAS:
- 64318-79-2
Gemeprost treats obstetric bleeding and induces abortion up to 24 weeks when used with mifepristone.
Formula:C₂₃H₃₈O₅
Purity:98%
Color and Shape:Solid
Molecular weight:394.54
Ref: TM-T20855
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Mini Gastrin I, human
CAS:
- 54405-27-5
Mini Gastrin I, human, is a truncated form of the human gastrin peptide, encompassing amino acids 5-17 of the original sequence.
Formula:C₇₄H₉₉N₁₅O₂₆S
Purity:98%
Color and Shape:Solid
Molecular weight:1646.73
Ref: TM-TP1821
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SRA880 malonate
CAS:
- 573984-99-3
SRA880: non-peptide sst(1) antagonist, low affinity for other sst receptors, binds dopamine D4, boosts SRIF, antidepressant-like effects.
Formula:C₂₉H₃₆N₄O₈
Purity:98%
Color and Shape:Solid
Molecular weight:568.62
Ref: TM-T26225
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CH-0076989
CAS:
- 954371-52-9
CH-0076989 is a chemokine receptor CCR3 agonist.
Formula:C₂₄H₂₂Br₂N₂O₂
Color and Shape:Solid
Molecular weight:530.25
Ref: TM-T30865
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Prosaptide TX14(A)
CAS:
- 196391-82-9
GPR37L1/GPR37 agonist with EC50 of 5/7 nM, activates G proteins, enhances ERK, myelin synthesis, neuro/glioprotection.
Formula:C₆₉H₁₁₀N₁₆O₂₆
Purity:98%
Color and Shape:Solid
Molecular weight:1579.72
Ref: TM-TP1970
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16-phenoxy tetranor Prostaglandin F2α methyl ester
CAS:
- 51638-90-5
Prostaglandin F2α (PGF2α) drives luteolysis and smooth muscle contraction by activating the FP receptor.
Formula:C₂₃H₃₂O₆
Color and Shape:Solid
Molecular weight:404.503
Ref: TM-T37937
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Fpl 14294
CAS:
- 154132-95-3
Fpl 14294 is a novel CCK-8 agonist with effective intranasal anorectic activity in the rat.
Formula:C₄₅H₅₆N₈O₁₃S₃
Purity:98%
Color and Shape:Solid
Molecular weight:1013.17
Ref: TM-T25437
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Levitide
CAS:
- 114281-19-5
Levitide is a neurohormone-like peptide which is from the skin of Xenopus laevis.
Formula:C₆₆H₁₁₉N₂₁O₁₉S
Purity:98%
Color and Shape:Solid
Molecular weight:1542.85
Ref: TM-T20704
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Velmupressin acetate
CAS:
- 1647120-04-4
Potent, selective, short-acting peptidic V2R agonist; EC50: 0.07 nM (hV2R), 0.02 nM (rV2R).
Formula:C₄₄H₆₄ClN₁₁O₁₀S₂
Purity:98%
Color and Shape:Solid
Molecular weight:1006.63
Ref: TM-TP1205
+ Info
Colulintide
CAS:
- 2891912-36-8
Colulintide is an analog of amylin, utilized in obesity research.
Color and Shape:Solid
Ref: TM-TP3252
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Flunarizine
CAS:
- 52468-60-7
Flunarizine is an orally administered peripheral vasodilator, a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist.
Formula:C₂₆H₂₆F₂N₂
Purity:99.9%
Color and Shape:Solid
Molecular weight:404.50
Ref: TM-T21392
+ Info
Eletriptan
CAS:
- 143322-58-1
Eletriptan, second-generation triptans used to treat migraines, is used as an abortion drug.
Formula:C₂₂H₂₆N₂O₂S
Color and Shape:Solid
Molecular weight:382.52
Ref: TM-T0216L
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S(-)-Bisoprolol fumarate
CAS:
- 1426853-23-7
S(-)-Bisoprolol fumarate is a selective β1-blocker for hypertension and heart research.
Formula:C₁₈H₃₁NO₄·xC₄H₄O₄
Color and Shape:Solid
Molecular weight:441.521
Ref: TM-T74156
+ Info
Galanin (1-19), human
CAS:
- 136005-51-1
Galanin (1-19), human: a fragment of GAL neuropeptide influencing hormone release, pain response, and eating behavior.
Formula:C₈₉H₁₃₀N₂₆O₂₅
Purity:98%
Color and Shape:Solid
Molecular weight:1964.14
Ref: TM-TP1529
+ Info
Besipirdine hydrochloride
CAS:
- 130953-69-4
Besipirdine hydrochloride is a non-receptor-dependent cholinomimetic compound with cardiovascular activity that inhibits the uptake of biogenic amines.
Formula:C₁₆H₁₈ClN₃
Purity:98.45%
Color and Shape:Soild
Molecular weight:287.79
Ref: TM-T26778L
+ Info
Mirtazapine N-oxide
CAS:
- 155172-12-6
Mirtazapine N-oxide, a mirtazapine metabolite, is produced by CYP1A2 and CYP3A4 in human liver.
Formula:C₁₇H₁₉N₃O
Color and Shape:Solid
Molecular weight:281.359
Ref: TM-T37430
+ Info
SRI-37330
CAS:
- 2322245-42-9
SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production, and reverses hepatic steatosis.
Formula:C₁₆H₁₉F₃N₄O₂S
Purity:99.65%
Color and Shape:Solid
Molecular weight:388.41
Ref: TM-T60004
+ Info
MI 1544
CAS:
- 87565-51-3
MI 1544 is a LHRH antagonist.
Formula:C₇₁H₉₄ClN₁₇O₁₃
Color and Shape:Solid
Molecular weight:1429.09
Ref: TM-T25808
+ Info
(R)-Zevaquenabant
(R)-Zevaquenabant ((R)-MRI-1867) is the enantiomer of Zevaquenabant. Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual antagonist of the cannabinoid CB1 receptor and inducible nitric oxide synthase (iNOS). It is beneficial in improving chronic kidney disease (CKD) caused by obesity.
Color and Shape:Odour Solid
Ref: TM-TYD-02102
+ Info
Fasitibant chloride hydrochloride
CAS:
- 869880-33-1
Fasitibant chloride( MEN16132) is an effective and selective non-peptide antagonist of kinin B2 receptor.
Formula:C₃₆H₅₀Cl₄N₆O₆S
Color and Shape:Solid
Molecular weight:836.7
Ref: TM-T31747
+ Info
DOTA-EB-TATE
DOTA-EB-TATE is formed by combining the SST peptide derivative DOTA-octreotate with an Evans blue analog (EB). This peptide drug conjugate (PDC) enhances the pharmacokinetics of SSTR2 analogs and reduces PRRT toxicity. Additionally, DOTA-EB-TATE serves in the synthesis/research of radiopharmaceutical conjugates (RDC).
Formula:C₁₀₅H₁₃₃N₂₁O₃₀S₅
Molecular weight:2329.63
Ref: TM-TP2996
+ Info
tcY-NH2
CAS:
- 327177-34-4
Selective PAR4 antagonist peptide. Inhibits endostatin release and platelet aggregation induced by thrombin.
Formula:C₄₀H₄₉N₇O₇
Purity:98%
Color and Shape:Solid
Molecular weight:739.87
Ref: TM-TP1925
+ Info
Alsactide
CAS:
- 34765-96-3
Alsactide, an adrenocorticotropic hormone (ACTH) agonist and a heptadecapeptide analogue, is utilized in the study of the central nervous system [1].
Formula:C₉₉H₁₅₅N₂₉O₂₁S
Color and Shape:Solid
Molecular weight:2119.53
Ref: TM-T76297
+ Info
M1145
CAS:
- 1172089-00-7
Potent GAL2 agonist with EC50 = 38 nM; Ki: 6.55 nM (GAL2), 497 nM (GAL3), 587 nM (GAL1); enhances galanin signaling.
Formula:C₁₂₈H₂₀₅N₃₇O₃₂
Purity:98%
Color and Shape:Solid
Molecular weight:2774.26
Ref: TM-TP1991
+ Info
[D-Trp8,Tyr11] Somatostatin
CAS:
- 75176-06-6
[D-Trp8,Tyr11] Somatostatin, an analogue of the hormone somatostatin that modulates numerous bodily functions, is characterized by the substitution of DTrp8,
Formula:C₇₆H₁₀₄N₁₈O₂₀S₂
Molecular weight:1653.88
Ref: TM-T83494
+ Info
PACAP (1-38) free acid TFA
PACAP (1-38) free acid TFA, an endogenous neuropeptide, effectively enhances antral motility and somatostatin secretion, while concurrently suppressing gastrin
Color and Shape:Odour Solid
Ref: TM-T81571
+ Info
ELA-32(human)
CAS:
- 1680205-79-1
Potent apelin receptor agonist with IC50 = 0.27 nM; does not bind GPR15/GPR25. Boosts hESC self-renewal and angiogenesis.
Formula:C₁₇₀H₂₈₉N₆₃O₃₉S₄
Purity:98%
Color and Shape:Solid
Molecular weight:3967.8
Ref: TM-TP2097
+ Info
FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS
FTSDVSKQMEEEAVRLFIEWLKNGGPSSGAPPPS is an Exendin-4 peptide derivative.
Color and Shape:Solid
Molecular weight:3692.15
Ref: TM-T75859
+ Info
Onvitrelin ucalontide
CAS:
- 1174415-90-7
Onvitrelin ucalontide is a LHRH analogue with anticancer effect; halts breast, ovarian, and prostate tumors in mice.
Formula:C₁₆₃H₂₄₃N₄₃O₃₂
Molecular weight:3316.94
Ref: TM-T76558
+ Info
TAK-683 acetate
TAK-683 acetate: potent KISS1R agonist (IC50=170 pM), stable, nonapeptide. Affects GnRH, FSH, LH, testosterone; potential in prostate cancer research.
Formula:C₆₆H₈₇N₁₇O₁₅
Color and Shape:Solid
Molecular weight:1358.5
Ref: TM-T76048
+ Info
Linaclotide acetate
CAS:
- 851199-60-5
Linaclotide acetate, an oral guanylate cyclase C agonist with 14 amino acids, treats constipation-predominant IBS and chronic constipation.
Formula:C₆₁H₈₃N₁₅O₂₃S₆
Purity:98%
Color and Shape:Solid
Molecular weight:1586.79
Ref: TM-T11852L
+ Info
WAY-639418
CAS:
- 643042-43-7
WAY-639418 has potential anti-inflammatory and anti-HIV activity and can be used to study CCR5-mediated inflammatory and immunomodulatory diseases.
Formula:C₁₇H₁₆ClN₅
Purity:99.62%
Color and Shape:Solid
Molecular weight:325.8
Ref: TM-T9942
+ Info
PY-60
CAS:
- 2765218-56-0
PY-60 can effectively activate YAP transcriptional activity against annexin A2 (ANXA2).Cost-effective and quality-assured.
Formula:C₁₆H₁₅N₃O₂S
Purity:99.5% - 99.67%
Color and Shape:Solid
Molecular weight:313.37
Ref: TM-T9566
+ Info
AZ7976
CAS:
- 2813866-27-0
AZ7976 (Compound 42), a potent and highly selective agonist for Relaxin Family Peptide Receptor 1 (RXFP1) with a pEC 50 value greater than 10.5, operates through an allosteric mechanism to enhance RXFP1's cAMP signaling, which physiologically elevates heart rate. This property makes AZ7976 a valuable tool in cardiovascular disease research [1].
Formula:C₃₀H₃₃F₇N₂O₆S
Color and Shape:Solid
Molecular weight:682.65
Ref: TM-T85783
+ Info
γ-1-Melanocyte Stimulating Hormone (MSH), amide
γ-1-Melanocyte Stimulating Hormone (MSH), amide, a peptide consisting of 11 amino acids, plays a critical role in regulating sodium (Na+) balance and blood
Formula:C₇₂H₉₇N₂₁O₁₄S
Color and Shape:Solid
Molecular weight:1512.9
Ref: TM-T75971
+ Info
SR142948A
CAS:
- 184162-21-8
SR142948A is a selective and reversible non-peptide neurotensin receptor antagonist blocking hypothermia and analgesic effects, NMDA-induced dopamine release.
Formula:C₃₉H₅₂ClN₅O₆
Purity:98%
Color and Shape:Solid
Molecular weight:722.31
Ref: TM-T28845
+ Info
[bAla8]-Neurokinin A(4-10)
CAS:
- 122063-01-8
[bAla8]-Neurokinin A(4-10) is a neurokinin 2 (NK2) receptor agonist.
Formula:C₃₅H₅₆N₈O₁₀S
Purity:98%
Color and Shape:Solid
Molecular weight:780.94
Ref: TM-TP1100
+ Info
ECPLA
CAS:
- 2349367-50-4
ECPLA is an LSD analog and a potent 5-HT2A agonist (EC50 of 14.6 nM), capable of stimulating Gq-mediated calcium flux. It exhibits high affinity for most serotonin receptors, α2-adrenergic receptors, and D2-like dopamine receptors.
Formula:C₂₁H₂₅N₃O
Color and Shape:Solid
Molecular weight:335.44
Ref: TM-T203569
+ Info
Cloprostenol isopropyl ester
CAS:
- 157283-66-4
(+)-Chloprostol is a PGF2α agonist, mimics prostaglandin F2α, induces luteal dissolution in mares without side effects or stress.
Formula:C₂₅H₃₅ClO₆
Color and Shape:Solid
Molecular weight:466.99
Ref: TM-T29246
+ Info
Baloncibart
CAS:
- 2988795-75-9
Baloncibart is a human IgG4K monoclonal antibody that targets NPR1.
Color and Shape:Liquid
Ref: TM-T9901A-888
+ Info
Neuropeptide Y (18-36) (porcine)
CAS:
- 114495-97-5
"Neuropeptide Y (18-36) (porcine) is a NPY heart receptor blocker, halts I-NPY binding, aids in heart failure research."
Formula:C₁₁₂H₁₇₄N₃₆O₂₇
Color and Shape:Solid
Molecular weight:2456.8
Ref: TM-T76357
+ Info
Utreglutide
CAS:
- 2460862-12-6
Utreglutide is a potent glucagon-like peptide 1 (GLP-1) receptor agonit [1] .
Formula:C₁₉₁H₂₉₈N₄₆O₅₈
Color and Shape:Solid
Molecular weight:4166.67
Ref: TM-T76237
+ Info
Substance P (4-11)
CAS:
- 53749-60-3
Substance P (4-11), a C-terminal fragment of Substance P, acts as a highly selective agonist for NK1 receptors, demonstrating specificity in its interaction.
Formula:C₄₆H₆₇N₁₁O₁₀S
Color and Shape:Solid
Molecular weight:966.16
Ref: TM-T76455
+ Info
Syk Inhibitor II hydrochloride
CAS:
- 2490508-82-0
Syk signaling is key in lupus. Syk inhibitors reduce inflammation and sepsis severity in FcgRIIb-/- mice, lowering cytokines and organ damage.
Formula:C₁₄H₁₆ClF₃N₆O
Purity:99.05%
Color and Shape:Solid
Molecular weight:376.77
Ref: TM-T9543
+ Info
8-iso-15-keto Prostaglandin F2α
CAS:
- 191919-01-4
8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans.
Formula:C₂₀H₃₂O₅
Color and Shape:Solid
Molecular weight:352.471
Ref: TM-T36166
+ Info
M871
CAS:
- 908844-75-7
GAL2 receptor antagonist; Ki: 13.1 nM (GAL2), 420 nM (GAL1); inhibits GAL2-induced pain.
Formula:C₁₀₈H₁₆₃N₂₇O₂₈
Purity:98%
Color and Shape:Solid
Molecular weight:2287.64
Ref: TM-TP1994
+ Info
MLGFFQQPKPR-NH2
CAS:
- 1802883-75-5
MLGFFQQPKPR-NH2 is a reversed Substance P peptide. Substance P is a neuropeptide [1] .
Formula:C₆₃H₉₈N₁₈O₁₃S
Color and Shape:Solid
Molecular weight:1347.63
Ref: TM-T76451
+ Info
ALD1613
ALD1613 is a potent neutralizing monoclonal antibody targeting adrenocorticotropic hormone (ACTH). It neutralizes ACTH-induced signaling and inhibits cyclic adenosine monophosphate accumulation in ACTH-stimulated Y1 (mouse adrenal cell line) via all five melanocortin receptors. ALD1613 significantly reduces plasma corticosterone levels in wild-type rats and is applicable in studies involving elevated ACTH-related conditions.
Color and Shape:Odour Liquid
Ref: TM-T9901A-967
+ Info
Galanin (1-30), human
CAS:
- 119418-04-1
Galanin (1-30), human is a neuropeptide agonist for GalR1/R2 receptors with 1 nM affinity, influencing endocrine, metabolism, and neurotransmission.
Formula:C₁₃₉H₂₁₀N₄₂O₄₃
Purity:98%
Color and Shape:Solid
Molecular weight:3157.46
Ref: TM-TP1732
+ Info
K-(D-1-Nal)-FwLL-NH2 TFA
K-(D-1-Nal)-FwLL-NH2 TFA: potent ghrelin inverse agonist; Ki=4.9 nM (COS7), 31 nM (HEK293T); blocks Gq/G13 signaling.
Formula:C₅₃H₆₈F₃N₉O₈
Color and Shape:Solid
Molecular weight:1016.16
Ref: TM-T75948
+ Info
JNJ-10181457 (hydrochloride)
CAS:
- 544707-20-2
JNJ-10181457 (hydrochloride) is a non-imidazole H3 receptor antagonist that is brain-penetrating and selective, increasing NE and acetylcholine concentrations
Formula:C₂₀H₃₀Cl₂N₂O
Color and Shape:Solid
Molecular weight:385.37
Ref: TM-T37220
+ Info
SB-206606
CAS:
- 116049-78-6
SB-206606 is a novel, highly specific radioactive ligand for the β3-adrenergic receptor.
Formula:C₁₉H₂₂ClNO₄
Color and Shape:Solid
Molecular weight:363.83
Ref: TM-T34540
+ Info
Ecnoglutide
CAS:
- 2459531-73-6
Ecnoglutide (XW003) is a glucagon-like peptide 1 (GLP-1) receptor agonist [1] .
Formula:C₁₉₄H₃₀₄N₄₈O₆₁
Color and Shape:Solid
Molecular weight:4284.76
Ref: TM-T76234
+ Info
ANQ-11125 TFA
ANQ-11125 TFA is a motilin antagonist with a pKd of 8.24, inhibiting motilide contractions in rabbits.
Formula:C₈₈H₁₂₆F₃N₁₉O₂₃
Color and Shape:Solid
Molecular weight:1875.05
Ref: TM-T75861
+ Info
GLP-1(9-36)amide TFA
GLP-1(9-36)amide TFA, a DPP-4 metabolite of GLP-1(7-36) amide, antagonizes human pancreatic GLP-1 receptor.
Formula:C₁₄₂H₂₁₅F₃N₃₆O₄₅
Color and Shape:Solid
Molecular weight:3203.43
Ref: TM-T75822
+ Info
Corazonin
CAS:
- 122929-08-2
Corazonin, a neuropeptide in insects, regulates caste identity and behavior, mainly in workers/foragers.
Formula:C₆₂H₈₃N₁₇O₁₉
Color and Shape:Solid
Molecular weight:1370.42
Ref: TM-T76183
+ Info
GHRF, porcine
CAS:
- 88384-73-0
GHRF, porcine, a growth hormone releasing factor (GHRF) peptide (porcine), binds to the growth hormone secretagogue receptor (GHSR), thereby inducing the
Formula:C₂₁₉H₃₆₅N₇₃O₆₆S
Color and Shape:Solid
Molecular weight:5108.76
Ref: TM-T76318
+ Info
dCNP
dCNP binds to NPR-B/C receptors (NPR-B/C receptor), initiating the cGMP signaling pathway and regulating vascular function. It exhibits anti-hypoxic effects by downregulating hypoxia-related genes such as HIF1α and HIF2α. Additionally, dCNP inhibits tumor stroma induction, demonstrating antifibrotic properties. It also enhances immune response by upregulating CTL, NK cells, and conventional type 1 dendritic cells in tumors.
Formula:C₁₄₁H₂₄₈N₃₈O₃₆S₃
Color and Shape:Solid
Molecular weight:3147.91
Ref: TM-TP3063
+ Info
[Nle11]-Substance P
CAS:
- 57462-42-7
'[Nle11]-Substance P is a gut and brain peptide, resisting methionine oxidation and causing excitatory neural effects.'
Formula:C₆₄H₁₀₀N₁₈O₁₃
Purity:98%
Color and Shape:Solid
Molecular weight:1329.59
Ref: TM-TP1831
+ Info
NI-203
NI-203 is a monoclonal antibody inhibitor that targets amylin and shows potential for research in type 2 diabetes.
Color and Shape:Odour Liquid
Ref: TM-T9901A-993
+ Info
PG106 TFA
PG106 TFA is a potent hMC3 antagonist (IC50=210 nM), inactive at hMC4 (EC50=9900 nM) and hMC5 receptors.
Formula:C₅₃H₇₀F₃N₁₃O₁₁
Color and Shape:Solid
Molecular weight:1122.2
Ref: TM-T75848
+ Info
Human growth hormone-releasing factor TFA
Human growth hormone-releasing factor TFA is a hypothalamic peptide that promotes GH secretion by targeting pituitary GHRHR.
Formula:C₂₁₇H₃₅₉F₃N₇₂O₆₈S
Color and Shape:Solid
Molecular weight:5153.67
Ref: TM-T75713
+ Info
NSC380324
NSC380324 is a P2Y12 receptor antagonist with antiplatelet properties, which can be employed in research on atherosclerotic cardiovascular diseases.
Formula:C₃₁H₂₄N₄O₄
Color and Shape:Solid
Molecular weight:516.55
Ref: TM-T205528
+ Info
Paynantheine
CAS:
- 4697-66-9
Paynantheine is an alkaloid with antinociceptive properties, found in Mitragyna speciosa. It also acts as an agonist at 5-HT1AR and 5-HT2BR receptors, inducing lower lip contraction and providing antinociception in rats.
Formula:C₂₃H₂₈N₂O₄
Color and Shape:Solid
Molecular weight:396.48
Ref: TM-T203202
+ Info
Adrenomedullin (11-50), rat
CAS:
- 163648-32-6
Adrenomedullin 11-50 rat is a peptide, stimulates CGRP1 receptor for vasodilation, used in bone growth research.
Formula:C₁₉₄H₃₀₄N₅₈O₅₉S₄
Purity:98%
Color and Shape:Solid
Molecular weight:4521.17
Ref: TM-TP1625
+ Info
5-HT1AR/5-HT6R ligand-1
5-HT1AR/5-HT6R ligand-1 (Compound PP13) functions as a ligand for the 5-HT receptor, demonstrating high affinity for 5-HT1AR, 5-HT6R, and 5-HT7R with Ki values of 19, 69, and 198 nM, respectively. In HEK293 cells, it inhibits cAMP production with EC50 values of 1535, 488, and 53 nM for these receptors. Additionally, 5-HT1AR/5-HT6R ligand-1 exhibits antiproliferative effects on several cancer cell lines, including 1321N1, U87MG, MCF7, and AsPC-1, with IC50 values of 9.6, 13.6, 19.3, and 14.6 μM, respectively. The compound also shows antagonistic activity towards the dopamine receptor D2R, with a Ki of 1903 nM.
Formula:C₂₅H₂₉ClN₄O₂S
Color and Shape:Solid
Molecular weight:485.04
Ref: TM-T205634
+ Info
A6770
CAS:
- 1331754-16-5
A6770 inhibits S1P lyase, causing [3H]dhS1P build-up in IT-79MTNC3 cells (EC50 <0.01 μM); less effective with vitamin B6 (EC50 <100 μM).
Formula:C₆H₈N₂O₂
Color and Shape:Solid
Molecular weight:140.142
Ref: TM-T36833
+ Info
Urotensin I
CAS:
- 83930-33-0
Urotensin I, 41-aa neuropeptide, agonist for human/rat CRF receptors, lowers blood pressure in rats, isolated from white suckers.
Formula:C₂₁₀H₃₄₀N₆₂O₆₇S₂
Purity:98%
Color and Shape:Solid
Molecular weight:4869.46
Ref: TM-TP1199
+ Info
WS 9326A
CAS:
- 125774-71-2
WS 9326A is an antagonist of tachykinin receptor from Streptomyces violaceusniger.
Formula:C₅₄H₆₈N₈O₁₃
Purity:98%
Color and Shape:Solid
Molecular weight:1037.181
Ref: TM-T26333
+ Info
Neuropeptide W-30 (rat)
CAS:
- 383415-90-5
Neuropeptide W-30 (rat) acts as a crucial stress mediator within the central nervous system, influencing the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. It serves as an endogenous ligand for the two related orphan G-protein-coupled receptors (GPCRs), GPR7 and GPR8. NPW-30 binds and activates both GPR7 and GPR8 at comparable effective doses [1] [2] [3].
Formula:C₁₆₅H₂₄₉N₄₉O₃₈S
Color and Shape:Solid
Molecular weight:3559.11
Ref: TM-TP2611
+ Info
CCR8 antagonist 1
CAS:
- 723304-76-5
CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.
Formula:C₂₆H₂₉N₃O₅S
Purity:99.51%
Color and Shape:Solid
Molecular weight:495.59
Ref: TM-T9983
+ Info
PF-232798
CAS:
- 849753-15-7
PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity.
Formula:C₂₉H₄₀FN₅O₂
Color and Shape:Solid
Molecular weight:509.66
Ref: TM-T28381
+ Info
PROTAC(H-PGDS)-8
CAS:
- 2761281-51-8
PROTAC(H-PGDS)-8 is a PROTAC degrader targeting Hematopoietic prostaglandin D synthase (H-PGDS), exhibiting an IC50 of 0.14 μM [1].
Formula:C₄₁H₄₀N₈O₇
Color and Shape:Solid
Molecular weight:756.81
Ref: TM-T84924
+ Info
(-)-Eseroline fumarate
CAS:
- 70310-73-5
(-)-Eseroline fumarate, a Physostigmine metabolite and AChE inhibitor, triggers cancer cell LDH release and neuronal cell death.
Formula:C₁₇H₂₂N₂O₅
Color and Shape:Solid
Molecular weight:334.37
Ref: TM-T73930
+ Info
MGV354
MGV354 is a soluble activator of guanylate cyclase(sGC) with EC 50 s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively [1] [2].
Formula:C₃₅H₃₇N₅O₃
Purity:98%
Color and Shape:Solid
Molecular weight:575.7
Ref: TM-T12888
+ Info
GS-2278
CAS:
- 2750508-72-4
GS-2278 is an antagonist of LPAR1 (lysophosphatidic acid receptor 1) with potential applications in the study of idiopathic pulmonary fibrosis (IPF).
Formula:C₂₂H₁₆F₅N₉O₃
Color and Shape:Solid
Molecular weight:549.41
Ref: TM-T203480
+ Info
L-797,591
CAS:
- 217480-24-5
L-797,591 is a selective agonist of somatostatin receptor subtype 1.
Formula:C₃₈H₄₉N₅O₂
Color and Shape:Solid
Molecular weight:607.83
Ref: TM-T27787
+ Info
9-deoxy-9-methylene Prostaglandin E2
CAS:
- 61263-32-9
9-deoxy-9-methylene PGE2: stable PGE2 analog with similar effects, less side effects, equal potency in rats, gerbils, primates.
Formula:C₂₁H₃₄O₄
Color and Shape:Solid
Molecular weight:350.499
Ref: TM-T36728
+ Info
Sarafotoxin S6a
CAS:
- 126738-34-9
Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.
Formula:C₁₀₅H₁₅₆N₂₈O₃₄S₅
Purity:98%
Color and Shape:Solid
Molecular weight:2514.85
Ref: TM-TP2119
+ Info
Poly-D-lysine hydrobromide (MW 150000-300000)
Poly-D-lysine hydrobromide (MW 150000-300000) enhances neural cell adhesion in culture and acts as a calcium-sensing receptor agonist peptide in research.
Color and Shape:Odour Solid
Ref: TM-TCL-01090
+ Info
Hemopressin (human, mouse)
CAS:
- 1314035-51-2
Endogenous peptide, inhibits ep24.15/24.16/ACE with Ki of 27.76/3.43/1.87 μM. Lowers blood pressure, CB1 inverse agonist, reduces pain in vivo.
Formula:C₅₀H₇₉N₁₃O₁₂
Purity:98%
Color and Shape:Solid
Molecular weight:1054.26
Ref: TM-TP1900
+ Info
α1A-AR Degrader 9c
CAS:
- 2863635-02-1
α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM.
Formula:C₃₈H₄₃N₁₁O₁₁
Purity:98%
Color and Shape:Solid
Molecular weight:829.82
Ref: TM-T74557
+ Info
5-HT2A receptor agonist-5
CAS:
- 2957888-63-8
5-HT2A receptor agonist-5 (compound I-3) is a potent 5-HT2A agonist with a Ki value of 0.017 µM and exhibits antidepressant activity.
Formula:C₂₃H₂₉N₃O
Color and Shape:Solid
Molecular weight:363.5
Ref: TM-T203649
+ Info
Upacicalcet HCl
Upacicalcet HCl, a calcium mimetic, reduces blood PTH by targeting parathyroid receptors; treats secondary hyperparathyroidism.
Formula:C₁₁H₁₅Cl₂N₃O₆S
Purity:98.56%
Color and Shape:Soild
Molecular weight:388.22
Ref: TM-T29067L
+ Info
Prostaglandin D2 methyl ester
CAS:
- 49852-81-5
PGD2: made in mast cells during allergic reactions, causes vasodilation and inhibits blood clots. PGD2 methyl ester is a similar, fat-soluble prodrug.
Formula:C₂₁H₃₄O₅
Color and Shape:Solid
Molecular weight:366.498
Ref: TM-T36545
+ Info
PG 106 acetate
PG 106 acetate: Selective hMC3 receptor antagonist, IC50=210 nM; inactive on hMC5 and hMC4, EC50=9900 nM.
Formula:C₅₃H₇₃N₁₃O₁₁
Purity:98.24%
Color and Shape:Solid
Molecular weight:1068.23
Ref: TM-TP1952L
+ Info
GLP-1 moiety from Dulaglutide
GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide which is a glucagon-like peptide 1 receptor (GLP-1) agonist.
Formula:C₁₄₉H₂₂₁N₃₇O₄₉
Purity:98%
Color and Shape:Solid
Molecular weight:3314.62
Ref: TM-TP1316
+ Info
Cannabidiolic acid methyl ester
CAS:
- 55658-71-4
Cannabidiolic acid methyl ester (HU-580) is an orally active analogue of cannabidiolic acid. It enhances the activation of 5-HT1A receptors and increases the expression of c-Fos and NeuN in specific hypothalamic nuclei in rats. Cannabidiolic acid methyl ester exhibits anti-nausea, anxiolytic, and anti-nociceptive effects.
Formula:C₂₃H₃₂O₄
Color and Shape:Solid
Molecular weight:372.5
Ref: TM-T203571
+ Info
Surfagon
CAS:
- 52435-06-0
Surfagon is an effective LHRH agonist.
Formula:C₅₆H₇₈N₁₆O₁₂
Purity:98%
Color and Shape:Solid
Molecular weight:1167.34
Ref: TM-T26239
+ Info
AR ligand 40
AR ligand 40 (compound 19c) is an Adenosine A1 Receptor ligand with antagonistic activity. It exhibits antiproliferative effects on SW480, SW48, HCT116, K562, MDA-MB-231, and A549 cells, with EC50 values of 7, 10, 12, 13, 15, and 39 μM, respectively.
Formula:C₂₁H₂₅N₅
Color and Shape:Solid
Molecular weight:347.211
Ref: TM-T207383
+ Info
INCB 3284 dimesylate
CAS:
- 887401-93-6
INCB 3284 dimesylate: oral CCR2 antagonist, blocks MCP-1/hCCR2 binding (IC50: 3.7 nM), potential in acute liver failure research.
Formula:C₂₈H₃₉F₃N₄O₁₀S₂
Purity:98%
Color and Shape:Solid
Molecular weight:712.76
Ref: TM-T11647
+ Info
Histamine H4 receptor antagonist-1
CAS:
- 1246207-84-0
Histamine H4 receptor antagonist-1 is a potent antagonist of the histamine H4 receptor.
Formula:C₃₀H₃₈N₈O₂
Color and Shape:Solid
Molecular weight:542.68
Ref: TM-T38634
+ Info
GPR55 agonist 4
GPR55 agonist 4 (Compound 28), with an EC50 of 131 nM for hGPR55 and 1.41 nM for rGPR55, effectively induces β-arrestin recruitment to human GPR55 [1].
Formula:C₁₉H₁₆FN₅O₂
Color and Shape:Solid
Molecular weight:365.36
Ref: TM-T79744
+ Info
O-Desethyl Dapagliflozin
CAS:
- 864070-37-1
O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM.
Formula:C₁₉H₂₁ClO₆
Purity:98.33%
Color and Shape:Solid
Molecular weight:380.82
Ref: TM-T67849
+ Info
Cetirizine Impurity D
CAS:
- 346451-15-8
Cetirizine Impurity D, an antihistamine derivative, acts as a long-lasting H1-receptor antagonist with antiallergic effects.
Formula:C₃₀H₂₈Cl₂N₂
Color and Shape:Solid
Molecular weight:487.46
Ref: TM-T40430
+ Info
ACT-1016-0707
CAS:
- 2569467-78-1
ACT-1016-0707 is a selective, insurmountable LPA1 antagonist with antifibrotic and anti-inflammatory activity in lung fibrosis models
Formula:C₁₉H₂₃ClN₄O₄S
Purity:99.905%
Color and Shape:Solid
Molecular weight:438.93
Ref: TM-T85589
+ Info
J-115814
CAS:
- 329716-61-2
J-115814 is a potent feeding stimulant.
Formula:C₂₉H₃₈ClN₅O₃S
Color and Shape:Solid
Molecular weight:572.16
Ref: TM-T32246
+ Info
Agaridoxin
CAS:
- 58298-77-4
Agaridoxin is a mushroom metabolite.
Formula:C₁₁H₁₄N₂O₅
Color and Shape:Solid
Molecular weight:254.242
Ref: TM-T29709
+ Info
(R)-V-0219 hydrochloride
(R)-V-0219 hydrochloride: Oral GLP-1R PAM, enantiomer of V-0219, triggers Ca2+ flux in hGLP-1R HEK cells.
Formula:C₂₀H₂₆ClF₃N₄O₂
Color and Shape:Solid
Molecular weight:446.89
Ref: TM-T74264
+ Info
GM-60186
GM-60186, a potent inhibitor of the 5-HT receptor 2B (HTR2B) with an IC50 of 257 nM, effectively suppresses the proliferation and migration of colorectal cancer cells.
Formula:C₃₀H₃₃FN₂O₄
Color and Shape:Solid
Molecular weight:504.59
Ref: TM-T201190
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Femoxetine
CAS:
- 59859-58-4
Femoxetine: antidepressant, enhances morphine, inhibits MAO-A/B, boosts mice's exercise capacity.
Formula:C₂₀H₂₅NO₂
Purity:99.1% - 99.35%
Color and Shape:Solid
Molecular weight:311.42
Ref: TM-T68069
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CB1R agonist 1
CB1R agonist 1 (Compound '1350) is a potent full agonist of the cannabinoid-1 receptor (CB1R) with a Ki value of 0.95 nM. It demonstrates significant pain-relieving effects in various pain models, including acute thermal pain, inflammatory pain, and neuropathic pain.
Formula:C₂₀H₁₈F₃N₃O₃S
Color and Shape:Solid
Molecular weight:437.435
Ref: TM-T206337
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[Sar9] Substance P
CAS:
- 77128-75-7
[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.
Formula:C₆₄H₁₀₀N₁₈O₁₃S
Purity:98%
Color and Shape:Solid
Molecular weight:1361.66
Ref: TM-TP1862
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Neuropeptide Y 13-36 (porcine)
CAS:
- 113662-54-7
Neuropeptide Y 13-36 (porcine) is a selective neuropeptide Y2 receptor agonist.
Formula:C₁₃₅H₂₀₉N₄₁O₃₆
Color and Shape:Solid
Molecular weight:2982.408
Ref: TM-T36447
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Substance P (1-9)
CAS:
- 57468-17-4
Substance P (1-9), a nonapeptide, slows its own inactivation and stimulates neurons.
Formula:C₅₂H₇₇N₁₅O₁₂
Purity:98%
Color and Shape:Solid
Molecular weight:1104.26
Ref: TM-TP1819
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2-Methyl-N,N-dimethyltryptamine
CAS:
- 1080-95-1
2-Methyl-N,N-dimethyltryptamine (2,N,N-TMT, compound 15) exhibits binding affinity for the serotonin (5-HT) receptor, with a pA2 value of 6.04. It plays a significant role in neurological disease research.
Formula:C₁₃H₁₈N₂
Color and Shape:Solid
Molecular weight:202.3
Ref: TM-T203691
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8-iso Prostaglandin E2
CAS:
- 27415-25-4
"8-iso PGE2: Isoprostane from arachidonic acid, potent rat renal vasoconstrictor, reduces GFR and renal flow by 80%, no BP effect."
Formula:C₂₀H₃₂O₅
Color and Shape:Solid
Molecular weight:352.47
Ref: TM-T36160
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3-Deoxyglucosone
CAS:
- 4084-27-9
3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein
Formula:C₆H₁₀O₅
Purity:95%
Color and Shape:Solid
Molecular weight:162.14
Ref: TM-T19117
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RF9 acetate
RF9 acetate is an effective and selective antagonist of Neuropeptide FF receptor with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
Formula:C₂₈H₄₂N₆O₅
Purity:99.77%
Color and Shape:Solid
Molecular weight:542.67
Ref: TM-T16738L
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Ramelteon metabolite M-II
CAS:
- 896736-21-3
Ramelteon M-II binds MT1/MT2 with IC50s: 208/1470 pM; it's the main metabolite and a melatonin receptor agonist.
Formula:C₁₆H₂₁NO₃
Purity:98%
Color and Shape:Solid
Molecular weight:275.34
Ref: TM-T12689
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MK-7246 S enantiomer
MK-7246 S enantiomer is a potent and selective CRTH2 antagonist.
Formula:C₂₁H₂₁FN₂O₄S
Purity:98%
Color and Shape:Solid
Molecular weight:416.47
Ref: TM-T12067
+ Info
Spns2-IN-2
Spns2-IN-2 (compound 3a) is an inhibitor of SPNS2.
Formula:C₂₂H₃₀ClN₃O₂
Color and Shape:Solid
Molecular weight:403.95
Ref: TM-T200979
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Vicasinabin
CAS:
- 1433361-02-4
Vicasinabin: potent CB2 agonist; researches chronic pain, atherosclerosis, bone mass, neuroinflammation.
Formula:C₁₅H₂₂N₁₀O
Color and Shape:Solid
Molecular weight:358.41
Ref: TM-T38912
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GLP-1R agonist 16
CAS:
- 2763329-13-9
Compound 115a, a GLP-1R agonist, effectively activates the GLP-1 receptor with an EC50 of 0.15 nM [1].
Formula:C₅₀H₅₈FN₁₀O₆P
Color and Shape:Solid
Molecular weight:945.03
Ref: TM-T74610
+ Info
σ1 Receptor ligand 1
σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.
Formula:C₂₂H₂₈N₂O₂
Color and Shape:Solid
Molecular weight:352.47
Ref: TM-T201225
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PD 142893
CAS:
- 143037-36-9
PD 142893 is a functional endothelin-stimulated vasoconstriction antagonist.
Formula:C₅₀H₆₅N₇O₁₀
Purity:98%
Color and Shape:Solid
Molecular weight:924.09
Ref: TM-T25922
+ Info
Neuropeptide FF
CAS:
- 99566-27-5
Endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively).
Formula:C₅₄H₇₆N₁₄O₁₀
Purity:98%
Color and Shape:Solid
Molecular weight:1081.27
Ref: TM-TP1074
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Hemokinin 1, human TFA
Hemokinin-1 is a human TFA and selective NK1 agonist; also activates NK2 & NK3 and induces opioid-independent analgesia.
Formula:C₅₆H₈₅F₃N₁₄O₁₆S
Color and Shape:Solid
Molecular weight:1299.42
Ref: TM-T75840
+ Info
Neuropeptide Y5 receptor ligand-1
CAS:
- 322723-35-3
Neuropeptide Y5 receptor ligand-1 (Compound 54), a carbazole derivative, acts as a powerful antagonist to the neuropeptide Y5 (NPY-5) receptor [1].
Formula:C₁₉H₁₇N₃O₂
Color and Shape:Solid
Molecular weight:319.36
Ref: TM-T74654
+ Info
Fenoldopam
CAS:
- 67227-56-9
Fenoldopam is a selective D1-like dopamine receptor partial agonist (EC50 = 57 nM).
Formula:C₁₆H₁₆ClNO₃
Purity:98%
Color and Shape:Solid
Molecular weight:305.76
Ref: TM-T22779
+ Info
GB-110 hydrochloride
GB-110 HCl: potent, nonpeptidic oral PAR2 agonist; triggers Ca2+ release in HT29 cells; EC50 0.28 μM.
Formula:C₃₃H₄₉ClN₆O₅
Color and Shape:Solid
Molecular weight:645.23
Ref: TM-T73854
+ Info
Pramlintide TFA
Pramlintide TFA, a polypeptide analogue of human amylin and an antidiabetic agent, exhibits antineoplastic properties in colorectal cancer [1].
Formula:C₁₇₃H₂₆₈N₅₁F₃O₅₅S₂
Color and Shape:Solid
Molecular weight:4063.4
Ref: TM-T75709
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15-keto Latanoprost
CAS:
- 135646-98-9
Latanoprost, a PG analog for ocular pressure, metabolizes into 15-keto latanoprost, a less potent variant reducing intraocular pressure and pupil size.
Formula:C₂₆H₃₈O₅
Color and Shape:Solid
Molecular weight:430.58
Ref: TM-T37932
+ Info
Benzoquinamide hydrochloride
CAS:
- 113-69-9
Benzoquinamide hydrochloride (3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride) is an antiemetic
Formula:C₂₂H₃₃ClN₂O₅
Purity:97.13% - 99.56%
Color and Shape:Solid
Molecular weight:440.96
Ref: TM-T9881
+ Info
d[Leu4,Lys8]-VP
CAS:
- 42061-33-6
Vasopressin V1B agonist; Ki: 0.16nM V1B, 64nM oxytocin; weak antidiuretic/vasopressor; minimal oxytocic action.
Formula:C₄₇H₆₇N₁₁O₁₁S₂
Purity:98%
Color and Shape:Solid
Molecular weight:1026.2
Ref: TM-TP1927
+ Info
Dexchlorpheniramine free base
CAS:
- 25523-97-1
Dexchlorpheniramine Maleate, a histamine receptor antagonist, is used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus.
Formula:C₁₆H₁₉ClN₂
Purity:98%
Color and Shape:Oily Liquid Solid
Molecular weight:274.79
Ref: TM-T0785L
+ Info
Alosetron
CAS:
- 122852-42-0
Alosetron, a 5-HT3 antagonist, is used for the management of severe diarrhea-predominant irritable bowel syndrome (IBS) in women only.
Formula:C₁₇H₁₈N₄O
Purity:98%
Color and Shape:Crystalline Powder
Molecular weight:294.36
Ref: TM-T21235
+ Info
[D-Trp8]-γ-MSH
CAS:
- 321351-81-9
[D-Trp8]-γ-MSH is a selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively).
Formula:C₇₄H₉₉N₂₁O₁₆S
Purity:98%
Color and Shape:Solid
Molecular weight:1570.79
Ref: TM-TP1893
+ Info
Galanin Receptor Ligand M35
CAS:
- 142846-71-7
M35, a galanin(1-13)-bradykinin(2-9) amide, acts as a galanin antagonist in rats and inhibits mouse pancreatic islets.
Formula:C₁₀₇H₁₅₃N₂₇O₂₆
Purity:98%
Color and Shape:Solid
Molecular weight:2233.6
Ref: TM-TP1662
+ Info
Sphinganine 1-phosphate
CAS:
- 19794-97-9
Sphinganine 1-phosphate has protects kidney and liver through activation of the S1P1 receptor in mice and acts as an agonist for S1P4 in Homo sapien.
Formula:C₁₈H₄₀NO₅P
Color and Shape:Solid
Molecular weight:381.49
Ref: TM-T39401
+ Info
B7-33
CAS:
- 1818415-56-3
B7-33 is a single-chain relaxin analog and a selective agonist for relaxin receptor 1 (RXFP1). It binds to RXFP1 and preferentially activates the pERK pathway in cells expressing RXFP1, rather than cAMP. B7-33 serves as an antifibrotic agent and provides cardioprotective effects.
Formula:C₁₃₁H₂₂₉N₄₁O₃₆S
Color and Shape:Solid
Molecular weight:2986.54
Ref: TM-TP2903
+ Info
[Ala11,D-Leu15]-Orexin B acetate
[Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM).
Formula:C₁₂₂H₂₁₀N₄₄O₃₇S
Purity:98.18%
Color and Shape:Solid
Molecular weight:2917.31
Ref: TM-TP1975L
+ Info
(±)14(15)-EpETE
CAS:
- 131339-24-7
(±)14(15)-EpETE is an intestinal microbial lipid metabolite that attenuates cisplatin chemotherapy-induced nausea in rats by inhibiting Substance P release.
Formula:C₂₀H₃₀O₃
Color and Shape:Solid
Molecular weight:318.45
Ref: TM-T37234
+ Info
Protease-Activated Receptor-1 antagonist 2
CAS:
- 1454588-34-1
Orally active PAR-1 antagonist with 7 nM IC50; potential for CVD research.
Formula:C₂₄H₂₃F₂N₃O₂
Color and Shape:Solid
Molecular weight:423.46
Ref: TM-T74266
+ Info
Spantide I
CAS:
- 91224-37-2
Spantide antagonizes both bombesin & substance P. It is also tachykinin receptor antagonist.
Formula:C₇₅H₁₀₈N₂₀O₁₃
Purity:98%
Color and Shape:Solid
Molecular weight:1497.79
Ref: TM-T20413
+ Info
γ1-MSH
CAS:
- 72629-65-3
Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4.
Formula:C₇₂H₉₇N₂₁O₁₄S
Purity:98%
Color and Shape:Solid
Molecular weight:1512.76
Ref: TM-TP1892
+ Info
S 16474
CAS:
- 149250-10-2
S 16474 is an antagonist of Neurokinin-1 Receptor.
Formula:C₄₄H₄₈N₆NaO₈
Purity:98%
Color and Shape:Solid
Molecular weight:811.892
Ref: TM-T26169
+ Info
DOAM
CAS:
- 63779-90-8
DOAM is an antagonist of the 5-HT2 receptor.
Formula:C₁₆H₂₇NO₂
Color and Shape:Solid
Molecular weight:265.39
Ref: TM-T203364
+ Info
GLP-1R agonist 27
GLP-1R agonist 27 (compound 21) is a potent and orally active GLP-1R agonist. It enhances the accumulation of cyclic adenosine monophosphate (cAMP), reduces blood glucose levels, and decreases food intake. GLP-1R agonist 27 shows potential for research in obesity and type 2 diabetes mellitus (T2DM).
Formula:C₃₂H₃₃N₅O₄Se
Color and Shape:Solid
Molecular weight:630.6
Ref: TM-T204289
+ Info
MDL 29913
CAS:
- 135721-56-1
NK2 tachykinin receptor selective antagonist.
Formula:C₄₀H₅₆N₈O₆
Purity:98%
Color and Shape:Solid
Molecular weight:745
Ref: TM-TP1998
+ Info
BMS-604992 free base
CAS:
- 760944-56-7
BMS-604992 (EX-1314), a selective GHSR agonist, binds strongly (ki=2.3 nM), is orally active, and increases rodent food intake.
Formula:C₂₄H₃₁N₇O₅
Color and Shape:Solid
Molecular weight:497.556
Ref: TM-T40876
+ Info
Conessine hydrobromide
CAS:
- 5913-82-6
Conessine hydrobromide is a naturally occurring steroid alkaloid and has been used in traditional herbal medicine as a treatment for amoebic dysentery.
Formula:C₂₄H₄₁BrN₂
Color and Shape:Solid
Molecular weight:437.51
Ref: TM-T31006
+ Info
Vapiprost hydrochloride
CAS:
- 87248-13-3
Vapiprost hydrochloride is a biochemicla.
Formula:C₃₀H₄₀ClNO₄
Color and Shape:Solid
Molecular weight:514.1
Ref: TM-T35038
+ Info
MM 07
CAS:
- 1876450-21-3
Biased agonist for apelin/G protein pathway, enhances eNOS and cell growth, reduces apoptosis, improves heart function, and dilates vessels.
Formula:C₆₇H₁₀₆N₂₂O₁₄S₃
Purity:98%
Color and Shape:Solid
Molecular weight:1539.9
Ref: TM-TP2000
+ Info
Mosliciguat
CAS:
- 2231749-54-3
Mosliciguat is a guanylate cyclase activator.
Formula:C₄₁H₃₆ClF₃N₂O₅
Color and Shape:Solid
Molecular weight:729.19
Ref: TM-T39723
+ Info
Obestatin(rat)
CAS:
- 869705-22-6
Endogenous peptide that suppresses food intake and body weight-gain
Formula:C₁₁₄H₁₇₄N₃₄O₃₁
Purity:98%
Color and Shape:Solid
Molecular weight:2516.81
Ref: TM-TP2279
+ Info
5-HT2C agonist-4
CAS:
- 2730085-33-1
Compound 3i, a 5-HT2C agonist-4, acts as an agonist for the 5-HT2C receptor with an EC50 of 5.7 nM. It is capable of reducing locomotor activity in zebrafish larvae.
Formula:C₂₄H₂₅N₅O
Color and Shape:Solid
Molecular weight:399.49
Ref: TM-T203570
+ Info
ARC 239 dihydrochloride
CAS:
- 55974-42-0
ARC 239 dihydrochloride is a selective α2B adrenoceptor antagonist (pKD values are 8.8, 6.7 and 6.4 at α2B, α2A, and α2D receptors respectively).
Formula:C₂₄H₃₁Cl₂N₃O₃
Purity:99.72%
Color and Shape:Solid
Molecular weight:480.43
Ref: TM-T22033
+ Info
Tecastemizole
CAS:
- 75970-99-9
Tecastemizole (R 43512) is a selective antagonist of H1 receptor and a major metabolite of astemizole with anti-inflammatory effects.
Formula:C₁₉H₂₁FN₄
Purity:99.70%
Color and Shape:Solid
Molecular weight:324.4
Ref: TM-T26253
+ Info
HAEGTFTSDVS acetate
HAEGTFTSDVS acetate is the first N-terminal 1-11 residues of GLP-1 which stimulates insulin secretion from pancreatic β-cells.
Formula:C₅₀H₇₅N₁₃O₂₂
Purity:97.47%
Color and Shape:Solid
Molecular weight:1210.2
Ref: TM-TP1382L
+ Info
Brexpiprazole S-oxide
CAS:
- 1191900-51-2
Brexpiprazole S-oxide is the main metabolite of Brexpiprazole, a human 5-HT1A and dopamine receptor partial agonist (Ki: 0.12, 0.3 nM).
Formula:C₂₅H₂₇N₃O₃S
Purity:98%
Color and Shape:Solid
Molecular weight:449.57
Ref: TM-T10612
+ Info
Dapoxetine
CAS:
- 119356-77-3
Dapoxetine (Dapoxetina) is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation.
Formula:C₂₁H₂₃NO
Purity:99.73%
Color and Shape:White To Off-White Crystalline Powder
Molecular weight:305.42
Ref: TM-T0039
+ Info
Eledoisin Related Peptide
CAS:
- 2990-43-4
Eledoisin Related Peptide (Eledoisin RP) is a tachykinin receptor ligand.
Formula:C₃₄H₅₈N₈O₆S
Purity:98%
Color and Shape:Solid
Molecular weight:706.94
Ref: TM-T7631
+ Info
Maridebart
CAS:
- 2761478-99-1
Maridebart is a humanized IgG1-kappa monoclonal antibody that targets the GIPR (gastric inhibitory polypeptide receptor) [1].
Color and Shape:Liquid
Ref: TM-T81862
+ Info
Tiaprost
CAS:
- 71116-82-0
Tiaprost is a analog of prostaglandin F2α .
Formula:C₂₀H₂₈O₆S
Purity:98%
Color and Shape:Solid
Molecular weight:396.5
Ref: TM-T17092
+ Info
Oxyntomodulin
CAS:
- 62340-29-8
GLP-1 analog modulates appetite, boosts metabolism, and curbs gastric acid. Increases cAMP, mildly stimulates glucagon receptor.
Formula:C₁₉₂H₂₉₅N₅₉O₆₀S
Purity:98%
Color and Shape:Solid
Molecular weight:4421.86
Ref: TM-TP1976
+ Info
(3R,5R,6S)-Atogepant
(3R,5R,6S)-Atogepant (MK-8031) is a CGRP antagonist enantiomer used in migraine research.
Formula:C₂₉H₂₃F₆N₅O₃
Color and Shape:Solid
Molecular weight:603.52
Ref: TM-T73703