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GPCR/G-Protein

GPCR/G-Protein

GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.

Subcategories of "GPCR/G-Protein"

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Found 5378 products of "GPCR/G-Protein"

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  • Metaraminol
    Targetmol
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    Metaraminol

    CAS:
    <p>Metaraminol is a sympathomimetic agent that acts predominantly at alpha-1 adrenergic receptors.</p>
    Formula:C9H13NO2
    Color and Shape:Solid
    Molecular weight:167.21

    Ref: TM-T0279L

  • BMS-604992 dihydrochloride
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    BMS-604992 dihydrochloride

    CAS:
    <p>BMS-604992 dihydrochloride is a selective GHSR agonist with high affinity (Ki=2.3 nM) and potent activity (EC50=0.4 nM), stimulating rodent appetite.</p>
    Formula:C24H33Cl2N7O5
    Color and Shape:Solid
    Molecular weight:570.47

    Ref: TM-T38959

  • CCR6 inhibitor 1
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    CCR6 inhibitor 1

    CAS:
    <p>CCR6 inhibitor 1 selectively blocks CCR6 (0.45 nM in monkeys, 6 nM in humans), aiding in vitro/vivo disease studies.</p>
    Formula:C24H23F3N4O3S
    Purity:99.89%
    Color and Shape:Solid
    Molecular weight:504.52

    Ref: TM-T10715

  • Des His1, Glu8 Exendin-4
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    Des His1, Glu8 Exendin-4

    <p>Des His1, Glu8 Exendin-4 is a glucagon-like peptide-1 receptor (GLP1R) antagonist that regulates blood glucose and is used in the study of diabetes and obesity.</p>
    Formula:C179H277N47O59S
    Purity:99.92%
    Color and Shape:Solid
    Molecular weight:4063.46

    Ref: TM-T76291

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    JKC363 TFA

    <p>JKC363 TFA is an MC4 receptor antagonist with 90x more affinity than MC3 (IC50: 0.5 nM vs 44.9 nM), blocks α-MSH's effect on TRH, and is anti-hyperalgesic.</p>
    Formula:C71H93F3N19O18S2
    Color and Shape:Solid
    Molecular weight:1620.73

    Ref: TM-T75850

  • PSB 0777 ammonium salt
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    PSB 0777 ammonium salt

    CAS:
    <p>adenosine A2A receptor full agonist</p>
    Formula:C18H24N6O7S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:500.55

    Ref: TM-T23196

  • (+)-Oxypeucedanin methanolate
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    (+)-Oxypeucedanin methanolate

    CAS:
    <p>(+)-Oxypeucedanin methanolate (compound 9) is a natural compound that inhibits prostaglandin E2 production [1].</p>
    Formula:C17H18O6
    Color and Shape:Solid
    Molecular weight:318.32

    Ref: TM-T75620

  • PEN (human)
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    PEN (human)

    CAS:
    <p>PEN (human) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.</p>
    Formula:C97H159N27O32
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2215.49

    Ref: TM-TP1949

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    a-Helical Corticotropin Releasing Factor (9-41)

    CAS:
    <p>α-Helical CRF (9-41) is a CRF antagonist that lowers in vivo plasma GH levels.</p>
    Formula:C166H273N45O54S2
    Color and Shape:Solid
    Molecular weight:3827.34

    Ref: TM-T76204

  • [D-Trp34]-Neuropeptide Y Acetate
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    [D-Trp34]-Neuropeptide Y Acetate

    <p>[D-Trp34]-Neuropeptide Y Acetate is a potent Y5 receptor agonist that increases rat food intake; less potent at Y1, Y2, Y4, Y6.</p>
    Formula:C198H293N55O58
    Purity:99.73%
    Color and Shape:Soild
    Molecular weight:4371.78

    Ref: TM-TP1984L

  • Luseogliflozin hydrate
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    Luseogliflozin hydrate

    CAS:
    <p>Luseogliflozin hydrate: SGLT2 inhibitor, IC50 2.26 nM, oral, for type 2 diabetes research.</p>
    Formula:C23H32O7S
    Color and Shape:Solid
    Molecular weight:452.56

    Ref: TM-T38539

  • Dexbrompheniramine maleate
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    Dexbrompheniramine maleate

    CAS:
    <p>Dexbrompheniramine is an antihistamine used for hay fever and urticaria, blocking H1 receptors in the body.</p>
    Formula:C20H23BrN2O4
    Color and Shape:Solid
    Molecular weight:435.318

    Ref: TM-T31396

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    GLP-1 moiety from Dulaglutide

    <p>GLP-1 moiety from Dulaglutide is a 31-amino acid fragment of Dulaglutide which is a glucagon-like peptide 1 receptor (GLP-1) agonist.</p>
    Formula:C149H221N37O49
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3314.62

    Ref: TM-TP1316

  • J-115814
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    J-115814

    CAS:
    <p>J-115814 is a potent feeding stimulant.</p>
    Formula:C29H38ClN5O3S
    Color and Shape:Solid
    Molecular weight:572.16

    Ref: TM-T32246

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    Glucagon-like peptide 1 (1-37), human TFA

    <p>Human Glucagon-like peptide 1 (1-37) TFA is a potent GLP-1 receptor agonist derived from proglucagon.</p>
    Formula:C188H276N51F3O61
    Purity:98%
    Color and Shape:Solid
    Molecular weight:4283.5

    Ref: TM-TP1147

  • Substance P (1-9)
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    Substance P (1-9)

    CAS:
    <p>Substance P (1-9), a nonapeptide, slows its own inactivation and stimulates neurons.</p>
    Formula:C52H77N15O12
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1104.26

    Ref: TM-TP1819

  • (Iso)-RJW100
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    (Iso)-RJW100

    CAS:
    <p>Potent LRH-1/NR5A2 and SF-1/NR5A1 agonist; pEC50: 6.4 (LRH-1), 7.2 (SF-1).</p>
    Formula:C28H34O
    Purity:99.79%
    Color and Shape:Soild
    Molecular weight:386.57

    Ref: TM-T64363

  • K41498
    Targetmol
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    K41498

    CAS:
    <p>Potent CRF2α/β antagonist; Ki: 0.66/0.62 nM, weak for CRF1 (425 nM). Blocks sauvagine in hCRF2 cells and urocortin hypotension in rats.</p>
    Formula:C162H276N48O46
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3632.26

    Ref: TM-TP2009

  • Asenapine citrate
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    Asenapine citrate

    CAS:
    <p>Asenapine citrate: atypical antipsychotic for schizophrenia, bipolar disorder; targets serotonin, adrenoceptors, dopamine, histamine (pKi: 8.2-10.5).</p>
    Formula:C23H24ClNO8
    Color and Shape:Solid
    Molecular weight:477.89

    Ref: TM-T63129

  • [Ala11,D-Leu15]-Orexin B(human)
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    [Ala11,D-Leu15]-Orexin B(human)

    CAS:
    <p>OX2 receptor agonist with 400x selectivity vs OX1. EC50: 0.13 nM (OX2), 52 nM (OX1).</p>
    Formula:C120H206N44O35S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:2857.28

    Ref: TM-TP1975

  • Bay 55-9837
    Targetmol
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    Bay 55-9837

    CAS:
    <p>Selective VPAC2 agonist; EC50: 0.4 nM (VPAC2), 100 nM (VPAC1), &gt;1000 nM (PAC1). Enhances insulin secretion, reduces HIV-1 replication.</p>
    Formula:C167H270N52O46
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3742.29

    Ref: TM-TP2071

  • Cenicriviroc Mesylate
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    Cenicriviroc Mesylate

    CAS:
    <p>Cenicriviroc Mesylate (TBR-652 Mesylate) is an oral dual CCR2/CCR5 antagonist exhibiting anti-inflammatory and anti-fibrotic effects for liver fibrosis.</p>
    Formula:C42H56N4O7S2
    Purity:98.819%
    Color and Shape:Solid
    Molecular weight:793.05

    Ref: TM-T10756

  • MI 1544
    Targetmol
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    MI 1544

    CAS:
    <p>MI 1544 is a LHRH antagonist.</p>
    Formula:C71H94ClN17O13
    Color and Shape:Solid
    Molecular weight:1429.09

    Ref: TM-T25808

  • 15-keto Latanoprost
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    15-keto Latanoprost

    CAS:
    <p>Latanoprost, a PG analog for ocular pressure, metabolizes into 15-keto latanoprost, a less potent variant reducing intraocular pressure and pupil size.</p>
    Formula:C26H38O5
    Color and Shape:Solid
    Molecular weight:430.58

    Ref: TM-T37932

  • BIMU 8
    Targetmol
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    BIMU 8

    CAS:
    <p>BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.</p>
    Formula:C19H27ClN4O2
    Purity:99.87%
    Color and Shape:Solid
    Molecular weight:378.9

    Ref: TM-T21946

  • Syk Inhibitor II hydrochloride
    Targetmol
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    Syk Inhibitor II hydrochloride

    CAS:
    <p>Syk signaling is key in lupus. Syk inhibitors reduce inflammation and sepsis severity in FcgRIIb-/- mice, lowering cytokines and organ damage.</p>
    Formula:C14H16ClF3N6O
    Purity:99.05%
    Color and Shape:Solid
    Molecular weight:376.77

    Ref: TM-T9543

  • Tau conotoxin CnVA
    Targetmol
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    Tau conotoxin CnVA

    CAS:
    <p>Tau conotoxin CnVA, a small peptide found in the venom of Conus consors (cone snail), is a member of the T1 cone snail peptide superfamily. It demonstrates high selectivity for the somatostatin sst3 receptor with a Ki value of 1.5 µM. Tau conotoxin CnVA is unique as the only known toxin interacting with this subfamily of G protein-coupled receptors (GPCR). This compound is useful for research related to diseases associated with the sst3 receptor, such as pancreatic cancer or pituitary adenomas.</p>
    Formula:C72H116N24O17S4
    Color and Shape:Solid
    Molecular weight:1718.1

    Ref: TM-TP2735

  • CCR2 antagonist 1
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    CCR2 antagonist 1

    CAS:
    CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).
    Formula:C28H32BrF3N2O
    Color and Shape:Solid
    Molecular weight:549.47

    Ref: TM-T10711

  • Cetirizine methyl ester
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    Cetirizine methyl ester

    CAS:
    <p>Cetirizine methyl ester is a Cetirizine impurity, a long-acting, oral H1-antihistamine and hydroxyzine metabolite.</p>
    Formula:C22H27ClN2O3
    Color and Shape:Solid
    Molecular weight:402.91

    Ref: TM-T73933

  • (R)-CJ 11974
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    (R)-CJ 11974

    CAS:
    <p>(R)-CJ 11974: non-peptide NK1 receptor antagonist, may relieve pain and prevent chemo-induced vomiting.</p>
    Formula:C31H38N2O
    Purity:97.15%
    Color and Shape:Soild
    Molecular weight:454.65

    Ref: TM-T68068L

  • Fasitibant chloride
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    Fasitibant chloride

    CAS:
    <p>Fasitibant chloride, a potent B2R blocker, alleviates pain and swelling in arthritis.</p>
    Formula:C36H49Cl3N6O6S
    Color and Shape:Solid
    Molecular weight:800.23

    Ref: TM-T38544

  • Beraprost
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    Beraprost

    CAS:
    Beraprost is a stable prostacyclin analog.
    Formula:C24H30O5
    Color and Shape:Solid
    Molecular weight:398.49

    Ref: TM-T30426

  • SB 216641
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    SB 216641

    CAS:
    <p>SB 216641 is a 5-HT (1B/1D) antagonist with anxiolytic activity for the study of anxiety disorders and depression.</p>
    Formula:C28H30N4O4
    Purity:98.09%
    Color and Shape:Solid
    Molecular weight:486.56

    Ref: TM-T85323

  • Misoprostol
    Targetmol
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    Misoprostol

    CAS:
    <p>Misoprostol, a prostaglandin E1 derivative, has a strong inhibitory effect on gastric acid secretion, while having a contractile effect on pregnancy.</p>
    Formula:C22H38O5
    Purity:99.78%
    Color and Shape:Water-Soluble Viscous Liquid
    Molecular weight:382.53

    Ref: TM-T2573

  • Tamuzimod
    Targetmol
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    Tamuzimod

    CAS:
    <p>Tamuzimod, an effective immunomodulator, exhibits modulatory activity on S1P Receptors with EC50 values below 1 μM [1] [2].</p>
    Formula:C21H13Cl3F3N5O3
    Color and Shape:Solid
    Molecular weight:546.71

    Ref: TM-T74747

  • CRL-42872 free base
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    CRL-42872 free base

    CAS:
    <p>CRL-42872 free base is a bioactive chemical.</p>
    Formula:C22H26N6O6S
    Color and Shape:Solid
    Molecular weight:502.54

    Ref: TM-T31098

  • SFNGGP-NH2
    Targetmol
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    SFNGGP-NH2

    CAS:
    SFNGGP-NH2 is a biologically active peptide that interacts with Protease-Activated Receptor 3 (PAR-3), a high-affinity thrombin receptor.
    Formula:C25H36N8O8
    Color and Shape:Solid
    Molecular weight:576.6

    Ref: TM-T80234

  • BE-24566B
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    BE-24566B

    CAS:
    BE-24566B, a polyketide from S. violaceusniger, inhibits various bacteria and blocks ET receptors (ETA IC50=11 μM, ETB=3.9 μM).
    Formula:C27H24O7
    Color and Shape:Solid
    Molecular weight:460.482

    Ref: TM-T38167

  • Ramelteon metabolite M-II
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    Ramelteon metabolite M-II

    CAS:
    <p>Ramelteon M-II binds MT1/MT2 with IC50s: 208/1470 pM; it's the main metabolite and a melatonin receptor agonist.</p>
    Formula:C16H21NO3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:275.34

    Ref: TM-T12689

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    Guanylin(human) TFA

    <p>Guanylin (human) TFA, a 15-amino acid peptide, activates intestinal guanylate cyclase, regulating electrolyte and water transport via cGMP.</p>
    Color and Shape:Liquid

    Ref: TM-T37960

  • JNJ-5207787
    Targetmol
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    JNJ-5207787

    CAS:
    <p>JNJ-5207787, a blood-brain barrier-crossing Y2 receptor antagonist, is &gt;100x selective against Y1/Y4/Y5 and inhibits human/rat Y2 with pIC50s of 7.0/7.1.</p>
    Formula:C32H38N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:510.67

    Ref: TM-T15620

  • BM213 acetate
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    BM213 acetate

    <p>BM213 acetate is a selective C5aR1 agonist with antitumor activity that induces C5aR1-mediated calcium mobilization and pERK1/2 signaling.</p>
    Formula:C45H74N12O12
    Purity:99.88%
    Color and Shape:Solid
    Molecular weight:975.14

    Ref: TM-T35399L

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    Y1 receptor antagonist 1 formic

    <p>H 409-22 isomer formic, a formate salt of Y1 receptor antagonist 1, is an antagonist of the neuropeptide Y1 receptor (neuropeptide Y1 receptor). This compound effectively blocks the actions of the receptor, playing a crucial role in modulating physiological responses.</p>
    Formula:C29H35N5O5
    Color and Shape:Solid
    Molecular weight:533.62

    Ref: TM-T200259

  • Litoxetine HCl
    Targetmol
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    Litoxetine HCl

    <p>Litoxetine HCl, an SSRI and 5-HT antagonist, treats urinary incontinence and relaxes rat oesophageal muscles without antimuscarinic effects.</p>
    Formula:C16H20ClNO
    Purity:99.56% - 99.75%
    Color and Shape:Soild
    Molecular weight:277.79

    Ref: TM-T67956L

  • GV-150013X
    Targetmol
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    GV-150013X

    CAS:
    <p>GV-150013X ((S)-1-(1-(adamantan-1-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-3-phenylurea) is a potent CCKB antiagonist, pKi</p>
    Formula:C33H34N4O3
    Purity:99.94%
    Color and Shape:Soild
    Molecular weight:534.65

    Ref: TM-T27503L

  • Lintitript
    Targetmol
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    Lintitript

    CAS:
    <p>Lintitript (SR 27897) is a selective antagonist of CCK1 with EC50s of 6 nM and 200 nM for CCK1 and CCK2. The Ki value is 0.2 nM for CCK1.</p>
    Formula:C20H14ClN3O3S
    Purity:99.28%
    Color and Shape:Solid
    Molecular weight:411.86

    Ref: TM-T15759

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    CCR6 antagonist 2

    <p>CCR6 antagonist2 (Compound 20c) acts as a CCR6 antagonist with a Ki of 1.1 nM. It inhibits CCL20-induced calcium influx with an IC50 of 4.9 nM and suppresses the chemotactic migration of CCR6+ T cells with an IC50 of 190 nM.</p>
    Formula:C19H24N4O4
    Color and Shape:Solid
    Molecular weight:372.42

    Ref: TM-T205072

  • (Phe2,Orn8)-Oxytocin
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    (Phe2,Orn8)-Oxytocin

    CAS:
    <p>(Phe2,Orn8)-Oxytocin: Selective V1 agonist, induces rabbit epididymis contractility, EC50=280 nM.</p>
    Formula:C42H65N13O11S2
    Color and Shape:Solid
    Molecular weight:992.18

    Ref: TM-T76629

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    Orexin A (human, rat, mouse) (TFA)

    Endogenous orexin receptor agonist with Ki of 20 nM (OX1) and 38 nM (OX2), promotes feeding, may regulate sleep-wake cycle.
    Formula:C154H244N47F3O46S4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:3675.12

    Ref: TM-TP1550

  • Drinabant
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    Drinabant

    CAS:
    <p>Drinabant (AVE-1625) is an orally active CB1 receptor antagonist.</p>
    Formula:C23H20Cl2F2N2O2S
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:497.38

    Ref: TM-T21861