GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,025 products)
- Adenosine Receptor(248 products)
- Adrenergic Receptor(2,994 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(154 products)
- CaSR(34 products)
- Cannabinoid Receptor(216 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(445 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(22 products)
- Glucagon Receptor(191 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(41 products)
- Opioid Receptor(325 products)
- PAFR(14 products)
- PKA(59 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5963 products of "GPCR/G-Protein"
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AR-C126313
CAS:AR-C126313 is a thiouracil derivative.
Formula:C28H23N7O3SColor and Shape:SolidMolecular weight:537.59GLP-2(1-33)(human)
CAS:GLP-2(1-33) (human) is an enteroendocrine hormone which stimulates the growth of the intestinal epithelium.Formula:C165H254N44O55SPurity:98%Color and Shape:SolidMolecular weight:3766.19(+)-Dropropizine
CAS:(+)-Dropropizine can inhibit histamine receptor, anti-allergic, and reduce a cough by modulation of neuropeptides involved in the cough reflex.Formula:C13H20N2O2Purity:>99.99%Color and Shape:White Or Off White Crystalline PowderMolecular weight:236.31Galanin Receptor Ligand M35
CAS:M35, a galanin(1-13)-bradykinin(2-9) amide, acts as a galanin antagonist in rats and inhibits mouse pancreatic islets.Formula:C107H153N27O26Purity:98%Color and Shape:SolidMolecular weight:2233.6GLP-1(7-37)
CAS:GLP-1 (7-37) is a truncated, bioactive form of GLP-1 that is the product of proglucagon processing in intestinal endocrine L cells.Formula:C151H228N40O47Purity:98%Color and Shape:SolidMolecular weight:3355.67Atrial natriuretic peptide (3-28) (human)
CAS:Atrial natriuretic peptide (3-28) (human) (ANP (3-28) (human)), a peptide hormone produced by the atrial myocardium, plays a critical role in the regulation ofFormula:C118H187N43O36S3Purity:98%Color and Shape:SolidMolecular weight:2880.21TE-8105
TE-8105 is a GLP-1 receptor agonist that demonstrates prolonged and enhanced efficacy in models of diabetes, obesity, and non-alcoholic steatohepatitis (NASH).Color and Shape:Odour SolidTriamterene
CAS:Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.Formula:C12H11N7Purity:99.77%Color and Shape:Yellow Yellow SolidMolecular weight:253.26HHS-0701
CAS:HHS-0701: SuTEx ligand, strong PTGR2 inhibitor, blocks 15-Keto-PGE2 metabolism.Formula:C20H20N4O3SPurity:97.24%Color and Shape:SoildMolecular weight:396.46Conopeptide rho-TIA
CAS:Conopeptide rho-TIA, a peptide from Conus tulipa venom, acts as a selective, noncompetitive inhibitor at the human α1B-Adrenergic Receptor and as a competitiveFormula:C105H160N36O21S4Purity:98%Color and Shape:SolidMolecular weight:2390.88SHU 9119
CAS:SHU 9119 is a potent antagonist for human MC3R/MC4R and partial agonist for MC5R with IC50 values of 0.23, 0.06, 0.09 nM.Formula:C54H71N15O9Purity:98%Color and Shape:SolidMolecular weight:1074.258D3R ligand 1
D3R Ligand 1 (compound 23b) is a potent, selective antagonist of the dopamine D3 receptor (Ki=66 nM), incorporating a THPB template.Formula:C27H37NO5Purity:98%Color and Shape:SolidMolecular weight:455.598-iso Prostaglandin A2
CAS:8-iso Prostaglandin A2 is an isoprostane produced by the nonenzymatic oxidation of arachidonic acid.Formula:C20H30O4Color and Shape:SolidMolecular weight:334.4517-trifluoromethylphenyl trinor Prostaglandin F2α
CAS:A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma.Formula:C24H31F3O5Color and Shape:SolidMolecular weight:456.502PZ-1922
PZ-1922 (Compound 16), able to cross the blood-brain barrier, is a dual antagonist for 5-HT6R and 5-HT3R with K i values of 17 nM and 0.45 nM, respectively.Purity:98%Color and Shape:Odour Solid5-HT6R antagonist 6
5-HT6R antagonist 6 (Compound PP15) exhibits high affinity and selectivity for the 5-HT6R receptor, with a Ki of 42 nM. It demonstrates weak antiproliferative activity on tumor cells and low toxicity toward normal cells. 5-HT6R antagonist 6 is applicable in tumor research.Formula:C24H26N4O2SColor and Shape:SolidMolecular weight:434.55CB2R agonist 2
CB2R agonist 2 (cis-17-para) is a CB2R agonist [1].Purity:98%Color and Shape:Odour Solid(R)-Preclamol hydrochloride
CAS:(R)-Preclamol HCl is a dopamine agonist stimulating both auto and postsynaptic receptors.Formula:C14H22ClNOColor and Shape:SolidMolecular weight:255.78Amylin (1-37), human acetate
Amylin (1-37), human acetate, a peptide hormone containing 37 amino acids secreted by the pancreas in conjunction with insulin, inhibits glucagon secretion.Purity:96.21%Color and Shape:Odour SolidAntibacterial agent 189
Antibacterialagent 189 (compound 3a) is a potent antibacterial agent with high binding affinity to the target proteins OMPA/exo-1,3-β-glucanase. It demonstrates effective antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Candida albicans, and Aspergillus flavus. Additionally, Antibacterialagent 189 exhibits strong binding affinity to the target proteins SMO and SUFU/GLI-1.Formula:C37H28N4OMolecular weight:544.22631Phoenixin-14
CAS:Phoenixin-14 (PNX-14), an active endogenous isoform, induces an anxiolytic effect by activating the AHA GnRH system in mice and protects against ischemia/
Formula:C75H110N18O20Purity:98%Color and Shape:SolidMolecular weight:1583.78GIP/GLP-1 dual receptor agonist-1 sodium
GIP/GLP-1 dual receptor agonist-1 (Compound 4) (sodium) functions as a GIP/GLP-1 receptor agonist. This compound is applicable for research into metabolic disorders and liver diseases, including non-alcoholic steatohepatitis (NASH) and non-alcoholic fatty liver disease (NAFLD).Color and Shape:Odour Solid[Gly8]-GLP-1(7-37) acetate
[Gly8]-GLP-1(7-37) acetate is a derivative of GLP-1, where glycine at position 8 is replaced with alanine. [Gly8]-GLP-1(7-37) acetate is also a peptide fragment of the GLP-1 receptor (GLP-1R) agonist, Dulaglutide.Color and Shape:Odour SolidGalanin (2-29) (rat)
CAS:Peptide agonist for galanin receptorsFormula:C139H208N42O40Purity:98%Color and Shape:SolidMolecular weight:3107.4Uroguanylin (human)
CAS:Uroguanylin (human) serves as a natural ligand for the Guanylyl Cyclase C (GCC) receptor in metastatic colorectal cancer tumors and exhibits anti-tumor effectsFormula:C64H102N18O26S4Purity:98%Color and Shape:SolidMolecular weight:1667.864-Methylhistamine
CAS:4-Methylhistamine serves as a potent agonist for the histamine 4 receptor (H4R), holding promise for research into immune-related diseases, including cancer andFormula:C6H11N3Purity:98%Color and Shape:SolidMolecular weight:125.17ELA-11(human)
CAS:Apelin receptor agonist with high affinity (Ki = 14 nM). Blocks cAMP production and promotes β-arrestin activation; derived from ELA-32.Formula:C58H90N16O13S2Purity:98%Color and Shape:SolidMolecular weight:1283.57GLP-1R agonist 14
CAS:GLP-1R agonist 14, also known as Compound 14, is a potent agonist of the GLP-1 receptor, demonstrating an EC50 range of 0-20 nM against human GLP-1 [1].Formula:C45H42F2N10O5Color and Shape:SolidMolecular weight:840.88BE-24566B
CAS:BE-24566B, a polyketide from S. violaceusniger, inhibits various bacteria and blocks ET receptors (ETA IC50=11 μM, ETB=3.9 μM).Formula:C27H24O7Color and Shape:SolidMolecular weight:460.482H4R antagonist 3
CAS:H4R antagonist 3 is a novel histamine-4 receptor (H4R) antagonist with an EC50 <10 mM.H4R antagonist 3 has potential inflammatory activity for the study ofFormula:C19H21ClN4SPurity:98%Color and Shape:SolidMolecular weight:372.92α-CGRP(human)
CAS:Endogenous calcitonin gene-related peptide receptor (CGRP) agonist.Formula:C163H267N51O49S2Purity:98%Color and Shape:SolidMolecular weight:3789.33GLP-1 receptor agonist 9 citrate
GLP-1 receptor agonist 9 citrate is an agonist of GLP-1.
Formula:C38H39ClFN3O12Purity:98.76%Color and Shape:SolidMolecular weight:784.18SR 142948 dihydrochloride
SR 142948 dihydrochloride is a selective oral non-peptide NT antagonist, IC50 <4 nM, with brain penetration and potential for psychiatric research.Formula:C39H53Cl2N5O6Color and Shape:SolidMolecular weight:758.77MEN 11270
CAS:B2 bradykinin receptor peptide antagonist, pKi 10.3; improves hypotension, bronchoconstriction; B2-selective over 29 receptors/ion channels.Formula:C60H90N20O11SPurity:98%Color and Shape:SolidMolecular weight:1299.56γ-2-MSH (41-58), amide
CAS:Melanocortin (MC) 3-MSH (Melanocyte-Stimulating Hormone) is believed to signal through the MC 3 receptor.Formula:C74H100N22O15SPurity:98%Color and Shape:SolidMolecular weight:1569.79SB 258585
CAS:SB 258585: Selective 5-HT6 antagonist, binds human receptors, used in cognitive and antipsychotic assays.Formula:C18H22IN3O3SPurity:99.77%Color and Shape:SoildMolecular weight:487.36(S)-Osanetant
CAS:(S)-Osanetant, an S-enantiomer, is a selective NK3 antagonist with potential for treating schizophrenia and has anxiolytic and antidepressant effects.Formula:C35H41Cl2N3O2Color and Shape:SolidMolecular weight:606.62Ornipressin
CAS:Ornipressin is a vasoconstrictor, haemostatic and renal agent.Formula:C45H63N13O12S2Purity:98%Color and Shape:White PowderMolecular weight:1042.19TGR5 agonist 2
TGR5 agonist 2 (compound 19) serves as a highly potent agonist of TGR5, demonstrating an EC50 value of 0.27 µM [1].Formula:C29H50NNaO6SColor and Shape:SolidMolecular weight:563.7713,14-dihydro-15-keto Prostaglandin F1α
CAS:13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been reported in the rat stomach.Formula:C20H36O5Color and Shape:SolidMolecular weight:356.5KSK67
CAS:KSK67 is a selective dual antagonist of sigma-2 and histamine H3 receptors with inhibitory effects on H3 receptors, sigma-1, and sigma-2 receptors, with KiFormula:C22H27N3O2Purity:99.94%Color and Shape:SoildMolecular weight:365.47Halometasone
CAS:Halometasone: synthetic corticosteroid for psoriasis and eczema treatment.
Formula:C22H27ClF2O5Color and Shape:SolidMolecular weight:444.9Bradykinin (1-7)
CAS:Bradykinin (1-7), an amino-truncated peptide derived from Bradykinin, is a metabolite formed through enzymatic cleavage by endopeptidase.Formula:C35H52N10O9Purity:98%Color and Shape:White Lyophilized PowderMolecular weight:756.85Cortistatin 29
Cortistatin 29: neuropeptide, relieves neuropathic pain, binds SS receptors (IC50: 2.8-13.7 nM), anti-fibrotic.Formula:C161H242N46O41S2Color and Shape:SolidMolecular weight:3539.77Haloperidol D4
CAS:Haloperidol D4 is deuterium-labeled haloperidol.Formula:C21H23ClFNO2Purity:98%Color and Shape:SolidMolecular weight:379.89Lintitript
CAS:Lintitript (SR 27897) is a selective antagonist of CCK1 with EC50s of 6 nM and 200 nM for CCK1 and CCK2. The Ki value is 0.2 nM for CCK1.Formula:C20H14ClN3O3SPurity:99.28%Color and Shape:SolidMolecular weight:411.86Ref: TM-T15759
1mg50.00€2mg71.00€5mg105.00€10mg160.00€25mg344.00€50mg645.00€100mg864.00€1mL*10mM (DMSO)117.00€BQ-123 TFA
BQ-123 TFA: Potent ETA antagonist, IC50 = 7.3 nM, Ki = 25 nM, inhibits ET-1 cell proliferation, lowers rat BP.Formula:C33H43F3N6O9Color and Shape:SolidMolecular weight:724.72Minaprine
CAS:Minaprine is a reversible inhibitor of MAO-A, used in the treatment of various depressive states.Formula:C17H22N4OPurity:98%Color and Shape:SolidMolecular weight:298.38Pasireotide L-aspartate salt
CAS:Pasireotide L-aspartate, a stable cyclohexapeptide, mimics somatostatin with high affinity for sst1/2/3/4/5 receptors (pKi=8.2/9.0/9.1/<7.0/9.9).Formula:C62H73N11O13Purity:98%Color and Shape:SolidMolecular weight:1180.33CB2R/FAAH modulator-1
CAS:CB2R/FAAH modulator-1: agonizes CB2R, inhibits FAAH (IC50=4 μM), alters cytokine production; used in inflammation research. Ki: CB2R=14.8 nM, CB1R=241.3 nM.Formula:C24H27NO2Purity:99.77%Color and Shape:SoildMolecular weight:361.48Ref: TM-T67896
1mg52.00€5mg111.00€10mg162.00€25mg235.00€50mg330.00€100mg452.00€200mg607.00€1mL*10mM (DMSO)114.00€
