GPCR/G-Protein
GPCR/G-Protein inhibitors are compounds that target G-protein coupled receptors (GPCRs) and associated G-proteins, which play critical roles in transmitting signals from the outside to the inside of cells. These inhibitors are essential for studying the signaling pathways mediated by GPCRs, which are involved in numerous physiological processes, including sensory perception, immune response, and neurotransmission. GPCR inhibitors are also important in drug development, as many therapeutic agents target these receptors. At CymitQuimica, we offer a wide range of high-quality GPCR/G-Protein inhibitors to support your research in pharmacology, cell biology, and related fields.
Subcategories of "GPCR/G-Protein"
- 5-HT Receptor(1,024 products)
- Adenosine Receptor(249 products)
- Adrenergic Receptor(3,030 products)
- Bombesin Receptor(35 products)
- Bradykinin Receptor(61 products)
- CXCR(159 products)
- CaSR(34 products)
- Cannabinoid Receptor(217 products)
- Cholecystokinin(1 products)
- Dopamine Receptor(443 products)
- Endothelin Receptor(86 products)
- GNRH Receptor(84 products)
- GPCR19(33 products)
- GRK(33 products)
- GTPase(22 products)
- Glucagon Receptor(196 products)
- Hedgehog/Smoothened(49 products)
- Histamine Receptor(385 products)
- LPA Receptor(21 products)
- Melatonin Receptor(26 products)
- OX Receptor(42 products)
- Opioid Receptor(326 products)
- PAFR(14 products)
- PKA(53 products)
- S1P Receptor(17 products)
- SGLT(31 products)
- Sigma receptor(46 products)
Show 19 more subcategories
Found 5981 products of "GPCR/G-Protein"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
A 77636 hydrochloride
CAS:<p>A 77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM).</p>Formula:C20H28ClNO3Purity:99.57%Color and Shape:SolidMolecular weight:365.89GLP-1 receptor agonist 13
Compound (S)-9, a GLP-1 receptor agonist, exhibits an EC50 of 76 nM for the glucagon GLP-1 receptor [1].Formula:C25H23ClF2N6OColor and Shape:SolidMolecular weight:496.94Relaxin H3 (human) TFA
Relaxin H3 (human) (TFA) is a relaxin peptide that exerts antifibrotic effects through the RXFP1 receptor.Formula:C237H374N70O69S6·xC2HF3O21a,1b-dihomo Prostaglandin E1
CAS:1a,1b-dihomo Prostaglandin E1 is a class of prostaglandin compounds.Formula:C22H38O5Color and Shape:SolidMolecular weight:382.541Myristoylated ARF6 (2-13)
Myristoylated ARF6 (2-13) inhibits the MyD88–ARNO–ARF6 signaling axis by inactivating ARF6.Formula:C74H128N16O18Molecular weight:1528.959258-iso Prostaglandin E2
CAS:"8-iso PGE2: Isoprostane from arachidonic acid, potent rat renal vasoconstrictor, reduces GFR and renal flow by 80%, no BP effect."Formula:C20H32O5Color and Shape:SolidMolecular weight:352.47Orexin A (human, rat, mouse) (TFA)
Endogenous orexin receptor agonist with Ki of 20 nM (OX1) and 38 nM (OX2), promotes feeding, may regulate sleep-wake cycle.Formula:C154H244N47F3O46S4Purity:98%Color and Shape:SolidMolecular weight:3675.12[Gln8]-C517 (LH-RH), chicken
CAS:[Gln8] LH-RH: Avian hypothalamic peptide; prompts anterior pituitary to release gonadotropins, controlling reproduction.Formula:C54H71N15O14Purity:98%Color and Shape:SolidMolecular weight:1154.23Veldoreotide
CAS:Veldoreotide (Somatoprim): a somatostatin analogue targeting receptors 2, 4, 5, reduces GH in pituitary adenomas.Formula:C60H74N12O10Purity:98%Color and Shape:SolidMolecular weight:1123.3Urocortin III, mouse
CAS:Mouse UcnIII, linked to stress behaviors, mainly occurs in the brain and rises in the hypothalamus post-restraint.Formula:C186H312N52O52S2Purity:98%Color and Shape:SolidMolecular weight:4172.97GLP-1R agonist 20
GLP-1R agonist 20 (Compound I-132) is an agonist of the glucagon-like peptide-1 receptor (GLP-1 receptor), with an EC50 value of 0.0162 nM.Formula:C31H30Cl2F2N4O5Molecular weight:646.15613Orexin B, rat, mouse
CAS:Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.Formula:C126H215N45O34SPurity:98%Color and Shape:SolidMolecular weight:2936.45BIBP3226
CAS:BIBP3226 is a potent and selective antagonist for the Neuropeptide Y receptor Y1 and the neuropeptide FF receptor.Formula:C27H31N5O3Color and Shape:SolidMolecular weight:473.57PZ-128
CAS:PZ-128, a PAR1 antagonist, is used potentially for the treatment of thrombosis.Formula:C55H99N13O9Purity:98%Color and Shape:SolidMolecular weight:1086.46JKC363
CAS:<p>MC4 receptor antagonist; IC50: 0.5 nM (MC4), 44.9 nM (MC3). Blocks α-MSH, reduces TRH, food intake, and pain.</p>Formula:C69H91N19O16S2Purity:98%Color and Shape:SolidMolecular weight:1506.72LGnRH-III, lamprey
CAS:GnRH III triggers luteinizing and follicle-stimulating hormone release, part of the conserved GnRH family.Formula:C59H74N18O14Purity:98%Color and Shape:SolidMolecular weight:1259.33AP 811
CAS:AP 811: Selective NPR3 antagonist, Ki of 0.48 nM, >20,000x selective over NPR1, blocks ANP-induced pump stimulation.Formula:C46H66N12O8Molecular weight:915.11Sulamserod
CAS:Sulamserod (RS 100302) is a potent 5-HT4 receptor antagonist with antiarrhythmic activity for the study of atrial fibrillation and cardiovascular relatedFormula:C19H28ClN3O5SPurity:98.76%Color and Shape:SolidMolecular weight:445.96GR 94800
CAS:Potent and selective tachykinin NK2 receptor antagonistFormula:C49H61N9O8Purity:98%Color and Shape:SolidMolecular weight:904.082Galanin Receptor Ligand M35
CAS:M35, a galanin(1-13)-bradykinin(2-9) amide, acts as a galanin antagonist in rats and inhibits mouse pancreatic islets.Formula:C107H153N27O26Purity:98%Color and Shape:SolidMolecular weight:2233.6Tirzepatide hydrochloride
Tirzepatide HCl is a dual GIP and GLP-1 receptor agonist.Formula:C225H349N48O68ClPurity:98%Color and Shape:SolidMolecular weight:4849.91GLP-1R agonist 16
CAS:Compound 115a, a GLP-1R agonist, effectively activates the GLP-1 receptor with an EC50 of 0.15 nM [1].Formula:C50H58FN10O6PColor and Shape:SolidMolecular weight:945.03Tienoxolol FA
Tienoxolol FA, a beta-blocker for treating heart disease, hypertension, and ischemia.Formula:C22H30N2O7SPurity:97.05% - 98.53%Color and Shape:SoildMolecular weight:466.55LY-426965 hydrochloride
CAS:LY-426965 hydrochloride is a bioactive chemical.Formula:C28H39ClN2O2Color and Shape:SolidMolecular weight:471.07des-Gln14-Ghrelin
CAS:Endogenous rat ghrelin gene variant binds GHS-R1a; strong Ca2+ release (EC50=2.4 nM); boosts GH secretion in vivo.Formula:C142H237N43O40Purity:98%Color and Shape:SolidMolecular weight:3186.7MI 1544
CAS:MI 1544 is a LHRH antagonist.Formula:C71H94ClN17O13Color and Shape:SolidMolecular weight:1429.09Leukotriene B4 Ethanolamide
CAS:<p>LTB4 binds to BLT1 (high affinity) and BLT2. LTB4-EA, a metabolite, is a stronger BLT1 antagonist, suggesting anti-inflammatory properties.</p>Formula:C22H37NO4Color and Shape:SolidMolecular weight:379.541GRK-IN-1
CAS:<p>4-Amino-5-(bromomethyl)-2-methylpyrimidine used in vitamin B1 analogs and esters synthesis.</p>Formula:C6H10Br3N3Color and Shape:SolidMolecular weight:363.87919(S)-HETE
CAS:19-HETE, a CYP450 arachidonic acid metabolite from kidneys, consists of 70% (S) and 30% (R) isomers and dilates renal vessels.Formula:C20H32O3Color and Shape:SolidMolecular weight:320.473Dexchlorpheniramine free base
CAS:Dexchlorpheniramine Maleate, a histamine receptor antagonist, is used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus.Formula:C16H19ClN2Purity:98%Color and Shape:Oily Liquid SolidMolecular weight:274.79ELA-11(human)
CAS:Apelin receptor agonist with high affinity (Ki = 14 nM). Blocks cAMP production and promotes β-arrestin activation; derived from ELA-32.Formula:C58H90N16O13S2Purity:98%Color and Shape:SolidMolecular weight:1283.57SB234551
CAS:SB234551 is a selective antagonist of endothelin ETA receptor.Formula:C34H34N2O9Color and Shape:SolidMolecular weight:614.64Secretin (28-54), human
CAS:Secretin (28-54), human, is a 27-amino acid residue peptide with a C-terminal amidation, acting on human secretin receptors.Formula:C130H220N44O40Purity:98%Color and Shape:PowderMolecular weight:3039.46PAMP-12(human, porcine)
CAS:Potent endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 57.2 nM). Corresponds to amino acids 9 to 20 of proadrenomedullin.Formula:C77H119N25O14Purity:98%Color and Shape:SolidMolecular weight:1618.95Navafenterol
CAS:AZD-8871, a potential COPD and asthma treatment, may work well with ICS.Formula:C38H42N6O6S2Color and Shape:SolidMolecular weight:742.91ACT-373898
CAS:<p>ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETBdual antagonist macitentan .1</p>Formula:C15H17BrN4O5SColor and Shape:SolidMolecular weight:445.29[Des-Arg10]-HOE I40 TFA
<p>[Des-Arg10]-HOE I40 TFA is a potent antagonist of the bradykinin B1 receptor.</p>Formula:C53H77N15O12S·xC2HF3O2Color and Shape:SolidJNJ-40929837 succinate
CAS:JNJ-40929837 succinate is a selective, orally active inhibitor of LTA 4 H (leukotriene A 4 hydrolase). This compound effectively inhibits aminopeptidase activity, leading to the accumulation of Pro-Gly-Pro in serum, and can be utilized in asthma research [1].Formula:C22H24N4O2S·xC4H6O4Color and Shape:SolidHS014
CAS:Potent MC4 antagonist; Ki: 3.16 nM (MC4), 108 (MC1), 54.4 (MC3), 694 (MC5). Boosts rat appetite, mouse pain, blocks IL-1β Fos in hypothalamus.Formula:C71H94N20O17S2Purity:98%Color and Shape:SolidMolecular weight:1563.77GLP-1R agonist 4
CAS:GLP-1R agonist 4, potentially for diabetes research, is a potent GLP-1R stimulator linked to hypoglycemia.Formula:C32H30ClF2N3O5Color and Shape:SolidMolecular weight:610.05Proglumide hemicalcium
CAS:Proglumide hemicalcium is a antagonist of nonpeptide and orally active cholecystokinin (CCK)-A/B receptors, has antiepileptic and antioxidant activities.Formula:C18H28CaN2O4Purity:98%Color and Shape:SolidMolecular weight:376.51Etelcalcetide
CAS:Etelcalcetide (AMG 416), a synthetic peptide CaSR activator, treats secondary hyperparathyroidism in hemodialysis patients.Formula:C38H73N21O10S2Purity:98%Color and Shape:SolidMolecular weight:1048.26GUB03385
GUB03385 is a long-acting PrRP31 analogue and an effective dual agonist for GPR10 (full agonist, EC50: 0.4 nM) and NPFF2R (partial agonist, EC50: 20 nM), with anti-obesity properties.Formula:C198H322N60O52SMolecular weight:4404.41173Asenapine citrate
CAS:Asenapine citrate: atypical antipsychotic for schizophrenia, bipolar disorder; targets serotonin, adrenoceptors, dopamine, histamine (pKi: 8.2-10.5).Formula:C23H24ClNO8Color and Shape:SolidMolecular weight:477.89Glucagon (19-29), human
CAS:Glucagon, a 29-amino-acid hormone, is produced by alpha cells in the pancreas' islets of Langerhans.Formula:C61H89N15O18SPurity:98%Color and Shape:SolidMolecular weight:1352.53Ro60-0175
CAS:<p>Ro60-0175 is a selective 5-HT2B and 5-HT2C serotonin receptor agonist, often used as fumarate.</p>Formula:C11H12ClFN2Purity:97.09%Color and Shape:SolidMolecular weight:226.68JNJ-39933673
CAS:JNJ-39933673 is a bio-active chemical.Formula:C48H54F2N2O11Color and Shape:SolidMolecular weight:872.96Sar-[D-Phe8]-des-Arg9-Bradykinin
CAS:Potent bradykinin B1 agonist, EC50 = 9.02 nM, enzyme resistant, induces hypotension and angiogenesis.Formula:C47H66N12O11Purity:98%Color and Shape:SolidMolecular weight:975.11Neurokinin B (TFA)
CAS:Neurokinin B TFA, a tachykinin, targets NK1R, NK2R, nk3r GPCRs, modulating effects.Formula:C59H81F6N13O18S2Purity:98%Color and Shape:SolidMolecular weight:1438.47palm11-PrRP31
<p>Palm11-PrRP31 is a lipid-modified analog of the endogenous appetite-suppressing neuropeptide (PrRP). It functions as a potent dual agonist for GPR10 (EC50 = 39 pM) and NPFF-R2. By mimicking the natural activity of PrRP, palm11-PrRP31 binds to these receptors to reduce food intake. It has potential applications as an anti-obesity agent and is useful in studying neuropeptide and receptor interactions.</p>Formula:C181H289N55O46SMolecular weight:4001.16865
![[Gln8]-C517 (LH-RH), chicken](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1648.webp&w=3840&q=75)
![Sar-[D-Phe8]-des-Arg9-Bradykinin](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FTM%2Fthumb-webp%2FTP1917.webp&w=3840&q=75)
