GPCR/G-Protein

Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a 5-HT and dopamine receptor antagonist.

ICI-118551 Hydrochloride (ICI-118,551) is a highly selective β2-adrenergic receptor antagonist with Ki values of 0.7, 49.5 and 611 nM for β2, β1 and β3

Diclofensine (Ro 8-4650) inhibits the uptake of serotonin, noradrenaline and dopamine.

S 25585 is a neuropeptide Y (NPY) Y5 receptor antagonist.

R-138727 is a novel P2Y12 receptor inhibitor.

Caerulein, desulfated (FI-6934, desulfated) is a desulfated compound formed after caerulein hydrolysis, a neuropeptide with lower smooth muscle activity.

Roxatidine acetate: anti-ulcer, blocks histamine, reduces acid. Safer at lower doses.

Litorin suppresses appetite and stimulates smooth muscle, gastrin, gastric acid, and pancreatic secretion.

Penbutolol sulfate ((-)-Terbuclomine) is able to bind to both β2-adrenergic receptor and β1-adrenergic receptor, thus making it a non-selective β blocker.

Isoproterenol sulfate anhydrous is a useful alkaloid. It is used for biological research.

MCI-225 dehydratase is an oral, selective inhibitor of noradrenaline reuptake, and functions as a 5-HT3 antagonist, exhibiting antidepressant effects in vivo .

Atenolol Hydrochloride is a selective antagonist of ß1 receptor.

Bethanidine sulfate and its ortho-chloro derivative (BW 392C60) are potent adrenergic neuron blockers exhibiting sympathomimetic effects similar to those of bromobenzamine and guanethidine in various animal models, particularly in cats. These compounds inhibit the release of norepinephrine during neural stimulation and enhance the responsiveness of smooth muscle to epinephrine and norepinephrine. Notably, bethanidine sulfate increases the pressor response to tyramine, although this effect diminishes with higher doses. Unlike guanethidine, bethanidine sulfate does not deplete pressor amines in the iris of cats following administration. Additionally, it temporarily suppresses autonomic cholinergic mechanisms and can cause transient neuromuscular paralysis at large doses, contrasting its long-term adrenergic neuron blocking effects.

6-Hydroxy Buspirone, an active metabolite of the anxiolytic compound buspirone, is produced via the cytochrome P450 (CYP) isoform CYP3A4.

SB 271046 hydrochloride (SB 271046A) is selective, orally active 5-HT6 antagonist and is > 200-fold selective over 55 other receptors, enzymes and ion channels.

Vanoxerine is an antagonist of dopamine transporter (Ki: 16.9nM).

Ciproxifan (FUB-359) is a highly effective and specific histamin H3-receptor antagonist (IC50: 9.2 nM).

Dehydroabiethylamine (NSC-2955) boosts liver CYP2B, blocks PDKs & cholesterol transport, and has anti-tumor effects.

Compound AMTHAMINE DIHYDROBROMIDE is a useful organic compound for research related to life sciences.

Tivumecirnon (FLX475) is a selective and oral CCR4 antagonist inhibits the infiltration and migration of Treg into the tumour microenvironment, antitumour