Polycyclic Compounds

<p>Applications Indole-3-acetonitrile is an indole derivative involved in the biosynthesis of the plant hormone indole acetic acid (I577340) via the indole-3-acetaldoxime pathway.<br>References Kong, W., et al.: Plant Cell Physiol, 56, 715-726 (2015)<br></p>

<p>Impurity Famciclovir USP Related Compound F<br>Applications Famciclovir USP Related Compound F<br></p>

<p>Applications Indoleacetic Acid is the most common and naturally occuring plant hormone in the auxin class of hormones. It effects cell elongation, cell division as well as plant growth and development.<br></p>

<p>Applications 2-Amino-6-hydroxy-8-mercaptopurine (cas# 6324-72-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Butoxyquinoline-4-carboxylic Acid is used in the organic synthesis of o-(β-diethylaminoethyl)cinchoninaldoxime with local anesthetic activity<br>References Rossi, S., et al.: Farmaco, Edizione Scientifica, 34, 486 (1979)<br></p>

<p>Applications 5-Fluoroindole is a reactant used in various syntheses. It was used in the synthesis of Spirotetrahydro β-Carbolines (Spiroindolones), which is a new class of potent and orally efficacious compounds for the treatment of malaria. 5-Fluoroindole was also a reactant in direct indole and pyrrole couplings to carbonyl compound in total synthesis of Acremoauxin A and Oxazinin 3.<br>References Richter, J., et al.: J. Am. Chem. Soc., 129, 12857 (2007); Yeung, B., et al.: J. Med. Chem., 53, 5155 (2010);<br></p>

<p>Applications Isoquinoline-5-sulfonic Acid (cas# 27655-40-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 6,7-Dimethoxyisoquinoline is used as an organocatalyst in the chemoselective O-tert-butoxycarbonylation of phenols.<br>References Saito, Yukako, et al.: Tetrahedron Let., 51(52), 6915-6917 (2010)<br></p>

<p>Applications A naturally occurring purine derivative. Pharmaceuticals, Intermediates &amp; Fine Chemicals<br>References Jansen, R., et al.: Clin. Biochem., 38, 362 (2005), Vorst, O., et al.: Metabolomics, 1, 169 (2005), Want, E., et al.: ChemBioChem., 6, 1941 (2005), van der Werf, M., et al.: Anal. Biochem., 370, 17 (2007),<br></p>

<p>Applications This compound has estrogenic activity. It exhibits bright blue fluorescence in neutral or acid solution, and greenish-yellow fluorescence in strong alkali solution.<br>References Wolfbeis, O.S. &amp; K. Schaffner: Photochem. Photobiol., 32, 143(1980), Bickoff et al.: J.Am. Chem Soc. 80, 3969 (1958)<br></p>

<p>Applications 4,4'-Di-tert-butyl-2,2'-bipyridine acts as a reagent in the preparation, antiproliferative and cytotoxic activity of apoptotic ruthenium nitrogen heterocyclic complexes via combinatorial library synthesis.<br>References Mulcahy, S. P., et al.: Dalton Trans., 39, 177 (2010)<br></p>

<p>Applications Indazole-3-carboxylic Acid is an indole derivatives useful in treatment of pain and inflammation.<br>References Khanna P., et al.: Biochemistry, 40, 1441 (2001);<br></p>

<p>Applications 5,6-Dihydroxyindole is an intermediate in melanogenesis, the production of melanin which is found in our skin, eyes, hair, and inner ear.<br>References S. Ito., et al.: Photochem. Photobiol., 84, 582-92 (2008);<br></p>

<p>Applications 8-Hydroxyquinoline (cas# 148-24-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Hydroxyindole is a mutation product of toluene-4-monooxygenase (T4MO), that gets spontaneously converted to indigo. Used in the preparation of indolyl-oxadiazoles with anticonvulsant activity.<br>References Rajak, H. et al.: Int. J. Pharm. Sci. Nanotech., 2, 661 (2009); McClay, K. et al.: Appl. Environ. Microbiol., 71, 5476 (2005); Berry, A. et al.: J. Ind. Microbiol. Biotech., 28, 127 (2002)<br></p>

<p>Applications 3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline is used to prepare artificial HMG-CoA reductase inhibitors. It is also used to synthesize pitavastatin calcium via stereoselective Wittig olefination reaction.<br>References Hiyama, T., et al.: Bull. Chem. Soc. Japan, 68, 364 (1995); Fabris, J., et al.: Synth., 44, 1700 (2012)<br></p>

<p>Applications 1,1’-Bicyclohexyl is a hydrocarbon component present in diesel fuel.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patino, P. et al.: Energy. Fuel., 16, 1470 (2002); Shokri, S. et al.: Chem. Tech., An Ind. J., 1, 119 (2006);<br></p>

<p>Stability Hygroscopic<br>Applications Oxythiamine HCl (cas# 136-16-3) is a useful research chemical.<br></p>

<p>Applications 2-azaspiro[4.5]decane-1,3-dione (cas# 1197-80-4) is related to gabapentin (G117250).<br></p>

<p>2-(3,5-Dimethyl-1H-pyrazol-1-yl)quinolin-8-amine is a fine chemical that belongs to the group of versatile building blocks. It can be used as a reagent or as a speciality chemical in research and development. 2-(3,5-Dimethyl-1H-pyrazol-1-yl)quinolin-8-amine is also a useful scaffold for the synthesis of complex compounds and has been shown to be an effective inhibitor of protein tyrosine kinases.</p>

<p>9-Phenanthryl)methyl methacrylate is a fluorescent pigment that is used as a nanomaterial. It is an acidic material and can be used in coatings to improve the properties of materials. 9-Phenanthryl)methyl methacrylate has been shown to have fluorescence resonance energy transfer (FRET) properties, which may be due to its monolayer structure and chromophore. The diameter of this particle ranges from 10-20 nm, with a water permeability of 20% at pH 7.0 and 0.1% at pH 2.0. This pigment has a high degree of surface roughness, which is due to its morphology and the microenvironment in which it exists.</p>

<p>1-Acetyl-3-indolecarboxaldehyde is a ligand that binds to the cannabinoid receptor 1 (CB1). It has been shown to bind to the CB1 receptor with high affinity and selectivity. In addition, it has been demonstrated to inhibit the proliferation of human breast cancer cells in vitro. The compound is used as a fluorescent probe for cb1 receptor binding. Data obtained from molecular modelling studies have suggested that the hydroxyl group might be involved in binding to the CB1 receptor. 1-Acetyl-3-indolecarboxaldehyde also binds carotenoids, which are molecules responsible for giving plants and other photosynthetic organisms their coloration. This compound can be found in many different plants, such as carrots and bananas, where it acts as an antioxidant.</p>

<p>2,2':6',2''- Terpyridine-4'-methanol is a high quality reagent that is used as an intermediate in the synthesis of other fine chemicals. It has been shown to be a useful scaffold for synthesis of complex compounds with interesting biological and chemical properties. 2,2':6',2''- Terpyridine-4'-methanol has also been found to be a versatile building block for the preparation of new speciality chemicals. This compound can be used as a reaction component in many organic reactions.</p>

<p>2,6-Dichloro-3-deazapurine is an isomer of the nucleoside guanosine. It has been shown to inhibit the synthesis of viruses in cell cultures and may be useful in the treatment of leukemia. The synthesis of 2,6-dichloro-3-deazapurine can be achieved through a solid-phase synthesis that uses synthons as starting materials. The molecular modelling studies have shown that this molecule has a potential to bind to adenosine receptor subtypes A2a, A2b, and A3.</p>

<p>8-Fluoroquinoline is a quinoline derivative that has been shown to have in vitro anticancer activity against colon adenocarcinoma cells. It is a chiral molecule that can exist as two stereoisomers, (R)-8-fluoroquinoline and (S)-8-fluoroquinoline. These isomers may have different interactions with the tumorigenic cells, but both of them have anticancer activity. 8-Fluoroquinoline also interacts with cytochrome P450 enzymes, enhancing their ability to metabolize carcinogens.</p>

<p>1-Phenanthrol is a naturally occurring phenanthrene derivative that is used in the treatment of cervical cancer. It has been shown to be effective in the chemiluminescence method using urine samples, which indicates that it may have an effect on the body's metabolism. 1-Phenanthrol has also been shown to inhibit the production of s-phenylmercapturic acid, which is a metabolite of aromatic amines. This inhibition may be due to its receptor binding properties as it binds to and activates the peroxisome proliferator-activated receptor alpha (PPARα) and PPARγ. 1-Phenanthrol also inhibits angiotensin II type 1 receptors and can cause vasorelaxation by reducing blood pressure.</p>

<p>Please enquire for more information about Methyl 3-formyl-6-methoxy-1-(4-methoxybenzyl)-1H-indole-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Isoimperatorin is a naturally occurring furanocoumarin, which is a phytochemical compound found in certain plants, particularly within the Apiaceae family, such as Angelica dahurica. It is extracted from these botanical sources through processes like solvent extraction. Isoimperatorin exhibits a diverse mode of action, including the inhibition of various enzymes and modulation of signaling pathways. It has demonstrated significant effects on cytochrome P450 enzymes, potentially influencing drug metabolism. Additionally, Isoimperatorin has shown antioxidant properties and the ability to interfere with cell proliferation and apoptosis mechanisms.</p>

<p>5-Methylindole is a molecule that has been found to be active against Staphylococcus aureus. This drug interferes with the synthesis of glycogen, which is an important energy storage molecule in animals. 5-Methylindole inhibits glycogen synthase kinase 3 (GSK-3) activity and thereby reduces the production of proinflammatory cytokines. This drug has also been shown to have cardiac effects, such as tachycardia and arrhythmias in mice. The optical properties of 5-methylindole are characterized by fluorescence and absorbance spectra, as well as its chemical reactions. 5-Methylindole is detectable at concentrations of 10 µg/mL and reacts with aminoglycosides by forming an adduct that can be detected using chromatographic methods.</p>

<p>5-Fluoro-3-methylindole is a reactive compound that is not soluble in water. It has a molecular weight of 288.5 and an ionization potential of 7.8 eV. 5-Fluoro-3-methylindole can act as a potent antagonist by binding to the pharmacophore, which is the three hydrogen bonding sites on the benzodiazepine receptor. This drug has been shown to be reactive with halides, nitro, and magnesium, as well as with some endogenous compounds such as nitroarenes and amides. 5-Fluoro-3-methylindole also reacts with fluorescence ligands and transfer agents.</p>

<p>(1R)-(-)-2-Azabicyclo[2.2.1]hept-5-en-3-one is a carbocyclic nucleoside that has been used as a flow rate standard to measure the rate of liquid chromatography. It is an organic solvent, which has been shown to have kinetic properties in the ring opening of lactams and the hydrolysis of esters. (1R)-(-)-2-Azabicyclo[2.2.1]hept-5-en-3-one can be synthesized by reacting with a cocatalyst and a reaction time of less than 5 minutes at room temperature in a high performance liquid chromatography method or by liquid chromatography with preparative methods.br&gt;br&gt;<br>(1R)-(-)-2-Azabicyclo[2.2.1]hept-5-en-3-one is used as a binding agent for</p>

<p>Please enquire for more information about Methyl 1-(2-chloro-4-fluorobenzyl)-3-formyl-6-methoxy-1H-indole-2-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ethyl 5-Nitroindole-2-Carboxylate is a precursor to the anti-HIV drug Delavirdine. It is synthesized by condensation of ethyl pyruvate and urea derivative in the presence of thionyl chloride. This compound can be used as an intermediate in the synthesis of other compounds such as ethyl ester and ethyl pyruvate. The chemical reaction is carried out at room temperature using a chlorinated solvent such as methylene chloride or chloroform. Ethyl 5-nitroindole-2-carboxylate can also be used for the synthesis of other drugs, including antitumor agents.</p>

<p>Indole-2-carboxylic acid is a potent inducer of the cytochrome P450 enzyme. It has been shown to bind to the active site of the enzyme and inhibit its activity. Indole-2-carboxylic acid is an acidic molecule with two hydrogen atoms that are capable of forming an intermolecular hydrogen bond, which may be responsible for its ability to bind to the enzyme. This compound has been shown to inhibit the activity of other enzymes such as xanthine oxidase and phosphodiesterase, which are involved in chemical reactions that produce reactive oxygen species (ROS). ROS are implicated in neuronal death and Parkinson's disease.</p>

<p>Quinoline 2,4-dicarboxylic acid (QDA) is a novel cytotoxic agent that targets cervical cancer cells. It inhibits the uptake of glucose and other nutrients by cervical cancer cells, leading to cell death through apoptosis. QDA also inhibits the expression of genes involved in cross-linking reactions, which are important for the structural integrity of proteins. This agent has been shown to inhibit the growth of aniline-induced breast cancer cells and glutamate-stimulated PC12 cells. QDA binds to DNA and forms covalent bonds with nucleotide bases, inhibiting DNA synthesis, as well as interfering with protein synthesis and cell division. The QDA mechanism is similar to that of benzoquinolines and estrone sulfate.</p>

<p>4-Nitrobenzyl (4R,5R,6S)-3-[(diphenylphosphono)oxy]-6-[(R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylat e is a synthetic compound that is used as an alkalizer and impurity scavenger in the manufacture of pesticides and other organic chemicals. It has been shown to be a stereoselective herbicide with acetonitrile as its primary degradation product. The compound has also been found to be a potent inhibitor of the enzyme carbapenemase, which may lead to increased resistance to antibiotics such as monosodium salt of ertapenem.</p>

<p>8-HQ, liberated by enzymatic activity, is a strong metal chelator and forms insoluble, grey precipitates with several metal cations such as Fe3+</p>

<p>5-Formylindole is a non-selective and irreversible inhibitor of protein α, which is the catalytic subunit of the enzyme AMP-activated protein kinase. It binds to the hydroxyl group at position Cys177 in the ATP binding pocket of protein α, thereby inhibiting its activity. 5-Formylindole has been shown to inhibit tumor growth in xenografts and also inhibits fat accumulation in 3T3-L1 preadipocytes by inhibition of fatty acid synthesis. This compound has also been used to study molecular modeling in order to understand hydrogen bond interactions between aldehyde groups and intramolecular hydrogen. The genus that this compound belongs to is stilbene derivatives.</p>

<p>Bergamottin is a furanocoumarin compound, which is primarily found in grapefruit juice and other citrus fruits. It is derived from natural sources, specifically within the fruit and peel of grapefruits. The mode of action of Bergamottin involves the inhibition of the cytochrome P450 enzymes, particularly CYP3A4, which play a significant role in the metabolism of various drugs. This inhibitory effect can alter the pharmacokinetics of certain medications by increasing their bioavailability.</p>

<p>3-(3-Piperidinopropoxy)-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole is a compound that functions as an actuator. It can be used to implement force, such as controlling a change in the position of a control or actuation, and it can also be used to shift control. 3-(3-Piperidinopropoxy)-1-[3-(Trifluoromethyl)Phenyl]-1H-Indazole is an actuation method that can be controlled by implementing force.</p>

<p>5-Methoxypsoralen is a light-activated compound, which is a naturally derived organic substance found in certain plants, particularly from the Apiaceae family. This compound functions as a furocoumarin that interacts with DNA through photoactivation, forming cross-links upon exposure to ultraviolet A (UVA) light. These cross-links disrupt DNA replication, ultimately inhibiting cell proliferation.</p>

<p>6-Mercaptopurine is a purine analog that suppresses the production of white blood cells by inhibiting the enzyme thiopurine methyltransferase. It has been used to treat bowel disease and also for long-term suppression of the immune system in patients with autoimmune diseases. 6-Mercaptopurine is metabolized to 6-mercaptopurine, which is then converted to dinucleotide phosphate (dNTP) by group P2 enzymes. This conversion allows 6-mercaptopurine to inhibit dNTP synthesis and cell division. The effects of 6-mercaptopurine are potentiated when given in conjunction with azathioprine, another drug that inhibits purine metabolism. 6-Mercaptopurine is not active against human serum albumin or erythrocytes because it cannot be cleaved into an active form by these proteins. However, it does inhibit enzyme activities such as DNA polymerase, RNA polymerase, and protein</p>

<p>7-Nitroindole-2-carboxylic acid is a molecule that has been shown to inhibit the activity of cytidine deaminase, an enzyme involved in the synthesis of DNA. This drug also inhibits the replication of dna and can be used for the treatment of cancer. 7-Nitroindole-2-carboxylic acid binds to basic proteins and has a helical structure. The affinity constants for this compound have not been reported, but it is thought that hydrogen bonding interactions are involved in its binding.</p>

<p>6-Benzylamino-7-deazapurine is a drug that has been shown to be effective in the treatment of pancreatic cancer. It is a monomer that reacts with nucleophiles such as 6-mercaptopurine, which are present in the human lung. The reaction generates an exergonic molecule that can be used to generate ATP and regenerate NAD+ during irradiation. This process has been observed using kinetic studies on human colon adenocarcinoma cells. 6-Benzylamino-7-deazapurine can also react with triazole compounds to form a linker and increase the rate of polymerization. The optimization of this reaction time could lead to more efficient cancer treatments.</p>

<p>3-(4-Fluorobenzoyl)-6-Methoxy-2-Methyl-1H-Indole-1-Acetic Acid is a prodrug that is metabolized to 6-fluoro-3,4 dioxo tamoxifen in the liver. It has been shown to have anticholinergic, cytosolic calcium and c1-4 alkyl properties. 3-(4-Fluorobenzoyl)-6-Methoxy-2-Methylindole Acetic Acid also has a basic group, cyclopentane ring, and pyridine ring.</p>

<p>5-Chloroindole-3-acetic acid (5CI3A) is a compound that belongs to the indole class of compounds. It is structurally similar to the amino acid tryptophan, which makes it a good template molecule for the synthesis of other indoles. 5CI3A is mainly found in plants and bacteria, where it acts as an auxin. In plants, 5CI3A stimulates cell elongation and leaf growth by interacting with plant hormones such as auxins and gibberellins. This compound also binds to serum albumin, which may be responsible for its low toxicity in humans. 5CI3A has been shown to inhibit the activity of human serum albumin by forming hydrogen bonds with it. This inhibition reduces the binding affinity of 5CI3A for other proteins in serum, making it less likely to interact with them than if there were no binding competition.</p>

<p>2,4-Dihydroxyquinoline is a malonic acid derivative that is used as an antimicrobial agent. It is a diazonium salt that can be synthesized from 2-chloro-4-nitrobenzene and malonic acid. The reaction mechanism for this compound involves the formation of a diazo intermediate, which reacts with the amine to form a quinoline. This compound has been shown to have antibiotic properties and is able to inhibit the growth of bacteria such as Salmonella typhi, Mycobacterium tuberculosis, Escherichia coli, and Staphylococcus aureus. 2,4-Dihydroxyquinoline has also been shown to have anticancer activity in vitro on human liver cells (HepG2) and human hepg2 cells.</p>

<p>Piperacillin is a β-lactam antibiotic that inhibits the synthesis of bacterial cell walls by binding to penicillin-binding proteins. It is used for the treatment of serious infections caused by gram-negative organisms such as Aerogenes, Enterobacter, and Klebsiella. Piperacillin has a high MIC90 value against Staphylococcus and other gram-positive bacteria, but it is not active against β-lactamase producing strains of bacteria such as E. coli or Klebsiella pneumoniae. The MIC90 values are determined through an analytical method on different strains of bacteria and validated with a sample preparation before use in clinical trials.</p>

<p>Vindoline is a monoterpenoid indole alkaloid that is found in plants of the genus Vinca. It has been used to prepare samples for thin-layer chromatography, and can be detected by sephadex g-100. The reaction mechanism of vindoline is thought to be similar to other indole alkaloids, such as tryptamine, where two molecules are combined through a covalent bond between the amine group and the carbonyl group. Vindoline has been shown to inhibit polymerase chain reactions and also has a number of biological properties that could be useful in tissue culture. This natural product structure has been shown to have steric interactions with enzymes, including tyrosinase, which is involved in plant metabolism. Vindoline may also be able to inhibit plant physiology by altering photosynthesis or respiration.</p>

<p>Psoralen is a naturally occurring furocoumarin compound, which is derived from various plants, including those in the Apiaceae family, such as parsley and celery. Its mode of action involves intercalating into DNA and forming covalent cross-links when activated by ultraviolet A (UVA) light. This photoreactivity enables it to modify the biological activity of nucleic acids, making it a valuable tool in both therapeutic and experimental settings.</p>

<p>4,4'-Dinitro-2,2'-bipyridine-N,N'-dioxide is a fine chemical with a high quality. It is a versatile building block with a wide range of applications in research and as a reagent. The compound is used in the synthesis of organic compounds and many other products. This product can be used as an intermediate for the production of more complex compounds or scaffolds. 4,4'-Dinitro-2,2'-bipyridine-N,N'-dioxide has been shown to be useful in the synthesis of pharmaceuticals and agrochemicals.</p>

<p>Please enquire for more information about 5-Methyl-4,5-dihydro-1,2,4-triazino[5,6-b]indole-3-thione including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 3-(3,4-dimethoxyphenyl)-4-(hydroxyimino)-1,6,6-trimethyl-5,6,7-trihydro1H-indazole including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Xanthine sodium salt monohydrate is a dietary supplement that is used to treat metabolic disorders such as hyperuricemia and gout. It also has antiviral effects against herpes simplex virus-1 (HSV-1) and type-2 (HSV-2). Xanthine sodium salt monohydrate inhibits the production of viral DNA polymerase, which causes cell death by inhibiting the synthesis of proteins vital for cell division. Xanthine sodium salt monohydrate can be used to inhibit the growth of cancer cells in vitro. The mechanism of action is not yet fully understood, but it is thought that xanthine may inhibit phosphodiesterase activity or have a direct effect on the cell membrane.</p>

<p>6-Chloro-7-iodo-7-deazapurine is a nucleoside analogue that is synthesized by a cross-coupling reaction between 6-chloro-2,4(1H,3H)-pyrimidinedione and 7-iodo-7-(trifluoromethyl)purine. 6CIDP has been shown to inhibit growth of epidermal cells at concentrations as low as 0.1 µM, with cytostatic effects seen at 10 µM. 6CIDP has also been shown to potently inhibit the replication of the human papilloma virus in vitro and in vivo. 6CIDP is currently being investigated for the treatment of AIDS and other viral infections. The molecular modeling studies on this compound have revealed that it may be a potent inhibitor of the epidermal growth factor receptor (EGFR).</p>

<p>N-Amino-2-methylindoline HCl is an organic chemical compound that belongs to the class of acylating agents. It is a colorless solid that is soluble in water and methanol. The compound has been used in the acylation reaction with triethylamine and chloride to synthesize dioxane. N-Amino-2-methylindoline HCl is also a substance that can be found in nature, such as in the leaves of plants. Organic chemistry deals with the study of compounds and their reactions, which includes N-Amino-2-methylindoline HCl and its uses.</p>

<p>Thiamine sulfate inner salt is a hyaluronic acid that is used in skin cancer treatment. It has been shown to have antimicrobial properties, which may be due to its ability to disrupt the cell membrane. Thiamine sulfate inner salt has also been shown to increase the germination rate of damaged seeds and can be used as a stabilizer for carrageenan. This compound is an acidic substance with a pH of 2-3. It is soluble in water and hydrochloric acid and reacts with magnesium salts, ethylene diamine, diamine tetraacetic acid, and antimicrobial peptides.</p>

<p>2,6-Diaminopurine is a nucleotide analogue that is synthesized from guanosine. It inhibits the enzyme ribonucleotide reductase and blocks the synthesis of DNA precursors, which are necessary for viral replication. 2,6-Diaminopurine has been shown to inhibit hiv infection in tissue culture and animal models by decreasing the levels of nucleotides in cells. This drug can be used as an anti-viral agent against HIV and other retroviruses. 2,6-Diaminopurine has also been shown to be effective against murine sarcoma virus. The compound binds to the enzyme ribonucleotide reductase, which is important for DNA synthesis, and prevents its activity by mimicking adenosine triphosphate (ATP). The binding of 2,6-diaminopurine to ATP results in a coordination geometry that causes a long hydrogen bond with one oxygen</p>

<p>Extensive research has been conducted on the antimicrobial activity of 6-fluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-(1,3)thiazeto(3,2a)quinoline-3-carboxylic acid (FPMT). FPMT is a levorotatory compound that is rapidly metabolized by esterases to 6FMT, which is also active against bacteria. FPMT inhibits bacterial growth, but does not inhibit mammalian cell growth. The main mechanism of action for FPMT is probably through its ability to inhibit the synthesis of bacterial DNA and RNA. This drug has been shown to be effective against sinusitis caused by bacterial rhinosinusitis and urinary tract infections caused by Escherichia coli and Pseudomonas aeruginosa. FPMT can be used as an alternative to prulifloxacin for the treatment of these types of infections</p>

<p>Also called Skatole.  It occurs naturally in the feces of mammals and birds and is the primary contributor to fecal odour.</p>

<p>2-Hydroxyisoquinoline-1,3(2H,4H)-dione (2HIQ) is a potent anti-viral agent that has been shown to inhibit the replication of viruses in cell cultures. 2HIQ inhibits viral replication by binding to the enzyme reverse transcriptase and inhibiting its ability to synthesize DNA from RNA. This drug also has inhibitory properties against human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). 2HIQ binds to the active site of the enzyme HIV reverse transcriptase, which is a key enzyme in viral replication. It also binds to HCV NS5B polymerase, which is an essential protein in HCV replication. These interactions lead to inhibition of viral replication and thus prevention of disease progression.</p>

<p>Brequinar sodium is a drug that belongs to the class of quinoline carboxylic acid derivatives. It has been shown to be effective in the treatment of infectious diseases and bowel disease. Brequinar sodium inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Brequinar also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.</p>

<p>(+/-)-Heraclenin is a naturally occurring coumarin, which is a class of organic compounds notable for diverse biological activities. This compound is primarily sourced from various plant species belonging to the family Apiaceae, such as Heracleum species. Coumarins like (+/-)-heraclenin are known for their ability to modify biological responses due to their chemical structure.</p>

<p>6-Methylpurine is a product of the nucleotide metabolism in E. coli, which is a model organism for protein synthesis. 6-Methylpurine inhibits protein synthesis and exerts significant cytotoxicity. It has been shown to inhibit the enzyme activities of DNA polymerase alpha, DNA ligase, and RNA polymerase, as well as other enzymes involved in nitrogen metabolism. 6-Methylpurine has been shown to be an analog of adenine and has a similar reaction mechanism. The uptake of 6-methyl purine by cells is mediated by hydrogen bonds with amino acid residues on the cell membrane surface. This molecule also forms glycosidic bonds with ribose sugar groups on cellular surfaces. 6-Methylpurine plays an important role in energy metabolism through its incorporation into glucose and glycogen molecules.</p>

<p>Calycanthoside is a phenolic glycoside, which is a type of natural compound characterized by a glycosidic bond linking a phenolic moiety. It is derived from the plant Calycanthus chinensis, known for its rich array of bioactive compounds. The extraction and isolation processes of Calycanthoside involve sophisticated chromatographic techniques to ensure its purity and activity.</p>

<p>2-Thioxanthine is a hydrated form of xanthine, which is a purine base that occurs in all living cells. This compound has been shown to be able to inhibit the growth of resistant mutants and the formation of atherosclerotic lesions in mice. 2-Thioxanthine also inhibits the transfer reactions that are required for bacterial DNA synthesis. The stability of 2-thioxanthine can be increased by forming stable complexes with hydrochloric acid and by reducing the pH to less than 7. 2-Thioxanthine has been shown to have genotoxic effects on mouse liver cells and human fibroblasts, as well as pharmacological properties against cardiovascular disease.</p>

<p>5-Cyano-1H-indole-2-carboxylic acid is a high quality reagent that is used as an intermediate in the synthesis of complex compounds. It can also be used as a building block for the synthesis of speciality chemicals and research chemicals. The versatile nature of this compound makes it useful as a reaction component in the synthesis of many different types of compounds, including fine chemicals and pharmaceuticals. 5-Cyano-1H-indole-2-carboxylic acid is available commercially with CAS No. 169463-44-9.</p>

<p>6-Hydroxy-4-methylcoumarin is a chemical compound that serves as a lactone derivative. It is commonly derived from synthetic sources through various organic reactions involving resorcinol and ethyl acetoacetate. The compound functions primarily through its ability to absorb ultraviolet light and fluoresce, making it highly valuable in spectroscopic analyses.</p>

<p>Isoquinoline-4-carbaldehyde is an aldehyde chemical that has been synthesized in the laboratory. It is a chiral molecule with one asymmetric carbonyl group. Isoquinoline-4-carbaldehyde is a potential precursor to naphthyridine, which can be used as a building block for the synthesis of natural products. Isoquinoline-4-carbaldehyde has been shown to have phosphine properties, and it can be used as a ligand in transition metal complexes. The molecule has been shown to exist in two forms, which coexist in equilibrium and can undergo interconversion.</p>

<p>2-Aminoacridone is a fluorescent dye.  The applications of 2-Aminoacridone are extensive in biochemical and analytical research. It is commonly employed in glycoprotein and glycoconjugate studies, leveraging its high sensitivity and specificity in detecting saccharide structures. Researchers utilize this dye in various assays, including high-performance liquid chromatography (HPLC) and electrophoresis, to analyze carbohydrate content and structure. Its role is critical in advancing our understanding of carbohydrate-related biological processes, such as cell signaling and disease pathogenesis, facilitating developments in both diagnostics and therapeutic strategies.</p>

<p>4,4'-Dipyridyl is a cyclic peptide with a basic structure. It has been found to have inhibitory effects against the growth of bacteria in human serum and group P2. The x-ray crystal structures reveal that it has strong intermolecular hydrogen bonding interactions. Experimental solubility data and coordination models show that 4,4'-dipyridyl is soluble in anhydrous sodium. Structural analysis and kinetic energy calculations indicate that the inhibitor binding site is located on the hydroxyl groups of the backbone of the molecule. This ligand also binds to metal ions such as copper or zinc.</p>

<p>Indole-3-acetyl-L-valine (IAV) is a naturally occurring amino acid that binds to the surface glycoprotein of wild-type viruses. It inhibits viral replication by inhibiting the production of basic proteins, which are necessary for viral life. IAV also has inhibitory properties against the toll-like receptor, which may be due to its ability to inhibit growth factor signaling. IAV has been shown to decrease the number of opportunistic fungal and bacterial infections in humans, with no adverse effects on human health. This drug has no effect on healthy cells and can be used as an adjuvant for the treatment of HIV and other viral infections.</p>

<p>6-Amino-9H-purine-9-propanoic acid is an acid lactam that belongs to the class of dihedral molecules. It is a colorless solid that crystallizes in plates, which have been shown to have a strong affinity for ammonium ions. 6-Amino-9H-purine-9-propanoic acid has been shown to be a substrate for the enzyme purine nucleoside phosphorylase, which catalyzes the phosphorolysis of nucleosides with the release of inorganic phosphate and ribose 5'-phosphate. The molecule can also react with electron radiation to form gamma rays, which may lead to its use as a molecular probe.</p>

<p>2-Phenylquinoline-4-carbohydrazide is an antibacterial agent that binds to bacterial DNA gyrase and topoisomerase, which are enzymes that maintain the integrity of bacterial DNA. It also has significant anti-inflammatory activity and can be used for the treatment of skin disorders, such as acne. 2-Phenylquinoline-4-carbohydrazide has been shown to induce apoptosis in human dermal fibroblast cells. This drug has been shown to have anticancer activity in vitro and in vivo. The anticancer activity of this drug may be due to its ability to inhibit cancer cell proliferation by binding to DNA gyrase and topoisomerase, which are enzymes that maintain the integrity of bacterial DNA.</p>

<p>4,5,6-Trimethoxyindole is a chemical compound that is found in the plant Chinensis. This compound has been shown to have potent anticancer properties and can be used as a treatment for inflammatory diseases. 4,5,6-Trimethoxyindole has been shown to modulate the activity of some bacteria and it has been hypothesized that this may be due to its interaction with formylation. The acidic nature of 4,5,6-Trimethoxyindole makes it soluble in ethanol. It can also be synthesised from butyric acid and other chemicals.</p>

<p>5-Cyanoindole is a hydrophobic molecule that has been shown to have an inhibitory effect on the trifluoroacetic acid-induced fluorescence in the presence of chloride ions. It is also able to bind peptides and has been used as an antimicrobial peptide. 5-Cyanoindole can be synthesized electrochemically or by electrochemical impedance spectroscopy. The synthesis of 5-cyanoindole can be achieved through a Friedel-Crafts reaction, followed by a hydrolysis with hydrogen peroxide and then a reduction with sodium borohydride.<br>!-- END OF PRODUCT DESCRIPTION --&gt;</p>

<p>4'-Iodo-2,2':6',2''-terpyridine is a transoid that has two conformations: one with the pyridine ring in the cisoid position and one with the pyridine ring in the transoid position. It can form intermolecular interactions with other molecules of 4'-iodo-2,2':6',2''-terpyridine. These interactions may be due to stacking or planar interactions.</p>

<p>4-Aminoindole hydrochloride is a white crystalline solid that can be used as a versatile building block in organic synthesis. It is also used as an intermediate in the production of various pharmaceuticals and other chemical compounds. 4-Aminoindole hydrochloride is soluble in most polar solvents, but insoluble in ethers and oils. This compound is also a useful reagent for the conversion of nitrobenzenes to aminobenzoic acids. CAS Number 174854-93-4</p>

<p>4-Fluoroisoquinoline is a synthetic compound that can be produced by the reduction of an acetonitrile-chlorinated isoquinoline compound. It is also possible to produce 4-fluoroisoquinoline by the reaction of chlorinating agents with an aldehyde, followed by the addition of phosphorus oxychloride and fluorine. The reductive sulfonation of 4-fluoroisoquinoline can be achieved by reacting it with sulfur trioxide, which is in turn generated from phosphorous oxychloride and sulfur dioxide. This process produces the desired product in good yields.</p>

<p>2,9-Dibromo-1,10-phenanthroline is a molecule that has been shown to be an effective sensitizer for the photochemical conversion of chlorine dioxide to ozone. It has been used as a model compound in molecular orbital calculations and has been shown to enhance the yield of ozone by up to 3%. The emission spectrum of 2,9-dibromo-1,10-phenanthroline displays a peak at 362 nm, which lies in the ultraviolet region. The molecule is orthorhombic and crystallizes in space group P2/c with cell dimensions a = 17.8 Å and c = 18.7 Å.</p>

<p>4-Acetoxyindole is a chromophore that belongs to the pyrrole family of compounds. It has been shown to react with an ionic liquid under acidic conditions to form a protonated intermediate, which can be deprotonated by a nucleophile. This reaction yields an acetate anion and a fluorescing product. 4-Acetoxyindole also reacts with deuterium gas, yielding an acetate, a deuterium atom, and fluorescing product. The reaction is reversible and the yield of the product depends on the concentration of the reactants. 4-Acetoxyindole has strong carbonyl groups that make it reactive towards other functional groups. These reactions are useful for synthesizing heterocycles such as indoles and isoquinolines.</p>