Enzyme Modulators
Enzyme modulators are compounds that can enhance or inhibit the activity of enzymes, thereby regulating the rate of biochemical reactions. These modulators play a critical role in controlling metabolic pathways, cell signaling, and various physiological processes. Enzyme modulators are widely used in research and drug development to study enzyme functions and to develop therapeutic agents. At CymitQuimica, we offer a comprehensive range of high-quality enzyme modulators to support your research in enzyme regulation and drug discovery.
Subcategories of "Enzyme Modulators"
Found 693 products of "Enzyme Modulators"
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Sorafenib - Bio-X ™
CAS:Sorafenib is a drug that belongs to the class of multikinase inhibitors. It inhibits a number of kinases, including the Mcl-1 protein, which is involved in apoptosis along with blocking picolinic acid (PA), an endogenous metabolite involved in apoptosis signal transduction. Sorafenib also binds to epidermal growth factor receptor (EGFR) on the surface of cancer cells, inhibiting the production of proteins that are required for angiogenesis, thus blocking the formation of new blood vessels. Sorafenib may also inhibit P-glycoprotein (Pgp) activity. Overall, these cytotoxic effects give Sorafenib anti-tumor properties, inhibiting angiogenesis and cellular transformation, which are the two main processes of tumor growth and metastasis. Sorafenib has been shown to be effective against a range of solid tumors such as breast, prostate and lung cancers and is also used for the treatment of metastatic colorectal cancer and renal cell carcinoma. A combination therapy group found that sorafenib was more effective when used with interferon alfa-2b for the treatment of advanced renal cell carcinoma. Sorafenib also has the potential for drug interactions with other drugs that are metabolized by cytochrome P450 enzymes. Sorafenib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C21H16ClF3N4O3Purity:Min. 98%Color and Shape:PowderMolecular weight:464.82 g/molMLN 4924
CAS:MLN 4924 is a selective small molecule that acts as an inhibitor of the Nedd8-activating enzyme. This compound is synthetically derived and functions by inhibiting the conjugation of Nedd8 to cullin proteins. By blocking this pathway, MLN 4924 disrupts the activity of the SCF (Skp, Cullin, F-box containing complex) E3 ubiquitin ligase, leading to an accumulation of proteins that can induce apoptosis and cell cycle arrest.
Formula:C21H25N5O4SPurity:Min. 95%Color and Shape:White PowderMolecular weight:443.52 g/molN-Desmethyl ibandronate sodium
CAS:N-Desmethyl ibandronate sodium is a white crystalline solid with a melting point of 238-240 °C. It has versatile building block, complex compound and research chemicals applications. It is an intermediate used in the synthesis of other compounds, such as speciality chemicals, useful intermediates and useful scaffolds. N-Desmethyl ibandronate sodium can be used in reactions that require high quality and high purity products.Formula:C8H20NO7P2·xNaPurity:(%) Min. 95%Color and Shape:PowderMolecular weight:327.18 g/molSeratrodast - Bio-X ™
CAS:Seratrodast is a thromboxane receptor antagonist that is used to treat asthma. However, this drug does not affect thrombus formation as other thromboxane synthase inhibitors do such as ozagrel.Formula:C22H26O4Purity:Min. 95%Color and Shape:PowderMolecular weight:354.44 g/molEpacadostat
CAS:Inhibitor of dioxygenase IDO1Formula:C11H13BrFN7O4SPurity:Min. 95%Color and Shape:White PowderMolecular weight:438.23 g/molXL184
CAS:Pan-tyrosine kinase inhibitor (VEGFR2, c-MET, RET, KIT); anti-neoplasticFormula:C28H24FN3O5Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:501.51 g/molAminopterin
CAS:Aminopterin is an antineoplastic agent and antifolate, which is a synthetic derivative of pteroylglutamic acid. It functions as a chemotherapeutic agent by inhibiting dihydrofolate reductase, an enzyme crucial in the folic acid pathway, thereby preventing the conversion of dihydrofolate to tetrahydrofolate. This disruption leads to impaired synthesis of purine nucleotides and thymidylate, which are essential for DNA synthesis and cell division.Formula:C19H20N8O5Purity:Min. 97 Area-%Color and Shape:Slightly Yellow PowderMolecular weight:440.41 g/molFinasteride - Bio-X ™
CAS:Finasteride is an antiandrogenic drug that belongs to the group of 5-alpha reductase inhibitors, which are used for the treatment of benign prostatic hyperplasia and male pattern baldness. The conversion of testosterone to 5α-dihydrotestosterone (DHT) is blocked by type II 5α-reductase inhibition, which then results in significant increase in prostatic testosterone concentrations and minimal to moderate increases in serum and tissue DHT concentrations. A reduction in DHT concentration will cause a reduction in prostatic volume as DHT appears to be the main androgen responsible for stimulating prostatic growth.
Formula:C23H36N2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:372.54 g/molRofecoxib - Bio-X ™
CAS:Controlled ProductRofecoxib is a non-steroidal anti-inflammatory drug that is used to treat osteoarthritis, acute pain and migraine attacks. This drug is also a COX-2 inhibitor. As a result, it reduces inflammation and pain.Formula:C17H14O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:314.36 g/molSacubitril sodium
CAS:Inhibitor of metalloendopeptidase neprilysinFormula:C24H28NNaO5Purity:Min. 95%Color and Shape:PowderMolecular weight:433.47 g/molIbandronate sodium monohydrate
CAS:Farnesyl pyrophosphate synthase inhibitorFormula:C9H24NNaO8P2Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:359.23 g/molLestaurtinib
CAS:Lestaurtinib is a multitarget tyrosine kinase inhibitor of the JAK, FLT-3 and TrkA families of tyrosine kinases at nanomolar concentrations. It inhibits proliferation and induces apoptosis in vitro. Lestaurtinib is a FDA approved orphan drug for acute myeloid leukemia.Formula:C26H21N3O4Purity:Min. 95%Color and Shape:PowderMolecular weight:439.46 g/molBL 918
CAS:A potent small-molecule activator of UNC-51-like kinase 1 (ULK1), a serine-threonine kinase involved in autophagy. Promotes cytoprotective autophagy in MPP+-treated SH-SY5Y cells, via the ULK complex. Improves motor dysfunction and reduces loss of dopaminergic neurons, mediated by MPTP, in in vivo models of Parkinson’s disease.
Formula:C23H15F8N3OSPurity:Min. 95%Color and Shape:PowderMolecular weight:533.44 g/molRosuvastatin calcium - Bio-X ™
CAS:Rosuvastatin is a drug that belongs to the group of statins. It is used for the treatment of high cholesterol and as an adjunct therapy for patients with coronary heart disease. Rosuvastatin reduces serum cholesterol by inhibiting HMG-CoA reductase, which is the rate-limiting enzyme in the production of cholesterol. Furthermore, this drug has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis.Formula:C22H27FN3O6SCaPurity:(%) Min. 95%Color and Shape:PowderMolecular weight:500.57 g/molCP 671305
CAS:Inhibitor of PDE4 enzyme
Formula:C23H19FN2O7Purity:Min. 95%Color and Shape:SolidMolecular weight:454.4 g/molSNS 314 mesylate
CAS:Inhibitor of Aurora kinases A, B and CFormula:C18H15ClN6OS2•CH4O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:527.04 g/molWM 8014
CAS:Selective and potent inhibitor of lysine acetyltransferases KAT6A and KAT6B with IC50 values of 8 nM and 28 nM, respectively. The compound is a reversible competitor of acetyl coenzyme A domain of KAT6A/B enzymes. It inhibits MYST-catalysed histone acetylation and potentiates senescence in vitro and in zebrafish model of hepatocellular carcinoma. The compound opened the door to a new class of cancer therapeutics that could potentially direct the cancer cells in senescence or permanent dormancy.Formula:C20H17FN2O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:384.43 g/molOxaprozin - Bio-X ™
CAS:Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of osteoarthritis and rheumatoid arthritis. This drug relieves swelling and inflammation by inhibiting the enzyme cyclooxygenase which in turn inhibits prostaglandin synthesis.Formula:C18H15NO3Purity:Min. 95%Color and Shape:PowderMolecular weight:293.32 g/molKV 37
CAS:Inhibitor of AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase)Formula:C23H25NO3Purity:Min. 95%Color and Shape:PowderMolecular weight:363.45 g/molTenatoprazole
CAS:H+/K+ ATPase inhibitorFormula:C16H18N4O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:346.41 g/molCamostat mesylate - Bio-X ™
CAS:Camostat is a serine protease inhibitor that is used for the treatment of chronic pancreatitis. This drug has shown to reduce inflammation and pain. Studies have shown that Camostat has also inhibited the entry of SARS-CoV-2 in lung cells by inhibiting the priming process of S-protein, necessary for the viral entry into host cells.Formula:C20H22N4O5•CH4O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:494.52 g/molSquarunkin A
CAS:Selective inhibitor of the interaction between the UNC119 chaperone and its cargo. Squarunkin A inhibits activation of Src kinase by interrupting the interaction between the myristoylated peptide at the N-terminus of the Src kinase and UNC119A chaperone (IC50 = 10 nM). Squarunkin A impairs the UNC119-mediated enrichment of plasma membrane with non-receptor protein tyrosine kinase Src, resulting in the decrease in Src autophosphorylation and decreased oncogenic Src signalling.Formula:C25H32F3N5O4Purity:Min. 95%Color and Shape:SolidMolecular weight:523.55 g/molGefitinib - Bio-X ™
CAS:Gefitinib is an inhibitor of the epidermal growth factor receptor (EGFR) protein. This inhibition is on the EGFR tyrosine kinase domain, where Gefitinib bindings to the ATP-binding site. As a a tyrosine kinase inhibitor, Gefitinib blocks tumor growth and has led to its use in slowing the progression of non-small cell lung cancer. Gefitinib also inhibits invasion and metastasis through inhibition of macrophage receptor interacting protein kinase 2 (RIPK2), rather than EGFR.Formula:C22H24ClFN4O3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:446.9 g/molPentoxifylline
CAS:Controlled ProductPhosphodiesterase inhibitorFormula:C13H18N4O3Purity:Min. 95%Color and Shape:White PowderMolecular weight:278.31 g/molO6-Benzylguanine - Bio-X ™
CAS:O6-Benzylguanine is a guanine analog that is an antineoplastic agent. It works by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA alkyltransferase. This results to an interruption of DNA repair so that damage can occur to local tumor targets.Formula:C12H11N5OPurity:Min. 95%Color and Shape:PowderMolecular weight:241.25 g/mol3-(4-Phenylbutyl)-4-propyloxetan-2-one
CAS:Cis/trans-form of GK 563 [2351820-19-2]Formula:C16H22O2Purity:Min. 95%Color and Shape:SolidMolecular weight:246.34 g/molTrilostane
CAS:Controlled ProductInhibitor of 3β-hydroxysteroid dehydrogenase in steroid biosynthesis
Formula:C20H27NO3Purity:Min. 95%Color and Shape:White PowderMolecular weight:329.43 g/molMK 4827
CAS:Inhibitor of PARP1 and PARP2 enzymes
Formula:C19H20N4OPurity:Min. 96 Area-%Color and Shape:White PowderMolecular weight:320.39 g/molRucaparib camsylate
CAS:Inhibitor of poly (ADP-ribose) polymerase enzyme; antineoplasticFormula:C19H18FN3O•C10H16O4SPurity:Min. 95%Color and Shape:Off-White To Yellow SolidMolecular weight:555.66 g/molAbiraterone acetate - Bio-X ™
CAS:Controlled ProductAbiraterone is an antiandrogen drug used in the treatment of metastatic prostate cancer. It is a derivative of steroidal progesterone. This drug inhibits the enzyme CYP17 irreversibly, thus inhibiting the synthesis of androgen. It specifically inhibits the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone to decrease serum levels of testosterone and other androgens.Formula:C26H33NO2Purity:Min. 95%Color and Shape:PowderMolecular weight:391.55 g/molEtoposide phosphate
CAS:Topoisomerase II inhibitor; chemotherapeutic drugFormula:C29H33O16PPurity:Min. 95%Color and Shape:PowderMolecular weight:668.54 g/molDiacerein - Bio-X ™
CAS:Diacerein is a slow-onset anthraquinone IL-1 inhibitor that is used in the treatment of joint diseases such as osteoarthritis. This drug is also being studied for the treatment of insulin resistance and diabetes mellitus. Diacerein works to decrease inflammation and cartilage destruction by reducing the level of interleukin-1.Formula:C19H12O8Purity:Min. 95%Color and Shape:PowderMolecular weight:368.29 g/molFlurbiprofen
CAS:Inhibitor of cytochrome P450; inhibitor of prostaglandin synthesis
Formula:C15H13FO2Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:244.26 g/molImiquimod - Bio-X ™
CAS:Imiquimod is a toll-like receptor 7 agonist drug that is used for the treatment of genital warts, basal cell carcinoma and condyloma acuminata. This drug works by relieving and controlling wart production. Studies in mice have shown that this drug may induce cytokines such as interleukins. Imiquimod helps to increase apoptosis of diseased tissues and an infiltration of lymphocytes into tumor lesions.Formula:C14H16N4Purity:Min. 95%Color and Shape:PowderMolecular weight:240.3 g/molBrivanib alaninate
CAS:VEGFR2 a tyrosine kinase receptor inhibitor; antineoplasticFormula:C22H24FN5O4Purity:Min. 95%Color and Shape:PowderMolecular weight:441.18123Lenalidomide - Bio-X ™
CAS:Controlled ProductLenalidomide is a thalidomide derivative that is used to treat multiple myeloma and anemia. This drug exerts immunomodulatory effects by altering cytokine production. Lenalidomide also directly inhibits the cullin ring E3 ubiquitin ligase complex.Formula:C13H13N3O3Purity:Min. 95%Color and Shape:PowderMolecular weight:259.26 g/molLeflunomide - Bio-X ™
CAS:Controlled ProductLeflunomide is a pyrimidine synthesis inhibitor drug that is used to treat rheumatoid arthritis. Although its mechanism of action is not fully determined, this drug has shown to interfere with cell cycle progression by inhibiting dihydroorotate dehydrogenase and has shown antiproliferative activity. As a result of this, it interferes with the expansion of activated autoimmune lymphocytes. Additionally, Leflunomide is a tyrosine kinase inhibitor.Formula:C12H9F3N2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:270.21 g/molSU 0268
CAS:Inhibitor of 8-oxoguanine DNA glycosylase OGG1 with IC50 of 0.059 μM and excellent specificity over other DNA repair enzymes. OGG1 and its substrate 8-oxoguanine are involved in mutagenesis, genotoxicity, inflammation and cancer. The compound can cause accumulation of 8-oxoguanine in DNA in vitro and is a potent tool for the study of OGG1 biology.Formula:C26H25N3O4SPurity:Min. 95%Color and Shape:White PowderMolecular weight:475.56 g/molGboxin
CAS:Inhibitor of oxidative phosphorylation which acts on the F0F1 ATP synthase in the inner mitochondrial membrane and causes acute increase in mitochondrial membrane potential. Gboxin was shown to accumulate in mitochondria of cancer cells, to cause cellular toxicity and cell growth inhibition in mouse glioblastoma. However, Gboxin did not inhibit growth of mouse embryonic fibroblasts or neonatal astrocytes.Formula:C22H33N2O2•ClPurity:Min. 95%Color and Shape:SolidMolecular weight:392.96 g/molArbutin - Synthetic origin
CAS:Inhibitor of tyrosinase in melanocytes: skin whitener
Formula:C12H16O7Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:272.25 g/molNVP-BGJ398
CAS:Inhibits FGFR family of kinases; antineoplastic; anti-angiogenicFormula:C26H31Cl2N7O3Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:560.48 g/molPravastatin sodium salt - Bio-X ™
CAS:Pravastatin is an HMG-CoA reductase inhibitor that is used to lower lipid levels and manage cardiovascular events such as strokes and myocardial infarction. This drug inhibits HMG-CoA reductase allowing for a reduction in the level of cholesterol.Formula:C23H35NaO7Purity:Min. 95%Color and Shape:PowderMolecular weight:446.51 g/molSB 1317
CAS:Inhibitor of CDK2, JAK2 and FLT3; anticancerFormula:C23H24N4OPurity:Min. 95%Color and Shape:Off-White PowderMolecular weight:372.46 g/molD,L-Carbidopa
CAS:Controlled ProductInhibits aromatic amino acid decarboxylaseFormula:C10H14N2O4Purity:Min. 95%Color and Shape:PowderMolecular weight:226.23 g/molAdefovir dipivoxil - Bio-X ™
CAS:Adefovir is an antiviral acyclic nucleoside phosphonate (ANP) analogue that works by blocking reverse transcriptase. This drug is used to treat infections associated with Hepatitis B.Formula:C20H32N5O8PPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:501.47 g/molGSK 1120212B
CAS:Inhibits MEK1 and MEK2 kinases; targeted therapy for melanomaFormula:C26H23FIN5O4•C2H6OSPurity:Min. 95%Color and Shape:PowderMolecular weight:693.53 g/molPomalidomide - Bio-X ™
CAS:Controlled ProductPomalidomide is an immunomodulatory agent that inhibits transcriptional regulation by interacting with the pomalidomide-binding protein, which prevents its interaction with RNA polymerase II and thereby prevents DNA transcription. The study with U266 cells demonstrated that pomalidomide targets CRBN, part of an E3 ligase complex, and inhibits its autoubiquinitation and supresses a critical gene (IRF4, interferon regulatory factor 4) for myeloma cell growth with concentrations up to 10 μM. In vitro assays have shown that pomalidomide has inhibitory effects on cell signaling pathways, such as the NF-κB pathway. Pomalidomide also decreases the production of proinflammatory cytokines, such as TNFα and IL-1β, by inhibiting their synthesis or their release from activated monocytes. Recently, the promoting effect of pomalidomide, as its analog lenalidomide, on erythropoiesis (production of red blood cells) has been investigated, demonstrating positive results for its use as a potential new therapy agent for β-hemoglobinopathies. Pomalidomide is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.Formula:C13H11N3O4Purity:Min. 99 Area-%Color and Shape:PowderMolecular weight:273.24 g/molFebuxostat - Bio-X ™
CAS:Febuxostat is a non-purine xanthine oxidase inhibitor that is used for the treatment and management of hyperuricemia and chronic gouty arthritis. Febuxostat inhibits the uptake of uric acid from the blood into cells and thereby reduces its concentration in plasma. Additionally, this drug has been shown to have anti-inflammatory and antioxidant effects.Formula:C16H16N2O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:316.38 g/molIrinotecan
CAS:Inhibitor of DNA topoisomerase IFormula:C33H38N4O6Purity:Min. 98 Area-%Color and Shape:Beige PowderMolecular weight:586.68 g/molEdoxaban tosylate
CAS:Inhibitor of Factor Xa; anti-thrombotic
Formula:C24H30ClN7O4S·C7H8O3SPurity:Min. 95%Color and Shape:White PowderMolecular weight:720.3 g/molAZD 1208
CAS:Inhibits proto-oncogene Pim kinases (Pim-1, Pim-2 and Pim-3); antineoplasticFormula:C21H21N3O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:379.48 g/molODQ
CAS:Inhibitor of guanylyl cyclaseFormula:C9H5N3O2Purity:Min. 95%Color and Shape:PowderMolecular weight:187.16 g/molOmeprazole - Bio-X ™
CAS:Omeprazole is a proton pump inhibitor (PPI) that inhibits the production of gastric acid in the stomach. This is due to Omeprazole binding through a stable disulphide bond to the H+/K+ ATPase enzyme found on parietal cells, and preventing hydrogen ion transport. Consequently, gastric acid secretion is supressed. As a PPI, Omerprazole can be used to treat disorders where gastric acid is over-secreted. Examples of these disorders are gastroesophageal reflux disease (GERD) and peptic ulcer disease.Formula:C17H19N3O3SPurity:Min. 95%Color and Shape:PowderMolecular weight:345.42 g/molALW-II-41-27
CAS:LW-II-41-27 is a novel Eph receptor tyrosine kinase inhibitor used for cancer treatment.Formula:C32H32F3N5O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:607.69 g/molGKT-137831
CAS:NADPH oxidase inhibitor; anti-inflammatory
Formula:C21H19ClN4O2Purity:Min. 95%Color and Shape:Off-White PowderMolecular weight:394.85 g/molA 66
CAS:Specific inhibitor of the phosphoinositide 3-kinase (PI3K) alpha subunit with IC50 of 32 nM. In heart muscle it negatively regulates hypertrophic growth, causes increase in late sodium current and leads to arrhythmias. In tumours it inhibits the p110α subunit of PI3K and blocks growth factor signalling resulting in reduced tumour growth.
Formula:C17H23N5O2S2Purity:Min. 95%Color and Shape:SolidMolecular weight:393.53 g/molOxyphenbutazone hydrate
CAS:Inhibitor of COX-1 and COX-2 cyclooxygenasesFormula:C19H20N2O3•H2OPurity:Min. 95%Color and Shape:PowderMolecular weight:342.39 g/molLapatinib base - Bio-X ™
CAS:Lapatinib is an antineoplastic agent used to treat breast and lung cancer. This drug is also a tyrosine kinase inhibitor and inhibits human epidermal growth factor receptor type 2 (HER2/ERBB2) and epidermal growth factor receptor (HER1/EGFR/ERBB1). Lapatinib has shown to inhibit ERBB-driven tumor cell growth in vitro and in various animal models.Formula:C29H26ClFN4O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:581.06 g/molIrsogladine maleate - Bio-X ™
CAS:Irsogladine is a gastroprotective drug that is used for the treatment of GERD and gastric ulcers. This drug also has antioxidant properties. Irsogladine is a phosphodiesterase-4 inhibitor and increases levels of cAMP. It helps to prevent and heal damage to the stomach lining.Formula:C13H11Cl2N5O4Purity:Min. 95%Color and Shape:PowderMolecular weight:372.16 g/molEntinostat
CAS:Inhibits histone deacetylase (HDAC)
Formula:C21H20N4O3Purity:Min. 95%Color and Shape:Off-White PowderMolecular weight:376.15354Chymostatin
CAS:Inhibitor of chymotrypsinFormula:C31H41N7O6Color and Shape:White To Yellowish SolidMolecular weight:607.7 g/molPX 866
CAS:Potent and irreversible inhibitor of phosphoinositide-3-kinase (PtdIns-3-kinase) with IC50 of 0.1 nM. PX 866 inhibited cell motility and growth of 3D spheroids of glioblastoma, breast, prostate and colon cancer cell lines at low nanomolar concentrations. PX 866 also exhibited anti-tumoral activity in vivo in xenograft models for ovarian and lung cancer.Formula:C29H35NO8Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:525.59 g/molBAY 607550
CAS:A selective and potent inhibitor of phosphodiesterase 2 (PDE2). Raises cAMP and cGMP levels in neurons, improves social recognition and object memory in murine animals. Reverses anxiolytic effects induced by oxidative stress in mice by blocking cGMP-PKG signaling.
Formula:C27H32N4O4Purity:Min. 95%Color and Shape:PowderMolecular weight:476.24236MGCD 265
CAS:Inhibits MET, VEGFR1-3, Tie and Ron tyrosine kinases; antineoplasticFormula:C26H20FN5O2S2Purity:Min. 95%Molecular weight:517.60 g/molMK 886 - Bio-X ™
CAS:MK 886 is a leukotriene antagonist that has been studied for use in treating atherosclerosis. This drug inhibits the 5-lipoxygenase activating protein thus inhibiting 5-lipoxygenase.Formula:C27H34ClNO2SPurity:Min. 95%Color and Shape:PowderMolecular weight:472.08 g/molSCH 772984
CAS:Inhibitor of ERK1 and ERK2 serine/threonine kinasesFormula:C33H33N9O2Purity:Min. 95%Color and Shape:Light (Or Pale) Yellow To Yellow SolidMolecular weight:587.67 g/molSB 431542
CAS:Inhibitor of activin receptor-like kinases (ALK4, ALK5 and ALK7), members of TGFβ type I receptor family. Blocks activin- and TGFβ-mediated signaling and phosphorylation of Smad2 downstream. Suppresses tumor-promoting and tumor-suppressing effects of TGFβ. Promotes differentiation of human embryonic stem cells (hESCs), whilst sustaining mouse ESCs in the undifferentiated state.Formula:C22H16N4O3Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:384.4 g/moleCF506
CAS:Selective inhibitor of the Src kinase family with subnanomolar IC50 values and good selectivity over c-Abl, PDGFRα and c-Kit kinases. The compound is effective in inhibiting growth in drug resistant cancer cell lines. In a recent study, it inhibited the growth of HER2-positive breast cancer cell lines which were resistant to pan-HER family kinase inhibitors such as lapatinib.Formula:C26H38N8O3Purity:Min. 95%Color and Shape:SolidMolecular weight:510.63 g/molBLU 667
CAS:RET receptor tyroine kinase inhibitorFormula:C27H32FN9O2Purity:Min. 95%Color and Shape:White/Off-White SolidMolecular weight:533.6 g/molRigosertib sodium
CAS:Rigosertib sodium is an experimental chemotherapeutic agent that is a derivative of benzyl styryl sulfone. It is synthesized chemically and functions primarily by inhibiting key signaling pathways involved in cancer cell proliferation. Specifically, Rigosertib targets the RAS signaling pathway along with the phosphatidylinositol-3-kinase/AKT and polo-like kinase 1 (Plk1) pathways, impeding the progression of the cell cycle and inducing apoptosis in malignant cells.Formula:C21H24NNaO8SPurity:Min. 95%Color and Shape:White PowderMolecular weight:473.47 g/molAbemaciclib
CAS:Inhibitor of cyclin-dependent kinases CDK4 and CDK6Formula:C27H32F2N8Purity:Min. 95%Molecular weight:506.59 g/molGilteritinib
CAS:Inhibitor of FLT3 and AXL tyrosine kinasesFormula:C29H44N8O3Purity:Min. 95%Color and Shape:PowderMolecular weight:552.71 g/molSulindac - Bio-X ™
CAS:Sulindac is a non-steroidal anti-inflammatory drug that has anti-inflammatory and analgesic properties. It is used to relieve the pain of osteoarthritis and rheumatoid arthritis by reducing inflammation and inhibiting the production of prostaglandins, which are chemicals that cause inflammation.Formula:C20H17FO3SPurity:Min. 95%Color and Shape:PowderMolecular weight:356.41 g/mol(-)-Huperzine A
CAS:Acetylcholinesterase inhibitor; therapy for Alzheimer's diseaseFormula:C15H18N2OPurity:(%) Min. 98%Color and Shape:PowderMolecular weight:242.32 g/molLY 411575
CAS:Potent inhibitor of γ-secretase. LY 411575 inhibited production of amyloid β (Aβ) peptides with IC50 of 0.078 nM in vitro as well as decreased levels of Aβ40 and Aβ42 amyloids in brain of a mouse model for Alzheimer’s disease. In vitro studies confirmed that LY 411575 inhibited cleavage of Notch receptor at S3 site with IC50 of 0.39 nM, which blocked Notch activation and downstream signalling, leading to apoptosis in primary and immortalized Kaposi's sarcoma cells.Formula:C26H23F2N3O4Purity:Min. 95%Color and Shape:SolidMolecular weight:479.48 g/molMethocarbamol
CAS:Inhibitor of carbonic anhydrase; muscle relaxantFormula:C11H15NO5Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:241.24 g/molLovastatin - Bio-X ™
CAS:Lovastatin is an HMG-CoA reductase inhibitor that is used to lower LDL cholesterol levels and to aid in the management of cardiovascular diseases. Animal studies have demonstrated that this drug has vasculoprotective properties.Formula:C24H36O5Purity:Min. 95%Color and Shape:PowderMolecular weight:404.54 g/molFasudil hydrochloride
CAS:Fasudil hydrochloride is a Rho-kinase inhibitor, which is a synthetic compound derived from natural sources, primarily used in scientific research. The mode of action of Fasudil hydrochloride involves the inhibition of Rho-associated protein kinase (ROCK), a crucial player in the regulation of the actin cytoskeleton. By inhibiting ROCK, Fasudil alters various cellular functions, including contraction, motility, proliferation, and apoptosis.Formula:C14H17N3O2S•HClPurity:Min. 95%Color and Shape:White PowderMolecular weight:327.83 g/molBetrixaban
CAS:Inhibitor of factor XaFormula:C23H22ClN5O3Purity:Min. 95%Color and Shape:Off-White PowderMolecular weight:451.91 g/molMRK 560
CAS:γ-secretase inhibitor; reduces amyloid-β in brainÂ
Formula:C19H17ClF5NO4S2Purity:Min. 95%Molecular weight:517.92 g/molLarotrectinib sulphate
CAS:A potent ATP-competitive inhibitor of tropomyosin-related kinases (TRK1, TRK2 and TRK3), members of the receptor tyrosine kinase family of neurotrophin receptors. Tumors with oncogenic TRK fusions are sensitive to larotrectinib, leading to reduced proliferation and tumor growth in patients with soft tissue sarcoma, triple-negative breast cancer and lung cancer.Formula:C21H22F2N6O2H2SO4Purity:Min. 95%Molecular weight:526.51 g/molTacrolimus
CAS:Antirheumatic; immunosuppressant; neuroprotective; neuroregenerativeFormula:C44H69NO12Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:804.02 g/molGNE 6776
CAS:Specific inhibitor of the ubiquitin specific protease-7 (USP7), which is a validated deubiquitinase of the E3 ubiquitin-protein ligase MDM2. The compound inhibits the USP7 deubiquitinase activity by binding to acidic amino acid residues important for the interaction with ubiquitin. Induces tumor cell death and enhances cytotoxicity of chemotherapeutic agents.Formula:C20H20N4O2Purity:Min. 95%Molecular weight:348.4 g/mol5-Fluorouracil - Bio-X ™
CAS:5-Fluorouracil is a cytotoxic drug that inhibits the synthesis of DNA. It is used in combination therapy to treat cancer and is a pyrimidine analog. This drug inhibits the formation of thymidylate synthase from uracil. As a result, this leads to DNA and RNA synthesis inhibition and cell death.Formula:C4H3FN2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:130.08 g/molGRL 0617
CAS:A novel non-covalent inhibitor of the PLpro protease from SARS-CoV-2 and SARS-CoV viruses. GRL 0617 inhibits the proteolytic processing of the viral polypeptide. As PLpro also acts as a protease in pathways involved in innate immunity, there are indications that it can promote immunity against the virus.Formula:C20H20N2OPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:304.39 g/molOdiparcil
CAS:Dipeptidyl peptidase 4 (DPP4) inhibitor
Formula:C15H16O6SPurity:Min. 99%Color and Shape:PowderMolecular weight:324.35 g/molIdelalisib
CAS:Idelalisib is a pharmaceutical drug that functions as a PI3Kδ inhibitor, developed through synthetic chemical processes. Its mode of action involves selectively targeting and inhibiting phosphatidylinositol 3-kinase delta (PI3Kδ), a lipid kinase that plays a crucial role in the signaling pathways responsible for cell proliferation, survival, and differentiation. By inhibiting this enzyme, Idelalisib effectively impedes pathways that are often hyperactivated in certain hematologic malignancies, thereby exerting antitumor effects.Formula:C22H18FN7OPurity:Min. 95%Color and Shape:PowderMolecular weight:415.42 g/molTemsirolimus
CAS:mTOR serine/threonine kinase inhibitorFormula:C56H87NO16Purity:Min. 95%Color and Shape:PowderMolecular weight:1,030.29 g/molBKM 120
CAS:Inhibitor of pan-class I PI3K family of lipid kinases; antineoplastic
Formula:C18H21O2N6F3Purity:Min. 95%Color and Shape:White PowderMolecular weight:410.39 g/molN-Butyldeoxynojirimycin
CAS:Competitive inhibitor of ceramide-glycosyltransferase used for substrate reduction therapy in lysosomal storage disorders. It inhibits glucosylceramide synthase, which catalyses the initial step in glycosphingolipid biosynthetic pathway. This compound delays the onset of symptoms in type 1 Gaucher disease, Sandhoff disease and Tay-Sachs disease. It also reduces brain abnormalities in mucolipidosis type IV.Formula:C10H21NO4Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:219.28 g/molPKC 412
CAS:Inhibits multiple protein kinases, such as PKC and FLT3Formula:C35H30N4O4Purity:Min. 95%Color and Shape:PowderMolecular weight:570.64 g/molTivozanib
CAS:Inhibitor of VEGF receptorsFormula:C22H19ClN4O5Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:454.86 g/molPimasertib
CAS:A selective inhibitor of MEK1/2 kinase. Anti-proliferative and pro-apoptotic in multiple myeloma (MM) cells via G0/G1 cell cycle arrest and caspase 3 and PARP cleavage, respectively. Synergistic with other anti-MM therapies. Has anti-tumor effects in some solid tumors, such as in K-ras mutated colorectal cancer.Formula:C15H15FIN3O3Purity:Min. 95%Color and Shape:White To Yellow SolidMolecular weight:431.2 g/molDabigatran etexilate - Bio-X ™
CAS:Dabigatran is an anticoagulant that is used for the treatment of atrial fibrillation and prevention of venous thromboembolic events. It is a drug that acts as an inhibitor of the enzyme thrombin. Dabigatran inhibits platelet activation and aggregation, which reduces the risk of stroke or other vascular events. Dabigatran is a prodrug and does not have any activity in its active form.
Formula:C34H41N7O5Purity:Min. 95%Color and Shape:PowderMolecular weight:627.73 g/molTacrolimus monohydrate
CAS:Anti-rheumatic; immunosuppressant; neuroprotective; neuroregenerativeFormula:C44H69NO12·H2OPurity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:822.03 g/molJNJ 10198409
CAS:Selective inhibitor of the platelet derived growth factor receptor PDGFRβ with IC50 value of 4.2 nM. JNJ 10198409 inhibits the PDGFRβ kinase activity and its downstream signalling leading to anti-proliferative and anti-angiogenic effects, which were confirmed in various tumoral cell lines.Formula:C18H16FN3O2Purity:Min. 95%Color and Shape:SolidMolecular weight:325.34 g/molApatinib mesylate
CAS:Inhibitor of VEGFR; antineoplasticFormula:C24H23N5O·CH4O3SPurity:Min. 95%Molecular weight:493.58 g/molA 939572
CAS:Inhibitor of stearoyl-CoA desaturase SCD1 with IC50 of 6.3 nM, as measured in the SCD1-expressing human microsomes. A 939572 exhibited anticancer activity as it reduced cell proliferation and triggered cell killing in human non-small cell lung carcinoma cells. A 939572 inhibited tumour growth in an in vivo model for gastric carcinoma and reduced the oleic acid:stearic acid ratio in mouse liver and plasma.Formula:C20H22ClN3O3Purity:Min. 95%Color and Shape:PowderMolecular weight:387.86 g/molKU-0063794
CAS:Inhibits mTORC1 and mTORC2 serine/threonine kinasesFormula:C25H31N5O4Purity:Min. 95%Color and Shape:White To Beige To Yellow SolidMolecular weight:465.54 g/molNiacinamide
CAS:Vitamin B3; antioxidant; favours cell repairFormula:C6H6N2OPurity:98.5 To 101.5 Area-%Color and Shape:White PowderMolecular weight:122.12 g/mol
