Metabolismo

<p>G* peptide, also known as LVGRQLEEFL (mouse) TFA, is a segment corresponding to amino acids 113 to 122 ([113,122] apoJ) of apolipoprotein J.</p>

<p>ACAT-IN-4 inhibits ACAT and NF-κB-mediated transcription.</p>

<p>Captopril EP Impurity B, an antihypertensive thiol ACE inhibitor with IC50 of 0.025 μM.</p>

<p>Eubulus-A80 is a anti-tumor agent (WO2021/183702, Compound A80).</p>

<p>11R-CaN-AID is a potent, cell-permeant inhibitor of calcineurin [1] [2].</p>

<p>DSPE-PEG2000-K237 is a PEG compound consisting of DSPE and the KDR-targeting peptide (K237). K237 functionally disrupts the interaction between VEGF and KDR receptors, resulting in significant biological effects such as inhibition of angiogenesis and tumor growth. DSPE-PEG2000-K237 is applicable in drug delivery.</p>

<p>ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.</p>

hCES2A-IN-2 (compound 14n) is an orally active, highly specific, irreversible, covalent inhibitor of hCES2A with an IC50 of 0.04 nM. It targets and covalently binds to the catalytic serine residue (Ser-228) of hCES2A. hCES2A-IN-2 can significantly mitigate irinotecan-induced gastrointestinal toxicity (ITGT) without diminishing the antitumor efficacy of irinotecan in tumor-bearing mice.

<p>O-Demethyl Lenvatinib HCl is a Lenvatinib metabolite; an oral inhibitor targeting VEGFR, FGFR, PDGFR, KIT, RET with antitumor properties.</p>

<p>Camellianin B, a flavonoid from Camellianin A, has antioxidant effects and blocks ACE.</p>

<p>CAY10462 (CTK8E8405) is an effective and selective inhibitor of the 20-HETE synthase CYP4A11 with an IC50 of 8.8 nM.</p>

<p>PKR activator 4 (example 7A), a potent activator of pyruvate kinase R (PKR), holds promise for blood disorder research [1].</p>

<p>Oleic acid-2,6-diisopropylanilide: ACAT inhibitor, IC50 7 nM; lowers LDL &amp; raises HDL in high-fat fed rabbits/rats at 0.05%.</p>

<p>Pepticinnamin E is a naturally occurring bisubstrate farnesyltransferase inhibitor.</p>

<p>CYP1B1-IN-7 is a CYP1B1 inhibitor that can be used in synergy with anticancer compounds for the treatment of cancers.</p>

<p>D-LDH is an oxidoreductase turning D-lactate into pyruvate, using NAD+/NADP+; prevalent in bacteria and fungi, key for biochemical research.</p>

<p>CTL-12, a fatty acid synthase (FASN) inhibitor (IC50: 2.5 μM), induces apoptosis and disrupts the cell cycle at the Sub-G1/S phase.</p>

<p>Dihomo-γ-Linolenic acid methyl ester is the methyl ester form of Dihomo-γ-Linolenic acid which has anti-inflammatory and anti-proliferative effects.</p>

<p>LL P880 beta is a fungal metabolite.</p>

<p>YF704 (compound 4w), a selective allosteric inhibitor of SHP2, exhibits antiproliferative effects and induces apoptosis in cancer cells with an IC50 of 0.25 μM.</p>

<p>(24R)-MC 976 is a derivative of Vitamin D3.</p>

<p>Cholesteryl homo-γ-linolenate is a cholesterol ester.</p>

<p>O-desmethyl Mebeverine acid is a metabolite of Mebeverine.</p>

<p>Reticulol is an isocoumarin derivative produced by certain species of Streptomyces.</p>

<p>β-N-Acetylhexosaminidase is an exoglycosidase that catalyzes the hydrolysis of terminal non-reducing β-N-acetylgalactosamine and glucosamine residues in</p>

<p>Omfiloctocog alfa (SCT-800) is a recombinant FVIII for Hemophilia A research.</p>

<p>Rubrofusarin 6-O-β-D-glucopyranoside, a glycosidic derivative of Rubrofusarin, functions as an inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC50</p>

<p>Andrastin A is a useful organic compound for research related to life sciences. The catalog number is T125574 and the CAS number is 174232-42-9.</p>

<p>Compound 2058-74-4, with CAS No. 2058-74-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 2058-74-4 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>9c(i472) blocks 15-LO-1 (IC50=0.19μM), lowers NF-κB in RAW-Blue cells, &amp; cuts Nos2/lipid peroxidation in RAW 264.7 at 0.2-5μM.</p>

<p>L-Hisidine is an essential amino acid for infants and acts as an inhibitor of mitochondrial glutamine transport.</p>

<p>NADP+ is the oxidized cofactor form of NADPH, vital for cell survival, redox balance, and signaling; synthesized from NAD+ and ATP.</p>

<p>1,4-Dihydropyridine acts as an antagonist for calcium channels (calcium channel), specifically blocking the L-type calcium channels. This action reduces the influx of calcium ions into cardiac and vascular smooth muscle cells, consequently decreasing cardiac contractility and heart rate, dilating blood vessels, and lowering blood pressure.</p>

<p>CESs are enzymes in mammalian liver hydrolyzing esters and other substrates in biochemical studies.</p>

<p>Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.</p>

<p>PDE4-IN-4 is a compound acting as both a potent M3 antagonist (p IC 50 = 10.2) and a PDE4 inhibitor (p IC 50 = 8.8), designed for inhalation-based treatment of</p>

<p>Pyruvate kinase is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP [1] .</p>

<p>(R,S)-Carvedilol glucuronide is a racemic mix, metabolized by UGT1A1, UGT2B4, and UGT2B7.</p>

<p>H-Met-Val-OH is a dipeptide inhibiting FMO1 and FMO3 and promoting neurite outgrowth, relevant for neuroregenerative and enzymatic modulation studies.</p>

<p>(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into small compounds that can be utilized by the body.</p>

<p>Hydroxydehydro nifedipine carboxylate is a metabolite of nifedipine .1</p>

<p>Abieslacton possesses anti-tumor promoting activity isolated from several Abies genus.</p>

<p>LYP-IN-1 is a potent, selective inhibitor of lymphoid-specific tyrosine phosphatase useful for studying autoimmune disorders and immune signaling.</p>

<p>D-Fructose 1-phosphate disodium salt, a derivative of fructose, serves as a crucial intermediate in glucose metabolism.</p>

<p>1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides .</p>

<p>Furosine dihydrochloride, an early Maillard reaction marker, is linked to diseases like diabetes.</p>

<p>MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.</p>

<p>Phosmet oxon is a toxic byproduct of phosmet, an organophosphate insecticide for apple trees and various crops, targeting moths, aphids, mites, and flies.</p>

<p>Maltodextrin (DE 16.5-19.5) is an inactive pharma excipient that enhances drug stability, solubility, and processing.</p>

<p>ARL67156 trisodium hydrate inhibits ecto-ATPase, NTPDase1, NTPDase3, NPP1 (Kis 11-18µM), for calcific valve disease, asthma research.</p>

<p>Monaschromone, a polyketide, hinders B. cinerea, A. solani, M. oryzae, G. saubinettii growth; MICs 6.25-12.5 μM.</p>

<p>Alanine aminotransferase (ALT), a pyridoxal-dependent enzyme, catalyzes the reversible interconversion of L-alanine and 2-oxoglutarate into pyruvate and L-</p>

Aspartate Aminotransferase, Human is a biocatalyst and serves as a pivotal enzyme in new biotechnology. Enzyme engineering aims to improve the reaction kinetics, substrate specificity, and activity under extreme conditions (such as low or high pH). By introducing stimuli-responsive modifications to these enzymes, the dynamic regulation of activity can also be achieved.

<p>α-Lactose (hydrate) (α-D-Lactose (hydrate)), the main carbohydrate in mammalian milk, comprises two sugar units: glucose and galactose, and occurs as two</p>

<p>Calcium gluconate monohydrate is a useful organic compound for research related to life sciences. The catalog number is T35350 and the CAS number is 66905-23-5.</p>

<p>Lipoxygenase (LOX) is a dioxygenase that catalyzes the peroxidation of linoleic acid (LA) or arachidonic acid (AA) in the presence of molecular oxygen.</p>

<p>Amidases, belonging to the nitrilase superfamily, catalyze amide hydrolysis to yield carboxylic acid and ammonia.</p>

<p>α-Amylase/α-Glucosidase-IN-13 (Compound 5d) is a dual inhibitor of α-amylase and α-glucosidase, and is useful in diabetes research.</p>

<p>Carboxypeptidase B degrades peptides from C-terminal, freeing amino acids, and targets basic residues.</p>

RORγ Allosteric Probe-1 (Compound 12h), with excitation and emission wavelengths of 490/524 nm respectively, serves as an allosteric fluorescent probe for investigating RORγ allosteric inhibitors and the function of RORγ [1].

<p>Compound 4d, known as hCA XII-IN-6, is a potent inhibitor of human carbonic anhydrase XII (hCA XII) with a Ki value of 84.2 nM and exhibits anti-proliferative</p>

Creatine Kinase (CPK/CK), Bovine Heart (CK, CPK, Creatine Phosphokinase), is a biological material or organic compound suitable for use in life sciences research.

<p>TC HSD 21 is a potent and highly selective inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (IC50 = 14 nM).</p>

<p>α-Glucosidase-IN-65 (compound 5) is a Schiff base derivative of 3,4-dihydroxyphenylacetic acid. It acts as a potent α-glucosidase inhibitor with an IC50 of 12.84 μM.</p>

<p>SHP2-IN-36 (Compound B8) is an allosteric inhibitor of SHP2 with an IC50 of 9.0 nM, and it exhibits an IC50 of 40 nM against p-ERK. Moreover, SHP2-IN-36 demonstrates significant antitumor activity in the KYSE520 xenograft mouse model and is applicable for research in the field of antitumor studies.</p>

<p>O-Desisobutyl-O-n-propyl Febuxostat, an xanthine oxidase inhibitor.</p>

ASP8477 is a potent and selective FAAH inhibitor. It increases anandamide levels in the brain when administered orally. In rat models of neuropathic and osteoarthritic pain, ASP8477 demonstrates significant efficacy without causing motor coordination issues. A single oral dose of ASP8477 improves thermal hyperalgesia and cold allodynia in rats with chronic constriction nerve injury. Moreover, ASP8477 restores the decreased muscle pressure threshold in a myalgia model induced by reserpine. Research indicates that ASP8477 possesses analgesic effects effective for alleviating neuropathic and functional pain, making its pharmacological properties suitable for chronic pain treatment.

<p>Alpha-2-3,6-sialidase (BiNanH2) is a sialyltransferase for biochemical studies, transferring sialic acid to galactosides.</p>

<p>CAY10434, a potent CYP4A hydroxylase inhibitor, has an IC50 of 8.8 nM and boosts angiotensin II contraction, Emax 6764 mg.</p>

<p>BBOX-IN-1 (compound 58) is a potent BBOX inhibitor with an IC50 of 0.02 μM, and it is applicable in research related to triple-negative breast cancer (TNBC).</p>

<p>Trimetazidine-N-oxide, main active metabolite of Trimetazidine, blocks 3-ketoyl CoA thiolase (IC50: 75nM) and has multiple protective properties.</p>

<p>16,16-dimethyl PGA2, a stable analog of PGA2, greatly reduces Sendai virus growth and helps mice survive influenza and cancer.</p>

<p>BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.</p>

<p>α-glucosidase/PTP1B-IN-1 (compound 8a) is an effective inhibitor of both α-glucosidase and PTP1B, with IC50 values of 66.3 μM and 47.0 μM, respectively. It also exhibits strong inhibitory activity against α-amylase, having an IC50 of 30.62 μM. This compound is capable of binding to the active sites of α-glucosidase and PTP1B. α-glucosidase/PTP1B-IN-1 holds potential for reducing postprandial blood glucose levels and may be useful in managing type 2 diabetes.</p>

<p>IRC-083864 is a novel bis quinone CDC25 phosphatase active inhibitor against human cancer cells.</p>

<p>Ilexoside XLVIII, a triterpene saponin from Ilex kudincha leaves, inhibits ACAT.</p>

<p>TKL-IN-1 (compound 7r) serves as an inhibitor of transketolase (Transketolase) and can be utilized as an herbicide. This compound effectively hampers the growth of Digitaria sanguinalis (Ds) and Amaranthus retroflexus (Ar).</p>

<p>2-Nitrophenyl a-D-glucopyranoside is a substrate of β-glucosidase [1] .</p>

<p>DSPE-PEG5000-MPG is a PEG compound composed of DSPE and a peptide carrier (MPG). MPG is derived from the nuclear localization sequence (NLS) of the SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. This compound effectively delivers short oligonucleotides into cells independently of the endosomal pathway.</p>

<p>Cholesterol glucuronide is an endogenous metabolite of lipid generated by UDP glucuonyltransferase in the liver.</p>

<p>Plipastatin B 1 is a lipopeptide.</p>

<p>Berninamycin D, a cyclic peptide derived from Streptomyces bernensis through fermentation, is recognized as a fungal metabolite [1].</p>

<p>Angiotensin pentapeptide is a peptide.</p>

<p>Pepsin A is a protease and endopeptidase in the stomach, capable of breaking down proteins in food into small peptide fragments.</p>

<p>CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiological</p>

<p>DOTA-XYIMSR-01 is a molecular probe targeting CAIX, capable of being labeled with 177Lu for the treatment and localization of malignant gliomas. The uptake of [177Lu]Lu-XYIMSR-01 in U87MG tumors is 6.19% injected dose per gram (% ID/g), with a tumor-to-muscle uptake ratio of 20.14. In an orthotopic glioma model, co-administration with temozolomide significantly enhances survival rates and inhibits tumor growth in mice. DOTA-XYIMSR-01 shows potential for research in the field of cancer treatment.</p>

<p>DF-461 is an inhibitor of squalene synthase.</p>

<p>Laurencin is a component of the sea hare, Aplysia dactylomela.</p>

<p>Hexaglutamate folate, a natural folic acid form, requires deconjugation for absorption; its deficiency can lead to anemia and numerous chronic diseases.</p>

<p>23,25-Dihydroxy-24-oxovitamin D3, a prominent metabolite of 24(R),25-Dihydroxyvitamin D3, holds significant potential for studying metabolic disorders[1].</p>

<p>DSPE-PEG5000-K237 is a PEG compound composed of DSPE and the KDR-targeting peptide (K237). K237 effectively disrupts the interaction between VEGF and KDR receptors, yielding significant biological effects, such as inhibiting angiogenesis and tumor growth. DSPE-PEG5000-K237 is applicable for drug delivery.</p>

<p>N-Nitrosoglyphosate sodium, a nitrosamine degradation product and synthetic impurity of glyphosate herbicide [1], is a chemical compound resulting from the</p>

<p>Etavopivat activates PKR in RBCs; taken orally, prevents sickling.</p>

<p>Lurasidone metabolite 14326, an active metabolite of the atypical antipsychotic Lurasidone, functions effectively in the body.</p>

<p>ROC-0929 (13a) is a selective sPLA2 inhibitor with IC50 of 80 nM, targeting hGX and blocking ERK1/2, p-38 phosphorylation for inflammation research.</p>

<p>Impurity F of Calcipotriol is a impurity of Calcipotriol. Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.</p>

<p>DSPE-PEG1000-APRPG is a PEG compound composed of DSPE and the APRPG peptide. It is applicable for drug delivery.</p>

<p>CAXII-IN-2 (compound 3j) is a highly effective inhibitor of CAXII. It demonstrates inhibitory activity against CA IX and CAXII, with Ki values of 27.4 nM and 4.0 nM, respectively.</p>

<p>Myristelaidic Acid is a natural product for research related to life sciences. The catalog number is T37358 and the CAS number is 50286-30-1.</p>

<p>SHR168442 is a potent RORγ modulator, exhibiting an IC50 value of 0.035 μM.</p>